ENSG00000068024

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000493582 ENSG00000068024 HEK293_OSMI2_2hA HEK293_TMG_2hB HDAC4 protein_coding retained_intron 3.195772 3.866564 3.239944 0.4360617 0.1916021 -0.2543636 0.2287214 0.3274556 0.07146179 0.04816093 0.02330346 -2.0505025 0.07193750 0.08503333 0.02146667 -0.06356667 0.01846771 0.01499257 FALSE TRUE
ENST00000543185 ENSG00000068024 HEK293_OSMI2_2hA HEK293_TMG_2hB HDAC4 protein_coding protein_coding 3.195772 3.866564 3.239944 0.4360617 0.1916021 -0.2543636 1.3795427 1.6318605 1.47680447 0.25709640 0.10645225 -0.1431166 0.43517917 0.41830000 0.46196667 0.04366667 0.83742443 0.01499257 FALSE TRUE
ENST00000690129 ENSG00000068024 HEK293_OSMI2_2hA HEK293_TMG_2hB HDAC4 protein_coding retained_intron 3.195772 3.866564 3.239944 0.4360617 0.1916021 -0.2543636 0.2751664 0.6207422 0.12795735 0.23248311 0.12795735 -2.1928281 0.08145000 0.17536667 0.03533333 -0.14003333 0.21813201 0.01499257 FALSE TRUE
MSTRG.20150.3 ENSG00000068024 HEK293_OSMI2_2hA HEK293_TMG_2hB HDAC4 protein_coding   3.195772 3.866564 3.239944 0.4360617 0.1916021 -0.2543636 0.5879850 0.4707588 0.78992005 0.09521918 0.02665038 0.7345427 0.19334167 0.11950000 0.24580000 0.12630000 0.01499257 0.01499257 FALSE TRUE
MSTRG.20150.5 ENSG00000068024 HEK293_OSMI2_2hA HEK293_TMG_2hB HDAC4 protein_coding   3.195772 3.866564 3.239944 0.4360617 0.1916021 -0.2543636 0.1111593 0.0000000 0.28548681 0.00000000 0.16862168 4.8850218 0.03168333 0.00000000 0.08366667 0.08366667 0.15910424 0.01499257 FALSE TRUE
MSTRG.20150.7 ENSG00000068024 HEK293_OSMI2_2hA HEK293_TMG_2hB HDAC4 protein_coding   3.195772 3.866564 3.239944 0.4360617 0.1916021 -0.2543636 0.1763833 0.1020688 0.13436430 0.01394799 0.02255036 0.3653292 0.05664583 0.02640000 0.04236667 0.01596667 0.52678120 0.01499257 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000068024 E001 0.5117019 0.0299897671 0.1050005625 0.198099589 2 239048168 239048171 4 - 0.000 0.288 10.788
ENSG00000068024 E002 348.3922358 0.0097342128 0.0423562180 0.095370223 2 239048172 239052786 4615 - 2.477 2.581 0.347
ENSG00000068024 E003 43.5007275 0.0005234951 0.9994109100 1.000000000 2 239052787 239053045 259 - 1.628 1.651 0.078
ENSG00000068024 E004 25.8387848 0.0007315500 0.5450449295 0.675448262 2 239053046 239053136 91 - 1.384 1.448 0.219
ENSG00000068024 E005 32.5377579 0.0006735580 0.8322392002 0.894869229 2 239053460 239053601 142 - 1.500 1.536 0.122
ENSG00000068024 E006 23.8519596 0.0131551817 0.3943203120 0.538173593 2 239054749 239054833 85 - 1.419 1.369 -0.175
ENSG00000068024 E007 0.5944058 0.1749859566 0.6822152760 0.785689936 2 239055184 239055340 157 - 0.126 0.216 0.933
ENSG00000068024 E008 28.1961822 0.0007232057 0.4266389575 0.569450108 2 239066722 239066855 134 - 1.477 1.448 -0.099
