ENSG00000066279

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367409 ENSG00000066279 HEK293_OSMI2_2hA HEK293_TMG_2hB ASPM protein_coding protein_coding 16.26655 6.199424 20.19007 0.8455103 0.8573331 1.701829 8.602608 1.165652 14.46803 0.2323628 0.2103882 3.622332 0.4330625 0.1845333 0.7188333 0.5343000 1.184331e-18 6.307857e-32 FALSE TRUE
MSTRG.2790.6 ENSG00000066279 HEK293_OSMI2_2hA HEK293_TMG_2hB ASPM protein_coding   16.26655 6.199424 20.19007 0.8455103 0.8573331 1.701829 5.868776 4.661901 4.20152 0.5793350 0.5109730 -0.149669 0.4797333 0.7547000 0.2066667 -0.5480333 6.307857e-32 6.307857e-32 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000066279 E001 0.0000000       1 197084121 197084126 6 -      
ENSG00000066279 E002 0.2965864 0.3885933172 2.432626e-02   1 197084127 197084127 1 - 0.000 0.410 12.153
ENSG00000066279 E003 0.2965864 0.3885933172 2.432626e-02   1 197084128 197084139 12 - 0.000 0.410 14.188
ENSG00000066279 E004 55.3606545 0.0268566862 3.943458e-12 8.767026e-11 1 197084140 197084323 184 - 1.426 2.079 2.211
ENSG00000066279 E005 112.2715863 0.0168672663 1.410145e-15 5.229985e-14 1 197084324 197084426 103 - 1.763 2.337 1.926
ENSG00000066279 E006 158.3671688 0.0008202927 7.446784e-59 7.347765e-56 1 197086803 197086972 170 - 1.922 2.459 1.797
ENSG00000066279 E007 141.9645162 0.0010519710 1.827545e-29 2.916789e-27 1 197088256 197088432 177 - 1.919 2.336 1.395
ENSG00000066279 E008 125.8222474 0.0002841914 5.102146e-19 2.907901e-17 1 197089930 197090084 155 - 1.893 2.232 1.136
ENSG00000066279 E009 155.7462508 0.0002245985 4.160096e-24 4.166498e-22 1 197090196 197090388 193 - 1.982 2.327 1.153
ENSG00000066279 E010 145.6849540 0.0002314704 2.363262e-16 9.722322e-15 1 197090850 197091041 192 - 1.966 2.262 0.991
ENSG00000066279 E011 55.6508095 0.0004633404 3.533678e-06 2.604134e-05 1 197091907 197091930 24 - 1.565 1.837 0.921
ENSG00000066279 E012 83.3591698 0.0003566868 3.522283e-10 5.666491e-09 1 197091931 197092056 126 - 1.727 2.026 1.006
ENSG00000066279 E013 101.7435492 0.0115808933 5.739024e-03 1.792559e-02 1 197093052 197093261 210 - 1.832 2.045 0.713
ENSG00000066279 E014 80.8654185 0.0105729255 5.503069e-02 1.180492e-01 1 197094084 197094180 97 - 1.746 1.904 0.531
ENSG00000066279 E015 105.5955548 0.0004566951 3.288433e-04 1.496334e-03 1 197095998 197096164 167 - 1.859 2.026 0.561
ENSG00000066279 E016 1.4864328 0.2252688288 5.760074e-01 7.015247e-01 1 197097282 197097503 222 - 0.281 0.428 0.880
ENSG00000066279 E017 1.5093631 0.0342486213 7.198912e-01 8.146053e-01 1 197098664 197098828 165 - 0.336 0.259 -0.520
ENSG00000066279 E018 974.5013870 0.0021455324 3.009326e-15 1.070964e-13 1 197100431 197104717 4287 - 2.878 2.707 -0.569
ENSG00000066279 E019 93.1372102 0.0047008798 7.194118e-11 1.300109e-09 1 197104718 197105185 468 - 1.891 1.407 -1.649
