ENSG00000067992

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379162 ENSG00000067992 HEK293_OSMI2_2hA HEK293_TMG_2hB PDK3 protein_coding protein_coding 6.994223 8.776148 6.994073 1.076943 0.2458001 -0.3270366 0.6697375 0.9871450 0.8408736 0.3585478 0.2879727 -0.22885840 0.08848333 0.1050667 0.1218000 0.01673333 0.9555239589 0.0002130629 FALSE TRUE
ENST00000568479 ENSG00000067992 HEK293_OSMI2_2hA HEK293_TMG_2hB PDK3 protein_coding protein_coding 6.994223 8.776148 6.994073 1.076943 0.2458001 -0.3270366 2.3555497 1.2783775 3.0712390 0.4101871 0.2305779 1.25795525 0.35875417 0.1400667 0.4416333 0.30156667 0.0002130629 0.0002130629 FALSE TRUE
MSTRG.34034.1 ENSG00000067992 HEK293_OSMI2_2hA HEK293_TMG_2hB PDK3 protein_coding   6.994223 8.776148 6.994073 1.076943 0.2458001 -0.3270366 1.0192171 1.9085750 0.2722629 0.2893758 0.2722629 -2.76492384 0.15600833 0.2276333 0.0369000 -0.19073333 0.0886940625 0.0002130629 TRUE TRUE
MSTRG.34034.2 ENSG00000067992 HEK293_OSMI2_2hA HEK293_TMG_2hB PDK3 protein_coding   6.994223 8.776148 6.994073 1.076943 0.2458001 -0.3270366 0.4995805 1.4013693 0.0000000 0.7218510 0.0000000 -7.14095175 0.06153750 0.1719333 0.0000000 -0.17193333 0.1841167010 0.0002130629 FALSE TRUE
MSTRG.34034.3 ENSG00000067992 HEK293_OSMI2_2hA HEK293_TMG_2hB PDK3 protein_coding   6.994223 8.776148 6.994073 1.076943 0.2458001 -0.3270366 1.5706400 2.1520863 1.6943648 1.0161529 0.1187125 -0.34318994 0.20941250 0.2275000 0.2431667 0.01566667 0.8950821513 0.0002130629 FALSE TRUE
MSTRG.34034.4 ENSG00000067992 HEK293_OSMI2_2hA HEK293_TMG_2hB PDK3 protein_coding   6.994223 8.776148 6.994073 1.076943 0.2458001 -0.3270366 0.7360823 0.9868312 0.9479146 0.2099824 0.3270884 -0.05745211 0.10253750 0.1197667 0.1327000 0.01293333 0.9803477381 0.0002130629 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000067992 E001 0.2998086 0.0286386999 8.793371e-01   X 24382620 24382623 4 + 0.135 0.111 -0.326
ENSG00000067992 E002 7.5031323 0.0033243853 4.517533e-01 5.926813e-01 X 24382624 24382662 39 + 0.878 0.961 0.313
ENSG00000067992 E003 0.8084787 0.1289986993 1.606130e-01 2.759378e-01 X 24465244 24465269 26 + 0.390 0.112 -2.309
ENSG00000067992 E004 2.1615084 0.1383668518 3.085003e-03 1.051613e-02 X 24465270 24465285 16 + 0.760 0.112 -4.015
ENSG00000067992 E005 28.1071870 0.0195173741 1.619957e-02 4.316338e-02 X 24465286 24465561 276 + 1.582 1.346 -0.811
ENSG00000067992 E006 44.4805776 0.0118556250 3.464887e-01 4.906117e-01 X 24494742 24494883 142 + 1.697 1.620 -0.261
ENSG00000067992 E007 50.7173249 0.0069550386 5.501784e-01 6.798310e-01 X 24498829 24498900 72 + 1.734 1.683 -0.173
ENSG00000067992 E008 0.7342825 0.0163873919 9.581218e-03 2.773567e-02 X 24498901 24500155 1255 + 0.450 0.000 -12.098
ENSG00000067992 E009 82.1076384 0.0016266144 4.277824e-01 5.706096e-01 X 24503327 24503511 185 + 1.937 1.895 -0.141
ENSG00000067992 E010 42.9639152 0.0032650258 9.449241e-01 9.694407e-01 X 24505209 24505256 48 + 1.643 1.642 -0.004
ENSG00000067992 E011 46.1326288 0.0070197454 9.352631e-01 9.632347e-01 X 24505257 24505298 42 + 1.678 1.671 -0.021
ENSG00000067992 E012 56.5710805 0.0008997785 2.839433e-01 4.241385e-01 X 24518933 24519010 78 + 1.734 1.780 0.156
ENSG00000067992 E013 1.8499447 0.0076069546 6.458793e-04 2.701380e-03 X 24524183 24525396 1214 + 0.699 0.111 -3.782
ENSG00000067992 E014 1.7810697 0.1150691702 3.402114e-01 4.841722e-01 X 24525397 24526197 801 + 0.551 0.336 -1.129
ENSG00000067992 E015 56.8171670 0.0040330765 1.359815e-02 3.730169e-02 X 24526198 24526274 77 + 1.678 1.808 0.441
ENSG00000067992 E016 61.5575198 0.0007619299 1.707766e-02 4.511030e-02 X 24527574 24527675 102 + 1.731 1.835 0.352
ENSG00000067992 E017 69.9973710 0.0062014181 5.148694e-01 6.495899e-01 X 24528076 24528186 111 + 1.830 1.858 0.096
ENSG00000067992 E018 73.7597319 0.0006230942 1.255517e-01 2.279348e-01 X 24531657 24531770 114 + 1.837 1.895 0.196
ENSG00000067992 E019 83.4416046 0.0003785377 1.863881e-05 1.164638e-04 X 24533929 24534068 140 + 1.821 1.984 0.549
ENSG00000067992 E020 11.3563799 0.1120410743 7.320877e-01 8.236306e-01 X 24534069 24534656 588 + 1.047 1.120 0.263
ENSG00000067992 E021 2.3844316 0.4020386089 7.552001e-01 8.406115e-01 X 24534657 24535492 836 + 0.449 0.546 0.474
ENSG00000067992 E022 142.4586070 0.0002554646 6.341016e-10 9.764865e-09 X 24539134 24539726 593 + 2.038 2.218 0.603
ENSG00000067992 E023 40.2958418 0.0011979790 9.365631e-03 2.719595e-02 X 24539727 24540245 519 + 1.697 1.547 -0.509
ENSG00000067992 E024 898.3781376 0.0003466938 5.146965e-06 3.652384e-05 X 24540246 24550466 10221 + 2.979 2.927 -0.174