ENSG00000068024 E009 0.8114855 0.2134409617 0.6817708902 0.785392088 2 239066856 239066981 126 - 0.303 0.212 -0.679
ENSG00000068024 E010 23.7668369 0.0008511097 0.1930235919 0.317564318 2 239068489 239068607 119 - 1.419 1.350 -0.239
ENSG00000068024 E011 0.5848540 0.0343162732 0.1054267711 0.198748027 2 239080918 239081094 177 - 0.000 0.289 13.245
ENSG00000068024 E012 21.3406634 0.0024081958 0.0533366281 0.115087635 2 239081095 239081192 98 - 1.402 1.278 -0.433
ENSG00000068024 E013 26.7661912 0.0038307609 0.0625982887 0.131027303 2 239082102 239082221 120 - 1.491 1.381 -0.379
ENSG00000068024 E014 21.4836224 0.0010755076 0.0074614623 0.022415979 2 239084155 239084242 88 - 1.430 1.255 -0.609
ENSG00000068024 E015 13.6566782 0.0014355734 0.1562244001 0.270085543 2 239087559 239087614 56 - 1.208 1.102 -0.380
ENSG00000068024 E016 0.5212538 0.0212059450 0.6407339800 0.753935543 2 239089676 239090008 333 - 0.126 0.212 0.901
ENSG00000068024 E017 18.2504703 0.0151635139 0.7089708400 0.806484811 2 239090009 239090116 108 - 1.276 1.267 -0.030
ENSG00000068024 E018 0.0000000       2 239090117 239090410 294 -      
ENSG00000068024 E019 2.1014877 0.0072429030 0.3446626771 0.488751985 2 239091144 239091894 751 - 0.371 0.546 0.903
ENSG00000068024 E020 5.4153437 0.0034322602 0.0055584610 0.017441553 2 239094574 239094889 316 - 0.526 0.932 1.680
ENSG00000068024 E021 2.7477637 0.0173664089 0.0008285426 0.003361277 2 239094890 239095009 120 - 0.126 0.734 3.714
ENSG00000068024 E022 17.7350009 0.0013662220 0.3068660046 0.449044429 2 239095010 239095056 47 - 1.199 1.305 0.374
ENSG00000068024 E023 0.2214452 0.0366202116 0.5430234916   2 239102609 239102775 167 - 0.000 0.119 11.715
ENSG00000068024 E024 11.5736709 0.0014977780 0.4171833882 0.560566491 2 239102776 239102790 15 - 1.032 1.133 0.366
ENSG00000068024 E025 21.3978066 0.0010992695 0.0844861395 0.166579718 2 239102791 239102896 106 - 1.243 1.397 0.536
ENSG00000068024 E026 23.9637322 0.0009583147 0.2977090646 0.439063937 2 239108050 239108183 134 - 1.326 1.423 0.336
ENSG00000068024 E027 24.5656176 0.0009692330 0.9272815187 0.958230500 2 239111526 239111712 187 - 1.378 1.407 0.101
ENSG00000068024 E028 25.5482522 0.0007870666 0.8538472092 0.909579970 2 239115053 239115310 258 - 1.408 1.418 0.034
ENSG00000068024 E029 18.8566227 0.0043713844 0.1921346192 0.316433341 2 239126456 239126632 177 - 1.199 1.333 0.472
ENSG00000068024 E030 11.9555768 0.0310269531 0.6820412780 0.785599390 2 239126633 239126679 47 - 1.058 1.129 0.258
ENSG00000068024 E031 4.6436757 0.0048055345 0.0984073172 0.188088404 2 239126680 239126694 15 - 0.568 0.824 1.074
ENSG00000068024 E032 13.7929518 0.0029292246 0.9071197761 0.945020980 2 239134245 239134324 80 - 1.160 1.171 0.039
ENSG00000068024 E033 8.7129388 0.0027813331 0.8603996547 0.913949893 2 239134325 239134348 24 - 0.989 0.991 0.007
