ENSG00000064607

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337018 ENSG00000064607 HEK293_OSMI2_2hA HEK293_TMG_2hB SUGP2 protein_coding protein_coding 34.33496 34.42518 31.47021 3.080572 0.5608261 -0.129438 3.906085 1.848044 6.2454461 1.3153171 0.1672948 1.7513285 0.11783333 0.06023333 0.19836667 0.13813333 3.226359e-01 1.426935e-10 FALSE TRUE
ENST00000452918 ENSG00000064607 HEK293_OSMI2_2hA HEK293_TMG_2hB SUGP2 protein_coding protein_coding 34.33496 34.42518 31.47021 3.080572 0.5608261 -0.129438 12.194626 12.437407 10.8088339 1.0468202 0.3589557 -0.2023002 0.35456250 0.36183333 0.34330000 -0.01853333 7.424291e-01 1.426935e-10 FALSE TRUE
ENST00000593795 ENSG00000064607 HEK293_OSMI2_2hA HEK293_TMG_2hB SUGP2 protein_coding nonsense_mediated_decay 34.33496 34.42518 31.47021 3.080572 0.5608261 -0.129438 1.508292 2.812363 0.2116430 0.6437681 0.1064655 -3.6705935 0.04250417 0.08003333 0.00670000 -0.07333333 3.896194e-03 1.426935e-10   FALSE
ENST00000594773 ENSG00000064607 HEK293_OSMI2_2hA HEK293_TMG_2hB SUGP2 protein_coding nonsense_mediated_decay 34.33496 34.42518 31.47021 3.080572 0.5608261 -0.129438 3.529580 3.020273 3.5340298 0.4098945 0.1080703 0.2259428 0.10285000 0.08786667 0.11236667 0.02450000 3.505309e-01 1.426935e-10 TRUE TRUE
ENST00000600377 ENSG00000064607 HEK293_OSMI2_2hA HEK293_TMG_2hB SUGP2 protein_coding protein_coding 34.33496 34.42518 31.47021 3.080572 0.5608261 -0.129438 3.220909 1.217923 3.9869572 0.6203590 0.2851800 1.7026816 0.09372500 0.03266667 0.12676667 0.09410000 3.232199e-01 1.426935e-10 FALSE TRUE
MSTRG.16756.1 ENSG00000064607 HEK293_OSMI2_2hA HEK293_TMG_2hB SUGP2 protein_coding   34.33496 34.42518 31.47021 3.080572 0.5608261 -0.129438 1.176569 0.000000 1.9937444 0.0000000 0.5213223 7.6465546 0.03533750 0.00000000 0.06390000 0.06390000 1.426935e-10 1.426935e-10 TRUE TRUE
MSTRG.16756.26 ENSG00000064607 HEK293_OSMI2_2hA HEK293_TMG_2hB SUGP2 protein_coding   34.33496 34.42518 31.47021 3.080572 0.5608261 -0.129438 3.336704 7.457173 0.3966244 2.2309631 0.2112016 -4.1987936 0.09449583 0.20860000 0.01236667 -0.19623333 3.384248e-02 1.426935e-10 FALSE TRUE
MSTRG.16756.30 ENSG00000064607 HEK293_OSMI2_2hA HEK293_TMG_2hB SUGP2 protein_coding   34.33496 34.42518 31.47021 3.080572 0.5608261 -0.129438 1.982938 1.856869 1.2710488 0.5568386 0.6594399 -0.5432950 0.05759583 0.05786667 0.04003333 -0.01783333 8.200803e-01 1.426935e-10 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000064607 E001 1.0298353 0.0124260596 4.616529e-01 6.015719e-01 19 18990888 18990889 2 - 0.224 0.354 0.898
ENSG00000064607 E002 1.3567123 0.0397081721 5.475662e-01 6.776064e-01 19 18990890 18990890 1 - 0.303 0.411 0.638
ENSG00000064607 E003 2.6884194 0.0058562300 3.910676e-01 5.350091e-01 19 18990891 18990892 2 - 0.480 0.617 0.635
