ENSG00000065883

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340829 ENSG00000065883 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK13 protein_coding protein_coding 18.24333 15.03821 23.42191 0.5074637 0.5037446 0.638883 2.2393733 0.6594828 4.1842702 0.4046022 0.6052675 2.6473010 0.11191667 0.04316667 0.17920000 0.13603333 0.255609608 0.001304779 FALSE TRUE
ENST00000478563 ENSG00000065883 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK13 protein_coding processed_transcript 18.24333 15.03821 23.42191 0.5074637 0.5037446 0.638883 1.2660310 0.0000000 2.2182090 0.0000000 1.1140293 7.7997408 0.06158333 0.00000000 0.09276667 0.09276667 0.221863990 0.001304779 FALSE FALSE
ENST00000642626 ENSG00000065883 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK13 protein_coding protein_coding 18.24333 15.03821 23.42191 0.5074637 0.5037446 0.638883 1.0377112 1.4040797 0.6259993 0.2720387 0.2642153 -1.1527664 0.05959167 0.09246667 0.02703333 -0.06543333 0.137184654 0.001304779 FALSE FALSE
ENST00000643859 ENSG00000065883 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK13 protein_coding protein_coding 18.24333 15.03821 23.42191 0.5074637 0.5037446 0.638883 5.0074808 2.7348296 7.7072807 0.1898067 1.4153037 1.4913760 0.25730417 0.18160000 0.32810000 0.14650000 0.086682476 0.001304779 FALSE TRUE
ENST00000643915 ENSG00000065883 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK13 protein_coding protein_coding 18.24333 15.03821 23.42191 0.5074637 0.5037446 0.638883 0.9752385 1.5517482 1.5111115 0.6634289 0.8010208 -0.0380359 0.05806250 0.10270000 0.06596667 -0.03673333 0.805781516 0.001304779 FALSE TRUE
ENST00000644561 ENSG00000065883 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK13 protein_coding retained_intron 18.24333 15.03821 23.42191 0.5074637 0.5037446 0.638883 0.9256136 1.7849067 0.5643821 0.9107965 0.3695297 -1.6438262 0.06198750 0.11983333 0.02463333 -0.09520000 0.732332386 0.001304779 FALSE TRUE
ENST00000645826 ENSG00000065883 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK13 protein_coding retained_intron 18.24333 15.03821 23.42191 0.5074637 0.5037446 0.638883 2.4304530 3.8714192 0.9684099 0.4609915 0.5294694 -1.9880734 0.14839583 0.25773333 0.04106667 -0.21666667 0.001304779 0.001304779 FALSE TRUE
MSTRG.29772.1 ENSG00000065883 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK13 protein_coding   18.24333 15.03821 23.42191 0.5074637 0.5037446 0.638883 3.0153350 2.1716456 3.8925552 0.3141319 0.3430712 0.8390023 0.16315000 0.14456667 0.16596667 0.02140000 0.743334549 0.001304779 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000065883 E001 21.3451891 0.0128921318 4.878658e-02 1.070040e-01 7 39950088 39950120 33 + 1.385 1.239 -0.511
ENSG00000065883 E002 41.5242760 0.0026060743 1.357404e-01 2.421410e-01 7 39950121 39950255 135 + 1.629 1.581 -0.163
ENSG00000065883 E003 40.8580363 0.0111897596 1.390842e-01 2.468135e-01 7 39950256 39950359 104 + 1.631 1.563 -0.233
ENSG00000065883 E004 84.1448741 0.0086360119 1.097038e-02 3.109187e-02 7 39950360 39950753 394 + 1.956 1.852 -0.352
ENSG00000065883 E005 38.5061923 0.0133272557 4.535046e-03 1.464104e-02 7 39950754 39951017 264 + 1.645 1.459 -0.637
ENSG00000065883 E006 32.5960934 0.0061992723 2.215772e-06 1.706596e-05 7 39951018 39951301 284 + 1.609 1.282 -1.129
ENSG00000065883 E007 87.8634099 0.0081329948 4.930105e-02 1.079250e-01 7 39951302 39951750 449 + 1.958 1.893 -0.221
ENSG00000065883 E008 59.5394530 0.0011036943 4.968620e-01 6.334432e-01 7 39951751 39951852 102 + 1.760 1.770 0.033
ENSG00000065883 E009 3.4835619 0.0139684874 6.835462e-01 7.867224e-01 7 39951853 39952918 1066 + 0.608 0.704 0.410
ENSG00000065883 E010 0.6287620 0.0172671820 5.871339e-01 7.104861e-01 7 39984105 39987152 3048 + 0.167 0.279 0.942
ENSG00000065883 E011 84.7207801 0.0014821935 2.856349e-04 1.321433e-03 7 39987599 39987768 170 + 1.957 1.841 -0.392
ENSG00000065883 E012 47.4775655 0.0075537727 9.017898e-02 1.753946e-01 7 39987769 39987835 67 + 1.698 1.626 -0.243
ENSG00000065883 E013 128.3901716 0.0003699561 8.935319e-03 2.611654e-02 7 39987836 39988073 238 + 2.114 2.072 -0.143
