ENSG00000066926

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000382873 ENSG00000066926 HEK293_OSMI2_2hA HEK293_TMG_2hB FECH protein_coding protein_coding 20.27777 14.16847 28.55081 2.779334 1.646069 1.010335 9.845251 8.7337337 12.141065 1.4689412 1.1973188 0.4747614 0.50942917 0.622533333 0.42536667 -0.197166667 0.001593911 0.001593911 FALSE TRUE
ENST00000585494 ENSG00000066926 HEK293_OSMI2_2hA HEK293_TMG_2hB FECH protein_coding nonsense_mediated_decay 20.27777 14.16847 28.55081 2.779334 1.646069 1.010335 1.073028 0.1011063 2.656571 0.1011063 0.7867369 4.5849738 0.04322500 0.009566667 0.09250000 0.082933333 0.057602974 0.001593911 FALSE TRUE
ENST00000585747 ENSG00000066926 HEK293_OSMI2_2hA HEK293_TMG_2hB FECH protein_coding processed_transcript 20.27777 14.16847 28.55081 2.779334 1.646069 1.010335 1.185586 0.0000000 2.687828 0.0000000 1.4094469 8.0756547 0.04225000 0.000000000 0.08900000 0.089000000 0.243404956 0.001593911 FALSE FALSE
ENST00000652755 ENSG00000066926 HEK293_OSMI2_2hA HEK293_TMG_2hB FECH protein_coding protein_coding 20.27777 14.16847 28.55081 2.779334 1.646069 1.010335 1.248853 1.3378700 1.695330 0.3019712 0.4195172 0.3393695 0.06224167 0.093566667 0.05966667 -0.033900000 0.383281181 0.001593911 FALSE TRUE
MSTRG.15833.5 ENSG00000066926 HEK293_OSMI2_2hA HEK293_TMG_2hB FECH protein_coding   20.27777 14.16847 28.55081 2.779334 1.646069 1.010335 4.841480 2.9812834 6.436041 0.2424039 0.4133087 1.1076488 0.24151667 0.219700000 0.22803333 0.008333333 0.944968178 0.001593911 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000066926 E001 0.0000000       18 57544377 57544388 12 -      
ENSG00000066926 E002 223.3255136 0.0078426917 2.244111e-02 5.659631e-02 18 57544389 57549568 5180 - 2.288 2.423 0.449
ENSG00000066926 E003 28.5568739 0.0114538103 1.461179e-02 3.961872e-02 18 57549569 57549583 15 - 1.366 1.574 0.715
ENSG00000066926 E004 213.8231348 0.0048863178 6.804255e-07 5.856637e-06 18 57549584 57549975 392 - 2.225 2.443 0.725
ENSG00000066926 E005 263.3585443 0.0025851961 4.151391e-05 2.383599e-04 18 57549976 57550253 278 - 2.353 2.504 0.501
ENSG00000066926 E006 416.6701973 0.0001657100 2.344094e-02 5.866179e-02 18 57550254 57550846 593 - 2.600 2.659 0.198
ENSG00000066926 E007 2.1359325 0.0067682678 7.415522e-01 8.306863e-01 18 57551175 57551314 140 - 0.459 0.528 0.338
ENSG00000066926 E008 142.3763941 0.0002853836 1.206306e-01 2.208605e-01 18 57551315 57551374 60 - 2.130 2.197 0.224
ENSG00000066926 E009 3.7383086 0.0041271925 6.598101e-02 1.366692e-01 18 57551945 57554259 2315 - 0.785 0.527 -1.105
ENSG00000066926 E010 219.9176117 0.0002330812 3.266352e-01 4.700739e-01 18 57554260 57554424 165 - 2.350 2.348 -0.006
ENSG00000066926 E011 185.4898378 0.0002379739 4.918178e-03 1.570241e-02 18 57554845 57554952 108 - 2.298 2.247 -0.170
ENSG00000066926 E012 143.9465607 0.0003155886 6.244984e-05 3.434931e-04 18 57559145 57559243 99 - 2.207 2.109 -0.328
ENSG00000066926 E013 0.2998086 0.0275480210 8.089774e-01   18 57559244 57559545 302 - 0.103 0.144 0.557
ENSG00000066926 E014 150.8673773 0.0008329894 8.545263e-03 2.515303e-02 18 57562874 57562980 107 - 2.214 2.153 -0.204
ENSG00000066926 E015 135.4502925 0.0003325648 2.930563e-02 7.059847e-02 18 57566447 57566547 101 - 2.160 2.115 -0.151
ENSG00000066926 E016 94.4893655 0.0003546231 4.047917e-01 5.484899e-01 18 57566548 57566581 34 - 1.989 1.981 -0.027
ENSG00000066926 E017 0.8931848 0.0383389806 2.044082e-01 3.316775e-01 18 57567845 57567876 32 - 0.369 0.144 -1.766
ENSG00000066926 E018 182.6572781 0.0002680657 1.194139e-05 7.794449e-05 18 57571392 57571540 149 - 2.308 2.214 -0.316
ENSG00000066926 E019 2.0765868 0.0098823075 1.684461e-01 2.861514e-01 18 57571541 57571603 63 - 0.566 0.340 -1.176
ENSG00000066926 E020 0.4502799 0.0377051519 1.633763e-01 2.795671e-01 18 57572990 57573004 15 - 0.256 0.000 -10.083
ENSG00000066926 E021 1.8488119 0.0236058931 7.677535e-02 1.543303e-01 18 57573005 57573245 241 - 0.566 0.253 -1.762
ENSG00000066926 E022 142.3174213 0.0003860307 9.373535e-08 9.568855e-07 18 57573246 57573365 120 - 2.218 2.075 -0.478
ENSG00000066926 E023 6.7064762 0.0041924067 9.867547e-01 9.957744e-01 18 57580055 57580072 18 - 0.886 0.909 0.084
ENSG00000066926 E024 102.7260525 0.0051349787 7.875922e-04 3.214836e-03 18 57580073 57580199 127 - 2.082 1.926 -0.522
ENSG00000066926 E025 0.8406553 0.2454473492 1.410830e-01 2.495239e-01 18 57585864 57585973 110 - 0.103 0.411 2.554
ENSG00000066926 E026 0.4470576 0.0217681645 7.965506e-01 8.701455e-01 18 57586219 57586553 335 - 0.186 0.144 -0.442
ENSG00000066926 E027 60.0520942 0.0072523178 1.350856e-04 6.816057e-04 18 57586554 57586760 207 - 1.876 1.643 -0.790