ENSG00000066279 E020 56.6323701 0.0004124451 4.052049e-04 1.794787e-03 1 197117789 197117931 143 - 1.659 1.406 -0.866
ENSG00000066279 E021 37.0250638 0.0005474670 5.507340e-04 2.349491e-03 1 197117932 197117983 52 - 1.486 1.172 -1.096
ENSG00000066279 E022 0.0000000       1 197121839 197121866 28 -      
ENSG00000066279 E023 0.4439371 0.0215539496 1.000000e+00 1.000000e+00 1 197121867 197121914 48 - 0.143 0.000 -14.038
ENSG00000066279 E024 52.5475899 0.0004225532 2.395760e-08 2.750391e-07 1 197121915 197122008 94 - 1.647 1.172 -1.647
ENSG00000066279 E025 36.8926818 0.0045047242 2.089212e-04 1.002089e-03 1 197122009 197122043 35 - 1.492 1.122 -1.295
ENSG00000066279 E026 54.1916808 0.0004216688 1.462773e-10 2.511430e-09 1 197122159 197122301 143 - 1.665 1.094 -1.986
ENSG00000066279 E027 71.2855822 0.0005390915 1.012784e-08 1.246955e-07 1 197122388 197122595 208 - 1.770 1.362 -1.393
ENSG00000066279 E028 72.2676284 0.0003620414 4.811443e-10 7.554396e-09 1 197124110 197124331 222 - 1.779 1.330 -1.536
ENSG00000066279 E029 45.6652758 0.0004818863 1.441574e-09 2.073867e-08 1 197124870 197124955 86 - 1.592 0.999 -2.086
ENSG00000066279 E030 2.8871444 0.0053040443 2.212354e-01 3.519151e-01 1 197124956 197125045 90 - 0.524 0.259 -1.520
ENSG00000066279 E031 77.4323754 0.0003585773 4.316923e-12 9.537355e-11 1 197125046 197125191 146 - 1.812 1.313 -1.705
ENSG00000066279 E032 76.7790842 0.0003339138 2.078654e-11 4.106735e-10 1 197128490 197128665 176 - 1.807 1.330 -1.632
ENSG00000066279 E033 0.2924217 0.0295239244 1.000000e+00   1 197128666 197129186 521 - 0.100 0.000 -13.366
ENSG00000066279 E034 55.5906007 0.0004241188 1.162412e-07 1.166828e-06 1 197129187 197129317 131 - 1.666 1.238 -1.476
ENSG00000066279 E035 55.9165383 0.0004128259 6.620910e-10 1.015719e-08 1 197129915 197130056 142 - 1.676 1.147 -1.831
ENSG00000066279 E036 41.7558062 0.0004930986 1.091740e-09 1.607546e-08 1 197132285 197132352 68 - 1.559 0.921 -2.263
ENSG00000066279 E037 65.7371465 0.0004182519 1.150496e-09 1.686022e-08 1 197133350 197133595 246 - 1.741 1.277 -1.592
ENSG00000066279 E038 56.9727706 0.0031231381 2.567521e-08 2.930528e-07 1 197135096 197135242 147 - 1.681 1.196 -1.678
ENSG00000066279 E039 0.2924217 0.0295239244 1.000000e+00   1 197139576 197139766 191 - 0.100 0.000 -13.366
ENSG00000066279 E040 49.8552822 0.0023093784 4.157310e-08 4.557284e-07 1 197139767 197139871 105 - 1.626 1.122 -1.756
ENSG00000066279 E041 268.6952777 0.0006185046 1.033827e-39 3.491186e-37 1 197142331 197143810 1480 - 2.350 1.805 -1.828
ENSG00000066279 E042 48.9661569 0.0008491916 9.462500e-09 1.172505e-07 1 197143957 197144100 144 - 1.620 1.094 -1.834
ENSG00000066279 E043 82.7959466 0.0004143606 3.158179e-05 1.869010e-04 1 197146141 197146797 657 - 1.823 1.576 -0.836