ENSG00000067141

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000560328 ENSG00000067141 HEK293_OSMI2_2hA HEK293_TMG_2hB NEO1 protein_coding protein_coding 17.63303 18.47983 18.48839 0.2596363 1.037265 0.0006676825 5.1839971 8.028438 1.876233 0.2753285 0.4897166 -2.0914072 0.29693333 0.43420000 0.09960000 -0.33460000 7.906815e-08 3.703457e-11 FALSE TRUE
ENST00000560808 ENSG00000067141 HEK293_OSMI2_2hA HEK293_TMG_2hB NEO1 protein_coding retained_intron 17.63303 18.47983 18.48839 0.2596363 1.037265 0.0006676825 0.6596365 3.040296 0.000000 1.6511879 0.0000000 -8.2528054 0.03764583 0.16643333 0.00000000 -0.16643333 1.596886e-01 3.703457e-11 FALSE TRUE
MSTRG.11179.2 ENSG00000067141 HEK293_OSMI2_2hA HEK293_TMG_2hB NEO1 protein_coding   17.63303 18.47983 18.48839 0.2596363 1.037265 0.0006676825 2.0887387 0.000000 3.975912 0.0000000 0.9828757 8.6387660 0.11755000 0.00000000 0.22150000 0.22150000 3.703457e-11 3.703457e-11 FALSE TRUE
MSTRG.11179.6 ENSG00000067141 HEK293_OSMI2_2hA HEK293_TMG_2hB NEO1 protein_coding   17.63303 18.47983 18.48839 0.2596363 1.037265 0.0006676825 5.3873970 3.237273 7.663533 1.0698335 0.4063574 1.2406623 0.30501667 0.17360000 0.41516667 0.24156667 1.585274e-02 3.703457e-11 FALSE TRUE
MSTRG.11179.7 ENSG00000067141 HEK293_OSMI2_2hA HEK293_TMG_2hB NEO1 protein_coding   17.63303 18.47983 18.48839 0.2596363 1.037265 0.0006676825 1.5822595 1.510740 1.187216 0.2980996 0.8235929 -0.3450901 0.09017083 0.08170000 0.06066667 -0.02103333 7.415561e-01 3.703457e-11 FALSE TRUE
MSTRG.11179.8 ENSG00000067141 HEK293_OSMI2_2hA HEK293_TMG_2hB NEO1 protein_coding   17.63303 18.47983 18.48839 0.2596363 1.037265 0.0006676825 0.2818488 1.381112 0.000000 0.4376785 0.0000000 -7.1200944 0.01595000 0.07496667 0.00000000 -0.07496667 3.468702e-08 3.703457e-11 FALSE TRUE
MSTRG.11179.9 ENSG00000067141 HEK293_OSMI2_2hA HEK293_TMG_2hB NEO1 protein_coding   17.63303 18.47983 18.48839 0.2596363 1.037265 0.0006676825 1.2349043 0.000000 1.875923 0.0000000 0.4451805 7.5591269 0.06880417 0.00000000 0.10473333 0.10473333 5.924703e-10 3.703457e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000067141 E001 0.7363589 0.0155054194 2.128932e-02 5.419581e-02 15 73051710 73051841 132 + 0.397 0.000 -12.279
ENSG00000067141 E002 1.4663855 0.0097398453 3.811854e-01 5.254825e-01 15 73051842 73051910 69 + 0.446 0.315 -0.750
ENSG00000067141 E003 3.6526706 0.0043555454 3.419111e-02 8.012721e-02 15 73051911 73051964 54 + 0.784 0.495 -1.253
ENSG00000067141 E004 1.4456598 0.0096925359 3.803326e-01 5.246199e-01 15 73051965 73051992 28 + 0.446 0.315 -0.751
ENSG00000067141 E005 3.2421315 0.0047710083 1.077355e-01 2.021910e-01 15 73052463 73052483 21 + 0.714 0.496 -0.972
ENSG00000067141 E006 15.8626816 0.0011172988 4.276618e-05 2.448747e-04 15 73052484 73052609 126 + 1.358 1.039 -1.134
ENSG00000067141 E007 31.6756521 0.0074674487 1.589251e-06 1.263232e-05 15 73052610 73052805 196 + 1.646 1.321 -1.118
ENSG00000067141 E008 132.2916963 0.0054717126 9.638199e-09 1.192671e-07 15 73116540 73116857 318 + 2.224 1.995 -0.768
ENSG00000067141 E009 119.9183023 0.0079735019 4.031101e-08 4.429698e-07 15 73122525 73122633 109 + 2.191 1.936 -0.854
ENSG00000067141 E010 157.0753915 0.0115977875 2.097018e-06 1.623912e-05 15 73122634 73122800 167 + 2.300 2.066 -0.784
ENSG00000067141 E011 134.7883344 0.0079037936 9.344675e-06 6.253340e-05 15 73126417 73126570 154 + 2.217 2.027 -0.636
ENSG00000067141 E012 0.0000000       15 73126571 73126623 53 +      
ENSG00000067141 E013 116.1121397 0.0031862159 1.034952e-06 8.557834e-06 15 73135891 73135984 94 + 2.143 1.975 -0.562
ENSG00000067141 E014 80.5995681 0.0282187138 2.138697e-02 5.440628e-02 15 73135985 73136027 43 + 1.979 1.831 -0.499
