ENSG00000065000

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000586370 ENSG00000065000 HEK293_OSMI2_2hA HEK293_TMG_2hB AP3D1 protein_coding protein_coding 117.562 176.6272 76.03514 10.10144 0.5290542 -1.215861 16.39573 46.626656 0.2112946 4.649689 0.118395 -7.7193520 0.1009917 0.26660000 0.002733333 -0.2638667 9.254490e-08 7.034162e-12 FALSE TRUE
ENST00000643010 ENSG00000065000 HEK293_OSMI2_2hA HEK293_TMG_2hB AP3D1 protein_coding protein_coding 117.562 176.6272 76.03514 10.10144 0.5290542 -1.215861 10.84848 4.631931 11.9323755 2.335640 1.137454 1.3632930 0.1176167 0.02503333 0.156966667 0.1319333 3.176392e-01 7.034162e-12 FALSE TRUE
ENST00000643116 ENSG00000065000 HEK293_OSMI2_2hA HEK293_TMG_2hB AP3D1 protein_coding protein_coding 117.562 176.6272 76.03514 10.10144 0.5290542 -1.215861 28.18217 40.149106 26.4202313 2.199068 3.680028 -0.6035381 0.2452500 0.22783333 0.348166667 0.1203333 1.473676e-01 7.034162e-12 FALSE TRUE
ENST00000644728 ENSG00000065000 HEK293_OSMI2_2hA HEK293_TMG_2hB AP3D1 protein_coding protein_coding 117.562 176.6272 76.03514 10.10144 0.5290542 -1.215861 28.63902 52.233779 9.5885984 4.517047 0.807625 -2.4443636 0.2260000 0.29486667 0.126033333 -0.1688333 7.034162e-12 7.034162e-12 FALSE TRUE
MSTRG.16102.5 ENSG00000065000 HEK293_OSMI2_2hA HEK293_TMG_2hB AP3D1 protein_coding   117.562 176.6272 76.03514 10.10144 0.5290542 -1.215861 25.04044 26.595386 19.7489451 4.102195 2.842700 -0.4292124 0.2276583 0.14996667 0.259266667 0.1093000 8.187631e-02 7.034162e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000065000 E001 2.0146191 0.0492202594 4.605169e-01 6.005406e-01 19 2100988 2100988 1 - 0.529 0.409 -0.607
ENSG00000065000 E002 5.4326859 0.0902790134 2.571306e-01 3.941756e-01 19 2100989 2100994 6 - 0.586 0.836 1.039
ENSG00000065000 E003 15.2391967 0.0038647561 1.635152e-01 2.797201e-01 19 2100995 2100995 1 - 1.247 1.136 -0.395
ENSG00000065000 E004 437.1582243 0.0056061053 4.867898e-08 5.261345e-07 19 2100996 2101112 117 - 2.397 2.652 0.849
ENSG00000065000 E005 2436.2443017 0.0038054810 1.950170e-19 1.170269e-17 19 2101113 2101620 508 - 3.106 3.404 0.989
ENSG00000065000 E006 2936.6108068 0.0012992158 3.609341e-25 4.005734e-23 19 2101621 2102236 616 - 3.257 3.470 0.708
ENSG00000065000 E007 673.8699497 0.0027103264 5.738852e-04 2.436103e-03 19 2102237 2102268 32 - 2.686 2.813 0.423
ENSG00000065000 E008 898.0215696 0.0022368219 5.473623e-04 2.337130e-03 19 2108687 2108766 80 - 2.818 2.935 0.388
ENSG00000065000 E009 12.3231967 0.0014643381 4.520953e-01 5.929913e-01 19 2108767 2108876 110 - 1.002 1.099 0.356
ENSG00000065000 E010 733.1365843 0.0013393685 1.387712e-02 3.794880e-02 19 2109086 2109125 40 - 2.757 2.837 0.268
