ENSG00000065809

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378467 ENSG00000065809 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM107B protein_coding protein_coding 11.99599 5.599745 23.35461 0.6362301 0.7922422 2.058318 1.2684623 0.1730372 2.4287214 0.0851870 0.5450013 3.7359164 0.08692500 0.03353333 0.10326667 0.06973333 0.1523440839 0.0001505396 FALSE FALSE
ENST00000378470 ENSG00000065809 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM107B protein_coding protein_coding 11.99599 5.599745 23.35461 0.6362301 0.7922422 2.058318 6.0559985 4.1534444 9.7891757 0.9646369 0.6932965 1.2348828 0.59403750 0.72386667 0.41813333 -0.30573333 0.0425111620 0.0001505396 FALSE FALSE
ENST00000468747 ENSG00000065809 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM107B protein_coding protein_coding 11.99599 5.599745 23.35461 0.6362301 0.7922422 2.058318 3.4005194 0.6158902 7.3890903 0.3603231 0.6608569 3.5633664 0.21817917 0.12383333 0.31783333 0.19400000 0.4583764098 0.0001505396 FALSE FALSE
ENST00000491458 ENSG00000065809 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM107B protein_coding processed_transcript 11.99599 5.599745 23.35461 0.6362301 0.7922422 2.058318 0.3531019 0.6021093 0.3796031 0.1089152 0.1189650 -0.6517843 0.04651667 0.10880000 0.01653333 -0.09226667 0.0001505396 0.0001505396 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000065809 E001 0.4470576 0.0230252451 5.945612e-01 7.167750e-01 10 14518557 14518558 2 - 0.122 0.218 1.003
ENSG00000065809 E002 148.0482092 0.0124817055 1.125648e-04 5.796746e-04 10 14518559 14519158 600 - 2.028 2.287 0.867
ENSG00000065809 E003 152.8281405 0.0010534555 1.362078e-05 8.769465e-05 10 14519159 14519512 354 - 2.073 2.243 0.568
ENSG00000065809 E004 166.9852800 0.0014199687 7.684646e-15 2.572143e-13 10 14519513 14519901 389 - 2.076 2.353 0.923
ENSG00000065809 E005 308.1791225 0.0003539502 7.390950e-14 2.140641e-12 10 14519902 14520794 893 - 2.371 2.555 0.615
ENSG00000065809 E006 51.8311446 0.0005759153 4.189716e-01 5.622346e-01 10 14520795 14520850 56 - 1.658 1.631 -0.093
ENSG00000065809 E007 102.8576075 0.0003173933 1.069231e-02 3.043584e-02 10 14520851 14521016 166 - 1.965 1.877 -0.297
ENSG00000065809 E008 69.6141432 0.0003545660 2.627778e-02 6.450511e-02 10 14521017 14521072 56 - 1.799 1.704 -0.321
ENSG00000065809 E009 46.3701913 0.0018007719 1.175096e-02 3.293756e-02 10 14521073 14521088 16 - 1.634 1.482 -0.520
ENSG00000065809 E010 46.9052540 0.0017746457 1.257712e-03 4.835410e-03 10 14521089 14521095 7 - 1.647 1.443 -0.698
ENSG00000065809 E011 61.3291506 0.0003964841 2.687938e-03 9.338035e-03 10 14521096 14521136 41 - 1.754 1.603 -0.510
ENSG00000065809 E012 54.0421020 0.0004165636 1.880320e-03 6.854095e-03 10 14521137 14521157 21 - 1.704 1.535 -0.575
ENSG00000065809 E013 61.0146892 0.0004294091 9.888479e-03 2.848887e-02 10 14521158 14521193 36 - 1.749 1.624 -0.423
ENSG00000065809 E014 44.5119260 0.0004926829 1.768509e-02 4.645638e-02 10 14521194 14521200 7 - 1.617 1.482 -0.463
ENSG00000065809 E015 41.0722921 0.0005608030 4.241656e-02 9.547544e-02 10 14521201 14521206 6 - 1.580 1.463 -0.402
