ENSG00000068097

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000184956 ENSG00000068097 HEK293_OSMI2_2hA HEK293_TMG_2hB HEATR6 protein_coding protein_coding 17.3098 15.6793 15.21677 1.108332 0.5274471 -0.04317158 4.4874992 5.1809949 4.8977947 0.7705375 0.1343494 -0.08093618 0.26397917 0.34133333 0.323300000 -0.01803333 0.982382982 0.001225127 FALSE  
ENST00000583979 ENSG00000068097 HEK293_OSMI2_2hA HEK293_TMG_2hB HEATR6 protein_coding miRNA 17.3098 15.6793 15.21677 1.108332 0.5274471 -0.04317158 3.1387303 2.8094988 1.9944133 1.4071326 0.5817555 -0.49225875 0.17565833 0.16746667 0.128933333 -0.03853333 0.991024060 0.001225127    
ENST00000585976 ENSG00000068097 HEK293_OSMI2_2hA HEK293_TMG_2hB HEATR6 protein_coding protein_coding 17.3098 15.6793 15.21677 1.108332 0.5274471 -0.04317158 1.1276588 0.8309047 0.4283971 0.4991278 0.3151386 -0.93970398 0.06445000 0.04930000 0.027833333 -0.02146667 0.902644798 0.001225127 FALSE  
ENST00000587003 ENSG00000068097 HEK293_OSMI2_2hA HEK293_TMG_2hB HEATR6 protein_coding nonsense_mediated_decay 17.3098 15.6793 15.21677 1.108332 0.5274471 -0.04317158 1.8915311 1.1605083 1.3250149 0.5891395 0.6816962 0.18972061 0.10684167 0.06923333 0.089466667 0.02023333 0.991821189 0.001225127 FALSE  
ENST00000587314 ENSG00000068097 HEK293_OSMI2_2hA HEK293_TMG_2hB HEATR6 protein_coding nonsense_mediated_decay 17.3098 15.6793 15.21677 1.108332 0.5274471 -0.04317158 0.9190348 1.8837857 0.1393946 0.9424328 0.1393946 -3.66407365 0.05106250 0.12640000 0.008833333 -0.11756667 0.414401255 0.001225127 FALSE  
ENST00000590587 ENSG00000068097 HEK293_OSMI2_2hA HEK293_TMG_2hB HEATR6 protein_coding nonsense_mediated_decay 17.3098 15.6793 15.21677 1.108332 0.5274471 -0.04317158 1.0549012 0.3003127 1.3031670 0.0554684 0.3078180 2.08125553 0.06106667 0.01950000 0.084633333 0.06513333 0.001225127 0.001225127 FALSE  
MSTRG.14800.6 ENSG00000068097 HEK293_OSMI2_2hA HEK293_TMG_2hB HEATR6 protein_coding   17.3098 15.6793 15.21677 1.108332 0.5274471 -0.04317158 2.2771169 1.8894425 2.3830878 0.9572806 0.5073216 0.33329727 0.13337083 0.12443333 0.155433333 0.03100000 0.835830887 0.001225127 FALSE  
MSTRG.14800.7 ENSG00000068097 HEK293_OSMI2_2hA HEK293_TMG_2hB HEATR6 protein_coding   17.3098 15.6793 15.21677 1.108332 0.5274471 -0.04317158 0.8650183 0.7486853 1.2683903 0.5012299 0.2115481 0.75275482 0.05184583 0.04486667 0.084066667 0.03920000 0.581679170 0.001225127 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000068097 E001 110.3922806 0.0086674359 6.757928e-01 7.809525e-01 17 60041008 60043024 2017 - 2.024 2.061 0.125
ENSG00000068097 E002 172.8271336 0.0046578259 2.060852e-03 7.414301e-03 17 60043025 60043491 467 - 2.151 2.289 0.460
ENSG00000068097 E003 129.9369822 0.0041899249 1.121895e-04 5.778833e-04 17 60043492 60043562 71 - 2.002 2.182 0.602
ENSG00000068097 E004 123.7307480 0.0043526146 9.588412e-05 5.027249e-04 17 60043563 60043661 99 - 1.977 2.163 0.621
ENSG00000068097 E005 68.8456003 0.0062061778 7.239622e-03 2.184687e-02 17 60043662 60043672 11 - 1.741 1.902 0.542
ENSG00000068097 E006 128.3097873 0.0039405056 5.877170e-05 3.253498e-04 17 60043673 60043799 127 - 1.993 2.176 0.613
ENSG00000068097 E007 208.4174648 0.0003036870 4.831214e-07 4.284720e-06 17 60043800 60044134 335 - 2.233 2.368 0.452
ENSG00000068097 E008 95.5556489 0.0002847133 6.936177e-04 2.875608e-03 17 60046025 60046099 75 - 1.899 2.031 0.446
ENSG00000068097 E009 112.6437023 0.0002665093 7.007205e-06 4.826198e-05 17 60046100 60046229 130 - 1.953 2.114 0.540
ENSG00000068097 E010 76.1771903 0.0005792693 3.677255e-02 8.503448e-02 17 60047309 60047363 55 - 1.826 1.920 0.318
ENSG00000068097 E011 72.0254481 0.0024660644 2.497443e-01 3.856236e-01 17 60047364 60047405 42 - 1.821 1.882 0.205
ENSG00000068097 E012 93.8242845 0.0064005552 3.448052e-01 4.889028e-01 17 60048264 60048369 106 - 1.940 1.993 0.176
