ENSG00000064687

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263094 ENSG00000064687 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCA7 protein_coding protein_coding 7.195669 7.972474 4.114984 0.70661 0.1361934 -0.9524475 2.0312441 2.0991076 1.75258222 0.25737620 0.11727198 -0.25894212 0.30900417 0.26433333 0.42740000 0.16306667 4.740024e-02 9.836151e-11 FALSE TRUE
ENST00000433129 ENSG00000064687 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCA7 protein_coding retained_intron 7.195669 7.972474 4.114984 0.70661 0.1361934 -0.9524475 0.4024742 0.2559418 0.36795748 0.03371787 0.18466739 0.50711318 0.06111667 0.03246667 0.08850000 0.05603333 8.060983e-01 9.836151e-11 TRUE TRUE
ENST00000435683 ENSG00000064687 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCA7 protein_coding nonsense_mediated_decay 7.195669 7.972474 4.114984 0.70661 0.1361934 -0.9524475 0.4226390 0.1001252 0.22364929 0.05920051 0.11183338 1.08519978 0.05657917 0.01146667 0.05363333 0.04216667 5.983724e-01 9.836151e-11 TRUE TRUE
ENST00000525073 ENSG00000064687 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCA7 protein_coding protein_coding 7.195669 7.972474 4.114984 0.70661 0.1361934 -0.9524475 0.6623973 1.9233927 0.10232757 0.74463875 0.10232757 -4.10535064 0.08175000 0.24383333 0.02566667 -0.21816667 6.885838e-02 9.836151e-11 FALSE TRUE
ENST00000525238 ENSG00000064687 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCA7 protein_coding retained_intron 7.195669 7.972474 4.114984 0.70661 0.1361934 -0.9524475 0.3508883 0.1874385 0.34168739 0.03100453 0.05424990 0.83289060 0.05390000 0.02370000 0.08300000 0.05930000 6.808774e-03 9.836151e-11   FALSE
ENST00000532194 ENSG00000064687 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCA7 protein_coding retained_intron 7.195669 7.972474 4.114984 0.70661 0.1361934 -0.9524475 0.4456310 0.4328891 0.08784684 0.13137748 0.08784684 -2.17834852 0.05317083 0.05723333 0.02213333 -0.03510000 4.078877e-01 9.836151e-11 FALSE FALSE
ENST00000673773 ENSG00000064687 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCA7 protein_coding retained_intron 7.195669 7.972474 4.114984 0.70661 0.1361934 -0.9524475 0.6781363 0.5730082 0.55290391 0.05383864 0.11047204 -0.05062741 0.09598333 0.07210000 0.13310000 0.06100000 1.216893e-01 9.836151e-11 TRUE TRUE
MSTRG.16033.1 ENSG00000064687 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCA7 protein_coding   7.195669 7.972474 4.114984 0.70661 0.1361934 -0.9524475 0.6609827 0.2607372 0.35619464 0.14141328 0.18013180 0.43571735 0.09665833 0.03170000 0.08953333 0.05783333 8.144847e-01 9.836151e-11 FALSE TRUE
MSTRG.16033.11 ENSG00000064687 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCA7 protein_coding   7.195669 7.972474 4.114984 0.70661 0.1361934 -0.9524475 0.5367201 1.2250793 0.00000000 0.20669496 0.00000000 -6.94845989 0.06734583 0.15376667 0.00000000 -0.15376667 9.836151e-11 9.836151e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000064687 E001 0.0000000       19 1039870 1039996 127 +      
