ENSG00000067840

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000164640 ENSG00000067840 HEK293_OSMI2_2hA HEK293_TMG_2hB PDZD4 protein_coding protein_coding 6.551871 12.56621 4.073083 1.104656 0.280868 -1.622966 0.9941175 1.8029530 0.7153257 0.47322420 0.3688302 -1.321641 0.1676042 0.13943333 0.1861000 0.04666667 9.879169e-01 1.53603e-06 FALSE TRUE
ENST00000393758 ENSG00000067840 HEK293_OSMI2_2hA HEK293_TMG_2hB PDZD4 protein_coding protein_coding 6.551871 12.56621 4.073083 1.104656 0.280868 -1.622966 3.4251627 6.8337245 1.5739809 0.71452597 0.2080650 -2.111227 0.4801167 0.54276667 0.3830333 -0.15973333 2.364255e-02 1.53603e-06 FALSE TRUE
ENST00000484792 ENSG00000067840 HEK293_OSMI2_2hA HEK293_TMG_2hB PDZD4 protein_coding processed_transcript 6.551871 12.56621 4.073083 1.104656 0.280868 -1.622966 0.7573922 0.3726795 1.0097722 0.07743665 0.2592146 1.414038 0.1557083 0.03026667 0.2410667 0.21080000 1.536030e-06 1.53603e-06 FALSE FALSE
ENST00000544474 ENSG00000067840 HEK293_OSMI2_2hA HEK293_TMG_2hB PDZD4 protein_coding protein_coding 6.551871 12.56621 4.073083 1.104656 0.280868 -1.622966 1.2796437 3.3630261 0.6702864 0.45142294 0.3240780 -2.309829 0.1794333 0.27390000 0.1659000 -0.10800000 5.494515e-01 1.53603e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000067840 E001 0.3299976 0.0280388810 1.0000000000   X 153802166 153802167 2 - 0.000 0.134 9.383
ENSG00000067840 E002 654.0097293 0.0082864037 0.0000201380 0.0001247901 X 153802168 153804878 2711 - 2.563 2.754 0.636
ENSG00000067840 E003 44.4492102 0.0005656172 0.5297011498 0.6624306461 X 153804879 153804900 22 - 1.465 1.574 0.374
ENSG00000067840 E004 0.0000000       X 153805093 153805096 4 -      
ENSG00000067840 E005 79.4613237 0.0003616233 0.0794081711 0.1585944989 X 153805097 153805207 111 - 1.817 1.803 -0.047
ENSG00000067840 E006 58.3594642 0.0004786054 0.0019389789 0.0070373142 X 153805505 153805544 40 - 1.749 1.654 -0.324
ENSG00000067840 E007 55.8815504 0.0004177358 0.0385508322 0.0883689411 X 153805545 153805581 37 - 1.691 1.645 -0.157
ENSG00000067840 E008 48.6984365 0.0004671874 0.0023643494 0.0083509313 X 153805582 153805606 25 - 1.681 1.574 -0.364
ENSG00000067840 E009 61.5751549 0.0003821258 0.0002606355 0.0012192959 X 153806071 153806133 63 - 1.788 1.671 -0.398
ENSG00000067840 E010 59.8619013 0.0004409994 0.0132254945 0.0364377165 X 153806742 153806840 99 - 1.736 1.672 -0.214
ENSG00000067840 E011 35.7860989 0.0033890520 0.4660059231 0.6055852171 X 153807279 153807326 48 - 1.456 1.469 0.044
ENSG00000067840 E012 32.7172153 0.0014106220 0.8163099874 0.8837756275 X 153807327 153807369 43 - 1.356 1.441 0.292
ENSG00000067840 E013 3.6430024 0.0076295852 0.0006839987 0.0028404536 X 153807851 153807896 46 - 0.905 0.448 -1.962
ENSG00000067840 E014 6.8611688 0.0079455808 0.0002998233 0.0013788902 X 153807897 153808139 243 - 1.085 0.682 -1.551
ENSG00000067840 E015 18.5500349 0.0038642233 0.7937057902 0.8681341811 X 153808342 153808359 18 - 1.161 1.200 0.137
ENSG00000067840 E016 50.9439434 0.0088913249 0.8772712977 0.9251624717 X 153808360 153808595 236 - 1.545 1.629 0.286
ENSG00000067840 E017 0.2944980 0.3454593487 0.0483456936   X 153829546 153829732 187 - 0.337 0.000 -12.859
ENSG00000067840 E018 0.1472490 0.0426352994 0.1146001999   X 153829733 153829856 124 - 0.201 0.000 -13.090
ENSG00000067840 E019 0.2214452 0.0367499286 1.0000000000   X 153830127 153830238 112 - 0.000 0.072 10.279
ENSG00000067840 E020 30.8086730 0.0289529103 0.2357790655 0.3692981668 X 153830239 153830565 327 - 1.439 1.391 -0.164