ENSG00000067606

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378567 ENSG00000067606 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKCZ protein_coding protein_coding 21.85195 35.04593 14.60546 1.719741 0.2617473 -1.262163 14.199204 20.574529 12.040894 2.43930448 0.5139800 -0.7724203 0.65732500 0.58463333 0.8240 0.239366667 4.182108e-03 4.055405e-15 FALSE TRUE
ENST00000479263 ENSG00000067606 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKCZ protein_coding processed_transcript 21.85195 35.04593 14.60546 1.719741 0.2617473 -1.262163 3.642061 8.940212 0.000000 1.77363828 0.0000000 -9.8057781 0.14531250 0.25823333 0.0000 -0.258233333 4.055405e-15 4.055405e-15 FALSE TRUE
MSTRG.131.1 ENSG00000067606 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKCZ protein_coding   21.85195 35.04593 14.60546 1.719741 0.2617473 -1.262163 1.414027 2.260756 1.008611 0.08264059 0.1555418 -1.1565695 0.06417917 0.06466667 0.0693 0.004633333 9.312466e-01 4.055405e-15 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000067606 E001 8.7525110 0.1034899599 1.450174e-04 7.254966e-04 1 2050411 2050484 74 + 1.326 0.621 -2.667
ENSG00000067606 E002 13.0668492 0.0155971642 1.697148e-11 3.403044e-10 1 2050485 2050502 18 + 1.490 0.761 -2.649
ENSG00000067606 E003 65.0010961 0.0263646578 9.168103e-04 3.673660e-03 1 2050503 2050701 199 + 1.950 1.663 -0.969
ENSG00000067606 E004 0.4428904 0.4382977500 7.039928e-01 8.026095e-01 1 2050808 2051012 205 + 0.000 0.156 11.739
ENSG00000067606 E005 113.1726959 0.0130188828 4.139967e-02 9.362369e-02 1 2055441 2055562 122 + 2.083 1.956 -0.427
ENSG00000067606 E006 6.1112243 0.0037008386 4.977378e-04 2.151526e-03 1 2055563 2055678 116 + 1.073 0.632 -1.719
ENSG00000067606 E007 6.8251514 0.0464523293 3.276496e-01 4.711294e-01 1 2055679 2055876 198 + 0.941 0.792 -0.575
ENSG00000067606 E008 118.7225883 0.0014287074 1.918114e-01 3.160314e-01 1 2056484 2056573 90 + 2.051 1.995 -0.185
ENSG00000067606 E009 114.4571273 0.0007222884 3.739088e-01 5.183367e-01 1 2059541 2059591 51 + 2.022 1.984 -0.128
ENSG00000067606 E010 1.6898173 0.0090156608 5.334088e-01 6.656043e-01 1 2071299 2071536 238 + 0.308 0.422 0.671
ENSG00000067606 E011 0.1817044 0.0396851447 1.000000e+00   1 2073462 2073718 257 + 0.000 0.081 11.674
ENSG00000067606 E012 0.0000000       1 2073719 2073929 211 +      
ENSG00000067606 E013 0.1482932 0.0417522771 1.000000e+00   1 2073986 2074275 290 + 0.000 0.081 11.650
ENSG00000067606 E014 0.0000000       1 2074688 2074767 80 +      
ENSG00000067606 E015 0.4031496 0.0247269087 5.807198e-01 7.054182e-01 1 2074855 2075133 279 + 0.000 0.150 12.839
ENSG00000067606 E016 0.0000000       1 2075244 2075379 136 +      
ENSG00000067606 E017 0.0000000       1 2082248 2082460 213 +      
ENSG00000067606 E018 1.2825162 0.0178774038 2.149028e-01 3.443225e-01 1 2098347 2098555 209 + 0.486 0.260 -1.328
ENSG00000067606 E019 0.2214452 0.0389136926 1.000000e+00   1 2104716 2104738 23 + 0.000 0.081 11.684
ENSG00000067606 E020 0.2214452 0.0389136926 1.000000e+00   1 2104739 2104895 157 + 0.000 0.081 11.684
ENSG00000067606 E021 0.2214452 0.0389136926 1.000000e+00   1 2111654 2111817 164 + 0.000 0.081 11.684
ENSG00000067606 E022 0.1482932 0.0417522771 1.000000e+00   1 2116205 2116310 106 + 0.000 0.081 11.650
