ENSG00000064763

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000536681 ENSG00000064763 HEK293_OSMI2_2hA HEK293_TMG_2hB FAR2 protein_coding protein_coding 7.769684 5.256961 11.28953 0.3648821 0.1521416 1.10122 3.7309103 2.2724875 5.5839590 0.3015386 0.17750533 1.2932627 0.46004583 0.43330000 0.49503333 0.06173333 6.772401e-01 1.944179e-09 FALSE TRUE
ENST00000549080 ENSG00000064763 HEK293_OSMI2_2hA HEK293_TMG_2hB FAR2 protein_coding processed_transcript 7.769684 5.256961 11.28953 0.3648821 0.1521416 1.10122 0.4231276 0.6793203 0.2150619 0.0155397 0.02025108 -1.6148527 0.08094583 0.13040000 0.01906667 -0.11133333 1.944179e-09 1.944179e-09   FALSE
ENST00000551451 ENSG00000064763 HEK293_OSMI2_2hA HEK293_TMG_2hB FAR2 protein_coding protein_coding 7.769684 5.256961 11.28953 0.3648821 0.1521416 1.10122 1.4386463 0.3598032 2.6459809 0.3068279 0.23049512 2.8444153 0.15460000 0.07483333 0.23400000 0.15916667 1.798159e-01 1.944179e-09 FALSE TRUE
ENST00000686419 ENSG00000064763 HEK293_OSMI2_2hA HEK293_TMG_2hB FAR2 protein_coding protein_coding 7.769684 5.256961 11.28953 0.3648821 0.1521416 1.10122 1.1563856 1.2162024 1.4120311 0.4722715 0.13630565 0.2137558 0.16173750 0.22393333 0.12533333 -0.09860000 6.651728e-01 1.944179e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000064763 E001 0.0000000       12 29149016 29149037 22 +      
ENSG00000064763 E002 0.0000000       12 29149038 29149049 12 +      
ENSG00000064763 E003 0.1451727 0.0437698560 1.000000e+00   12 29149050 29149081 32 + 0.090 0.000 -9.786
ENSG00000064763 E004 0.1451727 0.0437698560 1.000000e+00   12 29149082 29149096 15 + 0.090 0.000 -12.085
ENSG00000064763 E005 0.9223296 0.0136968632 3.643088e-01 5.086802e-01 12 29149097 29149102 6 + 0.333 0.164 -1.333
ENSG00000064763 E006 2.8430474 0.0051878141 5.004168e-01 6.366713e-01 12 29149103 29149132 30 + 0.627 0.517 -0.498
ENSG00000064763 E007 2.9902964 0.0050595748 4.122234e-01 5.557812e-01 12 29149133 29149134 2 + 0.650 0.517 -0.598
ENSG00000064763 E008 9.1307582 0.0020614108 1.866864e-01 3.095763e-01 12 29149135 29149198 64 + 1.048 0.896 -0.564
ENSG00000064763 E009 9.4439056 0.0249177758 2.316336e-01 3.644072e-01 12 29149199 29149209 11 + 1.065 0.896 -0.625
ENSG00000064763 E010 16.0273444 0.0011268940 8.148247e-01 8.826720e-01 12 29149210 29149262 53 + 1.229 1.208 -0.076
ENSG00000064763 E011 14.5942538 0.0012193987 6.284926e-01 7.440279e-01 12 29149263 29149277 15 + 1.165 1.208 0.150
ENSG00000064763 E012 23.5621943 0.0012037216 7.564735e-01 8.415394e-01 12 29149278 29149302 25 + 1.386 1.362 -0.084
ENSG00000064763 E013 27.5124067 0.0007792033 8.991719e-01 9.396657e-01 12 29149303 29149319 17 + 1.440 1.448 0.026
ENSG00000064763 E014 35.2530755 0.0006976005 9.525882e-01 9.743119e-01 12 29149320 29149351 32 + 1.546 1.549 0.008
ENSG00000064763 E015 42.4141613 0.0008836771 8.425677e-01 9.019003e-01 12 29149352 29149407 56 + 1.629 1.616 -0.044
ENSG00000064763 E016 2.9903149 0.0214260619 7.787808e-05 4.180130e-04 12 29151396 29151874 479 + 0.229 0.871 3.212
ENSG00000064763 E017 8.1650980 0.0021469323 1.414531e-10 2.433293e-09 12 29171378 29172050 673 + 0.520 1.265 2.914
ENSG00000064763 E018 0.0000000       12 29223665 29223744 80 +      
ENSG00000064763 E019 0.0000000       12 29223745 29223894 150 +      
