ENSG00000066629

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262233 ENSG00000066629 HEK293_OSMI2_2hA HEK293_TMG_2hB EML1 protein_coding protein_coding 9.254874 7.052438 13.37608 0.7446473 1.038684 0.9224952 4.1000072 4.3072149 4.3345054 0.3172012 0.1488195 0.00909103 0.46469583 0.61936667 0.3291000 -0.29026667 0.005010918 0.00172284 FALSE TRUE
ENST00000553313 ENSG00000066629 HEK293_OSMI2_2hA HEK293_TMG_2hB EML1 protein_coding retained_intron 9.254874 7.052438 13.37608 0.7446473 1.038684 0.9224952 0.3293389 0.9021890 0.0000000 0.5181615 0.0000000 -6.51126079 0.04407083 0.11760000 0.0000000 -0.11760000 0.088501268 0.00172284   TRUE
ENST00000557741 ENSG00000066629 HEK293_OSMI2_2hA HEK293_TMG_2hB EML1 protein_coding protein_coding 9.254874 7.052438 13.37608 0.7446473 1.038684 0.9224952 0.3973352 0.7028725 0.2456267 0.3469308 0.1627986 -1.47960562 0.05008333 0.09210000 0.0178000 -0.07430000 0.148962605 0.00172284   FALSE
MSTRG.10167.10 ENSG00000066629 HEK293_OSMI2_2hA HEK293_TMG_2hB EML1 protein_coding   9.254874 7.052438 13.37608 0.7446473 1.038684 0.9224952 0.9055036 0.4732002 1.6446370 0.2979885 0.2991170 1.77582174 0.08850417 0.07026667 0.1267333 0.05646667 0.572152172 0.00172284 FALSE TRUE
MSTRG.10167.9 ENSG00000066629 HEK293_OSMI2_2hA HEK293_TMG_2hB EML1 protein_coding   9.254874 7.052438 13.37608 0.7446473 1.038684 0.9224952 2.3710198 0.2295802 4.6115790 0.2295802 0.2699887 4.26980517 0.23423750 0.03686667 0.3488333 0.31196667 0.031858644 0.00172284 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000066629 E001 0.0000000       14 99737693 99737748 56 +      
ENSG00000066629 E002 0.0000000       14 99737749 99737860 112 +      
ENSG00000066629 E003 0.0000000       14 99772949 99773703 755 +      
ENSG00000066629 E004 0.0000000       14 99773704 99774013 310 +      
ENSG00000066629 E005 0.0000000       14 99792648 99792683 36 +      
ENSG00000066629 E006 0.0000000       14 99792684 99792902 219 +      
ENSG00000066629 E007 0.7363589 0.0154352299 7.050316e-02 1.441792e-01 14 99793328 99793342 15 + 0.341 0.000 -13.239
ENSG00000066629 E008 0.8878743 0.0131277707 4.161705e-02 9.403334e-02 14 99793343 99793376 34 + 0.386 0.000 -13.500
ENSG00000066629 E009 1.7995948 0.0077937680 2.773696e-02 6.749147e-02 14 99793377 99793396 20 + 0.559 0.160 -2.561
ENSG00000066629 E010 2.9904999 0.0050139350 1.017916e-03 4.020622e-03 14 99793397 99793412 16 + 0.743 0.160 -3.350
ENSG00000066629 E011 6.2368117 0.0047189878 2.846090e-03 9.812253e-03 14 99793413 99793434 22 + 0.971 0.564 -1.646
ENSG00000066629 E012 19.3084599 0.0028551023 1.356323e-03 5.164022e-03 14 99793435 99793517 83 + 1.387 1.128 -0.911
ENSG00000066629 E013 15.9059257 0.0016912413 1.227996e-02 3.420426e-02 14 99793518 99793543 26 + 1.292 1.083 -0.744
ENSG00000066629 E014 0.0000000       14 99809451 99809684 234 +      
ENSG00000066629 E015 0.0000000       14 99839042 99839071 30 +      
ENSG00000066629 E016 3.8221820 0.0566776685 5.825855e-01 7.069277e-01 14 99850124 99850332 209 + 0.704 0.615 -0.380
ENSG00000066629 E017 0.1451727 0.0431955494 8.467023e-01   14 99850850 99850852 3 + 0.093 0.000 -10.914
ENSG00000066629 E018 16.0506460 0.0212196050 4.623879e-02 1.024766e-01 14 99850853 99850859 7 + 1.293 1.083 -0.747
ENSG00000066629 E019 63.0390274 0.0004041529 1.663384e-06 1.316249e-05 14 99850860 99851035 176 + 1.869 1.661 -0.701
ENSG00000066629 E020 32.4389730 0.0109040380 3.969916e-03 1.305778e-02 14 99865514 99865517 4 + 1.592 1.372 -0.756
ENSG00000066629 E021 55.7995767 0.0030566017 8.616039e-06 5.810904e-05 14 99865518 99865608 91 + 1.823 1.588 -0.795
ENSG00000066629 E022 42.2867283 0.0005039706 1.663234e-07 1.619608e-06 14 99865609 99865646 38 + 1.718 1.428 -0.992
ENSG00000066629 E023 2.1067757 0.0068165298 6.979187e-01 7.979589e-01 14 99874931 99874987 57 + 0.498 0.444 -0.271
