ENSG00000067369

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000382039 ENSG00000067369 HEK293_OSMI2_2hA HEK293_TMG_2hB TP53BP1 protein_coding protein_coding 12.49761 7.371851 14.11921 0.8536052 0.5701853 0.9366262 2.6562094 0.6157852 3.9380217 0.39407515 0.36262060 2.6573904 0.20035833 0.07520000 0.27776667 0.20256667 1.680190e-01 2.90336e-20 FALSE TRUE
ENST00000382044 ENSG00000067369 HEK293_OSMI2_2hA HEK293_TMG_2hB TP53BP1 protein_coding protein_coding 12.49761 7.371851 14.11921 0.8536052 0.5701853 0.9366262 1.5191925 1.2239357 2.1072602 0.10936611 0.07434170 0.7789314 0.12846667 0.16720000 0.14970000 -0.01750000 7.884563e-01 2.90336e-20 FALSE TRUE
ENST00000411772 ENSG00000067369 HEK293_OSMI2_2hA HEK293_TMG_2hB TP53BP1 protein_coding nonsense_mediated_decay 12.49761 7.371851 14.11921 0.8536052 0.5701853 0.9366262 2.2008567 2.9963333 0.7621540 0.39410696 0.11020462 -1.9610445 0.20290000 0.40706667 0.05416667 -0.35290000 2.903360e-20 2.90336e-20 FALSE TRUE
ENST00000450115 ENSG00000067369 HEK293_OSMI2_2hA HEK293_TMG_2hB TP53BP1 protein_coding protein_coding 12.49761 7.371851 14.11921 0.8536052 0.5701853 0.9366262 2.8169893 1.6081432 3.6737873 0.23982571 0.28961213 1.1868505 0.20917917 0.22646667 0.26140000 0.03493333 7.828007e-01 2.90336e-20 FALSE TRUE
ENST00000467474 ENSG00000067369 HEK293_OSMI2_2hA HEK293_TMG_2hB TP53BP1 protein_coding protein_coding 12.49761 7.371851 14.11921 0.8536052 0.5701853 0.9366262 1.2534943 0.0999366 1.6670707 0.05001396 0.46211122 3.9311999 0.09067083 0.01216667 0.11730000 0.10513333 7.429208e-04 2.90336e-20 FALSE TRUE
ENST00000476454 ENSG00000067369 HEK293_OSMI2_2hA HEK293_TMG_2hB TP53BP1 protein_coding retained_intron 12.49761 7.371851 14.11921 0.8536052 0.5701853 0.9366262 0.5959767 0.5795633 0.3112444 0.35921461 0.04953368 -0.8759753 0.05391667 0.07446667 0.02203333 -0.05243333 3.450356e-01 2.90336e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000067369 E001 169.6546118 0.0009719032 9.843155e-01 9.942828e-01 15 43403061 43407208 4148 - 2.235 2.232 -0.010
ENSG00000067369 E002 3.8461063 0.0061833166 1.956446e-03 7.090902e-03 15 43407209 43407213 5 - 0.842 0.338 -2.338
ENSG00000067369 E003 3.1315174 0.0745681889 1.197479e-01 2.196159e-01 15 43407214 43407215 2 - 0.726 0.411 -1.453
ENSG00000067369 E004 101.6702594 0.0021291806 4.626169e-15 1.600171e-13 15 43407216 43407570 355 - 1.843 2.160 1.062
ENSG00000067369 E005 109.2780955 0.0071063652 1.891895e-06 1.480009e-05 15 43407943 43408088 146 - 1.917 2.161 0.817
ENSG00000067369 E006 0.1451727 0.0440148568 7.075340e-01   15 43408661 43408896 236 - 0.104 0.000 -10.852
ENSG00000067369 E007 102.4507411 0.0101612131 2.987001e-06 2.235966e-05 15 43408897 43409009 113 - 1.874 2.140 0.893
ENSG00000067369 E008 89.1522578 0.0071641562 2.421853e-06 1.850126e-05 15 43409010 43409096 87 - 1.824 2.079 0.856
ENSG00000067369 E009 0.1472490 0.0434715822 7.077966e-01   15 43409097 43409646 550 - 0.104 0.000 -10.852
ENSG00000067369 E010 79.9612136 0.0005658037 3.275093e-08 3.660727e-07 15 43409647 43409741 95 - 1.802 2.020 0.732
ENSG00000067369 E011 0.5117906 0.2833015749 9.004560e-01 9.404992e-01 15 43412672 43412767 96 - 0.187 0.146 -0.432
ENSG00000067369 E012 100.1312556 0.0040528121 5.152440e-03 1.634485e-02 15 43413119 43413268 150 - 1.947 2.076 0.431
ENSG00000067369 E013 65.3405403 0.0080543605 1.483256e-02 4.011227e-02 15 43413269 43413328 60 - 1.754 1.900 0.494
ENSG00000067369 E014 37.1771370 0.0005956282 2.563384e-02 6.319215e-02 15 43413329 43413334 6 - 1.528 1.652 0.423
ENSG00000067369 E015 0.1451727 0.0440148568 7.075340e-01   15 43414048 43414116 69 - 0.104 0.000 -10.852
ENSG00000067369 E016 1.0393897 0.0120184016 1.409914e-02 3.845047e-02 15 43415222 43415593 372 - 0.461 0.000 -13.660
ENSG00000067369 E017 70.8991503 0.0003903594 2.657562e-04 1.240128e-03 15 43415594 43415721 128 - 1.789 1.938 0.502
ENSG00000067369 E018 47.9028612 0.0005380713 9.460198e-06 6.324169e-05 15 43415722 43415809 88 - 1.580 1.801 0.750