ENSG00000067141 E015 126.3895594 0.0251001294 2.138599e-02 5.440533e-02 15 73176403 73176557 155 + 2.166 2.033 -0.443
ENSG00000067141 E016 118.2685016 0.0177415674 1.248192e-02 3.469231e-02 15 73178307 73178427 121 + 2.136 2.002 -0.446
ENSG00000067141 E017 0.1451727 0.0430141010 5.280410e-01   15 73221693 73221735 43 + 0.113 0.000 -9.958
ENSG00000067141 E018 0.0000000       15 73221919 73222087 169 +      
ENSG00000067141 E019 58.9705473 0.0028136026 7.633452e-02 1.536398e-01 15 73236287 73236346 60 + 1.798 1.744 -0.181
ENSG00000067141 E020 160.9344291 0.0044593138 6.545959e-05 3.581759e-04 15 73236347 73236506 160 + 2.266 2.137 -0.432
ENSG00000067141 E021 146.8580135 0.0014353845 5.986113e-08 6.348030e-07 15 73244344 73244498 155 + 2.237 2.091 -0.486
ENSG00000067141 E022 128.9566350 0.0004461325 5.550252e-04 2.365957e-03 15 73249060 73249208 149 + 2.149 2.078 -0.237
ENSG00000067141 E023 101.3844702 0.0004450118 4.999343e-02 1.091682e-01 15 73249583 73249721 139 + 2.027 1.997 -0.101
ENSG00000067141 E024 75.5269350 0.0009133871 5.831346e-02 1.237336e-01 15 73253400 73253449 50 + 1.905 1.865 -0.135
ENSG00000067141 E025 72.7995643 0.0003449157 2.639317e-02 6.473277e-02 15 73254682 73254716 35 + 1.892 1.840 -0.177
ENSG00000067141 E026 124.7907202 0.0043021368 2.075673e-02 5.307464e-02 15 73254717 73254829 113 + 2.130 2.070 -0.202
ENSG00000067141 E027 131.3985313 0.0014081078 4.212109e-03 1.373657e-02 15 73258766 73258876 111 + 2.150 2.089 -0.203
ENSG00000067141 E028 0.0000000       15 73258877 73259111 235 +      
ENSG00000067141 E029 191.8120458 0.0038512739 2.486502e-01 3.843351e-01 15 73260271 73260465 195 + 2.285 2.281 -0.011
ENSG00000067141 E030 129.1026486 0.0002479901 7.005254e-01 7.999688e-01 15 73266316 73266411 96 + 2.099 2.126 0.092
ENSG00000067141 E031 1.5738911 0.0099208288 2.644781e-01 4.024483e-01 15 73270010 73270057 48 + 0.278 0.496 1.251
ENSG00000067141 E032 208.7219696 0.0002390900 7.280855e-02 1.480133e-01 15 73270058 73270233 176 + 2.324 2.319 -0.016
ENSG00000067141 E033 198.0017934 0.0020389610 3.576548e-02 8.313090e-02 15 73270316 73270454 139 + 2.312 2.283 -0.097
ENSG00000067141 E034 172.8401182 0.0002521060 6.008213e-02 1.267384e-01 15 73272455 73272562 108 + 2.245 2.233 -0.039
ENSG00000067141 E035 194.0534031 0.0018989622 1.800728e-01 3.012641e-01 15 73273811 73274005 195 + 2.291 2.288 -0.008
ENSG00000067141 E036 10.8919321 0.0017404495 3.511459e-01 4.953612e-01 15 73274692 73274724 33 + 0.998 1.128 0.472
ENSG00000067141 E037 116.8479327 0.0002498265 7.182317e-01 8.134125e-01 15 73278131 73278199 69 + 2.045 2.096 0.172
ENSG00000067141 E038 191.6587343 0.0001876934 6.348821e-01 7.492790e-01 15 73282964 73283111 148 + 2.270 2.297 0.092
ENSG00000067141 E039 275.6979378 0.0001651591 8.149935e-02 1.618999e-01 15 73288313 73288551 239 + 2.401 2.478 0.257
ENSG00000067141 E040 0.1515154 0.0426008659 5.275103e-01   15 73289074 73289145 72 + 0.113 0.000 -9.959
ENSG00000067141 E041 180.1295050 0.0010421821 9.884825e-04 3.919155e-03 15 73289146 73289238 93 + 2.182 2.321 0.464
ENSG00000067141 E042 221.8460290 0.0016000031 1.563075e-04 7.751831e-04 15 73293390 73293548 159 + 2.264 2.418 0.513
ENSG00000067141 E043 0.4847352 0.2306268362 6.705865e-01 7.769972e-01 15 73298299 73298347 49 + 0.204 0.132 -0.752
ENSG00000067141 E044 310.8947830 0.0022422751 6.076275e-06 4.243648e-05 15 73298348 73298611 264 + 2.398 2.573 0.582
ENSG00000067141 E045 249.8091401 0.0036977520 1.195152e-05 7.799985e-05 15 73301321 73301457 137 + 2.287 2.488 0.668
ENSG00000067141 E046 0.0000000       15 73301458 73301550 93 +      
ENSG00000067141 E047 1062.6584951 0.0093370576 1.266371e-11 2.593062e-10 15 73302613 73305205 2593 + 2.836 3.157 1.065