ENSG00000065883 E014 141.0587883 0.0006365175 1.875030e-02 4.878373e-02 7 39988074 39988258 185 + 2.150 2.118 -0.109
ENSG00000065883 E015 135.5727691 0.0054188816 2.027479e-01 3.296598e-01 7 39997494 39997664 171 + 2.124 2.112 -0.041
ENSG00000065883 E016 10.2090101 0.0204447029 6.216411e-07 5.397747e-06 7 39997665 39997983 319 + 0.655 1.314 2.477
ENSG00000065883 E017 1.3200789 0.0118949003 2.907195e-02 7.014523e-02 7 39998044 39998134 91 + 0.167 0.569 2.527
ENSG00000065883 E018 1.5864763 0.0878138189 6.486120e-02 1.348083e-01 7 39998250 39998836 587 + 0.231 0.614 2.144
ENSG00000065883 E019 0.5212538 0.0206205429 2.949159e-01 4.360216e-01 7 39998837 39999345 509 + 0.092 0.279 1.943
ENSG00000065883 E020 0.2924217 0.0290785164 3.970903e-01   7 39999346 39999360 15 + 0.167 0.000 -11.256
ENSG00000065883 E021 50.4662246 0.0043020491 1.078507e-02 3.065150e-02 7 39999361 39999388 28 + 1.738 1.629 -0.370
ENSG00000065883 E022 102.0213426 0.0003502532 7.106685e-08 7.424398e-07 7 39999389 39999500 112 + 2.055 1.896 -0.534
ENSG00000065883 E023 118.7927369 0.0003399112 1.409888e-08 1.691142e-07 7 40001861 40002031 171 + 2.119 1.965 -0.517
ENSG00000065883 E024 0.1472490 0.0432717302 8.154040e-01   7 40002032 40002249 218 + 0.092 0.000 -10.256
ENSG00000065883 E025 81.3885002 0.0036762724 2.848525e-02 6.898356e-02 7 40045836 40045929 94 + 1.927 1.863 -0.216
ENSG00000065883 E026 79.8920409 0.0027218755 2.392871e-01 3.732767e-01 7 40045930 40046025 96 + 1.898 1.887 -0.039
ENSG00000065883 E027 72.7510450 0.0026945898 1.953296e-01 3.203786e-01 7 40047821 40047877 57 + 1.861 1.841 -0.067
ENSG00000065883 E028 1.3338852 0.0101923831 9.521059e-01 9.740209e-01 7 40047878 40049206 1329 + 0.337 0.372 0.207
ENSG00000065883 E029 0.4407149 0.0230169438 9.274605e-01 9.583572e-01 7 40059215 40059279 65 + 0.167 0.162 -0.058
ENSG00000065883 E030 7.0337899 0.0241425840 3.447228e-04 1.558856e-03 7 40060820 40062510 1691 + 1.036 0.512 -2.133
ENSG00000065883 E031 2.1768218 0.0068401377 6.686893e-02 1.381665e-01 7 40062511 40062825 315 + 0.582 0.279 -1.641
ENSG00000065883 E032 90.8773921 0.0005419905 9.631458e-01 9.807207e-01 7 40062826 40062927 102 + 1.934 1.979 0.151
ENSG00000065883 E033 86.1624371 0.0018907340 4.863007e-01 6.240846e-01 7 40063023 40063100 78 + 1.924 1.936 0.042
ENSG00000065883 E034 0.8041237 0.0157664656 2.940701e-01 4.351582e-01 7 40066693 40066882 190 + 0.167 0.372 1.528
ENSG00000065883 E035 0.7480121 0.1069037338 4.667768e-01 6.063172e-01 7 40067260 40067973 714 + 0.288 0.161 -1.068
ENSG00000065883 E036 4.5675010 0.0034840472 1.796290e-02 4.705631e-02 7 40069310 40073143 3834 + 0.837 0.513 -1.379
ENSG00000065883 E037 0.0000000       7 40073618 40073692 75 +      
ENSG00000065883 E038 87.4073828 0.0003072589 7.664048e-01 8.489201e-01 7 40078005 40078100 96 + 1.922 1.954 0.106
ENSG00000065883 E039 49.0605166 0.0005363289 3.223479e-01 4.656622e-01 7 40078101 40078121 21 + 1.652 1.745 0.315
ENSG00000065883 E040 3.1938724 0.0158697550 2.315935e-01 3.643653e-01 7 40078414 40078719 306 + 0.677 0.512 -0.736
ENSG00000065883 E041 104.7879541 0.0002707279 6.126000e-01 7.314953e-01 7 40078720 40078851 132 + 1.987 2.048 0.204
ENSG00000065883 E042 0.8846520 0.0136581675 2.898074e-01 4.305453e-01 7 40085699 40085746 48 + 0.337 0.162 -1.380
ENSG00000065883 E043 159.5020514 0.0003788219 6.588745e-01 7.678669e-01 7 40088126 40088331 206 + 2.169 2.225 0.188
ENSG00000065883 E044 0.8921407 0.0130627890 3.909375e-02 8.936261e-02 7 40092247 40092784 538 + 0.382 0.000 -12.841
ENSG00000065883 E045 28.3075429 0.0007741036 7.864054e-01 8.632192e-01 7 40092785 40092964 180 + 1.428 1.488 0.207
ENSG00000065883 E046 227.5677888 0.0019264075 1.376366e-01 2.447951e-01 7 40092965 40093237 273 + 2.310 2.399 0.298
ENSG00000065883 E047 732.0458470 0.0084635744 1.740066e-06 1.371657e-05 7 40094130 40095555 1426 + 2.753 2.977 0.744
ENSG00000065883 E048 146.4951918 0.0029305706 2.876653e-03 9.901585e-03 7 40095556 40096966 1411 + 2.090 2.248 0.528
ENSG00000065883 E049 24.5225174 0.0010054135 2.320978e-02 5.818087e-02 7 40096967 40099580 2614 + 1.306 1.507 0.694
ENSG00000065883 E050 1.5104073 0.1179298896 3.488623e-01 4.930834e-01 7 40103294 40103383 90 + 0.459 0.278 -1.063