ENSG00000064933

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374826 ENSG00000064933 HEK293_OSMI2_2hA HEK293_TMG_2hB PMS1 protein_coding protein_coding 10.10041 6.428149 15.00416 0.1552302 0.5254619 1.221606 1.8407447 2.7464387 1.4770929 0.15349791 0.13226573 -0.8903107 0.24413333 0.42670000 0.09813333 -0.32856667 3.220839e-23 3.220839e-23 FALSE TRUE
ENST00000424766 ENSG00000064933 HEK293_OSMI2_2hA HEK293_TMG_2hB PMS1 protein_coding protein_coding 10.10041 6.428149 15.00416 0.1552302 0.5254619 1.221606 0.6240560 0.9111795 0.6998788 0.28829751 0.21893463 -0.3759094 0.07457500 0.14030000 0.04590000 -0.09440000 1.670581e-01 3.220839e-23 FALSE FALSE
ENST00000441310 ENSG00000064933 HEK293_OSMI2_2hA HEK293_TMG_2hB PMS1 protein_coding protein_coding 10.10041 6.428149 15.00416 0.1552302 0.5254619 1.221606 4.3089065 0.5949297 8.3706559 0.33567689 0.67525672 3.7922239 0.33970417 0.09406667 0.56226667 0.46820000 5.714280e-02 3.220839e-23 FALSE TRUE
ENST00000446877 ENSG00000064933 HEK293_OSMI2_2hA HEK293_TMG_2hB PMS1 protein_coding protein_coding 10.10041 6.428149 15.00416 0.1552302 0.5254619 1.221606 0.4411356 0.3986142 0.3167060 0.23728222 0.09404338 -0.3227463 0.05294583 0.06130000 0.02146667 -0.03983333 7.867946e-01 3.220839e-23   FALSE
ENST00000624204 ENSG00000064933 HEK293_OSMI2_2hA HEK293_TMG_2hB PMS1 protein_coding protein_coding 10.10041 6.428149 15.00416 0.1552302 0.5254619 1.221606 0.8805666 1.0295123 0.8222688 0.04971358 0.41216826 -0.3207854 0.11056250 0.16070000 0.05373333 -0.10696667 4.326660e-01 3.220839e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000064933 E001 15.2763913 0.0011862746 8.728178e-08 8.962692e-07 2 189784085 189784449 365 + 0.985 1.447 1.640
ENSG00000064933 E002 4.1809966 0.0633055118 1.914429e-01 3.155552e-01 2 189784450 189784488 39 + 0.610 0.832 0.916
ENSG00000064933 E003 4.8860191 0.2580005224 2.726864e-01 4.116388e-01 2 189784489 189784500 12 + 0.665 0.867 0.815
ENSG00000064933 E004 5.6977201 0.0430595349 3.708375e-01 5.152479e-01 2 189784501 189784507 7 + 0.742 0.873 0.518
ENSG00000064933 E005 7.4034225 0.0592333936 5.293614e-01 6.621563e-01 2 189784508 189784512 5 + 0.854 0.937 0.316
ENSG00000064933 E006 12.9485819 0.0441018514 2.491150e-01 3.848714e-01 2 189784513 189784526 14 + 1.053 1.195 0.512
ENSG00000064933 E007 12.8045551 0.0394144366 2.946845e-01 4.357984e-01 2 189784527 189784527 1 + 1.053 1.179 0.455
ENSG00000064933 E008 19.4017130 0.0467105932 1.247829e-01 2.268233e-01 2 189784528 189784542 15 + 1.204 1.387 0.638
ENSG00000064933 E009 18.5430841 0.0291031574 5.113934e-02 1.111988e-01 2 189784543 189784543 1 + 1.174 1.388 0.751
ENSG00000064933 E010 23.4374608 0.0131803946 5.006247e-02 1.092761e-01 2 189784544 189784564 21 + 1.284 1.457 0.599
ENSG00000064933 E011 29.3930443 0.0203095298 3.359050e-02 7.894917e-02 2 189784565 189784593 29 + 1.372 1.565 0.663
ENSG00000064933 E012 11.9545866 0.0226863151 1.363157e-08 1.638721e-07 2 189784594 189784770 177 + 0.782 1.442 2.398