ENSG00000064607 E004 8.1938579 0.0020983088 1.872466e-01 3.102767e-01 19 18990893 18990897 5 - 0.870 1.018 0.556
ENSG00000064607 E005 9.7406806 0.0017975936 1.176927e-01 2.166553e-01 19 18990898 18990898 1 - 0.925 1.090 0.608
ENSG00000064607 E006 10.0437115 0.0017400286 2.035910e-01 3.307061e-01 19 18990899 18990899 1 - 0.959 1.090 0.483
ENSG00000064607 E007 11.6949233 0.0014856080 4.424150e-01 5.840344e-01 19 18990900 18990901 2 - 1.059 1.132 0.265
ENSG00000064607 E008 14.9120747 0.0019761940 8.491975e-01 9.064158e-01 19 18990902 18990902 1 - 1.190 1.206 0.056
ENSG00000064607 E009 54.6330264 0.0071885899 8.930959e-06 6.006402e-05 19 18990903 18990944 42 - 1.561 1.853 0.990
ENSG00000064607 E010 234.1224316 0.0065873391 1.531483e-08 1.823715e-07 19 18990945 18991149 205 - 2.201 2.467 0.887
ENSG00000064607 E011 127.1204063 0.0022258722 1.755848e-12 4.133202e-11 19 18991150 18991267 118 - 1.928 2.208 0.941
ENSG00000064607 E012 113.2373042 0.0010580695 3.635963e-12 8.130576e-11 19 18991268 18991339 72 - 1.890 2.150 0.874
ENSG00000064607 E013 158.8224162 0.0007665707 1.809734e-14 5.740937e-13 19 18991340 18991553 214 - 2.048 2.289 0.808
ENSG00000064607 E014 124.6619718 0.0005279761 2.344375e-06 1.796299e-05 19 18991554 18991742 189 - 1.999 2.156 0.526
ENSG00000064607 E015 93.7507526 0.0032012993 1.089286e-03 4.267555e-03 19 18991743 18991805 63 - 1.882 2.030 0.498
ENSG00000064607 E016 218.5124633 0.0027476729 8.878402e-03 2.597623e-02 19 18991806 18992164 359 - 2.284 2.375 0.302
ENSG00000064607 E017 97.6785148 0.0003244519 5.258676e-01 6.591900e-01 19 18992165 18992366 202 - 1.978 2.000 0.073
ENSG00000064607 E018 67.9909086 0.0023938923 5.831864e-01 7.073503e-01 19 18992367 18992463 97 - 1.820 1.842 0.076
ENSG00000064607 E019 231.1332788 0.0002161954 3.176726e-01 4.605622e-01 19 18992464 18992924 461 - 2.349 2.372 0.074
ENSG00000064607 E020 217.6607905 0.0011985078 7.715972e-01 8.525913e-01 19 18992925 18993276 352 - 2.333 2.337 0.016
ENSG00000064607 E021 141.7768184 0.0033364290 1.115596e-01 2.078461e-01 19 18993277 18993461 185 - 2.188 2.117 -0.236
ENSG00000064607 E022 129.8307033 0.0011112289 6.691939e-02 1.382525e-01 19 18993462 18993637 176 - 2.147 2.081 -0.221
ENSG00000064607 E023 73.0949436 0.0010446131 7.989144e-01 8.716973e-01 19 18993638 18993647 10 - 1.874 1.863 -0.039
ENSG00000064607 E024 168.9725870 0.0028897696 1.831542e-01 3.051474e-01 19 18993648 18993740 93 - 2.199 2.250 0.171
ENSG00000064607 E025 122.7907094 0.0002909783 3.650742e-05 2.124089e-04 19 18993741 18994365 625 - 2.160 2.026 -0.449
ENSG00000064607 E026 285.2804139 0.0006730371 2.857896e-06 2.149125e-05 19 18994366 18994486 121 - 2.389 2.501 0.376
ENSG00000064607 E027 65.3385145 0.0090196954 2.522514e-01 3.885794e-01 19 18994487 18994597 111 - 1.859 1.784 -0.251
ENSG00000064607 E028 137.6547015 0.0056758549 2.807580e-02 6.816363e-02 19 18994598 18995143 546 - 2.194 2.085 -0.364
