ENSG00000068078

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340107 ENSG00000068078 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR3 protein_coding protein_coding 38.91011 38.80915 45.59805 4.198487 4.46664 0.23252 1.115162 3.365986 0.7631455 0.6033181 0.4435919 -2.1264969 0.02945833 0.08746667 0.01703333 -0.07043333 2.106646e-01 8.821544e-08 FALSE TRUE
ENST00000352904 ENSG00000068078 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR3 protein_coding protein_coding 38.91011 38.80915 45.59805 4.198487 4.46664 0.23252 1.896019 2.588801 0.5184302 0.2235003 0.2081339 -2.2980614 0.05041250 0.06936667 0.01110000 -0.05826667 6.685464e-03 8.821544e-08 FALSE TRUE
ENST00000440486 ENSG00000068078 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR3 protein_coding protein_coding 38.91011 38.80915 45.59805 4.198487 4.46664 0.23252 12.829563 12.215556 13.3687889 1.6567983 1.3032899 0.1300475 0.33524167 0.31290000 0.29983333 -0.01306667 9.231849e-01 8.821544e-08 FALSE TRUE
ENST00000469068 ENSG00000068078 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR3 protein_coding retained_intron 38.91011 38.80915 45.59805 4.198487 4.46664 0.23252 6.624889 3.663021 9.9326328 0.3836483 1.6516367 1.4366606 0.16752917 0.09466667 0.21533333 0.12066667 8.821544e-08 8.821544e-08 FALSE FALSE
ENST00000474521 ENSG00000068078 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR3 protein_coding retained_intron 38.91011 38.80915 45.59805 4.198487 4.46664 0.23252 4.763532 1.982664 7.0005753 1.1168988 1.0760864 1.8148346 0.11911250 0.04613333 0.15223333 0.10610000 9.912567e-02 8.821544e-08 FALSE FALSE
MSTRG.24448.12 ENSG00000068078 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR3 protein_coding   38.91011 38.80915 45.59805 4.198487 4.46664 0.23252 3.137195 5.930163 0.5431768 1.2964098 0.5431768 -3.4246900 0.08406667 0.15356667 0.01320000 -0.14036667 3.951722e-02 8.821544e-08 FALSE TRUE
MSTRG.24448.4 ENSG00000068078 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR3 protein_coding   38.91011 38.80915 45.59805 4.198487 4.46664 0.23252 1.001982 0.000000 4.2484505 0.0000000 2.3531853 8.7341848 0.02401667 0.00000000 0.09400000 0.09400000 1.935282e-01 8.821544e-08 FALSE TRUE
MSTRG.24448.8 ENSG00000068078 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR3 protein_coding   38.91011 38.80915 45.59805 4.198487 4.46664 0.23252 2.511668 3.504799 2.6291147 0.1799640 0.8869409 -0.4133882 0.06437917 0.09296667 0.05633333 -0.03663333 4.634874e-01 8.821544e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000068078 E001 0.7490443 0.0784144898 1.679537e-02 4.448499e-02 4 1793293 1793300 8 + 0.424 0.000 -11.748
ENSG00000068078 E002 0.7490443 0.0784144898 1.679537e-02 4.448499e-02 4 1793301 1793302 2 + 0.424 0.000 -11.761
ENSG00000068078 E003 9.9574390 0.0187395084 6.843792e-08 7.176265e-07 4 1793303 1793311 9 + 1.283 0.624 -2.502
ENSG00000068078 E004 14.1017286 0.0329031232 1.190702e-07 1.192887e-06 4 1793312 1793348 37 + 1.422 0.765 -2.397
ENSG00000068078 E005 17.1181510 0.0498206703 1.962193e-07 1.883110e-06 4 1793349 1793391 43 + 1.510 0.812 -2.516
ENSG00000068078 E006 19.2088933 0.0392519884 3.469026e-08 3.859506e-07 4 1793392 1793465 74 + 1.552 0.874 -2.420
ENSG00000068078 E007 23.6594931 0.0316810914 3.335143e-15 1.178353e-13 4 1793833 1793895 63 + 1.686 0.716 -3.501
