ENSG00000067208

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370331 ENSG00000067208 HEK293_OSMI2_2hA HEK293_TMG_2hB EVI5 protein_coding protein_coding 4.379714 1.168661 6.796854 0.06071521 0.207653 2.529839 0.35944090 0.08568492 0.0000000 0.08568492 0.0000000 -3.258292 0.15695000 0.07140000 0.00000000 -0.07140000 4.240239e-01 2.130996e-09 FALSE TRUE
ENST00000474806 ENSG00000067208 HEK293_OSMI2_2hA HEK293_TMG_2hB EVI5 protein_coding processed_transcript 4.379714 1.168661 6.796854 0.06071521 0.207653 2.529839 0.05642397 0.06064143 0.0000000 0.06064143 0.0000000 -2.820515 0.02650417 0.05053333 0.00000000 -0.05053333 3.938071e-01 2.130996e-09   FALSE
ENST00000540033 ENSG00000067208 HEK293_OSMI2_2hA HEK293_TMG_2hB EVI5 protein_coding protein_coding 4.379714 1.168661 6.796854 0.06071521 0.207653 2.529839 0.99077904 0.55443875 1.4303290 0.26444769 0.3194186 1.351509 0.27227917 0.49663333 0.21236667 -0.28426667 6.656900e-01 2.130996e-09 FALSE TRUE
ENST00000684568 ENSG00000067208 HEK293_OSMI2_2hA HEK293_TMG_2hB EVI5 protein_coding protein_coding 4.379714 1.168661 6.796854 0.06071521 0.207653 2.529839 0.99234450 0.43591992 2.0750057 0.21817369 0.2601835 2.225195 0.24306250 0.35516667 0.30433333 -0.05083333 1.000000e+00 2.130996e-09 FALSE TRUE
MSTRG.1606.7 ENSG00000067208 HEK293_OSMI2_2hA HEK293_TMG_2hB EVI5 protein_coding   4.379714 1.168661 6.796854 0.06071521 0.207653 2.529839 1.23169522 0.00000000 2.3167856 0.00000000 0.2891771 7.862194 0.16396250 0.00000000 0.33943333 0.33943333 2.130996e-09 2.130996e-09 FALSE TRUE
MSTRG.1606.8 ENSG00000067208 HEK293_OSMI2_2hA HEK293_TMG_2hB EVI5 protein_coding   4.379714 1.168661 6.796854 0.06071521 0.207653 2.529839 0.27197096 0.03197627 0.5349441 0.02461792 0.1072581 3.698462 0.05184583 0.02630000 0.07853333 0.05223333 2.965241e-01 2.130996e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000067208 E001 228.583618 0.0004583088 1.450068e-30 2.538919e-28 1 92508696 92512179 3484 - 2.194 2.471 0.927
ENSG00000067208 E002 45.094337 0.0213374921 3.067317e-02 7.327934e-02 1 92512180 92512865 686 - 1.525 1.731 0.704
ENSG00000067208 E003 41.130944 0.0006051723 2.411706e-03 8.496809e-03 1 92512866 92513571 706 - 1.487 1.684 0.669
ENSG00000067208 E004 11.875390 0.0014827502 3.725038e-01 5.169565e-01 1 92513572 92513676 105 - 1.044 0.943 -0.374
ENSG00000067208 E005 35.872123 0.0005597769 7.780753e-01 8.572262e-01 1 92513677 92513970 294 - 1.477 1.466 -0.038
ENSG00000067208 E006 26.977530 0.0037875094 8.756683e-01 9.241480e-01 1 92563642 92563737 96 - 1.352 1.347 -0.016
ENSG00000067208 E007 29.930282 0.0007220992 1.771143e-01 2.974757e-01 1 92605307 92605402 96 - 1.419 1.317 -0.352
ENSG00000067208 E008 0.000000       1 92607449 92607580 132 -      
