ENSG00000067167

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262213 ENSG00000067167 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAM1 protein_coding protein_coding 76.76757 21.93131 145.2073 5.361114 4.080381 2.726492 38.973727 20.69569658 67.65873 5.57116552 1.9652860 1.708462 0.68682917 0.9352333 0.46593333 -0.46930000 1.101481e-05 4.868229e-52 FALSE TRUE
ENST00000520700 ENSG00000067167 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAM1 protein_coding processed_transcript 76.76757 21.93131 145.2073 5.361114 4.080381 2.726492 9.121304 0.00000000 13.03088 0.00000000 0.9212372 10.348826 0.06710833 0.0000000 0.08983333 0.08983333 1.603557e-28 4.868229e-52 FALSE FALSE
MSTRG.31616.4 ENSG00000067167 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAM1 protein_coding   76.76757 21.93131 145.2073 5.361114 4.080381 2.726492 14.902516 0.74351327 32.68392 0.74351327 1.7917181 5.439245 0.11879167 0.0420000 0.22476667 0.18276667 8.244813e-02 4.868229e-52 FALSE TRUE
MSTRG.31616.7 ENSG00000067167 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAM1 protein_coding   76.76757 21.93131 145.2073 5.361114 4.080381 2.726492 12.313211 0.02959056 29.01683 0.02959056 0.8895779 9.518015 0.09128333 0.0009000 0.20013333 0.19923333 4.868229e-52 4.868229e-52 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000067167 E001 9.0560118 1.886855e-03 5.643798e-01 6.916722e-01 8 70573218 70573441 224 - 0.894 0.996 0.383
ENSG00000067167 E002 213.5025708 8.412816e-04 2.727419e-76 5.065700e-73 8 70573442 70573529 88 - 2.060 2.619 1.867
ENSG00000067167 E003 303.4152948 5.136614e-04 3.229218e-125 2.109537e-121 8 70573530 70573551 22 - 2.198 2.785 1.958
ENSG00000067167 E004 615.9676968 6.213827e-04 6.835409e-198 2.589895e-193 8 70573552 70573764 213 - 2.505 3.088 1.940
ENSG00000067167 E005 1935.7996409 2.161999e-03 1.924853e-03 6.992971e-03 8 70573765 70575005 1241 - 3.163 3.257 0.313
ENSG00000067167 E006 876.3328887 9.932984e-05 1.332483e-03 5.084492e-03 8 70583164 70583324 161 - 2.843 2.824 -0.066
ENSG00000067167 E007 660.4727392 6.395894e-04 7.768440e-06 5.292431e-05 8 70583650 70583705 56 - 2.729 2.658 -0.236
ENSG00000067167 E008 797.7323713 1.146091e-03 2.340132e-06 1.793745e-05 8 70583706 70583793 88 - 2.813 2.727 -0.284
ENSG00000067167 E009 809.1681432 1.884002e-04 1.774710e-07 1.718268e-06 8 70586895 70586999 105 - 2.816 2.755 -0.201
ENSG00000067167 E010 666.6064239 1.148511e-04 4.863888e-08 5.257611e-07 8 70587106 70587176 71 - 2.733 2.663 -0.235
ENSG00000067167 E011 0.0000000       8 70587517 70587680 164 -      
ENSG00000067167 E012 1.2190178 1.077221e-02 7.600094e-01 8.442286e-01 8 70594501 70594505 5 - 0.300 0.241 -0.423
ENSG00000067167 E013 693.4224734 1.271380e-04 1.218163e-11 2.502194e-10 8 70594506 70594590 85 - 2.754 2.658 -0.317
ENSG00000067167 E014 659.5770609 1.866602e-04 9.596912e-16 3.632580e-14 8 70596263 70596321 59 - 2.737 2.610 -0.425
ENSG00000067167 E015 0.4482035 2.870233e-02 1.000000e+00 1.000000e+00 8 70597891 70597894 4 - 0.155 0.001 -7.528
ENSG00000067167 E016 796.2797280 8.891731e-05 3.351717e-26 4.057333e-24 8 70597895 70598011 117 - 2.823 2.668 -0.517
ENSG00000067167 E017 693.3868140 1.097158e-04 1.145503e-24 1.212358e-22 8 70598134 70598252 119 - 2.764 2.598 -0.552
ENSG00000067167 E018 283.2916560 1.549483e-04 3.753936e-11 7.111007e-10 8 70598253 70598255 3 - 2.377 2.210 -0.556
ENSG00000067167 E019 473.4135715 1.810543e-04 1.645800e-16 6.895001e-15 8 70600019 70600082 64 - 2.598 2.435 -0.544
ENSG00000067167 E020 5.1099637 6.066156e-03 5.474990e-02 1.175600e-01 8 70606877 70606979 103 - 0.745 0.396 -1.616
ENSG00000067167 E021 7.1593307 1.149835e-02 2.526477e-01 3.890381e-01 8 70606980 70607525 546 - 0.844 0.674 -0.685
ENSG00000067167 E022 4.3212792 3.729545e-03 1.083645e-01 2.031200e-01 8 70607526 70607778 253 - 0.685 0.396 -1.371
ENSG00000067167 E023 397.0854127 1.294564e-04 2.400531e-12 5.536565e-11 8 70608077 70608136 60 - 2.519 2.375 -0.480
ENSG00000067167 E024 297.8496855 4.961101e-04 4.793754e-07 4.255482e-06 8 70608137 70608219 83 - 2.392 2.272 -0.401
ENSG00000067167 E025 191.1135812 2.567333e-03 4.344770e-03 1.410874e-02 8 70608220 70608262 43 - 2.196 2.098 -0.328
ENSG00000067167 E026 139.2440396 3.906279e-03 5.767294e-02 1.226341e-01 8 70608263 70608416 154 - 2.056 1.984 -0.243