ENSG00000064763 E020 35.0296463 0.0041384452 3.498303e-01 4.940213e-01 12 29270412 29270448 37 + 1.569 1.501 -0.230
ENSG00000064763 E021 58.1141602 0.0005047674 7.341508e-02 1.489857e-01 12 29270449 29270638 190 + 1.791 1.703 -0.295
ENSG00000064763 E022 0.0000000       12 29291416 29291494 79 +      
ENSG00000064763 E023 57.5057370 0.0034832974 1.981573e-01 3.238960e-01 12 29293300 29293475 176 + 1.781 1.707 -0.250
ENSG00000064763 E024 0.1451727 0.0437698560 1.000000e+00   12 29293476 29294388 913 + 0.090 0.000 -12.085
ENSG00000064763 E025 75.8464949 0.0098950321 2.855352e-01 4.258716e-01 12 29297021 29297200 180 + 1.898 1.832 -0.225
ENSG00000064763 E026 0.2944980 0.3706842199 5.892096e-01   12 29297201 29297929 729 + 0.165 0.000 -12.142
ENSG00000064763 E027 0.0000000       12 29302317 29302429 113 +      
ENSG00000064763 E028 75.7533303 0.0003854056 9.486656e-02 1.826906e-01 12 29307658 29307835 178 + 1.902 1.832 -0.236
ENSG00000064763 E029 26.8195096 0.0048373038 3.475669e-01 4.917845e-01 12 29309186 29309206 21 + 1.465 1.394 -0.246
ENSG00000064763 E030 28.9221313 0.0015739446 4.254274e-01 5.683776e-01 12 29309207 29309230 24 + 1.489 1.433 -0.191
ENSG00000064763 E031 1.3466870 0.1483916072 3.223502e-02 7.630577e-02 12 29309231 29311027 1797 + 0.489 0.000 -14.638
ENSG00000064763 E032 60.1809468 0.0015674154 7.548921e-01 8.403872e-01 12 29311028 29311146 119 + 1.774 1.788 0.047
ENSG00000064763 E033 0.4741261 0.0211592891 1.000000e+00 1.000000e+00 12 29311147 29311882 736 + 0.165 0.164 -0.011
ENSG00000064763 E034 53.1521187 0.0004203234 3.678912e-01 5.122814e-01 12 29311883 29311950 68 + 1.709 1.752 0.145
ENSG00000064763 E035 1.4780283 0.0091320969 8.568430e-02 1.684862e-01 12 29311951 29313721 1771 + 0.488 0.164 -2.182
ENSG00000064763 E036 0.2934659 0.0286010217 6.155440e-01   12 29316711 29316840 130 + 0.090 0.164 0.987
ENSG00000064763 E037 81.9644056 0.0003492182 6.077400e-01 7.276448e-01 12 29316841 29317012 172 + 1.918 1.897 -0.070
ENSG00000064763 E038 0.0000000       12 29317775 29318471 697 +      
ENSG00000064763 E039 0.2924217 0.0271230901 4.743903e-01   12 29319887 29320020 134 + 0.165 0.000 -13.172
ENSG00000064763 E040 64.1368476 0.0007878897 4.823381e-01 6.204972e-01 12 29321795 29321924 130 + 1.794 1.826 0.107
ENSG00000064763 E041 0.0000000       12 29321925 29321955 31 +      
ENSG00000064763 E042 0.2998086 0.0285492986 6.163589e-01   12 29331234 29331370 137 + 0.090 0.164 0.986
ENSG00000064763 E043 57.9896342 0.0046501744 4.713212e-02 1.040608e-01 12 29332600 29332727 128 + 1.718 1.831 0.381
ENSG00000064763 E044 0.1451727 0.0437698560 1.000000e+00   12 29332728 29332844 117 + 0.090 0.000 -12.085
ENSG00000064763 E045 1.2772056 0.4039594315 9.259450e-01 9.573706e-01 12 29332845 29332908 64 + 0.333 0.378 0.272
ENSG00000064763 E046 1.3037093 0.1589782960 7.209895e-01 8.155072e-01 12 29332909 29333631 723 + 0.379 0.285 -0.583
ENSG00000064763 E047 50.6181287 0.0004939459 6.235002e-05 3.430345e-04 12 29333632 29333734 103 + 1.622 1.817 0.659
ENSG00000064763 E048 209.7004399 0.0025573193 8.371081e-01 8.981420e-01 12 29333735 29335633 1899 + 2.316 2.307 -0.029
ENSG00000064763 E049 4.6120818 0.0716317445 4.829284e-02 1.061472e-01 12 29340808 29341121 314 + 0.577 0.953 1.523