ENSG00000064651

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262461 ENSG00000064651 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC12A2 protein_coding protein_coding 9.357071 2.770634 14.63212 0.1180739 0.6620767 2.396639 5.2375795 2.46566997 6.717589 0.26407901 0.1981520 1.442271 0.68309583 0.88946667 0.46050000 -0.42896667 3.587929e-02 3.364718e-09 FALSE TRUE
ENST00000343225 ENSG00000064651 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC12A2 protein_coding protein_coding 9.357071 2.770634 14.63212 0.1180739 0.6620767 2.396639 0.6538837 0.24871222 1.764225 0.24871222 0.2954083 2.777769 0.06581667 0.09163333 0.11926667 0.02763333 4.230410e-01 3.364718e-09 FALSE TRUE
ENST00000502849 ENSG00000064651 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC12A2 protein_coding retained_intron 9.357071 2.770634 14.63212 0.1180739 0.6620767 2.396639 0.6730334 0.03145378 1.384213 0.03145378 0.1444010 5.071804 0.05929167 0.01050000 0.09406667 0.08356667 3.864981e-04 3.364718e-09   FALSE
ENST00000507791 ENSG00000064651 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC12A2 protein_coding processed_transcript 9.357071 2.770634 14.63212 0.1180739 0.6620767 2.396639 0.7522905 0.00000000 1.128022 0.00000000 0.6533378 6.830384 0.05631667 0.00000000 0.07756667 0.07756667 6.623510e-02 3.364718e-09   FALSE
ENST00000628403 ENSG00000064651 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC12A2 protein_coding protein_coding 9.357071 2.770634 14.63212 0.1180739 0.6620767 2.396639 1.8622846 0.00000000 3.077919 0.00000000 0.4337242 8.270491 0.11705417 0.00000000 0.21256667 0.21256667 3.364718e-09 3.364718e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000064651 E001 7.6501917 0.0023034740 7.267585e-01 8.196813e-01 5 128083766 128083790 25 + 0.832 0.880 0.189
ENSG00000064651 E002 11.4188676 0.0015266473 1.268848e-01 2.298127e-01 5 128083791 128083847 57 + 1.011 0.920 -0.338
ENSG00000064651 E003 82.9167304 0.0015945041 1.417431e-11 2.879348e-10 5 128083848 128084710 863 + 1.862 1.576 -0.969
ENSG00000064651 E004 55.0810470 0.0004493961 2.310911e-06 1.773384e-05 5 128112814 128112933 120 + 1.677 1.481 -0.669
ENSG00000064651 E005 44.0909971 0.0004772574 4.062785e-04 1.798912e-03 5 128114212 128114287 76 + 1.575 1.437 -0.473
ENSG00000064651 E006 42.4537734 0.0005540751 4.475744e-07 3.997531e-06 5 128114586 128114681 96 + 1.578 1.302 -0.954
ENSG00000064651 E007 58.2592452 0.0109793547 2.478553e-03 8.699803e-03 5 128131067 128131206 140 + 1.693 1.560 -0.454
ENSG00000064651 E008 46.4129588 0.0043670954 8.090245e-03 2.400803e-02 5 128134165 128134275 111 + 1.588 1.503 -0.292
ENSG00000064651 E009 36.3526298 0.0007616485 2.922165e-02 7.043378e-02 5 128135700 128135808 109 + 1.478 1.426 -0.181
ENSG00000064651 E010 45.9578023 0.0019225776 1.015518e-04 5.290441e-04 5 128138597 128138724 128 + 1.598 1.426 -0.590
