ENSG00000066468

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358487 ENSG00000066468 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR2 protein_coding protein_coding 10.57292 7.262056 10.69698 0.3715681 0.2755796 0.5581169 2.5137625 1.6136359 4.6884289 0.2855566 0.5195187 1.5329502 0.25028750 0.22366667 0.44070000 0.21703333 4.631887e-02 2.217621e-18 FALSE TRUE
ENST00000613048 ENSG00000066468 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR2 protein_coding protein_coding 10.57292 7.262056 10.69698 0.3715681 0.2755796 0.5581169 1.1616226 0.6276073 0.4338666 0.3165167 0.4338666 -0.5225422 0.09837083 0.08650000 0.03923333 -0.04726667 5.390354e-01 2.217621e-18 FALSE TRUE
ENST00000638709 ENSG00000066468 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR2 protein_coding protein_coding 10.57292 7.262056 10.69698 0.3715681 0.2755796 0.5581169 0.5200252 1.4413815 0.3616967 0.3886167 0.3616967 -1.9652290 0.06546250 0.20076667 0.03270000 -0.16806667 9.681987e-02 2.217621e-18 FALSE TRUE
ENST00000682904 ENSG00000066468 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR2 protein_coding processed_transcript 10.57292 7.262056 10.69698 0.3715681 0.2755796 0.5581169 1.1388890 1.2055040 0.2947624 0.6373908 0.2947624 -1.9957979 0.11579167 0.15880000 0.02710000 -0.13170000 4.475458e-01 2.217621e-18 FALSE TRUE
MSTRG.4742.25 ENSG00000066468 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR2 protein_coding   10.57292 7.262056 10.69698 0.3715681 0.2755796 0.5581169 1.0408203 0.4749238 1.6698432 0.2740577 0.2776937 1.7924966 0.09700000 0.06206667 0.15770000 0.09563333 4.188570e-01 2.217621e-18 FALSE TRUE
MSTRG.4742.26 ENSG00000066468 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR2 protein_coding   10.57292 7.262056 10.69698 0.3715681 0.2755796 0.5581169 1.7445059 0.0000000 2.0857999 0.0000000 0.2677130 7.7113572 0.13634167 0.00000000 0.19393333 0.19393333 2.217621e-18 2.217621e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000066468 E001 0.2214452 0.0434504018 3.457978e-01   10 121478332 121478333 2 - 0.000 0.145 12.516
ENSG00000066468 E002 0.3729606 0.0328398074 7.959731e-01 8.697203e-01 10 121478334 121478346 13 - 0.103 0.145 0.561
ENSG00000066468 E003 2.1516236 0.1194885829 1.233901e-01 2.247832e-01 10 121478347 121478356 10 - 0.317 0.654 1.710
ENSG00000066468 E004 2.3333280 0.0137021910 2.833536e-02 6.867411e-02 10 121478357 121478363 7 - 0.317 0.694 1.878
ENSG00000066468 E005 2.4848434 0.0262680351 6.678803e-02 1.380420e-01 10 121478364 121478367 4 - 0.370 0.693 1.553
ENSG00000066468 E006 143.7220005 0.0156984836 6.994033e-04 2.896742e-03 10 121478368 121479071 704 - 2.035 2.276 0.809
ENSG00000066468 E007 37.4113267 0.0005846062 1.437106e-06 1.153918e-05 10 121479072 121479217 146 - 1.432 1.722 0.991
ENSG00000066468 E008 10.7857417 0.0164832169 1.419010e-03 5.369883e-03 10 121479218 121479226 9 - 0.855 1.236 1.394
ENSG00000066468 E009 63.7465373 0.0083651006 1.298000e-02 3.586462e-02 10 121479227 121479618 392 - 1.727 1.888 0.545
ENSG00000066468 E010 37.2909121 0.0005909387 2.675795e-01 4.059046e-01 10 121479619 121479670 52 - 1.545 1.624 0.270