ENSG00000068024 E034 14.6873687 0.0012253526 0.6415548003 0.754561223 2 239134349 239134443 95 - 1.199 1.181 -0.066
ENSG00000068024 E035 19.6068099 0.0013456064 0.5088514255 0.644228206 2 239134527 239134643 117 - 1.326 1.298 -0.099
ENSG00000068024 E036 16.3807124 0.0012763785 0.3684926874 0.512900301 2 239139684 239139796 113 - 1.259 1.207 -0.185
ENSG00000068024 E037 0.0000000       2 239140878 239140973 96 -      
ENSG00000068024 E038 14.5479865 0.0154898210 0.1910906861 0.315116747 2 239144583 239144714 132 - 1.235 1.127 -0.384
ENSG00000068024 E039 0.0000000       2 239154618 239155013 396 -      
ENSG00000068024 E040 0.0000000       2 239155481 239155575 95 -      
ENSG00000068024 E041 17.3610936 0.0010933893 0.0490699277 0.107501019 2 239156652 239156773 122 - 1.326 1.190 -0.481
ENSG00000068024 E042 10.8976580 0.0018197296 0.4660313787 0.605601681 2 239163803 239163832 30 - 1.095 1.044 -0.185
ENSG00000068024 E043 15.8184712 0.0010997212 0.4270798452 0.569922169 2 239163833 239163923 91 - 1.243 1.198 -0.158
ENSG00000068024 E044 12.5553540 0.0016715266 0.1546018197 0.267879298 2 239176413 239176452 40 - 1.190 1.079 -0.396
ENSG00000068024 E045 19.9238303 0.0362013116 0.7748687989 0.854929760 2 239176453 239176563 111 - 1.312 1.313 0.003
ENSG00000068024 E046 3.1374636 0.0529939617 0.0445296430 0.099333458 2 239186488 239187160 673 - 0.371 0.753 1.791
ENSG00000068024 E047 25.2356898 0.0373181169 0.5257801904 0.659102204 2 239189833 239190020 188 - 1.431 1.394 -0.125
ENSG00000068024 E048 14.5173084 0.0389289391 0.4020139397 0.545713594 2 239190021 239190077 57 - 1.226 1.147 -0.280
ENSG00000068024 E049 0.0000000       2 239190979 239191056 78 -      
ENSG00000068024 E050 15.6673958 0.0212724912 0.7117159661 0.808634077 2 239236593 239236664 72 - 1.217 1.204 -0.049
ENSG00000068024 E051 0.1472490 0.0424580504 0.4365392178   2 239236665 239236669 5 - 0.126 0.000 -12.492
ENSG00000068024 E052 0.0000000       2 239250990 239251200 211 -      
ENSG00000068024 E053 0.0000000       2 239298166 239298639 474 -      
ENSG00000068024 E054 0.0000000       2 239309087 239309212 126 -      
ENSG00000068024 E055 0.0000000       2 239324309 239324605 297 -      
ENSG00000068024 E056 25.2700623 0.0011982734 0.0050325489 0.016020859 2 239352678 239352918 241 - 1.496 1.325 -0.589
ENSG00000068024 E057 0.4375944 0.0260305482 0.0674698824 0.139146166 2 239400377 239400691 315 - 0.303 0.000 -14.120
ENSG00000068024 E058 2.3604757 0.0334878532 0.0148130375 0.040072047 2 239400692 239400949 258 - 0.702 0.289 -2.094
ENSG00000068024 E059 3.2367072 0.0915204905 0.0501780770 0.109477773 2 239400978 239401020 43 - 0.781 0.416 -1.653
ENSG00000068024 E060 4.6124466 0.0034901816 0.2869056077 0.427353620 2 239401402 239401671 270 - 0.805 0.679 -0.513