ENSG00000065150

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000403772 ENSG00000065150 HEK293_OSMI2_2hA HEK293_TMG_2hB IPO5 protein_coding protein_coding 80.68742 26.76737 123.7516 3.779031 1.981854 2.208478 5.074537 0.000000 14.378052 0.0000000 0.9705770 10.490656 0.03947917 0.00000000 0.11630000 0.11630000 5.540930e-36 5.54093e-36 FALSE FALSE
ENST00000470493 ENSG00000065150 HEK293_OSMI2_2hA HEK293_TMG_2hB IPO5 protein_coding retained_intron 80.68742 26.76737 123.7516 3.779031 1.981854 2.208478 2.872889 2.019560 4.080807 0.1433066 0.6603249 1.011218 0.05004167 0.07693333 0.03296667 -0.04396667 1.892402e-03 5.54093e-36 FALSE TRUE
ENST00000490680 ENSG00000065150 HEK293_OSMI2_2hA HEK293_TMG_2hB IPO5 protein_coding protein_coding 80.68742 26.76737 123.7516 3.779031 1.981854 2.208478 62.786718 17.317841 99.085465 0.9659515 3.1848380 2.515727 0.73865000 0.66216667 0.80030000 0.13813333 9.916767e-02 5.54093e-36 FALSE TRUE
MSTRG.8979.20 ENSG00000065150 HEK293_OSMI2_2hA HEK293_TMG_2hB IPO5 protein_coding   80.68742 26.76737 123.7516 3.779031 1.981854 2.208478 2.440152 5.710945 0.000000 1.9940390 0.0000000 -9.160110 0.07033333 0.20113333 0.00000000 -0.20113333 7.134769e-29 5.54093e-36 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000065150 E001 0.0000000       13 97953658 97953674 17 +      
ENSG00000065150 E002 0.0000000       13 97953675 97953682 8 +      
ENSG00000065150 E003 0.0000000       13 97953683 97953693 11 +      
ENSG00000065150 E004 0.0000000       13 97953694 97953713 20 +      
ENSG00000065150 E005 0.0000000       13 97953714 97953716 3 +      
ENSG00000065150 E006 0.0000000       13 97953717 97953925 209 +      
ENSG00000065150 E007 0.0000000       13 97953926 97953927 2 +      
ENSG00000065150 E008 0.0000000       13 97953928 97953958 31 +      
ENSG00000065150 E009 0.0000000       13 97953959 97954003 45 +      
ENSG00000065150 E010 0.0000000       13 97954004 97954095 92 +      
ENSG00000065150 E011 0.0000000       13 97954096 97954102 7 +      
ENSG00000065150 E012 0.0000000       13 97954103 97954118 16 +      
ENSG00000065150 E013 0.0000000       13 97954119 97954198 80 +      
ENSG00000065150 E014 0.0000000       13 97960192 97960217 26 +      
ENSG00000065150 E015 0.0000000       13 97960218 97960248 31 +      
ENSG00000065150 E016 0.0000000       13 97960249 97960258 10 +      
ENSG00000065150 E017 0.0000000       13 97960259 97960346 88 +      
ENSG00000065150 E018 0.0000000       13 97960347 97960403 57 +      
ENSG00000065150 E019 0.0000000       13 97963160 97963282 123 +      
ENSG00000065150 E020 0.0000000       13 97969723 97969780 58 +      
ENSG00000065150 E021 0.0000000       13 97969781 97969830 50 +      
ENSG00000065150 E022 0.0000000       13 97969831 97969905 75 +      
ENSG00000065150 E023 0.4783925 2.111493e-02 5.836093e-01 7.076902e-01 13 97975631 97975890 260 + 0.119 0.223 1.091
ENSG00000065150 E024 1.1415848 1.767531e-02 6.159369e-01 7.340908e-01 13 97975891 97975997 107 + 0.252 0.370 0.771