ENSG00000064651 E011 44.4888719 0.0069345078 1.737067e-03 6.399031e-03 5 128138824 128138908 85 + 1.581 1.438 -0.493
ENSG00000064651 E012 64.8707364 0.0011139659 4.343622e-07 3.888325e-06 5 128141830 128141981 152 + 1.749 1.549 -0.679
ENSG00000064651 E013 52.9652528 0.0004262581 1.675832e-04 8.248199e-04 5 128147622 128147729 108 + 1.652 1.521 -0.444
ENSG00000064651 E014 54.9751147 0.0041443955 1.908793e-02 4.952953e-02 5 128148754 128148877 124 + 1.656 1.608 -0.162
ENSG00000064651 E015 49.5908616 0.0005023916 2.721628e-01 4.110202e-01 5 128149997 128150098 102 + 1.595 1.638 0.148
ENSG00000064651 E016 57.6564017 0.0005160093 7.904610e-02 1.579859e-01 5 128151241 128151396 156 + 1.664 1.673 0.032
ENSG00000064651 E017 53.1970466 0.0004591447 1.604507e-01 2.757289e-01 5 128152706 128152805 100 + 1.626 1.653 0.092
ENSG00000064651 E018 0.0000000       5 128157988 128158048 61 +      
ENSG00000064651 E019 0.0000000       5 128158049 128158052 4 +      
ENSG00000064651 E020 65.2521412 0.0004171823 2.237747e-02 5.646060e-02 5 128158053 128158164 112 + 1.720 1.706 -0.048
ENSG00000064651 E021 75.2434428 0.0015867683 1.821607e-01 3.039118e-01 5 128161660 128161800 141 + 1.771 1.811 0.136
ENSG00000064651 E022 61.8094115 0.0026448085 2.226629e-01 3.535683e-01 5 128167761 128167867 107 + 1.688 1.725 0.125
ENSG00000064651 E023 1.0307671 0.3280628282 1.908297e-01 3.147871e-01 5 128167868 128171095 3228 + 0.156 0.577 2.683
ENSG00000064651 E024 51.9816784 0.0053379629 9.555225e-01 9.760935e-01 5 128171667 128171746 80 + 1.601 1.706 0.355
ENSG00000064651 E025 0.4482035 0.0262427705 5.932435e-01 7.156707e-01 5 128171747 128171882 136 + 0.157 0.001 -7.655
ENSG00000064651 E026 73.4113574 0.0003551365 9.873584e-01 9.961660e-01 5 128174541 128174666 126 + 1.746 1.857 0.378
ENSG00000064651 E027 43.6613340 0.0004926198 3.790698e-01 5.233543e-01 5 128177105 128177152 48 + 1.539 1.592 0.182
ENSG00000064651 E028 3.7078306 0.0400300874 2.720394e-02 6.640688e-02 5 128177549 128177639 91 + 0.650 0.239 -2.242
ENSG00000064651 E029 3.2664623 0.0046096568 3.292576e-02 7.765658e-02 5 128178380 128178566 187 + 0.606 0.239 -2.053
ENSG00000064651 E030 77.6406685 0.0021393619 3.868802e-02 8.860409e-02 5 128178567 128178689 123 + 1.793 1.791 -0.005
ENSG00000064651 E031 65.4095376 0.0011118821 5.667951e-01 6.936763e-01 5 128180883 128180994 112 + 1.705 1.786 0.271
ENSG00000064651 E032 46.2019929 0.0027105439 3.344383e-01 4.781869e-01 5 128182855 128182941 87 + 1.535 1.706 0.583
ENSG00000064651 E033 66.4552101 0.0004165032 3.576499e-01 5.020726e-01 5 128184366 128184501 136 + 1.692 1.849 0.531
ENSG00000064651 E034 0.0000000       5 128184502 128184507 6 +      
ENSG00000064651 E035 0.0000000       5 128184723 128184788 66 +      
ENSG00000064651 E036 53.6599290 0.0004772933 8.465984e-01 9.046711e-01 5 128184789 128184856 68 + 1.609 1.730 0.412
ENSG00000064651 E037 473.0900235 0.0170040930 9.033924e-11 1.606090e-09 5 128186496 128189677 3182 + 2.450 2.883 1.444