ENSG00000067900

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000635540	ENSG00000067900	HEK293_OSMI2_2hA	HEK293_TMG_2hB	ROCK1	protein_coding	nonsense_mediated_decay	14.90725	4.855832	22.98105	0.7567614	0.4992076	2.240314	8.2415681	3.5654190	11.7960513	0.6015693	0.1780756	1.7233423	0.61300833	0.73093333	0.5134667	-0.2174667	1.565289e-08	1.565289e-08	TRUE	TRUE
MSTRG.15545.2	ENSG00000067900	HEK293_OSMI2_2hA	HEK293_TMG_2hB	ROCK1	protein_coding		14.90725	4.855832	22.98105	0.7567614	0.4992076	2.240314	0.4827848	0.6668279	0.6050419	0.0508009	0.1419111	-0.1381044	0.05441667	0.14223333	0.0265000	-0.1157333	1.208395e-05	1.565289e-08	FALSE	TRUE
MSTRG.15545.5	ENSG00000067900	HEK293_OSMI2_2hA	HEK293_TMG_2hB	ROCK1	protein_coding		14.90725	4.855832	22.98105	0.7567614	0.4992076	2.240314	4.1664286	0.1679751	7.5276337	0.1679751	0.2852441	5.4043647	0.19676667	0.03143333	0.3273333	0.2959000	2.160686e-02	1.565289e-08	FALSE	TRUE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