ENSG00000064933 E013 4.0621643 0.0040180838 6.732208e-01 7.789775e-01 2 189785346 189785471 126 + 0.646 0.708 0.261
ENSG00000064933 E014 0.3666179 0.0276962226 3.843035e-01 5.284734e-01 2 189791700 189791789 90 + 0.072 0.201 1.705
ENSG00000064933 E015 23.7489873 0.0245244057 2.383880e-01 3.722697e-01 2 189791790 189791809 20 + 1.308 1.421 0.393
ENSG00000064933 E016 61.9998788 0.0031227049 5.136757e-02 1.115836e-01 2 189791810 189791941 132 + 1.719 1.820 0.341
ENSG00000064933 E017 90.0803100 0.0003803966 3.554764e-06 2.617331e-05 2 189795769 189795951 183 + 1.853 2.030 0.595
ENSG00000064933 E018 62.3285823 0.0008472446 2.261678e-02 5.695746e-02 2 189805652 189805754 103 + 1.721 1.828 0.362
ENSG00000064933 E019 1.7317242 0.0112155446 2.463623e-01 3.816862e-01 2 189805755 189806422 668 + 0.319 0.526 1.121
ENSG00000064933 E020 37.1334722 0.0021505710 1.353237e-44 6.162662e-42 2 189806423 189807054 632 + 1.111 1.963 2.932
ENSG00000064933 E021 50.8259768 0.0098794424 4.845476e-03 1.550165e-02 2 189818017 189818126 110 + 1.715 1.491 -0.762
ENSG00000064933 E022 38.3323970 0.0158298360 3.897281e-03 1.285614e-02 2 189818127 189818180 54 + 1.603 1.324 -0.961
ENSG00000064933 E023 0.3268771 0.0286862946 3.839675e-01   2 189818181 189818181 1 + 0.072 0.201 1.703
ENSG00000064933 E024 55.7735749 0.0147463218 6.007855e-04 2.535973e-03 2 189843964 189844080 117 + 1.764 1.469 -1.006
ENSG00000064933 E025 49.4250589 0.0044902601 1.618515e-07 1.579390e-06 2 189852655 189852777 123 + 1.728 1.334 -1.350
ENSG00000064933 E026 56.0824515 0.0004650008 9.683119e-09 1.197257e-07 2 189853939 189854082 144 + 1.777 1.419 -1.220
ENSG00000064933 E027 179.3582551 0.0042125500 1.017035e-09 1.506818e-08 2 189854239 189855128 890 + 2.260 1.994 -0.890
ENSG00000064933 E028 0.0000000       2 189855829 189855916 88 +      
ENSG00000064933 E029 0.2924217 0.0290785164 8.088966e-01   2 189857360 189857401 42 + 0.134 0.000 -9.970
ENSG00000064933 E030 0.2924217 0.0290785164 8.088966e-01   2 189857402 189857405 4 + 0.134 0.000 -9.970
ENSG00000064933 E031 0.2924217 0.0290785164 8.088966e-01   2 189857406 189857504 99 + 0.134 0.000 -9.970
ENSG00000064933 E032 69.2208964 0.0060244645 5.357979e-02 1.155136e-01 2 189863743 189863974 232 + 1.824 1.703 -0.409
ENSG00000064933 E033 40.4988639 0.0005570135 3.662426e-01 5.105862e-01 2 189863975 189864078 104 + 1.584 1.522 -0.210
ENSG00000064933 E034 31.7918353 0.0055594372 4.764701e-02 1.049942e-01 2 189864079 189864115 37 + 1.501 1.335 -0.574
ENSG00000064933 E035 49.2178268 0.0013347375 2.650443e-03 9.224184e-03 2 189864116 189864228 113 + 1.692 1.499 -0.657
ENSG00000064933 E036 53.7015048 0.0019895044 5.103781e-01 6.456017e-01 2 189867799 189867929 131 + 1.697 1.654 -0.145
ENSG00000064933 E037 59.2073118 0.0009899381 5.948770e-01 7.170475e-01 2 189873496 189873656 161 + 1.734 1.702 -0.109
ENSG00000064933 E038 58.8197509 0.0155143113 1.051089e-01 1.982494e-01 2 189877272 189877629 358 + 1.688 1.811 0.416