ENSG00000066468 E011 50.6800972 0.0006358180 8.263929e-02 1.636794e-01 10 121479671 121479784 114 - 1.663 1.765 0.346
ENSG00000066468 E012 49.2542114 0.0005171817 3.710861e-01 5.154935e-01 10 121479785 121479854 70 - 1.671 1.732 0.206
ENSG00000066468 E013 28.7867840 0.0006833762 5.582310e-01 6.865169e-01 10 121479855 121479856 2 - 1.448 1.502 0.185
ENSG00000066468 E014 74.0447949 0.0003630352 2.137218e-01 3.429147e-01 10 121479857 121480021 165 - 1.846 1.913 0.226
ENSG00000066468 E015 7.2328872 0.0085669127 7.037129e-01 8.023804e-01 10 121480022 121480113 92 - 0.887 0.949 0.235
ENSG00000066468 E016 1.8780403 0.2989835917 4.789578e-01 6.173820e-01 10 121480226 121480485 260 - 0.316 0.550 1.250
ENSG00000066468 E017 0.8846626 0.0141532222 8.029263e-02 1.600168e-01 10 121481835 121481855 21 - 0.103 0.412 2.559
ENSG00000066468 E018 4.4385391 0.0346284996 5.811152e-05 3.221753e-04 10 121481856 121482103 248 - 0.316 0.985 3.013
ENSG00000066468 E019 3.0130298 0.0056314421 3.070753e-04 1.408242e-03 10 121482104 121482177 74 - 0.256 0.840 2.879
ENSG00000066468 E020 2.9675946 0.0251410238 8.112504e-02 1.613007e-01 10 121482178 121483697 1520 - 0.701 0.412 -1.348
ENSG00000066468 E021 35.5655471 0.0057017018 2.715374e-01 4.103178e-01 10 121483698 121483717 20 - 1.525 1.617 0.315
ENSG00000066468 E022 56.9535143 0.0053975445 5.046437e-02 1.099912e-01 10 121483718 121483803 86 - 1.704 1.836 0.446
ENSG00000066468 E023 4.9592812 0.0058884288 2.011283e-01 3.275972e-01 10 121483804 121485394 1591 - 0.677 0.864 0.751
ENSG00000066468 E024 68.1400744 0.0020216350 8.322048e-04 3.374039e-03 10 121485395 121485532 138 - 1.758 1.930 0.580
ENSG00000066468 E025 36.9506867 0.0074408845 6.436959e-01 7.561714e-01 10 121487354 121487424 71 - 1.561 1.609 0.164
ENSG00000066468 E026 61.2092447 0.0006422388 3.386001e-01 4.824807e-01 10 121487991 121488113 123 - 1.806 1.780 -0.090
ENSG00000066468 E027 74.1843175 0.0003367302 3.804903e-01 5.247686e-01 10 121496532 121496722 191 - 1.886 1.867 -0.063
ENSG00000066468 E028 0.0000000       10 121496723 121496806 84 -      
ENSG00000066468 E029 54.0227226 0.0042276693 3.386421e-01 4.825149e-01 10 121498495 121498605 111 - 1.758 1.718 -0.136
ENSG00000066468 E030 64.1434480 0.0052887147 1.393689e-01 2.471822e-01 10 121500826 121500947 122 - 1.843 1.774 -0.233
ENSG00000066468 E031 69.3729391 0.0021860279 1.362500e-01 2.428190e-01 10 121503790 121503941 152 - 1.870 1.815 -0.186
ENSG00000066468 E032 2.8753973 0.0239975828 6.381450e-01 7.518516e-01 10 121503942 121506241 2300 - 0.533 0.621 0.395
ENSG00000066468 E033 0.1515154 0.0433727827 6.806738e-01   10 121510187 121510293 107 - 0.103 0.000 -11.690
ENSG00000066468 E034 17.5064889 0.0015520300 4.518733e-01 5.927862e-01 10 121515117 121515122 6 - 1.290 1.245 -0.159
ENSG00000066468 E035 50.3878436 0.0005771511 5.898037e-01 7.128194e-01 10 121515123 121515226 104 - 1.716 1.705 -0.035
ENSG00000066468 E036 52.2460279 0.0005495641 5.468753e-02 1.174474e-01 10 121515227 121515319 93 - 1.764 1.688 -0.259
ENSG00000066468 E037 2.5914212 0.0061074596 2.409002e-01 3.752338e-01 10 121517212 121517318 107 - 0.459 0.658 0.920
