ENSG00000067334

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359208 ENSG00000067334 HEK293_OSMI2_2hA HEK293_TMG_2hB DNTTIP2 protein_coding nonsense_mediated_decay 46.82812 19.25983 85.3136 1.0629 1.913101 2.146601 24.854619 6.998123 48.350129 0.8227499 0.5558163 2.7867182 0.4766292 0.3637000 0.56703333 0.20333333 1.811219e-03 2.372537e-05 TRUE TRUE
ENST00000496535 ENSG00000067334 HEK293_OSMI2_2hA HEK293_TMG_2hB DNTTIP2 protein_coding processed_transcript 46.82812 19.25983 85.3136 1.0629 1.913101 2.146601 1.630592 2.201825 1.586194 0.5922229 0.1192804 -0.4706011 0.0567500 0.1163667 0.01863333 -0.09773333 2.372537e-05 2.372537e-05 FALSE FALSE
MSTRG.1627.2 ENSG00000067334 HEK293_OSMI2_2hA HEK293_TMG_2hB DNTTIP2 protein_coding   46.82812 19.25983 85.3136 1.0629 1.913101 2.146601 19.521743 9.532689 33.888753 0.9344077 1.5387480 1.8287644 0.4455500 0.4929333 0.39683333 -0.09610000 4.088501e-02 2.372537e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000067334 E001 26.224691 0.0019533949 6.883749e-01 7.905300e-01 1 93866284 93869638 3355 - 1.371 1.377 0.023
ENSG00000067334 E002 8.368555 0.0048492142 4.265504e-01 5.693721e-01 1 93869639 93869779 141 - 0.949 0.816 -0.508
ENSG00000067334 E003 20.095728 0.0087962200 4.455759e-02 9.938544e-02 1 93869780 93869797 18 - 1.225 1.386 0.564
ENSG00000067334 E004 212.606577 0.0101062511 6.559163e-05 3.588258e-04 1 93869798 93869944 147 - 2.209 2.408 0.665
ENSG00000067334 E005 325.259774 0.0044454065 3.136629e-07 2.889918e-06 1 93870683 93870792 110 - 2.404 2.571 0.559
ENSG00000067334 E006 2.697031 0.0057423615 7.554473e-01 8.407740e-01 1 93870793 93870997 205 - 0.532 0.455 -0.376
ENSG00000067334 E007 460.421115 0.0009144826 5.486223e-13 1.402819e-11 1 93872072 93872236 165 - 2.565 2.698 0.443
ENSG00000067334 E008 346.263922 0.0001381794 1.640916e-13 4.528934e-12 1 93873119 93873214 96 - 2.441 2.570 0.428
ENSG00000067334 E009 13.314546 0.0139076107 4.118176e-03 1.347361e-02 1 93873215 93873422 208 - 1.005 1.291 1.026
ENSG00000067334 E010 206.943028 0.0002030552 2.151351e-04 1.028976e-03 1 93875645 93875665 21 - 2.234 2.311 0.257
ENSG00000067334 E011 361.056562 0.0001626815 3.069884e-02 7.332881e-02 1 93875666 93875783 118 - 2.491 2.510 0.064
ENSG00000067334 E012 887.993274 0.0001168210 1.935474e-02 5.010176e-02 1 93876268 93876758 491 - 2.900 2.840 -0.198
ENSG00000067334 E013 980.765835 0.0018455204 6.422871e-10 9.878977e-09 1 93876759 93877472 714 - 2.965 2.803 -0.539
ENSG00000067334 E014 159.053465 0.0119741080 2.015613e-02 5.181165e-02 1 93877473 93877489 17 - 2.179 2.006 -0.580
ENSG00000067334 E015 546.689980 0.0122308904 4.572554e-05 2.601226e-04 1 93877490 93877862 373 - 2.726 2.484 -0.808
ENSG00000067334 E016 1.659733 0.0084328741 8.365673e-01 8.978057e-01 1 93877863 93877883 21 - 0.406 0.349 -0.325
ENSG00000067334 E017 2.547516 0.0058219682 4.046202e-02 9.187064e-02 1 93878548 93879076 529 - 0.406 0.726 1.482
ENSG00000067334 E018 213.678523 0.0035366768 1.254777e-06 1.020449e-05 1 93879077 93879330 254 - 2.318 2.083 -0.783
ENSG00000067334 E019 2.774135 0.0487842347 8.776679e-01 9.254223e-01 1 93879331 93879918 588 - 0.532 0.540 0.036