ENSG00000065809 E016 39.9858488 0.0006080255 3.480354e-02 8.126888e-02 10 14521207 14521211 5 - 1.569 1.443 -0.432
ENSG00000065809 E017 70.0483989 0.0006405548 8.254389e-03 2.442852e-02 10 14521212 14521280 69 - 1.806 1.686 -0.405
ENSG00000065809 E018 50.7620369 0.0004807008 4.647328e-03 1.495181e-02 10 14521281 14521306 26 - 1.675 1.518 -0.535
ENSG00000065809 E019 35.8949446 0.0005386889 1.160049e-02 3.258474e-02 10 14521869 14521869 1 - 1.531 1.365 -0.573
ENSG00000065809 E020 43.1562654 0.0004791195 5.690892e-02 1.213050e-01 10 14521870 14521875 6 - 1.597 1.491 -0.360
ENSG00000065809 E021 48.9928972 0.0005066039 4.866817e-03 1.555941e-02 10 14521876 14521893 18 - 1.660 1.500 -0.544
ENSG00000065809 E022 71.6099110 0.0023983626 5.057135e-03 1.608750e-02 10 14521894 14521944 51 - 1.818 1.675 -0.484
ENSG00000065809 E023 85.9218304 0.0004328151 2.532130e-05 1.533288e-04 10 14521945 14522019 75 - 1.903 1.715 -0.634
ENSG00000065809 E024 0.2924217 0.0290785164 1.000000e+00   10 14522020 14522225 206 - 0.122 0.000 -11.433
ENSG00000065809 E025 0.2903454 0.2816397513 1.000000e+00   10 14527937 14528039 103 - 0.122 0.000 -10.466
ENSG00000065809 E026 1.7142353 0.0475800588 8.415492e-01 9.011800e-01 10 14529528 14529954 427 - 0.392 0.363 -0.166
ENSG00000065809 E027 1.8844001 0.0075261243 7.275019e-01 8.201752e-01 10 14529955 14530186 232 - 0.419 0.363 -0.316
ENSG00000065809 E028 96.5672635 0.0064509107 1.717428e-05 1.081295e-04 10 14530332 14530515 184 - 1.963 1.710 -0.852
ENSG00000065809 E029 0.0000000       10 14532587 14532710 124 -      
ENSG00000065809 E030 0.0000000       10 14534786 14534868 83 -      
ENSG00000065809 E031 0.2214452 0.0469587945 1.106749e-01   10 14542579 14542686 108 - 0.000 0.219 11.850
ENSG00000065809 E032 0.0000000       10 14548440 14548670 231 -      
ENSG00000065809 E033 9.4650788 0.0087024942 8.197065e-03 2.428352e-02 10 14553322 14553387 66 - 1.018 0.630 -1.530
ENSG00000065809 E034 0.0000000       10 14553388 14553454 67 -      
ENSG00000065809 E035 0.0000000       10 14554104 14554229 126 -      
ENSG00000065809 E036 0.0000000       10 14555821 14556015 195 -      
ENSG00000065809 E037 0.0000000       10 14556016 14556180 165 -      
ENSG00000065809 E038 0.2966881 0.0290785164 1.000000e+00   10 14556362 14556405 44 - 0.122 0.000 -11.433
ENSG00000065809 E039 0.0000000       10 14556406 14556414 9 -      
ENSG00000065809 E040 0.0000000       10 14571763 14571923 161 -      
ENSG00000065809 E041 0.0000000       10 14571924 14571990 67 -      
ENSG00000065809 E042 0.0000000       10 14571991 14572189 199 -      
ENSG00000065809 E043 0.0000000       10 14572229 14572339 111 -      
ENSG00000065809 E044 0.4439371 0.0216054922 6.005707e-01 7.217819e-01 10 14595624 14595680 57 - 0.172 0.000 -12.089
ENSG00000065809 E045 5.4010508 0.0076925149 1.199045e-07 1.200167e-06 10 14602457 14602850 394 - 0.445 1.167 2.937
ENSG00000065809 E046 25.7894923 0.0070834503 5.937838e-05 3.283629e-04 10 14604240 14604418 179 - 1.421 1.007 -1.469
ENSG00000065809 E047 0.0000000       10 14612489 14612552 64 -      
ENSG00000065809 E048 0.0000000       10 14667634 14667691 58 -      
ENSG00000065809 E049 0.0000000       10 14774253 14774897 645 -