ENSG00000065000 E011 940.8347464 0.0015325215 1.096840e-03 4.293422e-03 19 2109126 2109207 82 - 2.852 2.950 0.329
ENSG00000065000 E012 41.5354973 0.0048985803 3.053513e-05 1.813525e-04 19 2109208 2109872 665 - 1.739 1.491 -0.844
ENSG00000065000 E013 955.2919037 0.0004141481 4.930784e-08 5.322634e-07 19 2109873 2109958 86 - 2.848 2.958 0.367
ENSG00000065000 E014 917.5764361 0.0001690936 6.916730e-06 4.769515e-05 19 2110136 2110224 89 - 2.849 2.934 0.284
ENSG00000065000 E015 1096.1457016 0.0005775143 1.062446e-07 1.074031e-06 19 2110707 2110896 190 - 2.907 3.018 0.371
ENSG00000065000 E016 20.2622455 0.0009440529 1.608658e-04 7.958515e-04 19 2110897 2111284 388 - 1.457 1.183 -0.955
ENSG00000065000 E017 482.3424599 0.0001213472 1.499796e-08 1.789468e-07 19 2111285 2111332 48 - 2.537 2.665 0.425
ENSG00000065000 E018 20.9845746 0.0155147035 1.472355e-05 9.412925e-05 19 2111333 2111678 346 - 1.529 1.141 -1.355
ENSG00000065000 E019 661.5793689 0.0001169395 1.460010e-01 2.562412e-01 19 2111679 2111790 112 - 2.739 2.782 0.144
ENSG00000065000 E020 401.3256576 0.0011795013 3.397221e-01 4.836502e-01 19 2111791 2111828 38 - 2.559 2.556 -0.009
ENSG00000065000 E021 17.2054583 0.0010581194 4.319846e-12 9.542700e-11 19 2111829 2112823 995 - 1.530 0.986 -1.921
ENSG00000065000 E022 344.6948387 0.0001758446 1.634315e-02 4.348175e-02 19 2112860 2112931 72 - 2.511 2.479 -0.105
ENSG00000065000 E023 69.5530614 0.0003764945 6.607232e-06 4.576841e-05 19 2112932 2112967 36 - 1.921 1.741 -0.607
ENSG00000065000 E024 15.9166760 0.0234522606 1.139639e-03 4.436112e-03 19 2112968 2113335 368 - 1.386 1.050 -1.192
ENSG00000065000 E025 247.0582858 0.0001968387 5.963140e-02 1.259967e-01 19 2113336 2113413 78 - 2.294 2.362 0.229
ENSG00000065000 E026 807.7876621 0.0018022524 4.328051e-02 9.707525e-02 19 2114125 2114302 178 - 2.878 2.851 -0.088
ENSG00000065000 E027 696.9113820 0.0006092839 6.961730e-01 7.966025e-01 19 2114748 2114821 74 - 2.783 2.798 0.047
ENSG00000065000 E028 885.3727790 0.0003731588 4.133392e-01 5.568492e-01 19 2115219 2115346 128 - 2.873 2.907 0.114
ENSG00000065000 E029 622.7432162 0.0010578364 6.868730e-01 7.893171e-01 19 2115347 2115418 72 - 2.736 2.749 0.044
ENSG00000065000 E030 685.7104506 0.0013469737 3.652500e-01 5.095811e-01 19 2115538 2115613 76 - 2.785 2.788 0.007
ENSG00000065000 E031 637.6930158 0.0009502794 5.945130e-01 7.167320e-01 19 2116207 2116278 72 - 2.730 2.764 0.113
ENSG00000065000 E032 824.4761909 0.0017906629 5.140892e-01 6.488386e-01 19 2116605 2116746 142 - 2.861 2.870 0.029
ENSG00000065000 E033 4.0986669 0.0324162978 1.337018e-02 3.678070e-02 19 2116747 2116766 20 - 0.885 0.512 -1.566