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featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
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HEK293_TMG_2hB
HEK293_OSMI2_2hA
log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000067900	E001	8.3773832	0.0556461733	1.400707e-02	3.824399e-02	18	20946906	20948492	1587	-	0.773	1.171	1.487
ENSG00000067900	E002	18.1497320	0.0215592388	3.164001e-05	1.872367e-04	18	20948493	20949951	1459	-	1.053	1.522	1.648
ENSG00000067900	E003	253.4940064	0.0098535313	1.532752e-17	7.325308e-16	18	20949952	20950948	997	-	2.166	2.637	1.571
ENSG00000067900	E004	29.3324546	0.0007826487	4.538047e-08	4.936944e-07	18	20950949	20950967	19	-	1.264	1.674	1.414
ENSG00000067900	E005	89.9044613	0.0003104683	1.094423e-18	6.012746e-17	18	20950968	20951083	116	-	1.749	2.139	1.309
ENSG00000067900	E006	171.3103618	0.0037124726	4.434405e-09	5.833516e-08	18	20951084	20951387	304	-	2.074	2.346	0.910
ENSG00000067900	E007	0.1451727	0.0430482626	1.000000e+00		18	20953290	20953577	288	-	0.062	0.000	-8.743
ENSG00000067900	E008	108.4041572	0.0117078548	6.949619e-03	2.109235e-02	18	20953578	20953785	208	-	1.900	2.105	0.686
ENSG00000067900	E009	74.2799826	0.0003602359	1.316162e-03	5.030726e-03	18	20954783	20954853	71	-	1.742	1.927	0.622
ENSG00000067900	E010	109.7188846	0.0002963737	4.812471e-05	2.722980e-04	18	20954854	20955044	191	-	1.906	2.098	0.642
ENSG00000067900	E011	83.1025968	0.0003094897	3.659707e-02	8.470727e-02	18	20955167	20955245	79	-	1.805	1.934	0.434
ENSG00000067900	E012	0.4396707	0.0317387611	6.339342e-01	7.485240e-01	18	20955246	20955467	222	-	0.165	0.000	-10.327
ENSG00000067900	E013	96.4394062	0.0003284035	3.001705e-04	1.380253e-03	18	20959840	20959928	89	-	1.849	2.033	0.621
ENSG00000067900	E014	99.9775195	0.0003022833	2.634653e-02	6.464103e-02	18	20960136	20960206	71	-	1.881	2.008	0.427
ENSG00000067900	E015	0.1472490	0.0441758127	1.000000e+00		18	20960663	20960711	49	-	0.062	0.000	-8.743
ENSG00000067900	E016	131.6895648	0.0015483987	1.904329e-02	4.942995e-02	18	20966917	20967076	160	-	1.998	2.130	0.441
ENSG00000067900	E017	127.8089372	0.0007685690	5.620193e-01	6.897207e-01	18	20967752	20967940	189	-	2.005	2.063	0.196
ENSG00000067900	E018	0.7406253	0.0153963212	3.093543e-01	4.516407e-01	18	20968485	20968771	287	-	0.247	0.000	-11.065
ENSG00000067900	E019	87.4502721	0.0003407956	9.040764e-01	9.429497e-01	18	20968772	20968860	89	-	1.846	1.886	0.135
ENSG00000067900	E020	84.3964093	0.0003280755	5.184495e-01	6.526810e-01	18	20969115	20969208	94	-	1.825	1.890	0.217
ENSG00000067900	E021	2.8998418	0.0131635746	6.911630e-01	7.926939e-01	18	20969209	20969354	146	-	0.539	0.487	-0.250
ENSG00000067900	E022	5.9169072	0.0305229809	2.497282e-03	8.755477e-03	18	20969958	20970347	390	-	0.844	0.228	-3.116
ENSG00000067900	E023	97.4083291	0.0026555516	6.496763e-01	7.608662e-01	18	20970348	20970513	166	-	1.900	1.914	0.047
ENSG00000067900	E024	74.5659161	0.0040479425	3.860423e-01	5.302333e-01	18	20979910	20980004	95	-	1.792	1.778	-0.048
ENSG00000067900	E025	76.7024713	0.0004006035	6.903130e-01	7.920403e-01	18	20982763	20982832	70	-	1.787	1.841	0.182
ENSG00000067900	E026	121.5623827	0.0014656228	4.597225e-01	5.998350e-01	18	20984351	20984535	185	-	1.980	2.049	0.229
ENSG00000067900	E027	136.9772725	0.0002401949	1.045699e-02	2.987912e-02	18	20986950	20987110	161	-	2.062	1.998	-0.214
ENSG00000067900	E028	113.0448192	0.0013066578	5.500880e-04	2.347023e-03	18	20991176	20991326	151	-	1.992	1.866	-0.421
ENSG00000067900	E029	95.7291913	0.0004354852	8.006978e-02	1.596651e-01	18	20992831	20992937	107	-	1.904	1.858	-0.154
ENSG00000067900	E030	150.7695023	0.0002543877	1.609501e-03	5.991418e-03	18	21006351	21006593	243	-	2.107	2.025	-0.275
ENSG00000067900	E031	51.5842260	0.0004496340	1.126196e-03	4.391545e-03	18	21006594	21006597	4	-	1.666	1.487	-0.611
ENSG00000067900	E032	84.8192828	0.0003492741	9.827636e-05	5.139068e-04	18	21006699	21006790	92	-	1.875	1.711	-0.556
ENSG00000067900	E033	102.7219904	0.0002982180	3.751867e-06	2.748463e-05	18	21008059	21008194	136	-	1.958	1.776	-0.615
ENSG00000067900	E034	71.2656900	0.0003525278	6.562314e-06	4.547888e-05	18	21015431	21015479	49	-	1.807	1.583	-0.761
ENSG00000067900	E035	1.7916537	0.1785918368	9.484707e-01	9.716901e-01	18	21017021	21017098	78	-	0.378	0.382	0.024
ENSG00000067900	E036	66.4666096	0.0003642770	6.416395e-05	3.518079e-04	18	21020151	21020236	86	-	1.775	1.575	-0.678
ENSG00000067900	E037	31.9888237	0.0006133678	2.138657e-03	7.654536e-03	18	21020237	21020239	3	-	1.469	1.244	-0.779
ENSG00000067900	E038	58.0784619	0.0004408136	3.384734e-03	1.139312e-02	18	21023620	21023680	61	-	1.711	1.567	-0.490
ENSG00000067900	E039	92.3860825	0.0006336124	1.798740e-04	8.774709e-04	18	21028776	21028935	160	-	1.911	1.760	-0.509
ENSG00000067900	E040	75.7427453	0.0003636109	4.974809e-07	4.400946e-06	18	21039472	21039563	92	-	1.839	1.590	-0.843
ENSG00000067900	E041	84.2219259	0.0025111830	1.534381e-04	7.623098e-04	18	21042097	21042235	139	-	1.874	1.694	-0.607
ENSG00000067900	E042	84.1147058	0.0044172524	4.391434e-04	1.925084e-03	18	21042565	21042709	145	-	1.873	1.695	-0.604
ENSG00000067900	E043	63.9503448	0.0033987669	2.279537e-05	1.394374e-04	18	21044102	21044186	85	-	1.767	1.516	-0.852
ENSG00000067900	E044	0.0000000				18	21045045	21045291	247	-
ENSG00000067900	E045	84.5240467	0.0002973988	5.842665e-11	1.071723e-09	18	21045292	21045467	176	-	1.896	1.567	-1.116
ENSG00000067900	E046	81.6951759	0.0006973689	3.475362e-08	3.865419e-07	18	21049092	21049229	138	-	1.873	1.598	-0.928
ENSG00000067900	E047	71.8907381	0.0003868209	7.922526e-10	1.197462e-08	18	21049780	21049880	101	-	1.825	1.487	-1.151
ENSG00000067900	E048	55.1642216	0.0006500025	1.009662e-06	8.365876e-06	18	21070532	21070613	82	-	1.709	1.412	-1.016
ENSG00000067900	E049	149.6336378	0.0017077564	1.199981e-16	5.107454e-15	18	21110818	21111813	996	-	2.145	1.791	-1.190

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000067900

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3