ENSG00000064607 E029 328.6973251 0.0002110391 7.821536e-06 5.324924e-05 19 18995144 18995280 137 - 2.464 2.554 0.299
ENSG00000064607 E030 3.4310087 0.0047619166 3.148814e-01 4.576327e-01 19 18998924 18998985 62 - 0.731 0.583 -0.634
ENSG00000064607 E031 239.0411869 0.0030197935 3.366816e-01 4.805530e-01 19 19001613 19001674 62 - 2.360 2.394 0.115
ENSG00000064607 E032 6.5565582 0.0073291754 2.679400e-01 4.063240e-01 19 19003496 19003608 113 - 0.942 0.802 -0.538
ENSG00000064607 E033 243.8704035 0.0021030096 1.931672e-02 5.001976e-02 19 19004168 19004273 106 - 2.345 2.419 0.244
ENSG00000064607 E034 292.7348629 0.0023467393 1.601803e-02 4.277490e-02 19 19004274 19004429 156 - 2.424 2.499 0.250
ENSG00000064607 E035 339.4227030 0.0013761842 9.721965e-03 2.807918e-02 19 19004430 19004646 217 - 2.493 2.558 0.215
ENSG00000064607 E036 3.6652674 0.0959846211 2.387436e-01 3.726897e-01 19 19007347 19007447 101 - 0.783 0.546 -1.012
ENSG00000064607 E037 235.6674805 0.0002484645 4.485251e-01 5.898105e-01 19 19008317 19008428 112 - 2.364 2.380 0.055
ENSG00000064607 E038 459.9666378 0.0001191486 5.557433e-01 6.845641e-01 19 19009855 19010342 488 - 2.657 2.666 0.028
ENSG00000064607 E039 1.4382729 0.0091320969 7.391651e-02 1.497723e-01 19 19012270 19012380 111 - 0.526 0.212 -1.909
ENSG00000064607 E040 199.0835066 0.0024106238 4.362953e-01 5.783941e-01 19 19019109 19019229 121 - 2.317 2.286 -0.102
ENSG00000064607 E041 2.3100596 0.0691895150 1.850669e-01 3.075795e-01 19 19019887 19019966 80 - 0.371 0.615 1.212
ENSG00000064607 E042 690.6130073 0.0022908881 5.727647e-03 1.789389e-02 19 19024619 19025456 838 - 2.878 2.802 -0.252
ENSG00000064607 E043 175.0670744 0.0010194123 3.298727e-07 3.025728e-06 19 19025457 19025556 100 - 2.325 2.167 -0.528
ENSG00000064607 E044 332.4342475 0.0002513313 7.129540e-27 9.083187e-25 19 19025557 19025854 298 - 2.630 2.411 -0.730
ENSG00000064607 E045 246.1159455 0.0011849069 1.280711e-19 7.819107e-18 19 19025855 19026013 159 - 2.515 2.262 -0.846
ENSG00000064607 E046 257.9627207 0.0037190271 1.722635e-10 2.919817e-09 19 19026014 19026226 213 - 2.528 2.288 -0.799
ENSG00000064607 E047 130.9096460 0.0044667872 1.000930e-08 1.234125e-07 19 19030951 19031082 132 - 2.244 1.980 -0.883
ENSG00000064607 E048 0.3268771 0.0326487612 9.658799e-01   19 19031083 19031107 25 - 0.126 0.119 -0.102
ENSG00000064607 E049 1.1374321 0.0140966022 2.238372e-01 3.549966e-01 19 19033048 19033436 389 - 0.429 0.212 -1.422
ENSG00000064607 E050 47.2400939 0.0007292560 3.128957e-09 4.230456e-08 19 19033437 19033488 52 - 1.831 1.523 -1.046
ENSG00000064607 E051 12.6875764 0.0018147489 2.351978e-07 2.224095e-06 19 19033489 19033559 71 - 1.347 0.843 -1.832
ENSG00000064607 E052 7.2310010 0.0314931620 5.993944e-02 1.265065e-01 19 19033762 19034023 262 - 1.033 0.761 -1.035