ENSG00000064999

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360359 ENSG00000064999 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKS1A protein_coding protein_coding 14.02868 15.823 12.33444 0.6899125 0.2872684 -0.3590728 9.754869 9.183650 9.636271 0.9242986 0.5737568 0.0693336 0.7011792 0.5776667 0.7799667 0.2023 4.158452e-03 3.652582e-06 FALSE TRUE
MSTRG.28171.5 ENSG00000064999 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKS1A protein_coding   14.02868 15.823 12.33444 0.6899125 0.2872684 -0.3590728 2.846030 5.729833 1.832317 0.3031066 0.1600326 -1.6394874 0.1916375 0.3649667 0.1481667 -0.2168 3.652582e-06 3.652582e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000064999 E001 0.2903454 0.3470719331 2.194801e-01   6 34889255 34889264 10 + 0.221 0.000 -13.569
ENSG00000064999 E002 0.5838113 0.4435298379 4.219931e-01 5.651524e-01 6 34889265 34889269 5 + 0.300 0.118 -1.677
ENSG00000064999 E003 4.7502073 0.1004186084 6.047248e-02 1.274257e-01 6 34889270 34889313 44 + 0.884 0.595 -1.178
ENSG00000064999 E004 12.0114511 0.0340493985 2.761897e-03 9.558341e-03 6 34889314 34889475 162 + 1.247 0.943 -1.101
ENSG00000064999 E005 30.3082289 0.0015464697 4.565137e-05 2.597395e-04 6 34889476 34889599 124 + 1.583 1.401 -0.626
ENSG00000064999 E006 37.9497202 0.0011077603 2.502557e-06 1.906320e-05 6 34967239 34967319 81 + 1.684 1.494 -0.647
ENSG00000064999 E007 74.8086207 0.0008118054 2.148897e-06 1.659744e-05 6 34970010 34970166 157 + 1.939 1.823 -0.392
ENSG00000064999 E008 14.1812175 0.0140652149 3.162106e-01 4.589680e-01 6 34972581 34972643 63 + 1.186 1.159 -0.094
ENSG00000064999 E009 118.8426731 0.0027273050 2.810916e-05 1.682952e-04 6 34981690 34981986 297 + 2.117 2.031 -0.287
ENSG00000064999 E010 64.1187369 0.0050200443 3.465639e-03 1.162682e-02 6 34982752 34982827 76 + 1.847 1.768 -0.265
ENSG00000064999 E011 72.9228892 0.0046036411 1.428766e-03 5.402918e-03 6 34983113 34983214 102 + 1.907 1.823 -0.282
ENSG00000064999 E012 76.0421766 0.0003826884 1.895357e-09 2.665897e-08 6 34983324 34983425 102 + 1.965 1.804 -0.543
ENSG00000064999 E013 106.2852841 0.0072273118 6.738346e-06 4.659146e-05 6 34985082 34985278 197 + 2.106 1.951 -0.520
ENSG00000064999 E014 85.1403596 0.0039973410 4.890167e-06 3.489238e-05 6 34989224 34989316 93 + 2.003 1.867 -0.457
ENSG00000064999 E015 74.4024774 0.0003504509 4.992453e-09 6.517401e-08 6 34994302 34994422 121 + 1.954 1.797 -0.528
ENSG00000064999 E016 168.4662323 0.0003008052 9.787198e-05 5.120844e-04 6 35017473 35017958 486 + 2.237 2.211 -0.086
ENSG00000064999 E017 97.8722657 0.0003659931 4.657217e-04 2.029013e-03 6 35017959 35018059 101 + 2.014 1.970 -0.149
ENSG00000064999 E018 76.4772105 0.0004275822 2.092883e-02 5.343896e-02 6 35054099 35054165 67 + 1.892 1.879 -0.042
ENSG00000064999 E019 3.6805771 0.0044421537 4.663939e-01 6.059410e-01 6 35058248 35058677 430 + 0.564 0.736 0.740
ENSG00000064999 E020 106.1154253 0.0059166846 1.133669e-01 2.104254e-01 6 35060147 35060253 107 + 2.019 2.024 0.017
ENSG00000064999 E021 82.1788974 0.0038919061 4.688222e-01 6.081853e-01 6 35078558 35078656 99 + 1.886 1.932 0.155
ENSG00000064999 E022 99.1704937 0.0072897421 7.608613e-01 8.448381e-01 6 35079516 35079668 153 + 1.957 2.022 0.218
ENSG00000064999 E023 85.1645370 0.0107166566 8.169011e-01 8.841680e-01 6 35079821 35079928 108 + 1.869 1.971 0.343
ENSG00000064999 E024 92.2112143 0.0003118193 6.337199e-01 7.483467e-01 6 35080994 35081158 165 + 1.927 1.991 0.214
ENSG00000064999 E025 89.7465414 0.0008890797 5.799035e-01 7.047340e-01 6 35082691 35082816 126 + 1.919 1.979 0.201
ENSG00000064999 E026 94.7464588 0.0086743464 5.014785e-01 6.376295e-01 6 35083155 35083226 72 + 1.952 1.996 0.148
ENSG00000064999 E027 114.9089527 0.0024130169 3.845662e-02 8.820420e-02 6 35083417 35083503 87 + 2.059 2.060 0.003
ENSG00000064999 E028 148.9604173 0.0004536936 2.381361e-01 3.719744e-01 6 35084121 35084258 138 + 2.142 2.188 0.155
ENSG00000064999 E029 157.6267496 0.0010638765 4.755395e-01 6.142497e-01 6 35085766 35085936 171 + 2.161 2.220 0.198
ENSG00000064999 E030 0.3289534 0.0293229402 8.638121e-01   6 35086270 35086368 99 + 0.125 0.120 -0.067
ENSG00000064999 E031 119.3896050 0.0002805534 3.131621e-01 4.556973e-01 6 35086952 35087049 98 + 2.007 2.122 0.385
ENSG00000064999 E032 33.6042730 0.0023533826 2.050592e-03 7.382995e-03 6 35087050 35088605 1556 + 1.349 1.634 0.980
ENSG00000064999 E033 1419.6360565 0.0074307414 1.202472e-09 1.754638e-08 6 35088606 35091406 2801 + 2.986 3.245 0.862