ENSG00000067955

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000290858 ENSG00000067955 HEK293_OSMI2_2hA HEK293_TMG_2hB CBFB protein_coding protein_coding 21.44582 13.83128 38.50899 4.757887 2.00288 1.476593 2.4717774 0.0000000 8.25627251 0.0000000 2.30159855 9.69109312 0.06775000 0.00000000 0.21953333 0.21953333 8.081280e-10 5.524494e-17 FALSE TRUE
ENST00000412916 ENSG00000067955 HEK293_OSMI2_2hA HEK293_TMG_2hB CBFB protein_coding protein_coding 21.44582 13.83128 38.50899 4.757887 2.00288 1.476593 9.4371077 4.0549750 18.58143381 1.0603368 1.23645696 2.19331964 0.41253750 0.30816667 0.48180000 0.17363333 4.701900e-05 5.524494e-17 FALSE TRUE
ENST00000561924 ENSG00000067955 HEK293_OSMI2_2hA HEK293_TMG_2hB CBFB protein_coding protein_coding 21.44582 13.83128 38.50899 4.757887 2.00288 1.476593 7.2804249 6.7272345 7.17927696 3.1340640 2.89008312 0.09369017 0.37515833 0.44786667 0.18103333 -0.26683333 1.569557e-01 5.524494e-17 FALSE FALSE
ENST00000565389 ENSG00000067955 HEK293_OSMI2_2hA HEK293_TMG_2hB CBFB protein_coding protein_coding 21.44582 13.83128 38.50899 4.757887 2.00288 1.476593 0.3382800 1.8860803 0.00000000 1.0620431 0.00000000 -7.56687622 0.02637500 0.12010000 0.00000000 -0.12010000 5.227499e-02 5.524494e-17   FALSE
ENST00000566281 ENSG00000067955 HEK293_OSMI2_2hA HEK293_TMG_2hB CBFB protein_coding retained_intron 21.44582 13.83128 38.50899 4.757887 2.00288 1.476593 0.1444234 0.5564117 0.03556393 0.5564117 0.03556393 -3.63588695 0.02002083 0.06623333 0.00090000 -0.06533333 8.734567e-01 5.524494e-17   FALSE
ENST00000651988 ENSG00000067955 HEK293_OSMI2_2hA HEK293_TMG_2hB CBFB protein_coding processed_transcript 21.44582 13.83128 38.50899 4.757887 2.00288 1.476593 0.5799253 0.0000000 2.48271174 0.0000000 0.05566312 7.96157225 0.03425833 0.00000000 0.06496667 0.06496667 5.524494e-17 5.524494e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000067955 E001 0.1472490 0.0479598764 1.000000e+00   16 67028984 67028996 13 + 0.062 0.000 -10.993
ENSG00000067955 E002 0.5911862 0.0172671820 3.169613e-01 4.597772e-01 16 67028997 67029027 31 + 0.209 0.000 -12.988
ENSG00000067955 E003 1.4080839 0.0093278845 3.028965e-01 4.448226e-01 16 67029116 67029148 33 + 0.349 0.227 -0.850
ENSG00000067955 E004 1.4080839 0.0093278845 3.028965e-01 4.448226e-01 16 67029149 67029149 1 + 0.349 0.227 -0.850
ENSG00000067955 E005 3.8312454 0.0053928761 2.150196e-02 5.464607e-02 16 67029150 67029178 29 + 0.673 0.375 -1.436
ENSG00000067955 E006 40.5173457 0.0166131361 3.188426e-08 3.570807e-07 16 67029179 67029336 158 + 1.599 1.148 -1.568
ENSG00000067955 E007 34.4804829 0.0355313979 4.140848e-04 1.828391e-03 16 67029337 67029346 10 + 1.517 1.191 -1.136
ENSG00000067955 E008 72.0844509 0.0046381003 5.812626e-08 6.175328e-07 16 67029347 67029421 75 + 1.815 1.630 -0.628
ENSG00000067955 E009 79.3075476 0.0089798030 9.567996e-07 7.968647e-06 16 67029422 67029460 39 + 1.857 1.662 -0.660
ENSG00000067955 E010 73.9167804 0.0047455313 8.164104e-08 8.436048e-07 16 67029461 67029485 25 + 1.826 1.656 -0.576
ENSG00000067955 E011 139.3243496 0.0036546287 1.078520e-08 1.321791e-07 16 67029727 67029813 87 + 2.087 1.988 -0.332
ENSG00000067955 E012 1.8704550 0.1862720669 8.372119e-01 8.982228e-01 16 67029814 67030177 364 + 0.378 0.486 0.575
ENSG00000067955 E013 0.1451727 0.0457035218 1.000000e+00   16 67036427 67036638 212 + 0.062 0.000 -10.988
ENSG00000067955 E014 192.7218081 0.0025966469 1.538728e-09 2.203548e-08 16 67036639 67036755 117 + 2.219 2.158 -0.203
ENSG00000067955 E015 0.2934659 0.0272305755 4.166425e-01   16 67046152 67046269 118 + 0.062 0.226 2.147
ENSG00000067955 E016 218.5714544 0.0005601752 1.192313e-08 1.449251e-07 16 67066682 67066798 117 + 2.261 2.268 0.026
ENSG00000067955 E017 0.7289840 0.4590582524 1.000000e+00 1.000000e+00 16 67066799 67066962 164 + 0.208 0.223 0.126
ENSG00000067955 E018 1.1833027 0.4072369215 6.622569e-01 7.705979e-01 16 67079560 67079782 223 + 0.318 0.223 -0.688
ENSG00000067955 E019 0.9652040 0.5647717001 6.682356e-01 7.752880e-01 16 67082085 67082212 128 + 0.210 0.377 1.153
ENSG00000067955 E020 130.1449588 0.0003125061 2.414730e-07 2.278430e-06 16 67082213 67082215 3 + 2.042 2.027 -0.049
ENSG00000067955 E021 233.7049204 0.0002888591 1.418178e-08 1.700225e-07 16 67082216 67082308 93 + 2.286 2.307 0.070
ENSG00000067955 E022 71.4061855 0.0003734227 1.563944e-01 2.703278e-01 16 67082309 67082339 31 + 1.758 1.867 0.368
ENSG00000067955 E023 0.0000000       16 67093398 67093413 16 +      
ENSG00000067955 E024 0.2966881 0.0272521070 9.301626e-01   16 67093414 67093629 216 + 0.117 0.000 -11.989
ENSG00000067955 E025 1482.5693506 0.0073957782 2.020664e-16 8.360093e-15 16 67098710 67101058 2349 + 2.996 3.315 1.061