ENSG00000064687 E002 0.1817044 0.0406050999 0.7913609843   19 1039997 1040102 106 + 0.000 0.097 10.310
ENSG00000064687 E003 0.1817044 0.0406050999 0.7913609843   19 1040103 1040106 4 + 0.000 0.097 10.317
ENSG00000064687 E004 0.1817044 0.0406050999 0.7913609843   19 1040107 1040115 9 + 0.000 0.097 10.317
ENSG00000064687 E005 0.1817044 0.0406050999 0.7913609843   19 1040116 1040117 2 + 0.000 0.097 10.317
ENSG00000064687 E006 0.1817044 0.0406050999 0.7913609843   19 1040118 1040119 2 + 0.000 0.097 10.317
ENSG00000064687 E007 4.5600283 0.0035792460 0.5121423975 0.647067177 19 1040120 1040196 77 + 0.641 0.742 0.422
ENSG00000064687 E008 0.0000000       19 1041202 1041204 3 +      
ENSG00000064687 E009 0.0000000       19 1041205 1041224 20 +      
ENSG00000064687 E010 10.1835841 0.0017483198 0.9619893392 0.980024800 19 1041225 1041354 130 + 1.012 1.023 0.039
ENSG00000064687 E011 13.6205961 0.0042954064 0.3128573878 0.455386340 19 1041355 1041427 73 + 1.198 1.107 -0.324
ENSG00000064687 E012 0.5149242 0.2871597926 0.9575753219 0.977406468 19 1041428 1041509 82 + 0.153 0.178 0.256
ENSG00000064687 E013 9.9660276 0.0031273405 0.5691455982 0.695757183 19 1041510 1041515 6 + 1.046 0.991 -0.204
ENSG00000064687 E014 18.4588655 0.0038053871 0.2425011133 0.377101204 19 1041516 1041603 88 + 1.319 1.226 -0.325
ENSG00000064687 E015 4.1796979 0.0585195393 0.1606717642 0.275996117 19 1041604 1041830 227 + 0.839 0.603 -0.970
ENSG00000064687 E016 21.2028818 0.0009392815 0.0770322619 0.154738375 19 1041831 1041972 142 + 1.391 1.263 -0.447
ENSG00000064687 E017 1.6231864 0.0088224280 0.0059829428 0.018563506 19 1041973 1042063 91 + 0.641 0.177 -2.748
ENSG00000064687 E018 18.6490234 0.0011551514 0.1947983612 0.319750562 19 1042064 1042176 113 + 1.319 1.220 -0.348
ENSG00000064687 E019 8.2951237 0.0021397636 0.5856767814 0.709324775 19 1042315 1042319 5 + 0.975 0.918 -0.213
ENSG00000064687 E020 15.5731626 0.0011585629 0.0444290878 0.099164191 19 1042320 1042397 78 + 1.292 1.124 -0.594
ENSG00000064687 E021 14.2036478 0.0208463197 0.0005220994 0.002242372 19 1042398 1042745 348 + 1.361 0.984 -1.348
ENSG00000064687 E022 16.0956652 0.0020630560 0.0034368333 0.011543877 19 1042746 1042826 81 + 1.344 1.099 -0.868
ENSG00000064687 E023 23.1840935 0.0076883026 0.0168026146 0.044498566 19 1043041 1043251 211 + 1.467 1.277 -0.656
ENSG00000064687 E024 27.1708672 0.0008268316 0.0403426968 0.091653510 19 1043334 1043473 140 + 1.497 1.364 -0.458
ENSG00000064687 E025 23.8954408 0.0008380027 0.0923456802 0.178782800 19 1043725 1043841 117 + 1.434 1.319 -0.399
ENSG00000064687 E026 32.8713729 0.0006756515 0.1337304034 0.239335164 19 1044577 1044744 168 + 1.551 1.464 -0.299
ENSG00000064687 E027 36.5535834 0.0031063422 0.0060469938 0.018735238 19 1045002 1045231 230 + 1.648 1.483 -0.563
ENSG00000064687 E028 0.0000000       19 1045532 1045547 16 +      
ENSG00000064687 E029 0.4031496 0.0244453940 0.3850517603 0.529210473 19 1045548 1045562 15 + 0.000 0.177 11.319
ENSG00000064687 E030 0.8814403 0.0142288429 0.0632515747 0.132126988 19 1045563 1045619 57 + 0.000 0.353 12.637