ENSG00000067208 E009 20.621185 0.0008747701 4.752592e-01 6.139803e-01 1 92607581 92607615 35 - 1.258 1.199 -0.208
ENSG00000067208 E010 28.669217 0.0006582051 5.076191e-01 6.430720e-01 1 92607616 92607727 112 - 1.390 1.346 -0.155
ENSG00000067208 E011 37.199155 0.0006086794 1.535865e-01 2.665466e-01 1 92624176 92624334 159 - 1.506 1.410 -0.331
ENSG00000067208 E012 0.000000       1 92625690 92625793 104 -      
ENSG00000067208 E013 30.247119 0.0008543050 7.015744e-03 2.126443e-02 1 92625794 92625934 141 - 1.443 1.218 -0.784
ENSG00000067208 E014 27.745331 0.0008020741 9.141073e-03 2.663573e-02 1 92636202 92636336 135 - 1.406 1.179 -0.794
ENSG00000067208 E015 7.540218 0.0258720352 3.494226e-01 4.936322e-01 1 92662719 92662865 147 - 0.872 0.721 -0.598
ENSG00000067208 E016 10.105054 0.0016874002 5.582120e-01 6.864981e-01 1 92663420 92663452 33 - 0.973 0.906 -0.253
ENSG00000067208 E017 19.081638 0.0009676454 1.625603e-02 4.328826e-02 1 92665939 92665992 54 - 1.258 1.007 -0.900
ENSG00000067208 E018 20.633096 0.0097032444 2.131070e-02 5.424441e-02 1 92677158 92677218 61 - 1.290 1.036 -0.906
ENSG00000067208 E019 23.590240 0.0016531985 9.599480e-02 1.843629e-01 1 92693802 92693899 98 - 1.328 1.179 -0.522
ENSG00000067208 E020 21.497857 0.0009807501 3.465616e-01 4.906814e-01 1 92694299 92694388 90 - 1.279 1.199 -0.282
ENSG00000067208 E021 22.164410 0.0008830046 5.234097e-01 6.571133e-01 1 92695310 92695453 144 - 1.286 1.236 -0.174
ENSG00000067208 E022 23.156434 0.0016465159 2.850972e-01 4.254026e-01 1 92697860 92697985 126 - 1.309 1.218 -0.318
ENSG00000067208 E023 21.436282 0.0152761472 2.547828e-01 3.915651e-01 1 92702141 92702215 75 - 1.282 1.161 -0.429
ENSG00000067208 E024 38.674678 0.0008202654 1.249966e-07 1.246590e-06 1 92703395 92703619 225 - 1.568 1.114 -1.586
ENSG00000067208 E025 1.039390 0.0119700472 2.025100e-01 3.293492e-01 1 92703841 92703857 17 - 0.312 0.000 -9.948
ENSG00000067208 E026 1.816547 0.0076752490 3.503506e-01 4.945301e-01 1 92703858 92703921 64 - 0.423 0.232 -1.227
ENSG00000067208 E027 34.318318 0.0009887447 4.725634e-07 4.200127e-06 1 92704555 92704744 190 - 1.522 1.064 -1.609
ENSG00000067208 E028 30.160657 0.0006975254 5.182004e-05 2.908089e-04 1 92736398 92736559 162 - 1.459 1.089 -1.299
ENSG00000067208 E029 16.209055 0.0010928241 1.459013e-04 7.294955e-04 1 92736560 92736627 68 - 1.212 0.719 -1.855
ENSG00000067208 E030 2.364856 0.0064516380 8.323083e-01 8.949283e-01 1 92773906 92774023 118 - 0.447 0.494 0.233
ENSG00000067208 E031 0.000000       1 92774024 92774027 4 -      
ENSG00000067208 E032 21.173245 0.0026257805 8.172343e-02 1.622572e-01 1 92784836 92785142 307 - 1.282 1.114 -0.597
ENSG00000067208 E033 0.000000       1 92792344 92792404 61 -