ENSG00000065882

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261439 ENSG00000065882 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D1 protein_coding protein_coding 4.444594 5.313029 4.806805 0.3931989 0.122261 -0.1441709 0.2961697 0.41296651 0.4418641 0.07106691 0.06748368 0.09534553 0.06643750 0.079633333 0.09236667 0.01273333 8.439733e-01 1.659361e-09 FALSE TRUE
ENST00000443855 ENSG00000065882 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D1 protein_coding protein_coding 4.444594 5.313029 4.806805 0.3931989 0.122261 -0.1441709 0.1934715 0.05089234 0.3750109 0.05089234 0.14254277 2.66056662 0.04339167 0.009133333 0.07676667 0.06763333 1.293875e-01 1.659361e-09 FALSE FALSE
ENST00000446803 ENSG00000065882 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D1 protein_coding protein_coding 4.444594 5.313029 4.806805 0.3931989 0.122261 -0.1441709 0.2727320 0.00000000 0.5311771 0.00000000 0.06044513 5.75802878 0.06559583 0.000000000 0.11113333 0.11113333 1.659361e-09 1.659361e-09 FALSE TRUE
ENST00000509761 ENSG00000065882 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D1 protein_coding processed_transcript 4.444594 5.313029 4.806805 0.3931989 0.122261 -0.1441709 0.1480549 0.04553946 0.3277750 0.04553946 0.32777496 2.60447720 0.03363333 0.007800000 0.06606667 0.05826667 1.000000e+00 1.659361e-09 FALSE FALSE
ENST00000510573 ENSG00000065882 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D1 protein_coding protein_coding 4.444594 5.313029 4.806805 0.3931989 0.122261 -0.1441709 0.4118975 0.83531584 0.2052154 0.42602934 0.10423100 -1.97370943 0.08710417 0.171166667 0.04296667 -0.12820000 4.653754e-01 1.659361e-09 FALSE TRUE
ENST00000511238 ENSG00000065882 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D1 protein_coding retained_intron 4.444594 5.313029 4.806805 0.3931989 0.122261 -0.1441709 0.1726448 0.00000000 0.5002052 0.00000000 0.25340759 5.67300556 0.03836667 0.000000000 0.10623333 0.10623333 1.782554e-01 1.659361e-09 FALSE TRUE
MSTRG.24731.4 ENSG00000065882 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D1 protein_coding   4.444594 5.313029 4.806805 0.3931989 0.122261 -0.1441709 2.7049687 3.79462084 2.2835618 0.74068946 0.21862970 -0.73016290 0.61060833 0.700433333 0.47483333 -0.22560000 1.765981e-01 1.659361e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000065882 E001 0.0000000       4 37891084 37891086 3 +      
ENSG00000065882 E002 0.0000000       4 37891087 37891098 12 +      
ENSG00000065882 E003 1.2136160 0.0137370034 6.727702e-01 0.7786274025 4 37891099 37891348 250 + 0.270 0.349 0.517
ENSG00000065882 E004 10.5665647 0.0017104629 1.396448e-01 0.2475371114 4 37902003 37902512 510 + 1.130 0.983 -0.534
ENSG00000065882 E005 2.9398527 0.0055068351 4.590073e-01 0.5992402694 4 37952006 37952812 807 + 0.498 0.623 0.571
ENSG00000065882 E006 0.1451727 0.0434478458 2.862103e-01   4 37977304 37977309 6 + 0.155 0.000 -12.504
ENSG00000065882 E007 8.3524753 0.0036836428 5.300325e-03 0.0167486299 4 37977310 37977529 220 + 1.129 0.823 -1.140
ENSG00000065882 E008 28.6302862 0.0006711439 2.325468e-02 0.0582779871 4 38014509 38014882 374 + 1.539 1.396 -0.491
ENSG00000065882 E009 22.4257725 0.0008471790 6.608615e-01 0.7694610428 4 38014883 38014973 91 + 1.369 1.341 -0.097
ENSG00000065882 E010 30.0196022 0.0065988336 3.740185e-01 0.5184348240 4 38018354 38018443 90 + 1.511 1.450 -0.208
ENSG00000065882 E011 30.9104690 0.0008133465 2.752092e-01 0.4144808930 4 38020591 38020676 86 + 1.528 1.463 -0.222
ENSG00000065882 E012 19.3930637 0.0010160374 1.078230e-01 0.2023151265 4 38020677 38020695 19 + 1.369 1.249 -0.420
