ENSG00000067596

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262415 ENSG00000067596 HEK293_OSMI2_2hA HEK293_TMG_2hB DHX8 protein_coding protein_coding 44.73687 56.00509 35.90657 5.106524 0.1445198 -0.6411657 15.272829 20.116301 11.069941 2.2129685 0.1447462 -0.8611318 0.3361292 0.35793333 0.3083000 -0.04963333 6.247086e-02 6.574025e-22 FALSE TRUE
ENST00000587574 ENSG00000067596 HEK293_OSMI2_2hA HEK293_TMG_2hB DHX8 protein_coding protein_coding 44.73687 56.00509 35.90657 5.106524 0.1445198 -0.6411657 15.431549 25.103444 8.572604 1.5179788 0.2513748 -1.5489726 0.3252500 0.45190000 0.2387667 -0.21313333 1.576319e-08 6.574025e-22   FALSE
MSTRG.14413.14 ENSG00000067596 HEK293_OSMI2_2hA HEK293_TMG_2hB DHX8 protein_coding   44.73687 56.00509 35.90657 5.106524 0.1445198 -0.6411657 3.495771 2.678401 4.352968 0.4062153 0.4272547 0.6985615 0.0849625 0.04723333 0.1211667 0.07393333 2.333685e-06 6.574025e-22 FALSE TRUE
MSTRG.14413.7 ENSG00000067596 HEK293_OSMI2_2hA HEK293_TMG_2hB DHX8 protein_coding   44.73687 56.00509 35.90657 5.106524 0.1445198 -0.6411657 7.841633 6.796988 8.764309 1.2359280 0.2367964 0.3662690 0.1869625 0.11983333 0.2440667 0.12423333 5.774136e-06 6.574025e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000067596 E001 1.0360657 0.0372046511 4.057440e-01 5.493952e-01 17 43483865 43483950 86 + 0.401 0.263 -0.870
ENSG00000067596 E002 1.3327538 0.0122558496 1.295383e-01 2.335158e-01 17 43483951 43483959 9 + 0.516 0.264 -1.449
ENSG00000067596 E003 1.1844606 0.0103694793 5.540594e-02 1.186835e-01 17 43483960 43483962 3 + 0.516 0.192 -2.033
ENSG00000067596 E004 1.1844606 0.0103694793 5.540594e-02 1.186835e-01 17 43483963 43483963 1 + 0.516 0.192 -2.033
ENSG00000067596 E005 2.4806933 0.0082410222 2.351372e-01 3.685114e-01 17 43483964 43483972 9 + 0.645 0.470 -0.811
ENSG00000067596 E006 2.6279423 0.0063141174 1.509562e-01 2.629599e-01 17 43483973 43483974 2 + 0.681 0.470 -0.963
ENSG00000067596 E007 2.6279423 0.0063141174 1.509562e-01 2.629599e-01 17 43483975 43483976 2 + 0.681 0.470 -0.963
ENSG00000067596 E008 6.6020010 0.0025770157 8.240786e-02 1.633051e-01 17 43483977 43483983 7 + 0.988 0.799 -0.723
ENSG00000067596 E009 143.4120848 0.0049960247 7.353929e-07 6.288332e-06 17 43483984 43484139 156 + 2.263 2.060 -0.679
ENSG00000067596 E010 137.1849958 0.0105303223 1.696806e-04 8.336269e-04 17 43484140 43484185 46 + 2.239 2.044 -0.652
ENSG00000067596 E011 140.2133222 0.0074252664 2.743512e-03 9.502698e-03 17 43489449 43489534 86 + 2.216 2.082 -0.446
ENSG00000067596 E012 122.1145779 0.0083278371 8.742271e-04 3.523898e-03 17 43490391 43490463 73 + 2.171 2.009 -0.542
ENSG00000067596 E013 0.1515154 0.0439062661 3.561813e-01   17 43490464 43490493 30 + 0.140 0.000 -10.351
ENSG00000067596 E014 93.6817868 0.0120691693 1.644264e-03 6.102398e-03 17 43491165 43491193 29 + 2.067 1.886 -0.610
ENSG00000067596 E015 112.2663199 0.0003899900 4.248671e-10 6.740625e-09 17 43491194 43491250 57 + 2.153 1.960 -0.646
ENSG00000067596 E016 165.0419807 0.0011787127 1.543768e-12 3.666319e-11 17 43492183 43492292 110 + 2.324 2.118 -0.690
ENSG00000067596 E017 85.9744044 0.0003151533 2.614430e-10 4.291249e-09 17 43492681 43492686 6 + 2.053 1.832 -0.744
ENSG00000067596 E018 310.9495445 0.0002727403 8.343851e-20 5.177588e-18 17 43492687 43493040 354 + 2.582 2.410 -0.575
