ENSG00000066117

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394963 ENSG00000066117 HEK293_OSMI2_2hA HEK293_TMG_2hB SMARCD1 protein_coding protein_coding 97.90893 135.8011 80.51132 5.959431 1.682453 -0.7541584 53.677097 64.05532 49.79127 7.633014 1.692240 -0.36336119 0.5660208 0.4687000 0.6182000 0.14950000 2.452878e-02 4.292279e-10 FALSE TRUE
ENST00000548573 ENSG00000066117 HEK293_OSMI2_2hA HEK293_TMG_2hB SMARCD1 protein_coding protein_coding 97.90893 135.8011 80.51132 5.959431 1.682453 -0.7541584 24.669765 51.31108 10.28602 4.794947 1.047851 -2.31746514 0.2280875 0.3818667 0.1281667 -0.25370000 2.995006e-05 4.292279e-10 FALSE TRUE
ENST00000551966 ENSG00000066117 HEK293_OSMI2_2hA HEK293_TMG_2hB SMARCD1 protein_coding protein_coding 97.90893 135.8011 80.51132 5.959431 1.682453 -0.7541584 7.612675 9.70441 9.18187 1.906952 1.045122 -0.07976799 0.0766625 0.0705000 0.1137667 0.04326667 1.486928e-01 4.292279e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000066117 E001 0.1451727 4.275279e-02 2.580113e-01   12 50084853 50085199 347 + 0.158 0.000 -12.042
ENSG00000066117 E002 0.9932018 1.278848e-02 3.436000e-01 4.876511e-01 12 50085200 50085305 106 + 0.158 0.343 1.456
ENSG00000066117 E003 0.8480291 1.427696e-02 8.236721e-02 1.632463e-01 12 50085306 50085310 5 + 0.000 0.343 12.386
ENSG00000066117 E004 0.8480291 1.427696e-02 8.236721e-02 1.632463e-01 12 50085311 50085316 6 + 0.000 0.343 12.386
ENSG00000066117 E005 2.0251134 7.165040e-03 4.968603e-01 6.334432e-01 12 50085317 50085324 8 + 0.365 0.501 0.720
ENSG00000066117 E006 3.0131064 5.238754e-03 6.823902e-01 7.858388e-01 12 50085325 50085327 3 + 0.610 0.563 -0.212
ENSG00000066117 E007 31.9777731 5.043078e-03 1.593619e-01 2.742609e-01 12 50085328 50085341 14 + 1.531 1.453 -0.265
ENSG00000066117 E008 40.4409838 1.156768e-02 2.044733e-01 3.317648e-01 12 50085342 50085352 11 + 1.626 1.556 -0.239
ENSG00000066117 E009 361.4558190 1.323362e-02 2.813637e-02 6.828356e-02 12 50085353 50085546 194 + 2.588 2.493 -0.318
ENSG00000066117 E010 2.8097219 1.692516e-01 3.639021e-02 8.432636e-02 12 50085683 50085870 188 + 0.798 0.351 -2.082
ENSG00000066117 E011 677.1970056 5.325254e-03 2.488950e-04 1.170529e-03 12 50086161 50086348 188 + 2.869 2.760 -0.360
ENSG00000066117 E012 395.7031801 2.096754e-03 2.708584e-05 1.628477e-04 12 50086621 50086663 43 + 2.626 2.531 -0.315
ENSG00000066117 E013 632.4991724 2.992090e-03 6.736543e-05 3.674053e-04 12 50086756 50086878 123 + 2.829 2.736 -0.309
ENSG00000066117 E014 5.4973193 2.951437e-03 2.104305e-10 3.512373e-09 12 50086879 50086917 39 + 1.165 0.344 -3.496
ENSG00000066117 E015 566.8494631 1.800913e-03 4.103332e-05 2.359401e-04 12 50087363 50087485 123 + 2.772 2.693 -0.263
ENSG00000066117 E016 10.4511348 8.337663e-02 3.303123e-02 7.786751e-02 12 50088235 50088290 56 + 1.227 0.893 -1.218
ENSG00000066117 E017 315.3803105 1.017981e-03 8.124077e-04 3.303531e-03 12 50088521 50088524 4 + 2.507 2.445 -0.206
ENSG00000066117 E018 638.5694870 1.690129e-03 5.281458e-06 3.738162e-05 12 50088525 50088637 113 + 2.828 2.743 -0.282
ENSG00000066117 E019 25.5905233 2.422825e-02 4.188053e-16 1.660935e-14 12 50088638 50089422 785 + 1.777 0.941 -2.931
ENSG00000066117 E020 624.2701541 3.371233e-03 3.257866e-03 1.102583e-02 12 50089884 50089985 102 + 2.806 2.740 -0.220
ENSG00000066117 E021 794.7769282 3.037445e-03 6.517106e-03 1.996614e-02 12 50090241 50090402 162 + 2.903 2.849 -0.177
ENSG00000066117 E022 705.9405470 2.564156e-03 1.765884e-04 8.636447e-04 12 50090493 50090590 98 + 2.868 2.790 -0.260
ENSG00000066117 E023 748.9529144 9.249271e-04 3.606504e-09 4.819705e-08 12 50094437 50094505 69 + 2.901 2.811 -0.299
ENSG00000066117 E024 770.3544365 9.462200e-04 6.885915e-08 7.217238e-07 12 50094506 50094572 67 + 2.906 2.826 -0.266
ENSG00000066117 E025 3.1323697 5.043581e-03 2.437797e-01 3.786170e-01 12 50096659 50096849 191 + 0.695 0.533 -0.712
ENSG00000066117 E026 867.1142974 1.190819e-04 2.769959e-06 2.089430e-05 12 50096850 50096972 123 + 2.930 2.892 -0.126
ENSG00000066117 E027 16.3697010 1.324907e-03 7.274738e-04 2.997797e-03 12 50098495 50098713 219 + 1.369 1.108 -0.922
ENSG00000066117 E028 850.1039680 9.494401e-05 1.759711e-03 6.470979e-03 12 50098714 50098815 102 + 2.907 2.890 -0.057
ENSG00000066117 E029 1119.7016648 7.810086e-05 6.310324e-01 7.461393e-01 12 50098947 50099141 195 + 3.003 3.021 0.063
ENSG00000066117 E030 1347.8900197 8.679422e-04 1.257571e-03 4.835003e-03 12 50099142 50099429 288 + 3.040 3.121 0.269
ENSG00000066117 E031 748.1262554 2.319754e-03 9.279146e-04 3.712580e-03 12 50099430 50099486 57 + 2.759 2.875 0.385
ENSG00000066117 E032 877.1179881 2.133880e-03 1.836422e-03 6.716176e-03 12 50099487 50099565 79 + 2.836 2.942 0.353
ENSG00000066117 E033 1396.3759248 1.189585e-03 1.159522e-09 1.697720e-08 12 50099566 50099799 234 + 3.010 3.152 0.472
ENSG00000066117 E034 952.4803335 2.700558e-03 1.397328e-05 8.976287e-05 12 50099800 50099900 101 + 2.839 2.987 0.491
ENSG00000066117 E035 1168.5763787 2.877726e-03 4.331827e-06 3.125815e-05 12 50099901 50100053 153 + 2.923 3.078 0.514
ENSG00000066117 E036 1730.3594651 6.445380e-03 2.720239e-09 3.725448e-08 12 50100054 50100707 654 + 3.015 3.270 0.849