ENSG00000064687 E031 35.5811376 0.0014430889 0.3933176708 0.537219626 19 1046230 1046404 175 + 1.567 1.520 -0.159
ENSG00000064687 E032 13.4461241 0.0013168796 0.5808584792 0.705530388 19 1046405 1046406 2 + 1.161 1.116 -0.164
ENSG00000064687 E033 36.5223859 0.0005916184 0.5293189302 0.662118741 19 1046802 1047024 223 + 1.562 1.530 -0.108
ENSG00000064687 E034 27.7394018 0.0052295431 0.0951957706 0.183171874 19 1047157 1047378 222 + 1.497 1.380 -0.403
ENSG00000064687 E035 13.8039007 0.0014249528 0.1058261641 0.199340280 19 1047453 1047562 110 + 1.231 1.090 -0.505
ENSG00000064687 E036 14.9595894 0.0042504029 0.4453218697 0.586873959 19 1047563 1047654 92 + 1.220 1.155 -0.231
ENSG00000064687 E037 22.6412358 0.0008818482 0.9351195388 0.963147603 19 1048895 1049005 111 + 1.344 1.344 -0.001
ENSG00000064687 E038 30.3377744 0.0008226839 0.6690020174 0.775920616 19 1049266 1049414 149 + 1.479 1.457 -0.076
ENSG00000064687 E039 17.5530066 0.0012747831 0.4804188273 0.618719961 19 1049415 1049437 23 + 1.272 1.219 -0.187
ENSG00000064687 E040 30.5506269 0.0183616214 0.6819159691 0.785510947 19 1050921 1051052 132 + 1.491 1.460 -0.107
ENSG00000064687 E041 30.3746219 0.0065113478 0.5869999956 0.710400964 19 1051155 1051294 140 + 1.485 1.452 -0.114
ENSG00000064687 E042 27.2981867 0.0073532637 0.9899827754 0.997838167 19 1051449 1051586 138 + 1.406 1.417 0.037
ENSG00000064687 E043 43.5238060 0.0014493014 0.1847174862 0.307115822 19 1051942 1052126 185 + 1.656 1.588 -0.231
ENSG00000064687 E044 32.7482398 0.0044332055 0.0079184496 0.023572811 19 1052214 1052286 73 + 1.600 1.427 -0.591
ENSG00000064687 E045 49.2780784 0.0116869268 0.1108881962 0.206853650 19 1053329 1053531 203 + 1.731 1.631 -0.340
ENSG00000064687 E046 25.2621594 0.0039346967 0.0453867236 0.100902172 19 1053788 1053836 49 + 1.473 1.331 -0.492
ENSG00000064687 E047 30.8020481 0.0097541103 0.4941277313 0.631112450 19 1054006 1054075 70 + 1.497 1.453 -0.152
ENSG00000064687 E048 27.1579896 0.0198223337 0.5844395291 0.708378804 19 1054076 1054110 35 + 1.441 1.402 -0.135
ENSG00000064687 E049 28.0633263 0.0159127782 0.7597889365 0.844062901 19 1054193 1054341 149 + 1.407 1.442 0.121
ENSG00000064687 E050 21.5325930 0.0009550466 0.1279194607 0.231267516 19 1054570 1054694 125 + 1.231 1.359 0.446
ENSG00000064687 E051 25.5452055 0.0007739441 0.2534834595 0.390011134 19 1054780 1054878 99 + 1.327 1.417 0.310
ENSG00000064687 E052 1.5219323 0.0107435568 0.2661352553 0.404285902 19 1055083 1055096 14 + 0.493 0.302 -1.070
ENSG00000064687 E053 41.1387920 0.0032238534 0.1628732737 0.278890192 19 1055097 1055351 255 + 1.519 1.617 0.333
ENSG00000064687 E054 21.7799513 0.0008458081 0.4700334875 0.609256097 19 1055907 1055939 33 + 1.282 1.344 0.217
ENSG00000064687 E055 1.5144556 0.0098222183 0.3481875040 0.492408764 19 1055985 1056065 81 + 0.266 0.440 1.057
ENSG00000064687 E056 39.6302809 0.0005492791 0.0667956719 0.138056291 19 1056066 1056243 178 + 1.497 1.612 0.394
ENSG00000064687 E057 42.4046076 0.0005333856 0.9934322815 1.000000000 19 1056330 1056499 170 + 1.600 1.607 0.022
ENSG00000064687 E058 20.6192610 0.0049843348 0.0367368186 0.084966286 19 1056907 1056927 21 + 1.399 1.234 -0.574