ENSG00000067596 E019 186.1175434 0.0002784577 7.122547e-11 1.288281e-09 17 43493445 43493589 145 + 2.353 2.200 -0.512
ENSG00000067596 E020 261.2990148 0.0003692001 9.152829e-09 1.136661e-07 17 43493683 43493886 204 + 2.478 2.363 -0.382
ENSG00000067596 E021 163.7296701 0.0018322735 2.268549e-03 8.055341e-03 17 43496181 43496268 88 + 2.258 2.172 -0.287
ENSG00000067596 E022 188.5534048 0.0008068099 2.935814e-02 7.069441e-02 17 43498862 43498959 98 + 2.295 2.251 -0.148
ENSG00000067596 E023 244.2167725 0.0051629737 2.448045e-01 3.798071e-01 17 43499956 43500103 148 + 2.396 2.368 -0.093
ENSG00000067596 E024 260.6609561 0.0046667637 2.944845e-01 4.355771e-01 17 43504644 43504825 182 + 2.419 2.398 -0.073
ENSG00000067596 E025 283.9159175 0.0020656965 8.979015e-03 2.622766e-02 17 43507003 43507197 195 + 2.481 2.420 -0.203
ENSG00000067596 E026 306.5922063 0.0002042398 1.887535e-03 6.875512e-03 17 43507503 43507688 186 + 2.507 2.461 -0.153
ENSG00000067596 E027 327.4666642 0.0001773078 1.358115e-03 5.170221e-03 17 43507809 43508019 211 + 2.534 2.488 -0.153
ENSG00000067596 E028 283.5140234 0.0001775820 1.965973e-02 5.075948e-02 17 43508339 43508520 182 + 2.465 2.433 -0.105
ENSG00000067596 E029 287.6245323 0.0002223627 7.748735e-02 1.554276e-01 17 43513362 43513502 141 + 2.464 2.445 -0.065
ENSG00000067596 E030 310.5316820 0.0001617619 9.040679e-01 9.429497e-01 17 43517167 43517322 156 + 2.471 2.492 0.071
ENSG00000067596 E031 3.4301045 0.0084535993 3.956450e-02 9.022530e-02 17 43517323 43520129 2807 + 0.801 0.509 -1.255
ENSG00000067596 E032 265.0864353 0.0001835741 8.734293e-02 1.711065e-01 17 43520130 43520267 138 + 2.381 2.439 0.193
ENSG00000067596 E033 224.7819422 0.0001799984 2.698756e-04 1.257183e-03 17 43520751 43520879 129 + 2.275 2.384 0.364
ENSG00000067596 E034 154.5924217 0.0002437914 1.489411e-01 2.602489e-01 17 43521369 43521395 27 + 2.144 2.205 0.205
ENSG00000067596 E035 312.6221567 0.0017791628 3.323882e-03 1.121719e-02 17 43521396 43521565 170 + 2.421 2.520 0.329
ENSG00000067596 E036 253.8319157 0.0017032546 1.960189e-03 7.101235e-03 17 43522047 43522151 105 + 2.325 2.435 0.367
ENSG00000067596 E037 238.7843592 0.0017547262 6.459862e-03 1.981993e-02 17 43522152 43522226 75 + 2.305 2.407 0.339
ENSG00000067596 E038 644.3226185 0.0038039401 3.577436e-07 3.258025e-06 17 43523628 43524185 558 + 2.680 2.857 0.591
ENSG00000067596 E039 659.7147851 0.0014191429 1.522059e-28 2.256255e-26 17 43524186 43525670 1485 + 2.626 2.891 0.881
ENSG00000067596 E040 165.0261365 0.0046876119 1.293287e-12 3.113997e-11 17 43526218 43526386 169 + 1.972 2.308 1.125
ENSG00000067596 E041 130.4731889 0.0045813557 6.247253e-12 1.344302e-10 17 43526387 43526495 109 + 1.864 2.207 1.150
ENSG00000067596 E042 174.9035582 0.0034352162 3.485555e-18 1.794857e-16 17 43526496 43526803 308 + 1.965 2.342 1.264
ENSG00000067596 E043 6.2842043 0.0025543605 8.246311e-01 8.895313e-01 17 43536412 43536498 87 + 0.826 0.870 0.171
ENSG00000067596 E044 8.7881791 0.0021026002 6.402654e-01 7.535434e-01 17 43544162 43544463 302 + 1.005 0.971 -0.125
ENSG00000067596 E045 0.1817044 0.0392366224 6.552475e-01   17 43544785 43544815 31 + 0.000 0.107 9.185
ENSG00000067596 E046 0.0000000       17 43590088 43590165 78 +      
ENSG00000067596 E047 0.0000000       17 43590166 43590741 576 +      
ENSG00000067596 E048 0.1451727 0.0438730434 3.565319e-01   17 43609887 43610338 452 + 0.140 0.000 -10.350