ENSG00000065882 E013 0.2966881 0.0274147191 8.885821e-02   4 38020696 38020864 169 + 0.270 0.000 -13.561
ENSG00000065882 E014 30.1947110 0.0006774195 4.034499e-01 0.5472276571 4 38021586 38021718 133 + 1.505 1.456 -0.169
ENSG00000065882 E015 29.8586955 0.0014530753 6.270894e-01 0.7429330890 4 38027788 38027879 92 + 1.481 1.452 -0.099
ENSG00000065882 E016 0.2998086 0.0292505902 6.765487e-01   4 38030391 38030456 66 + 0.155 0.095 -0.808
ENSG00000065882 E017 37.5127190 0.0016573908 3.802630e-02 0.0873981593 4 38035588 38035698 111 + 1.635 1.515 -0.410
ENSG00000065882 E018 38.7145932 0.0197497532 8.630251e-02 0.1694836746 4 38044362 38044473 112 + 1.665 1.513 -0.518
ENSG00000065882 E019 23.6394634 0.0259821862 6.309117e-01 0.7460347090 4 38044474 38044490 17 + 1.400 1.346 -0.188
ENSG00000065882 E020 30.3569669 0.0077017292 6.390385e-01 0.7525235932 4 38045817 38045870 54 + 1.493 1.456 -0.127
ENSG00000065882 E021 25.4533477 0.0009907414 7.866945e-01 0.8633870386 4 38045871 38045903 33 + 1.407 1.391 -0.054
ENSG00000065882 E022 43.3175854 0.0005666830 4.525646e-02 0.1006598273 4 38049618 38049756 139 + 1.688 1.584 -0.352
ENSG00000065882 E023 51.6021063 0.0004528766 1.815600e-02 0.0474663255 4 38049757 38049898 142 + 1.771 1.661 -0.375
ENSG00000065882 E024 2.3938117 0.0206265495 3.985741e-02 0.0907687045 4 38051899 38052060 162 + 0.724 0.392 -1.550
ENSG00000065882 E025 1.6575400 0.0086484067 3.800365e-01 0.5242998664 4 38053106 38053225 120 + 0.498 0.349 -0.805
ENSG00000065882 E026 52.2431005 0.0005796571 1.653268e-02 0.0439126818 4 38054199 38054338 140 + 1.778 1.665 -0.381
ENSG00000065882 E027 0.0000000       4 38054980 38055042 63 +      
ENSG00000065882 E028 0.0000000       4 38060620 38060658 39 +      
ENSG00000065882 E029 63.9810188 0.0004470391 9.339575e-02 0.1804248729 4 38089932 38090117 186 + 1.836 1.766 -0.237
ENSG00000065882 E030 61.9101616 0.0004739839 9.268525e-01 0.9579556095 4 38095929 38096090 162 + 1.768 1.777 0.028
ENSG00000065882 E031 38.0406618 0.0005596534 3.175542e-02 0.0753795094 4 38102999 38103047 49 + 1.475 1.609 0.458
ENSG00000065882 E032 56.0276521 0.0005992088 2.078516e-01 0.3359054567 4 38103048 38103157 110 + 1.688 1.754 0.225
ENSG00000065882 E033 0.0000000       4 38110181 38110734 554 +      
ENSG00000065882 E034 0.0000000       4 38111902 38112101 200 +      
ENSG00000065882 E035 72.3156723 0.0004025301 9.496940e-01 0.9725120176 4 38115710 38115899 190 + 1.839 1.846 0.024
ENSG00000065882 E036 42.0605661 0.0013390426 4.749550e-01 0.6137337146 4 38115900 38115954 55 + 1.575 1.619 0.151
ENSG00000065882 E037 66.1817104 0.0006630030 8.925081e-02 0.1739984315 4 38118033 38118192 160 + 1.742 1.824 0.277
ENSG00000065882 E038 0.3332198 0.0313114171 6.795472e-01   4 38118193 38118396 204 + 0.155 0.096 -0.805
ENSG00000065882 E039 0.3634088 0.3827360400 5.010712e-01   4 38118397 38118585 189 + 0.000 0.175 10.732
ENSG00000065882 E040 0.0000000       4 38119954 38120108 155 +      
ENSG00000065882 E041 75.5479179 0.0003947776 3.678138e-02 0.0850517719 4 38124962 38125110 149 + 1.796 1.889 0.314
ENSG00000065882 E042 36.2790499 0.0006921139 8.009562e-01 0.8731456614 4 38125111 38125131 21 + 1.560 1.549 -0.035
ENSG00000065882 E043 0.0000000       4 38132707 38132759 53 +      
ENSG00000065882 E044 0.0000000       4 38132760 38132830 71 +      
ENSG00000065882 E045 0.1482932 0.0410053545 8.004756e-01   4 38132831 38133083 253 + 0.000 0.095 10.448
ENSG00000065882 E046 95.2374628 0.0010561711 9.659619e-04 0.0038417640 4 38133084 38133257 174 + 1.862 2.000 0.461
ENSG00000065882 E047 156.1369664 0.0036206779 1.257209e-05 0.0000816561 4 38137135 38139175 2041 + 2.044 2.220 0.590