ENSG00000065150 E025 1.0611596 3.370053e-02 6.964256e-01 7.967808e-01 13 97976303 97976404 102 + 0.289 0.223 -0.492
ENSG00000065150 E026 0.1451727 4.349394e-02 1.000000e+00   13 97976465 97976476 12 + 0.064 0.000 -9.381
ENSG00000065150 E027 0.1472490 4.485057e-02 1.000000e+00   13 97976477 97976502 26 + 0.064 0.000 -9.382
ENSG00000065150 E028 19.4800406 9.095879e-04 3.026860e-02 7.249243e-02 13 97976632 97976674 43 + 1.271 1.094 -0.629
ENSG00000065150 E029 58.9885503 3.836707e-04 6.301754e-06 4.385924e-05 13 97976675 97976692 18 + 1.742 1.504 -0.812
ENSG00000065150 E030 108.4888035 2.828173e-04 2.182654e-10 3.629397e-09 13 97976693 97976702 10 + 2.004 1.749 -0.860
ENSG00000065150 E031 268.7584918 3.419260e-03 1.544657e-09 2.211871e-08 13 97976703 97976786 84 + 2.390 2.173 -0.724
ENSG00000065150 E032 0.0000000       13 97976963 97977057 95 +      
ENSG00000065150 E033 0.0000000       13 97979870 97979943 74 +      
ENSG00000065150 E034 0.3299976 2.744240e-02 2.161030e-02   13 97981242 97981400 159 + 0.000 0.370 14.287
ENSG00000065150 E035 0.1472490 4.485057e-02 1.000000e+00   13 97982055 97982143 89 + 0.064 0.000 -9.382
ENSG00000065150 E036 349.2577837 1.473921e-04 1.528675e-18 8.225017e-17 13 97982503 97982583 81 + 2.499 2.316 -0.608
ENSG00000065150 E037 0.4804688 2.151026e-02 5.846495e-01 7.085200e-01 13 97982584 97982584 1 + 0.119 0.223 1.091
ENSG00000065150 E038 659.8408797 1.212645e-04 3.616013e-27 4.737502e-25 13 97985421 97985613 193 + 2.771 2.613 -0.526
ENSG00000065150 E039 0.5964967 2.061827e-02 8.344853e-01 8.963889e-01 13 97985614 97985622 9 + 0.168 0.223 0.504
ENSG00000065150 E040 0.0000000       13 97987990 97988101 112 +      
ENSG00000065150 E041 533.0481524 1.226662e-04 5.900705e-22 4.673373e-20 13 97989062 97989164 103 + 2.678 2.523 -0.516
ENSG00000065150 E042 506.2064206 1.247226e-04 1.441690e-17 6.933837e-16 13 97990126 97990222 97 + 2.653 2.518 -0.449
ENSG00000065150 E043 500.0196807 1.273413e-04 2.315318e-15 8.346908e-14 13 97990433 97990537 105 + 2.645 2.523 -0.408
ENSG00000065150 E044 5.6862837 2.859444e-03 8.035559e-01 8.749828e-01 13 97991581 97991696 116 + 0.758 0.756 -0.008
ENSG00000065150 E045 579.4761434 3.922939e-04 1.466039e-17 7.038437e-16 13 97992892 97993014 123 + 2.712 2.573 -0.465
ENSG00000065150 E046 426.3197914 4.311887e-03 4.345425e-04 1.907474e-03 13 97993105 97993149 45 + 2.571 2.471 -0.334
ENSG00000065150 E047 508.5330832 3.381816e-03 2.489470e-04 1.170744e-03 13 97993150 97993225 76 + 2.646 2.555 -0.303
ENSG00000065150 E048 490.1595962 2.466199e-03 2.859982e-03 9.852975e-03 13 97997531 97997618 88 + 2.624 2.565 -0.195
ENSG00000065150 E049 527.4118664 1.289878e-03 1.383000e-06 1.113873e-05 13 98000539 98000645 107 + 2.662 2.574 -0.294
ENSG00000065150 E050 27.1295385 2.405883e-03 1.091888e-09 1.607639e-08 13 98000646 98000922 277 + 1.216 1.693 1.645
ENSG00000065150 E051 23.5363387 8.062630e-04 2.699258e-01 4.084819e-01 13 98001646 98002466 821 + 1.323 1.266 -0.197