ENSG00000068097 E013 45.3647924 0.0097873891 3.170162e-01 4.598533e-01 17 60048370 60048388 19 - 1.614 1.687 0.248
ENSG00000068097 E014 102.1990982 0.0024358086 3.717423e-01 5.162114e-01 17 60049580 60049702 123 - 1.983 2.027 0.146
ENSG00000068097 E015 52.8293988 0.0004349323 3.033584e-01 4.452579e-01 17 60050843 60050860 18 - 1.752 1.711 -0.141
ENSG00000068097 E016 105.1210849 0.0003185598 2.838897e-01 4.240851e-01 17 60050861 60050977 117 - 1.996 2.041 0.151
ENSG00000068097 E017 95.2098288 0.0022914697 6.348009e-01 7.491971e-01 17 60055515 60055601 87 - 1.966 1.993 0.091
ENSG00000068097 E018 100.2205724 0.0003748819 7.589766e-01 8.434423e-01 17 60056115 60056237 123 - 2.005 2.002 -0.010
ENSG00000068097 E019 42.0900411 0.0005360952 3.485250e-02 8.136717e-02 17 60057048 60057056 9 - 1.689 1.583 -0.358
ENSG00000068097 E020 159.8966747 0.0002708672 1.430213e-01 2.521399e-01 17 60057057 60057403 347 - 2.222 2.189 -0.111
ENSG00000068097 E021 84.3984208 0.0003297820 6.918183e-01 7.932025e-01 17 60059422 60059521 100 - 1.934 1.926 -0.024
ENSG00000068097 E022 115.7508684 0.0024150244 6.420046e-01 7.549243e-01 17 60059890 60060096 207 - 2.069 2.058 -0.036
ENSG00000068097 E023 92.1872634 0.0134199044 9.406333e-01 9.666876e-01 17 60066209 60066386 178 - 1.961 1.963 0.006
ENSG00000068097 E024 0.0000000       17 60066387 60066396 10 -      
ENSG00000068097 E025 2.0744338 0.0373302371 9.817681e-01 9.926432e-01 17 60067431 60067433 3 - 0.491 0.493 0.012
ENSG00000068097 E026 117.7422137 0.0051875682 7.623899e-02 1.534899e-01 17 60067434 60067732 299 - 2.112 2.036 -0.255
ENSG00000068097 E027 67.9567466 0.0086771866 6.992277e-03 2.120416e-02 17 60069711 60069808 98 - 1.919 1.756 -0.550
ENSG00000068097 E028 45.5033002 0.0036830043 6.241730e-03 1.924824e-02 17 60069809 60069848 40 - 1.744 1.591 -0.521
ENSG00000068097 E029 61.8312088 0.0124550265 6.110733e-03 1.889934e-02 17 60070706 60070807 102 - 1.891 1.705 -0.627
ENSG00000068097 E030 29.4975148 0.0042544152 1.613489e-03 6.003670e-03 17 60072215 60072220 6 - 1.592 1.381 -0.725
ENSG00000068097 E031 64.5465399 0.0050017589 8.124399e-05 4.338670e-04 17 60072221 60072329 109 - 1.921 1.715 -0.697
ENSG00000068097 E032 50.2032904 0.0005036733 1.046375e-06 8.646630e-06 17 60073164 60073235 72 - 1.824 1.590 -0.791
ENSG00000068097 E033 46.4984923 0.0004968292 1.810132e-09 2.555511e-08 17 60073236 60073279 44 - 1.821 1.521 -1.021
ENSG00000068097 E034 53.6606458 0.0005290636 2.886748e-10 4.711689e-09 17 60073746 60073845 100 - 1.879 1.583 -1.001
ENSG00000068097 E035 35.0346271 0.0019897456 2.174589e-04 1.038648e-03 17 60073846 60073886 41 - 1.663 1.443 -0.753
ENSG00000068097 E036 6.7750137 0.0273066057 8.048703e-03 2.390272e-02 17 60073887 60073961 75 - 1.060 0.694 -1.411
ENSG00000068097 E037 12.4881729 0.0014340529 5.000387e-04 2.160240e-03 17 60073962 60074086 125 - 1.282 0.963 -1.148
ENSG00000068097 E038 13.3393080 0.0013906012 1.963053e-02 5.069696e-02 17 60074087 60074159 73 - 1.258 1.054 -0.730
ENSG00000068097 E039 0.5954526 0.0172671820 2.576629e-02 6.345795e-02 17 60075615 60075704 90 - 0.380 0.000 -10.461
ENSG00000068097 E040 0.7813216 0.0696001053 8.115065e-01 8.803788e-01 17 60075705 60075833 129 - 0.230 0.280 0.371
ENSG00000068097 E041 59.1919724 0.0005446901 2.639512e-08 3.005816e-07 17 60076130 60076237 108 - 1.902 1.656 -0.833
ENSG00000068097 E042 0.3289534 0.0295628372 9.093380e-01   17 60076273 60076701 429 - 0.130 0.115 -0.202
ENSG00000068097 E043 57.4744058 0.0004447609 2.616308e-06 1.985307e-05 17 60078696 60078807 112 - 1.871 1.662 -0.707
ENSG00000068097 E044 37.0461101 0.0005846076 4.348652e-04 1.908625e-03 17 60078808 60078919 112 - 1.676 1.483 -0.657
ENSG00000068097 E045 4.4684198 0.0038613882 1.776842e-01 2.982161e-01 17 60078920 60078928 9 - 0.819 0.638 -0.742
ENSG00000068097 E046 6.7994241 0.1275352069 5.415389e-01 6.725067e-01 17 60079007 60079803 797 - 0.939 0.867 -0.276