ENSG00000065613

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335753 ENSG00000065613 HEK293_OSMI2_2hA HEK293_TMG_2hB SLK protein_coding protein_coding 11.46527 3.058398 18.56291 0.04876994 1.11578 2.597643 10.2429403 3.04430695 15.981747 0.03585674 0.7319320 2.388411 0.90325833 0.995533333 0.8624667 -0.13306667 7.451961e-08 7.451961e-08 FALSE TRUE
ENST00000369755 ENSG00000065613 HEK293_OSMI2_2hA HEK293_TMG_2hB SLK protein_coding protein_coding 11.46527 3.058398 18.56291 0.04876994 1.11578 2.597643 0.4564744 0.01409069 1.525790 0.01409069 0.1408443 5.994362 0.03080000 0.004466667 0.0826000 0.07813333 9.051822e-06 7.451961e-08 FALSE TRUE
ENST00000474260 ENSG00000065613 HEK293_OSMI2_2hA HEK293_TMG_2hB SLK protein_coding processed_transcript 11.46527 3.058398 18.56291 0.04876994 1.11578 2.597643 0.5430196 0.00000000 1.026142 0.00000000 0.5220565 6.695078 0.04924583 0.000000000 0.0533000 0.05330000 3.447498e-02 7.451961e-08 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000065613 E001 0.4355181 0.6019221069 1.000000e+00 1.000000e+00 10 103966551 103967081 531 + 0.130 0.000 -8.936
ENSG00000065613 E002 7.1603523 0.0024249636 2.277261e-03 8.082076e-03 10 103967140 103967200 61 + 0.813 0.280 -2.601
ENSG00000065613 E003 50.0555768 0.0122752315 3.220711e-11 6.170651e-10 10 103967201 103967709 509 + 1.595 0.918 -2.397
ENSG00000065613 E004 65.2415656 0.0030238448 9.208168e-13 2.274987e-11 10 103967710 103967895 186 + 1.700 1.215 -1.673
ENSG00000065613 E005 79.7870033 0.0003345120 2.531458e-12 5.815876e-11 10 103990675 103990839 165 + 1.777 1.436 -1.163
ENSG00000065613 E006 55.0490350 0.0004036981 6.390477e-09 8.176245e-08 10 103992598 103992646 49 + 1.619 1.281 -1.164
ENSG00000065613 E007 94.3589327 0.0047982609 1.893246e-06 1.480944e-05 10 103992984 103993133 150 + 1.836 1.649 -0.631
ENSG00000065613 E008 78.4016308 0.0094041812 2.579580e-05 1.558881e-04 10 103998899 103998971 73 + 1.759 1.551 -0.708
ENSG00000065613 E009 93.1615477 0.0010627749 1.801573e-07 1.742140e-06 10 103999119 103999313 195 + 1.830 1.657 -0.585
ENSG00000065613 E010 43.0809867 0.0019062212 1.958973e-03 7.097644e-03 10 103999867 103999948 82 + 1.497 1.374 -0.425
ENSG00000065613 E011 72.5010259 0.0003919297 4.620925e-03 1.487798e-02 10 104001444 104001572 129 + 1.708 1.674 -0.116
ENSG00000065613 E012 466.1669776 0.0097230228 1.968545e-04 9.503221e-04 10 104002172 104003527 1356 + 2.509 2.470 -0.129
ENSG00000065613 E013 118.9013506 0.0002521636 1.462148e-04 7.308501e-04 10 104005561 104005691 131 + 1.919 1.877 -0.142
ENSG00000065613 E014 120.5043634 0.0002803427 2.309999e-04 1.095836e-03 10 104005912 104006035 124 + 1.923 1.887 -0.120
ENSG00000065613 E015 66.5570049 0.0103263978 9.539933e-02 1.834909e-01 10 104008177 104008197 21 + 1.663 1.670 0.024
ENSG00000065613 E016 134.1810583 0.0103850046 4.358764e-01 5.780208e-01 10 104008198 104008356 159 + 1.951 2.044 0.313
ENSG00000065613 E017 0.2944980 0.4109566579 1.000000e+00   10 104010816 104010908 93 + 0.091 0.000 -8.274
ENSG00000065613 E018 0.0000000       10 104013632 104013703 72 +      
ENSG00000065613 E019 108.9365138 0.0052958760 4.604672e-01 6.005100e-01 10 104018160 104018289 130 + 1.845 2.025 0.605
ENSG00000065613 E020 105.3761637 0.0016701489 4.868119e-01 6.245305e-01 10 104018784 104018908 125 + 1.833 2.004 0.575
ENSG00000065613 E021 1.8250794 0.1040028441 5.548296e-01 6.837631e-01 10 104018909 104019116 208 + 0.360 0.280 -0.508
ENSG00000065613 E022 146.5482426 0.0015777188 9.281266e-01 9.587394e-01 10 104019734 104019922 189 + 1.982 2.116 0.450
ENSG00000065613 E023 123.1236932 0.0018319678 7.792641e-01 8.580352e-01 10 104020488 104020613 126 + 1.904 2.055 0.507
ENSG00000065613 E024 112.5246734 0.0024497091 6.972280e-03 2.115130e-02 10 104021620 104021733 114 + 1.841 2.106 0.889
ENSG00000065613 E025 775.9005057 0.0337533987 5.475666e-06 3.863351e-05 10 104025574 104029233 3660 + 2.637 3.065 1.427