ENSG00000066468 E038 32.3269155 0.0010859153 1.115244e-02 3.153192e-02 10 121517319 121517333 15 - 1.586 1.444 -0.485
ENSG00000066468 E039 54.5747423 0.0004693002 8.596073e-03 2.527903e-02 10 121517334 121517463 130 - 1.793 1.684 -0.368
ENSG00000066468 E040 0.9943357 0.0136968632 6.925280e-01 7.937404e-01 10 121518682 121518829 148 - 0.317 0.253 -0.440
ENSG00000066468 E041 63.6141693 0.0004213785 1.205529e-02 3.366558e-02 10 121519979 121520169 191 - 1.851 1.756 -0.320
ENSG00000066468 E042 0.0000000       10 121526155 121526194 40 -      
ENSG00000066468 E043 0.0000000       10 121526195 121526250 56 -      
ENSG00000066468 E044 0.0000000       10 121526729 121526954 226 -      
ENSG00000066468 E045 0.0000000       10 121527676 121528003 328 -      
ENSG00000066468 E046 0.0000000       10 121530322 121530458 137 -      
ENSG00000066468 E047 0.0000000       10 121531267 121531354 88 -      
ENSG00000066468 E048 1.0223597 0.2897428897 1.149717e-01 2.127948e-01 10 121537966 121538410 445 - 0.103 0.473 2.877
ENSG00000066468 E049 58.1956219 0.0061567593 1.738953e-02 4.579873e-02 10 121538592 121538715 124 - 1.826 1.700 -0.425
ENSG00000066468 E050 64.8617951 0.0003929727 1.543972e-04 7.666721e-04 10 121551290 121551459 170 - 1.880 1.728 -0.511
ENSG00000066468 E051 0.0000000       10 121551460 121554260 2801 -      
ENSG00000066468 E052 0.0000000       10 121564324 121564324 1 -      
ENSG00000066468 E053 0.0000000       10 121564325 121564334 10 -      
ENSG00000066468 E054 1.5811763 0.0089486171 1.438347e-04 7.202268e-04 10 121564335 121564501 167 - 0.000 0.658 15.701
ENSG00000066468 E055 39.4696841 0.0007786869 1.419199e-02 3.866029e-02 10 121564502 121564579 78 - 1.653 1.529 -0.424
ENSG00000066468 E056 46.3380606 0.0058230979 4.755859e-03 1.524971e-02 10 121565438 121565636 199 - 1.737 1.569 -0.571
ENSG00000066468 E057 26.7908753 0.0013316063 2.812531e-02 6.826109e-02 10 121565637 121565704 68 - 1.499 1.364 -0.467
ENSG00000066468 E058 0.1482932 0.0408199072 3.494653e-01   10 121565705 121565911 207 - 0.000 0.144 12.528
ENSG00000066468 E059 0.0000000       10 121583302 121583574 273 -      
ENSG00000066468 E060 59.2161854 0.0044529252 8.357825e-04 3.386732e-03 10 121593709 121593967 259 - 1.846 1.671 -0.592
ENSG00000066468 E061 0.1482932 0.0408199072 3.494653e-01   10 121593968 121594111 144 - 0.000 0.144 12.528
ENSG00000066468 E062 0.0000000       10 121594112 121594554 443 -      
ENSG00000066468 E063 0.0000000       10 121594555 121594763 209 -      
ENSG00000066468 E064 0.1515154 0.0433727827 6.806738e-01   10 121594764 121595690 927 - 0.103 0.000 -11.690
ENSG00000066468 E065 0.0000000       10 121595691 121596476 786 -      
ENSG00000066468 E066 0.0000000       10 121596477 121596811 335 -      
ENSG00000066468 E067 37.8578017 0.0145119793 5.573737e-02 1.192425e-01 10 121597962 121598102 141 - 1.647 1.503 -0.494
ENSG00000066468 E068 27.2798766 0.0034811719 3.053755e-02 7.302300e-02 10 121598103 121598224 122 - 1.507 1.364 -0.491
ENSG00000066468 E069 14.8160333 0.0013572997 5.186692e-03 1.643672e-02 10 121598225 121598458 234 - 1.290 1.052 -0.850