ENSG00000064687 E059 19.5056620 0.0018836089 0.0991495037 0.189182741 19 1056928 1056933 6 + 1.353 1.227 -0.442
ENSG00000064687 E060 43.6786440 0.0005378769 0.2737815791 0.412875715 19 1056934 1057084 151 + 1.652 1.599 -0.182
ENSG00000064687 E061 6.3053274 0.1019905914 0.0010418743 0.004103704 19 1057085 1057313 229 + 1.148 0.518 -2.508
ENSG00000064687 E062 40.8151024 0.0245703195 0.5020606326 0.638163009 19 1057314 1057429 116 + 1.546 1.612 0.224
ENSG00000064687 E063 7.2748192 0.0023038516 0.0020419890 0.007356496 19 1057430 1057914 485 + 1.093 0.742 -1.334
ENSG00000064687 E064 30.8807069 0.0008170648 0.5489663525 0.678767180 19 1057915 1057968 54 + 1.441 1.486 0.157
ENSG00000064687 E065 30.2965178 0.0018633710 0.1254278488 0.227757401 19 1057969 1057999 31 + 1.391 1.503 0.386
ENSG00000064687 E066 35.1394555 0.0073041987 0.1506285042 0.262531448 19 1058000 1058059 60 + 1.454 1.567 0.388
ENSG00000064687 E067 0.9244034 0.0136968632 0.4162457950 0.559617253 19 1058060 1058145 86 + 0.153 0.302 1.252
ENSG00000064687 E068 45.9811563 0.0101315150 0.0409001674 0.092701011 19 1058146 1058269 124 + 1.536 1.694 0.538
ENSG00000064687 E069 2.0241579 0.0072803753 0.3640845070 0.508494361 19 1058270 1058617 348 + 0.548 0.399 -0.748
ENSG00000064687 E070 54.8169973 0.0066950165 0.0231967765 0.058157682 19 1058618 1058747 130 + 1.614 1.766 0.516
ENSG00000064687 E071 68.3175372 0.0076347754 0.0898681771 0.174924807 19 1058820 1058940 121 + 1.737 1.850 0.380
ENSG00000064687 E072 52.7572396 0.0109126593 0.0397406004 0.090545136 19 1059023 1059085 63 + 1.596 1.751 0.528
ENSG00000064687 E073 0.9995446 0.0131160269 0.2804811384 0.420332320 19 1059086 1059263 178 + 0.153 0.353 1.570
ENSG00000064687 E074 63.7930621 0.0157566763 0.1046110977 0.197528766 19 1061782 1061888 107 + 1.687 1.826 0.468
ENSG00000064687 E075 28.3566966 0.0136870578 0.1721057663 0.290933534 19 1062172 1062178 7 + 1.344 1.480 0.468
ENSG00000064687 E076 50.9071834 0.0083055538 0.0788342610 0.157652711 19 1062179 1062313 135 + 1.595 1.727 0.445
ENSG00000064687 E077 48.2961669 0.0059307881 0.0617636563 0.129589990 19 1063544 1063678 135 + 1.567 1.698 0.447
ENSG00000064687 E078 33.7650331 0.0102991979 0.0895256111 0.174403159 19 1063760 1063863 104 + 1.413 1.556 0.491
ENSG00000064687 E079 15.1010433 0.0208678584 0.7255495323 0.818782917 19 1063864 1064051 188 + 1.148 1.194 0.162
ENSG00000064687 E080 12.1296432 0.0170771744 0.8419937146 0.901479453 19 1064052 1064160 109 + 1.107 1.089 -0.065
ENSG00000064687 E081 39.0743945 0.0018728243 0.0490440899 0.107458083 19 1064161 1064253 93 + 1.485 1.614 0.443
ENSG00000064687 E082 0.4751703 0.0222370836 0.9110146356 0.947477397 19 1064659 1064747 89 + 0.153 0.177 0.249
ENSG00000064687 E083 49.1365598 0.0014132391 0.0037127929 0.012334113 19 1064931 1065171 241 + 1.551 1.722 0.579
ENSG00000064687 E084 15.6583480 0.0013821693 0.0962033625 0.184681094 19 1065270 1065290 21 + 1.078 1.239 0.573
ENSG00000064687 E085 41.9745186 0.0128567954 0.0800303863 0.159603312 19 1065291 1065572 282 + 1.502 1.653 0.514