ENSG00000066629 E024 74.1594827 0.0003968082 1.360097e-05 8.758796e-05 14 99878485 99878619 135 + 1.925 1.756 -0.572
ENSG00000066629 E025 1.3390940 0.2210380835 8.656904e-02 1.699173e-01 14 99883241 99883546 306 + 0.170 0.560 2.459
ENSG00000066629 E026 3.4621521 0.1556998025 5.893428e-02 1.248091e-01 14 99885873 99886105 233 + 0.426 0.869 1.942
ENSG00000066629 E027 39.0647150 0.0192540007 6.873849e-03 2.089653e-02 14 99891199 99891227 29 + 1.666 1.444 -0.757
ENSG00000066629 E028 0.1515154 0.0433655075 8.463164e-01   14 99894453 99894628 176 + 0.093 0.000 -10.915
ENSG00000066629 E029 64.2582182 0.0005678717 6.922882e-05 3.763110e-04 14 99894629 99894758 130 + 1.865 1.698 -0.564
ENSG00000066629 E030 58.5970145 0.0038713544 3.106359e-03 1.057903e-02 14 99897145 99897241 97 + 1.820 1.673 -0.497
ENSG00000066629 E031 47.2771717 0.0005344577 2.782597e-02 6.767243e-02 14 99897242 99897294 53 + 1.710 1.613 -0.331
ENSG00000066629 E032 44.2692042 0.0049105998 1.173079e-01 2.161054e-01 14 99898233 99898302 70 + 1.672 1.590 -0.279
ENSG00000066629 E033 0.7019140 0.0176038873 5.691991e-01 6.957936e-01 14 99899412 99899478 67 + 0.169 0.276 0.900
ENSG00000066629 E034 55.8354537 0.0051075558 9.266110e-01 9.577855e-01 14 99900929 99901039 111 + 1.734 1.757 0.078
ENSG00000066629 E035 0.7437457 0.0146474925 4.420410e-01 5.837075e-01 14 99906872 99907637 766 + 0.291 0.160 -1.103
ENSG00000066629 E036 60.5315594 0.0051980846 7.003972e-01 7.998826e-01 14 99907638 99907733 96 + 1.760 1.800 0.135
ENSG00000066629 E037 0.2966881 0.0272504608 4.100363e-01   14 99909309 99909344 36 + 0.169 0.000 -11.915
ENSG00000066629 E038 77.9374178 0.0112656209 9.687412e-01 9.844237e-01 14 99909345 99909479 135 + 1.878 1.897 0.064
ENSG00000066629 E039 73.7981526 0.0078976550 3.257219e-01 4.691613e-01 14 99910242 99910341 100 + 1.879 1.839 -0.136
ENSG00000066629 E040 82.5225028 0.0003593908 2.100271e-01 3.385693e-01 14 99911422 99911576 155 + 1.924 1.894 -0.102
ENSG00000066629 E041 77.1902168 0.0085187113 6.816345e-01 7.852789e-01 14 99914179 99914304 126 + 1.885 1.876 -0.031
ENSG00000066629 E042 33.8742449 0.0129927539 6.683434e-01 7.753750e-01 14 99914566 99914575 10 + 1.536 1.516 -0.068
ENSG00000066629 E043 69.4836503 0.0004024646 2.646114e-01 4.025749e-01 14 99914576 99914697 122 + 1.850 1.821 -0.097
ENSG00000066629 E044 0.0000000       14 99914698 99915412 715 +      
ENSG00000066629 E045 45.3344014 0.0005239058 1.795781e-01 3.006091e-01 14 99917782 99917815 34 + 1.679 1.626 -0.178
ENSG00000066629 E046 48.7884303 0.0004870762 7.171777e-02 1.462088e-01 14 99917816 99917849 34 + 1.718 1.644 -0.251
ENSG00000066629 E047 66.6234752 0.0004350361 4.933065e-01 6.303237e-01 14 99920789 99920877 89 + 1.826 1.816 -0.036
ENSG00000066629 E048 65.3910757 0.0080965473 9.161746e-01 9.510026e-01 14 99936029 99936126 98 + 1.807 1.817 0.033
ENSG00000066629 E049 0.5149242 0.2689717169 3.623443e-01 5.067326e-01 14 99936167 99936246 80 + 0.093 0.277 1.904
ENSG00000066629 E050 55.1396438 0.0005449468 8.518787e-02 1.677172e-01 14 99936247 99936334 88 + 1.696 1.798 0.345
ENSG00000066629 E051 62.5650480 0.0004326835 9.436920e-02 1.819381e-01 14 99937817 99937912 96 + 1.752 1.847 0.319
ENSG00000066629 E052 72.4418426 0.0004093950 1.444141e-02 3.922635e-02 14 99939197 99939327 131 + 1.801 1.923 0.410
ENSG00000066629 E053 239.2701308 0.0060459930 2.939351e-06 2.203693e-05 14 99939987 99940861 875 + 2.277 2.488 0.704
ENSG00000066629 E054 78.7052725 0.0061353255 6.829537e-07 5.877063e-06 14 99940862 99941015 154 + 1.758 2.045 0.968
ENSG00000066629 E055 59.7857168 0.0045534067 2.354476e-07 2.226346e-06 14 99941016 99941085 70 + 1.633 1.936 1.024
ENSG00000066629 E056 116.4979380 0.0020674539 3.167973e-15 1.122639e-13 14 99941086 99942060 975 + 1.905 2.225 1.073
ENSG00000066629 E057 0.7374030 0.0153787590 4.427923e-01 5.843575e-01 14 99942117 99942223 107 + 0.291 0.160 -1.103