ENSG00000065000 E034 3.0226594 0.0529923496 6.209039e-02 1.301559e-01 19 2116767 2116796 30 - 0.761 0.447 -1.406
ENSG00000065000 E035 6.6709451 0.0108977430 3.961064e-02 9.031149e-02 19 2116797 2117221 425 - 1.002 0.754 -0.951
ENSG00000065000 E036 614.2077536 0.0012941538 8.233268e-01 8.886706e-01 19 2117222 2117367 146 - 2.725 2.744 0.061
ENSG00000065000 E037 775.2796388 0.0013239337 4.964455e-01 6.331031e-01 19 2118601 2118820 220 - 2.834 2.842 0.028
ENSG00000065000 E038 365.8904495 0.0018760648 1.308131e-01 2.352854e-01 19 2118821 2118832 12 - 2.529 2.508 -0.071
ENSG00000065000 E039 900.0709094 0.0013289174 5.685907e-03 1.778167e-02 19 2120862 2121048 187 - 2.930 2.895 -0.118
ENSG00000065000 E040 561.3413905 0.0002821613 1.230021e-05 8.004113e-05 19 2121049 2121092 44 - 2.738 2.681 -0.191
ENSG00000065000 E041 923.1483053 0.0005612529 2.297580e-11 4.512437e-10 19 2121163 2121311 149 - 2.977 2.888 -0.297
ENSG00000065000 E042 900.8961349 0.0009954775 5.287072e-12 1.151420e-10 19 2121734 2121879 146 - 2.982 2.871 -0.370
ENSG00000065000 E043 595.9070296 0.0026890318 2.903227e-07 2.694663e-06 19 2123358 2123406 49 - 2.813 2.687 -0.419
ENSG00000065000 E044 590.8667505 0.0024272890 3.240896e-06 2.406907e-05 19 2123830 2123879 50 - 2.797 2.690 -0.357
ENSG00000065000 E045 602.4936627 0.0019420463 6.923393e-08 7.252508e-07 19 2127152 2127201 50 - 2.812 2.695 -0.390
ENSG00000065000 E046 637.5734563 0.0028748168 9.722835e-07 8.086583e-06 19 2129090 2129163 74 - 2.841 2.719 -0.405
ENSG00000065000 E047 770.6379825 0.0032292152 1.667503e-06 1.319178e-05 19 2129318 2129457 140 - 2.923 2.802 -0.403
ENSG00000065000 E048 698.6571164 0.0017500453 3.105204e-11 5.965034e-10 19 2130408 2130521 114 - 2.892 2.752 -0.464
ENSG00000065000 E049 376.0666359 0.0020114933 4.415250e-10 6.983269e-09 19 2130522 2130537 16 - 2.635 2.477 -0.526
ENSG00000065000 E050 625.7897463 0.0009530335 5.193118e-14 1.538903e-12 19 2132471 2132578 108 - 2.841 2.705 -0.451
ENSG00000065000 E051 6.1915676 0.0030880354 2.972951e-01 4.386181e-01 19 2133397 2133484 88 - 0.682 0.846 0.658
ENSG00000065000 E052 558.4297567 0.0008685888 3.458007e-17 1.573348e-15 19 2137011 2137091 81 - 2.804 2.649 -0.518
ENSG00000065000 E053 418.5727629 0.0003053856 1.085369e-12 2.646330e-11 19 2137727 2137807 81 - 2.657 2.535 -0.405
ENSG00000065000 E054 400.7883526 0.0019764986 4.698856e-15 1.622351e-13 19 2138619 2138714 96 - 2.688 2.490 -0.661
ENSG00000065000 E055 290.3642790 0.0026399203 7.402646e-29 1.128245e-26 19 2151239 2151566 328 - 2.631 2.290 -1.137
ENSG00000065000 E056 0.2214452 0.0381167768 1.000000e+00   19 2164356 2164468 113 - 0.000 0.087 8.299