ENSG00000067606 E023 0.8459408 0.0154442190 5.942063e-01 7.164672e-01 1 2133638 2134000 363 + 0.308 0.209 -0.742
ENSG00000067606 E024 0.8974367 0.7819200857 4.669937e-01 6.065111e-01 1 2134813 2134989 177 + 0.409 0.160 -1.816
ENSG00000067606 E025 1.1146155 0.4247726428 3.693907e-01 5.138218e-01 1 2134990 2135086 97 + 0.407 0.220 -1.237
ENSG00000067606 E026 151.3938829 0.0002865751 9.093640e-01 9.464326e-01 1 2135262 2135347 86 + 2.120 2.112 -0.028
ENSG00000067606 E027 184.0881821 0.0014354992 9.593643e-01 9.785113e-01 1 2144210 2144341 132 + 2.205 2.203 -0.006
ENSG00000067606 E028 0.0000000       1 2144451 2144584 134 +      
ENSG00000067606 E029 0.0000000       1 2145338 2145356 19 +      
ENSG00000067606 E030 0.1817044 0.0396851447 1.000000e+00   1 2145357 2145386 30 + 0.000 0.081 11.674
ENSG00000067606 E031 0.1817044 0.0396851447 1.000000e+00   1 2145387 2145388 2 + 0.000 0.081 11.674
ENSG00000067606 E032 1.3985426 0.2289287826 6.221476e-01 7.389779e-01 1 2145389 2145511 123 + 0.407 0.311 -0.566
ENSG00000067606 E033 184.9959724 0.0002578351 2.286938e-01 3.608862e-01 1 2146027 2146108 82 + 2.235 2.196 -0.131
ENSG00000067606 E034 160.3116580 0.0009174022 1.588927e-01 2.736755e-01 1 2148872 2148924 53 + 2.182 2.131 -0.169
ENSG00000067606 E035 304.6809131 0.0001925862 2.749720e-02 6.700134e-02 1 2150790 2150978 189 + 2.460 2.406 -0.178
ENSG00000067606 E036 0.5451131 0.6778556136 6.412244e-01 7.543065e-01 1 2150979 2150979 1 + 0.000 0.211 12.099
ENSG00000067606 E037 222.8689174 0.0002197035 2.521445e-01 3.884716e-01 1 2155995 2156092 98 + 2.309 2.274 -0.116
ENSG00000067606 E038 1.2210915 0.0114742951 4.311965e-01 5.737729e-01 1 2156093 2156728 636 + 0.406 0.261 -0.912
ENSG00000067606 E039 0.2214452 0.0389136926 1.000000e+00   1 2168848 2168974 127 + 0.000 0.081 11.684
ENSG00000067606 E040 0.8867258 0.0201488702 6.640311e-01 7.719417e-01 1 2168975 2169117 143 + 0.181 0.261 0.673
ENSG00000067606 E041 4.4189211 0.0036573362 8.422460e-01 9.016732e-01 1 2169118 2169517 400 + 0.664 0.690 0.112
ENSG00000067606 E042 198.4219734 0.0008236195 5.870751e-01 7.104584e-01 1 2169518 2169604 87 + 2.248 2.227 -0.069
ENSG00000067606 E043 2.6570846 0.0059089760 4.537069e-01 5.944425e-01 1 2171553 2171645 93 + 0.612 0.485 -0.592
ENSG00000067606 E044 247.9525892 0.0009537340 5.336077e-01 6.657779e-01 1 2172055 2172190 136 + 2.319 2.333 0.047
ENSG00000067606 E045 199.1215776 0.0003320813 2.495205e-01 3.853503e-01 1 2172301 2172388 88 + 2.215 2.244 0.097
ENSG00000067606 E046 195.2050379 0.0004423106 2.675175e-01 4.058424e-01 1 2173897 2174016 120 + 2.208 2.236 0.095
ENSG00000067606 E047 146.9780203 0.0002654235 3.172693e-01 4.601279e-01 1 2174754 2174833 80 + 2.083 2.112 0.096
ENSG00000067606 E048 185.3046918 0.0014045135 1.382090e-01 2.455941e-01 1 2175224 2175313 90 + 2.169 2.216 0.157
ENSG00000067606 E049 7.1962985 0.0023363972 9.859297e-01 9.952069e-01 1 2181832 2181914 83 + 0.857 0.855 -0.006
ENSG00000067606 E050 236.4849235 0.0007780841 1.862494e-05 1.163887e-04 1 2184583 2184698 116 + 2.216 2.338 0.407
ENSG00000067606 E051 389.3982902 0.0011949842 1.290796e-09 1.874568e-08 1 2184922 2185491 570 + 2.408 2.561 0.510
ENSG00000067606 E052 46.7136218 0.0005392128 9.637780e-01 9.811326e-01 1 2185585 2186450 866 + 1.615 1.613 -0.006