ENSG00000067369 E019 103.2819285 0.0003082078 1.830741e-02 4.780477e-02 15 43416225 43416416 192 - 1.982 2.061 0.265
ENSG00000067369 E020 5.0678507 0.0064521450 8.679596e-01 9.190778e-01 15 43416417 43417216 800 - 0.807 0.784 -0.090
ENSG00000067369 E021 140.1513630 0.0021533946 1.353078e-01 2.415466e-01 15 43420305 43420617 313 - 2.127 2.175 0.160
ENSG00000067369 E022 67.9444813 0.0003871955 1.249666e-03 4.809065e-03 15 43420618 43420735 118 - 1.776 1.910 0.453
ENSG00000067369 E023 41.3032909 0.0005741180 7.035169e-04 2.911678e-03 15 43421025 43421089 65 - 1.538 1.719 0.615
ENSG00000067369 E024 55.5766948 0.0004488288 4.289539e-03 1.395330e-02 15 43421090 43421174 85 - 1.691 1.822 0.443
ENSG00000067369 E025 5.1401501 0.0032029436 6.325750e-03 1.947057e-02 15 43421672 43421854 183 - 0.919 0.525 -1.634
ENSG00000067369 E026 124.6154369 0.0002752797 9.747288e-01 9.882447e-01 15 43421855 43422126 272 - 2.104 2.100 -0.012
ENSG00000067369 E027 94.6880013 0.0003302802 3.507522e-01 4.949284e-01 15 43428016 43428168 153 - 2.000 1.963 -0.123
ENSG00000067369 E028 151.5932097 0.0028795551 4.510088e-01 5.920105e-01 15 43432194 43432648 455 - 2.199 2.164 -0.117
ENSG00000067369 E029 30.6752154 0.0006723206 6.562769e-01 7.659354e-01 15 43432649 43432677 29 - 1.513 1.483 -0.106
ENSG00000067369 E030 53.0900916 0.0018387250 7.399347e-01 8.295015e-01 15 43438324 43438416 93 - 1.741 1.719 -0.074
ENSG00000067369 E031 0.0000000       15 43441259 43441525 267 -      
ENSG00000067369 E032 44.9701862 0.0005299782 6.627464e-02 1.371784e-01 15 43441526 43441583 58 - 1.708 1.608 -0.338
ENSG00000067369 E033 68.2192651 0.0003878946 2.591726e-01 3.965461e-01 15 43446387 43446532 146 - 1.867 1.817 -0.170
ENSG00000067369 E034 47.9462633 0.0008623198 5.091050e-01 6.444502e-01 15 43446533 43446590 58 - 1.708 1.670 -0.126
ENSG00000067369 E035 4.8535749 0.0595303930 8.042282e-01 8.754639e-01 15 43446766 43446910 145 - 0.787 0.728 -0.239
ENSG00000067369 E036 2.1005467 0.0297884370 5.001202e-01 6.363849e-01 15 43446911 43446914 4 - 0.536 0.410 -0.630
ENSG00000067369 E037 2.7514469 0.0192043937 1.130588e-01 2.099970e-01 15 43447155 43447365 211 - 0.680 0.409 -1.275
ENSG00000067369 E038 54.9301103 0.0004529077 4.137709e-01 5.571776e-01 15 43447366 43447485 120 - 1.770 1.728 -0.140
ENSG00000067369 E039 295.3789897 0.0030312117 9.228416e-07 7.716701e-06 15 43455892 43457218 1327 - 2.539 2.376 -0.543
ENSG00000067369 E040 73.0631245 0.0202033436 3.713842e-03 1.233675e-02 15 43469858 43470066 209 - 1.961 1.731 -0.774
ENSG00000067369 E041 0.1472490 0.0434715822 7.077966e-01   15 43470717 43470776 60 - 0.104 0.000 -10.852
ENSG00000067369 E042 43.8483916 0.0094718680 2.452077e-03 8.620287e-03 15 43474673 43474767 95 - 1.738 1.515 -0.760
ENSG00000067369 E043 42.0420182 0.0196420276 9.388302e-04 3.750154e-03 15 43475565 43475694 130 - 1.744 1.443 -1.028
ENSG00000067369 E044 49.0775161 0.0004961610 8.578688e-08 8.819703e-07 15 43477593 43477759 167 - 1.806 1.520 -0.971
ENSG00000067369 E045 49.5285999 0.0071824374 7.562594e-06 5.164898e-05 15 43479397 43479526 130 - 1.818 1.513 -1.037
ENSG00000067369 E046 52.4759204 0.0010103220 1.586017e-09 2.266300e-08 15 43479859 43480017 159 - 1.845 1.520 -1.100
ENSG00000067369 E047 50.2565073 0.0004915610 1.638985e-10 2.788262e-09 15 43480895 43481022 128 - 1.831 1.488 -1.164
ENSG00000067369 E048 49.2936439 0.0056099408 1.054388e-07 1.066759e-06 15 43491669 43491753 85 - 1.826 1.477 -1.185
ENSG00000067369 E049 50.7801206 0.0093674304 5.897810e-05 3.263970e-04 15 43492002 43492095 94 - 1.822 1.535 -0.976
ENSG00000067369 E050 55.4833187 0.0161601640 1.709992e-04 8.393646e-04 15 43492284 43492468 185 - 1.863 1.557 -1.036
ENSG00000067369 E051 23.0091960 0.0037628474 3.705120e-04 1.660297e-03 15 43493037 43493156 120 - 1.484 1.191 -1.020
ENSG00000067369 E052 0.0000000       15 43497438 43497538 101 -      
ENSG00000067369 E053 1.0622038 0.1497446215 5.941413e-01 7.164207e-01 15 43510370 43510728 359 - 0.371 0.250 -0.792