ENSG00000068078 E008 89.5618184 0.0084399716 2.401666e-07 2.267347e-06 4 1793896 1794043 148 + 2.077 1.816 -0.877
ENSG00000068078 E009 287.6615002 0.0019958025 1.194646e-05 7.797489e-05 4 1799254 1799523 270 + 2.502 2.411 -0.301
ENSG00000068078 E010 199.7646761 0.0026662808 7.242350e-05 3.918887e-04 4 1799747 1799800 54 + 2.350 2.249 -0.336
ENSG00000068078 E011 130.2380212 0.0048797911 2.495396e-03 8.750350e-03 4 1799801 1799812 12 + 2.166 2.065 -0.336
ENSG00000068078 E012 226.3923276 0.0010095000 4.357445e-03 1.414141e-02 4 1801367 1801461 95 + 2.374 2.332 -0.142
ENSG00000068078 E013 208.5500527 0.0008426934 8.199105e-01 8.863264e-01 4 1801462 1801536 75 + 2.300 2.329 0.099
ENSG00000068078 E014 118.2665514 0.0104445117 3.753582e-01 5.197893e-01 4 1801620 1801628 9 + 2.024 2.108 0.280
ENSG00000068078 E015 273.4476920 0.0023071136 3.515066e-01 4.957445e-01 4 1801629 1801743 115 + 2.394 2.460 0.222
ENSG00000068078 E016 225.2054000 0.0005866926 1.676325e-01 2.851130e-01 4 1801835 1801911 77 + 2.345 2.345 0.002
ENSG00000068078 E017 150.1416083 0.0013672038 1.859539e-01 3.086853e-01 4 1801912 1801923 12 + 2.175 2.167 -0.026
ENSG00000068078 E018 231.6348857 0.0025383626 1.761633e-01 2.962357e-01 4 1801924 1801986 63 + 2.363 2.357 -0.019
ENSG00000068078 E019 183.0384547 0.0058852183 6.935631e-02 1.422948e-01 4 1801987 1802025 39 + 2.282 2.240 -0.141
ENSG00000068078 E020 107.6574254 0.0024956653 6.029186e-01 7.237946e-01 4 1802914 1803064 151 + 2.019 2.034 0.049
ENSG00000068078 E021 19.4719235 0.0649936664 7.487635e-05 4.036394e-04 4 1803065 1803152 88 + 1.515 0.988 -1.865
ENSG00000068078 E022 277.1979535 0.0004518799 1.359273e-08 1.634363e-07 4 1803692 1803836 145 + 2.487 2.393 -0.316
ENSG00000068078 E023 362.1701947 0.0009348430 4.452423e-01 5.868099e-01 4 1804330 1804491 162 + 2.541 2.561 0.068
ENSG00000068078 E024 189.8855115 0.0001949094 1.270585e-01 2.300392e-01 4 1804492 1804520 29 + 2.275 2.271 -0.014
ENSG00000068078 E025 53.3703626 0.0004944735 7.147771e-10 1.090540e-08 4 1804521 1804820 300 + 1.860 1.596 -0.894
ENSG00000068078 E026 53.2055945 0.0053377136 1.296128e-04 6.570713e-04 4 1804821 1804823 3 + 1.824 1.632 -0.652
ENSG00000068078 E027 409.4595922 0.0001339081 1.272699e-02 3.527021e-02 4 1804824 1804969 146 + 2.610 2.602 -0.029
ENSG00000068078 E028 374.7316259 0.0002922480 2.386323e-02 5.952438e-02 4 1805355 1805476 122 + 2.573 2.564 -0.028
ENSG00000068078 E029 384.7521644 0.0001311725 8.239109e-02 1.632851e-01 4 1805559 1805669 111 + 2.577 2.581 0.013
ENSG00000068078 E030 424.1345503 0.0001520477 1.778675e-01 2.984629e-01 4 1805750 1805940 191 + 2.587 2.647 0.199
ENSG00000068078 E031 377.9073646 0.0018124290 9.845521e-01 9.944045e-01 4 1806051 1806173 123 + 2.552 2.589 0.125
ENSG00000068078 E032 261.8917766 0.0053770268 9.552194e-01 9.758861e-01 4 1806257 1806327 71 + 2.391 2.433 0.141
ENSG00000068078 E033 430.5754427 0.0021757230 4.706525e-01 6.098911e-01 4 1806546 1806683 138 + 2.594 2.655 0.205
ENSG00000068078 E034 423.8249749 0.0005392787 9.836917e-04 3.903755e-03 4 1806829 1806934 106 + 2.561 2.665 0.347
ENSG00000068078 E035 25.6051649 0.0008295582 5.891493e-01 7.122373e-01 4 1807113 1807115 3 + 1.423 1.420 -0.009
ENSG00000068078 E036 2037.2601785 0.0043960278 1.755734e-09 2.486310e-08 4 1807116 1809860 2745 + 3.182 3.385 0.675