ENSG00000065150 E052 301.8142418 1.093221e-03 2.318962e-05 1.416523e-04 13 98002467 98002475 9 + 2.421 2.332 -0.296
ENSG00000065150 E053 473.2894331 3.041881e-03 4.210565e-03 1.373249e-02 13 98002476 98002591 116 + 2.609 2.547 -0.207
ENSG00000065150 E054 6.2828848 2.564139e-03 1.664755e-02 4.416322e-02 13 98002592 98002683 92 + 0.854 0.479 -1.609
ENSG00000065150 E055 321.7588923 7.403396e-04 3.946195e-02 9.003261e-02 13 98002684 98002773 90 + 2.433 2.416 -0.056
ENSG00000065150 E056 470.8889472 4.044337e-04 8.777095e-02 1.717497e-01 13 98002864 98003008 145 + 2.594 2.598 0.013
ENSG00000065150 E057 319.0140726 3.113927e-04 2.274976e-03 8.074704e-03 13 98003009 98003037 29 + 2.434 2.398 -0.121
ENSG00000065150 E058 831.5365061 2.649676e-03 9.773058e-05 5.114294e-04 13 98006130 98006348 219 + 2.857 2.777 -0.265
ENSG00000065150 E059 0.2944980 4.011498e-01 1.000000e+00   13 98007362 98007587 226 + 0.119 0.000 -10.381
ENSG00000065150 E060 556.8652446 5.296820e-04 2.463316e-04 1.160048e-03 13 98008059 98008142 84 + 2.676 2.637 -0.128
ENSG00000065150 E061 720.9673639 2.799350e-03 3.772225e-02 8.681124e-02 13 98009881 98010013 133 + 2.785 2.755 -0.100
ENSG00000065150 E062 686.4282354 1.146180e-03 3.442836e-01 4.883607e-01 13 98010103 98010224 122 + 2.754 2.770 0.051
ENSG00000065150 E063 550.6837912 8.635078e-04 1.771663e-01 2.975393e-01 13 98012246 98012342 97 + 2.646 2.717 0.234
ENSG00000065150 E064 873.3759156 8.259795e-05 8.238463e-01 8.890148e-01 13 98014042 98014214 173 + 2.855 2.894 0.130
ENSG00000065150 E065 584.8953792 1.031421e-04 1.263178e-01 2.290266e-01 13 98015530 98015587 58 + 2.686 2.701 0.050
ENSG00000065150 E066 575.3308912 1.093046e-04 7.844977e-01 8.617410e-01 13 98015588 98015641 54 + 2.674 2.711 0.125
ENSG00000065150 E067 573.1202852 5.852695e-04 2.918099e-01 4.327263e-01 13 98015726 98015781 56 + 2.666 2.729 0.212
ENSG00000065150 E068 671.9851825 2.154771e-04 4.222462e-01 5.653994e-01 13 98016729 98016851 123 + 2.737 2.793 0.187
ENSG00000065150 E069 692.1414532 2.412751e-03 7.332203e-02 1.488384e-01 13 98018485 98018585 101 + 2.740 2.830 0.300
ENSG00000065150 E070 723.3501906 1.363626e-03 8.237176e-09 1.031536e-07 13 98018586 98018704 119 + 2.737 2.912 0.584
ENSG00000065150 E071 1.9261301 8.127685e-03 8.340929e-01 8.960972e-01 13 98019579 98019580 2 + 0.411 0.479 0.352
ENSG00000065150 E072 988.8984260 1.922987e-04 5.882894e-28 8.304744e-26 13 98019581 98019809 229 + 2.867 3.062 0.648
ENSG00000065150 E073 1.3337860 3.510580e-02 9.237638e-01 9.559889e-01 13 98019810 98019941 132 + 0.323 0.369 0.278
ENSG00000065150 E074 773.3365266 1.068086e-03 1.778486e-27 2.411803e-25 13 98020992 98021133 142 + 2.737 3.004 0.888
ENSG00000065150 E075 2.6289625 1.024632e-01 7.619023e-01 8.456519e-01 13 98021134 98021411 278 + 0.485 0.566 0.385
ENSG00000065150 E076 2320.2773671 8.394370e-03 1.733672e-08 2.044947e-07 13 98021736 98024296 2561 + 3.209 3.481 0.903