ENSG00000064652

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261369 ENSG00000064652 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX24 protein_coding protein_coding 5.104663 5.680558 5.573062 0.609677 0.4880477 -0.02751346 3.0725170 3.10613091 3.5306338 0.44160749 0.29280490 0.1842518 0.6124167 0.54276667 0.6442667 0.1015000 6.239006e-01 9.800193e-12 FALSE TRUE
ENST00000506996 ENSG00000064652 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX24 protein_coding protein_coding 5.104663 5.680558 5.573062 0.609677 0.4880477 -0.02751346 1.3058000 2.27027335 0.7058584 0.30519667 0.39972818 -1.6714607 0.2444542 0.39773333 0.1181000 -0.2796333 2.786259e-01 9.800193e-12 FALSE TRUE
ENST00000513881 ENSG00000064652 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX24 protein_coding protein_coding 5.104663 5.680558 5.573062 0.609677 0.4880477 -0.02751346 0.4454602 0.09540656 0.9863009 0.01434492 0.09836943 3.2406168 0.0837250 0.01713333 0.1767000 0.1595667 9.800193e-12 9.800193e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000064652 E001 0.0000000       5 122843439 122843615 177 +      
ENSG00000064652 E002 0.0000000       5 122844232 122844535 304 +      
ENSG00000064652 E003 3.9651541 0.0041278259 0.0003833656 0.00171033 5 122845518 122845604 87 + 0.902 0.368 -2.388
ENSG00000064652 E004 3.0666707 0.0050191953 0.0081387212 0.02413601 5 122845605 122845612 8 + 0.784 0.368 -1.928
ENSG00000064652 E005 6.2764442 0.0172517995 0.3167351890 0.45954263 5 122845613 122845625 13 + 0.919 0.780 -0.537
ENSG00000064652 E006 11.7851936 0.0113722288 0.6124265979 0.73136386 5 122845626 122845662 37 + 1.127 1.069 -0.207
ENSG00000064652 E007 16.2961211 0.0203434444 0.8689009713 0.91974634 5 122845663 122845693 31 + 1.243 1.218 -0.090
ENSG00000064652 E008 0.4783925 0.0211610521 0.6014987634 0.72263846 5 122853674 122853767 94 + 0.213 0.125 -0.928
ENSG00000064652 E009 0.6589510 0.0340016160 0.2956651380 0.43681567 5 122891027 122891125 99 + 0.120 0.301 1.655
ENSG00000064652 E010 0.0000000       5 122936733 122936733 1 +      
ENSG00000064652 E011 29.2519029 0.0175819166 0.5237036895 0.65732993 5 122936734 122936817 84 + 1.452 1.495 0.149
ENSG00000064652 E012 38.7197351 0.0049216351 0.4726402457 0.61168912 5 122946055 122946159 105 + 1.574 1.614 0.136
ENSG00000064652 E013 0.0000000       5 122948596 122948646 51 +      
ENSG00000064652 E014 0.0000000       5 122965443 122965521 79 +      
ENSG00000064652 E015 0.2924217 0.0276191996 0.2179421044   5 122983018 122983095 78 + 0.213 0.000 -12.074
ENSG00000064652 E016 0.6976476 0.1429686545 0.9292608155 0.95951292 5 122998208 122998268 61 + 0.213 0.224 0.089
ENSG00000064652 E017 0.3289534 0.0306718337 0.9780095129   5 122998269 122998337 69 + 0.120 0.125 0.073
ENSG00000064652 E018 38.3402432 0.0063004478 0.6274366661 0.74323763 5 122999912 123000006 95 + 1.581 1.612 0.104
ENSG00000064652 E019 27.2171386 0.0009841575 0.5489085183 0.67872668 5 123001405 123001437 33 + 1.437 1.477 0.138
ENSG00000064652 E020 33.6013564 0.0011502959 0.9717266773 0.98634639 5 123001940 123002004 65 + 1.544 1.548 0.015
ENSG00000064652 E021 9.0972344 0.0082573431 0.0325873677 0.07697729 5 123002005 123002080 76 + 0.866 1.112 0.913
ENSG00000064652 E022 3.2242487 0.1347452537 0.7358335403 0.82650392 5 123002081 123002145 65 + 0.587 0.684 0.421
ENSG00000064652 E023 160.1872589 0.0019264221 0.5828998991 0.70712835 5 123007682 123009205 1524 + 2.218 2.206 -0.040
ENSG00000064652 E024 0.3634088 0.5234788834 0.3004547065   5 123022307 123022427 121 + 0.000 0.224 10.198
ENSG00000064652 E025 0.4847352 0.2193070402 0.6734495293 0.77914706 5 123029238 123029354 117 + 0.214 0.125 -0.929