ENSG00000067715

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261205 ENSG00000067715 HEK293_OSMI2_2hA HEK293_TMG_2hB SYT1 protein_coding protein_coding 1.242645 0.7651187 1.686417 0.05236618 0.1662093 1.130002 0.08453061 0.0000000 0.2730810 0.00000000 0.06492059 4.8231433 0.07353333 0.0000 0.16610000 0.16610000 0.005425121 0.005425121 FALSE TRUE
ENST00000549559 ENSG00000067715 HEK293_OSMI2_2hA HEK293_TMG_2hB SYT1 protein_coding processed_transcript 1.242645 0.7651187 1.686417 0.05236618 0.1662093 1.130002 0.05225393 0.0000000 0.1660631 0.00000000 0.16606308 4.1380205 0.02562917 0.0000 0.08243333 0.08243333 0.920144031 0.005425121 FALSE FALSE
ENST00000551304 ENSG00000067715 HEK293_OSMI2_2hA HEK293_TMG_2hB SYT1 protein_coding protein_coding 1.242645 0.7651187 1.686417 0.05236618 0.1662093 1.130002 0.03076052 0.1148133 0.0000000 0.07928691 0.00000000 -3.6416992 0.02699167 0.1398 0.00000000 -0.13980000 0.124535318 0.005425121 FALSE FALSE
ENST00000552744 ENSG00000067715 HEK293_OSMI2_2hA HEK293_TMG_2hB SYT1 protein_coding protein_coding 1.242645 0.7651187 1.686417 0.05236618 0.1662093 1.130002 0.45561255 0.3470787 0.4780564 0.11988603 0.19786927 0.4508059 0.41686250 0.4561 0.29630000 -0.15980000 0.666039528 0.005425121 FALSE TRUE
MSTRG.7696.10 ENSG00000067715 HEK293_OSMI2_2hA HEK293_TMG_2hB SYT1 protein_coding   1.242645 0.7651187 1.686417 0.05236618 0.1662093 1.130002 0.60663474 0.2687307 0.7692167 0.17226718 0.12671898 1.4831525 0.44609167 0.3519 0.45513333 0.10323333 0.818867492 0.005425121 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000067715 E001 0.0000000       12 78863993 78864335 343 +      
ENSG00000067715 E002 0.4396707 0.0302045750 3.120972e-01 4.546256e-01 12 78864774 78864811 38 + 0.216 0.000 -9.845
ENSG00000067715 E003 0.5869198 0.1768061627 2.359526e-01 3.694837e-01 12 78864812 78864997 186 + 0.270 0.000 -11.828
ENSG00000067715 E004 1.0319011 0.0123150154 3.321497e-01 4.757755e-01 12 78864998 78865109 112 + 0.360 0.174 -1.395
ENSG00000067715 E005 0.0000000       12 78868710 78868771 62 +      
ENSG00000067715 E006 0.1472490 0.0436532005 1.000000e+00   12 78868772 78868911 140 + 0.085 0.000 -10.327
ENSG00000067715 E007 0.1472490 0.0436532005 1.000000e+00   12 78926597 78926720 124 + 0.085 0.000 -10.327
ENSG00000067715 E008 0.0000000       12 78955462 78955566 105 +      
ENSG00000067715 E009 0.0000000       12 78964035 78964150 116 +      
ENSG00000067715 E010 0.0000000       12 78977522 78977784 263 +      
ENSG00000067715 E011 0.0000000       12 78977785 78977798 14 +      
ENSG00000067715 E012 1.6575426 0.0082409741 3.684994e-01 5.129059e-01 12 78977799 78977931 133 + 0.468 0.297 -0.979
ENSG00000067715 E013 0.0000000       12 78995759 78995847 89 +      
ENSG00000067715 E014 3.1386742 0.0053750859 2.724162e-01 4.112915e-01 12 79045169 79045387 219 + 0.528 0.693 0.732
ENSG00000067715 E015 0.6287620 0.0184612141 4.110837e-01 5.546749e-01 12 79045631 79045704 74 + 0.156 0.297 1.190
ENSG00000067715 E016 1.7401578 0.0093169461 8.363640e-01 8.976636e-01 12 79045705 79045826 122 + 0.435 0.394 -0.224
ENSG00000067715 E017 0.1472490 0.0436532005 1.000000e+00   12 79046318 79046451 134 + 0.085 0.000 -10.327
ENSG00000067715 E018 4.2491527 0.0041328150 9.408277e-01 9.668244e-01 12 79047297 79047362 66 + 0.688 0.694 0.022
ENSG00000067715 E019 0.8095083 0.4513802055 2.118690e-01 3.406997e-01 12 79103014 79103055 42 + 0.085 0.412 2.881
ENSG00000067715 E020 6.9811241 0.0305801857 1.981864e-02 5.110084e-02 12 79217503 79217685 183 + 0.974 0.598 -1.504
ENSG00000067715 E021 8.2203871 0.0030723858 2.767870e-02 6.737333e-02 12 79285787 79285971 185 + 1.020 0.735 -1.098
ENSG00000067715 E022 0.0000000       12 79291799 79291854 56 +      
ENSG00000067715 E023 3.4981353 0.0081237722 4.482149e-01 5.895252e-01 12 79292008 79292016 9 + 0.668 0.539 -0.572
ENSG00000067715 E024 7.4141965 0.0714652768 5.224128e-01 6.562315e-01 12 79292017 79292130 114 + 0.942 0.812 -0.500
ENSG00000067715 E025 9.5272158 0.0024293649 2.075424e-01 3.355347e-01 12 79296069 79296236 168 + 1.046 0.897 -0.556
ENSG00000067715 E026 11.7037084 0.0014689677 2.282343e-01 3.603162e-01 12 79299384 79299551 168 + 1.123 0.994 -0.472
ENSG00000067715 E027 9.2764114 0.0019145495 1.360014e-01 2.424786e-01 12 79353502 79353619 118 + 1.046 0.869 -0.663
ENSG00000067715 E028 7.4021410 0.0189339222 3.083494e-01 4.506258e-01 12 79444073 79444206 134 + 0.953 0.807 -0.559
ENSG00000067715 E029 89.9159411 0.0006094419 8.481534e-07 7.155012e-06 12 79448918 79452020 3103 + 1.890 2.012 0.409