ENSG00000064601

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000484855 ENSG00000064601 HEK293_OSMI2_2hA HEK293_TMG_2hB CTSA protein_coding retained_intron 54.04968 75.29279 36.00969 3.178551 0.265913 -1.063917 2.623876 1.476219 2.342843 0.1857032 0.3677080 0.6627588 0.05302917 0.01943333 0.06490000 0.04546667 2.495555e-05 1.058559e-31 TRUE TRUE
ENST00000606394 ENSG00000064601 HEK293_OSMI2_2hA HEK293_TMG_2hB CTSA protein_coding nonsense_mediated_decay 54.04968 75.29279 36.00969 3.178551 0.265913 -1.063917 1.850444 0.000000 2.551990 0.0000000 0.3232963 8.0011210 0.04068333 0.00000000 0.07073333 0.07073333 1.058559e-31 1.058559e-31 FALSE FALSE
ENST00000646241 ENSG00000064601 HEK293_OSMI2_2hA HEK293_TMG_2hB CTSA protein_coding protein_coding 54.04968 75.29279 36.00969 3.178551 0.265913 -1.063917 43.220995 66.794805 25.905447 3.1144302 0.5138901 -1.3661396 0.78352500 0.88683333 0.71970000 -0.16713333 4.253650e-10 1.058559e-31 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000064601 E001 0.9932149 0.0392697894 4.553227e-01 5.958589e-01 20 45890144 45890253 110 + 0.171 0.321 1.184
ENSG00000064601 E002 0.8115105 0.0164202352 6.043905e-01 7.249645e-01 20 45890254 45890298 45 + 0.171 0.274 0.865
ENSG00000064601 E003 0.4815130 0.0219239834 9.145236e-01 9.498977e-01 20 45890299 45890340 42 + 0.171 0.158 -0.134
ENSG00000064601 E004 1.9478839 0.0634288638 3.511557e-01 4.953713e-01 20 45890341 45890867 527 + 0.533 0.369 -0.848
ENSG00000064601 E005 0.5879639 0.0207812632 7.088224e-02 1.448090e-01 20 45890868 45890962 95 + 0.388 0.086 -2.719
ENSG00000064601 E006 0.2934659 0.0291038840 5.477353e-01   20 45890963 45890970 8 + 0.171 0.086 -1.134
ENSG00000064601 E007 0.8041237 0.0152209754 6.562180e-01 7.658997e-01 20 45890971 45891071 101 + 0.293 0.220 -0.548
ENSG00000064601 E008 1.9102314 0.0074612807 8.150787e-01 8.828470e-01 20 45891072 45891172 101 + 0.388 0.441 0.284
ENSG00000064601 E009 3.5602854 0.0130480248 6.830166e-02 1.405629e-01 20 45891173 45891312 140 + 0.799 0.534 -1.132
ENSG00000064601 E010 3.5549868 0.0471570156 2.079579e-01 3.360401e-01 20 45891313 45891321 9 + 0.764 0.560 -0.872
ENSG00000064601 E011 12.6488615 0.0065148226 8.890467e-02 1.734486e-01 20 45891322 45891334 13 + 1.202 1.045 -0.565
ENSG00000064601 E012 18.3387551 0.0067343243 4.802058e-01 6.185101e-01 20 45891335 45891340 6 + 1.275 1.226 -0.171
ENSG00000064601 E013 24.2452851 0.0094655416 4.381907e-02 9.805681e-02 20 45891341 45891341 1 + 1.462 1.308 -0.531
ENSG00000064601 E014 24.7903982 0.0155817520 8.356489e-02 1.651259e-01 20 45891342 45891342 1 + 1.462 1.322 -0.483
ENSG00000064601 E015 29.1559586 0.0131743747 3.407715e-01 4.847144e-01 20 45891343 45891344 2 + 1.476 1.413 -0.215
ENSG00000064601 E016 98.2354849 0.0062151438 1.561410e-01 2.700010e-01 20 45891345 45891353 9 + 1.986 1.928 -0.194
ENSG00000064601 E017 100.2167034 0.0069303904 2.210276e-01 3.516496e-01 20 45891354 45891355 2 + 1.988 1.940 -0.162
ENSG00000064601 E018 116.3813763 0.0053705675 5.099285e-01 6.451951e-01 20 45891356 45891365 10 + 2.027 2.014 -0.045
ENSG00000064601 E019 131.4662655 0.0067932563 2.924991e-01 4.334700e-01 20 45891366 45891375 10 + 2.094 2.061 -0.112
ENSG00000064601 E020 134.9641046 0.0064850627 3.216898e-01 4.649417e-01 20 45891376 45891379 4 + 2.103 2.073 -0.099
ENSG00000064601 E021 1.1489717 0.0120190354 1.506726e-01 2.625841e-01 20 45891380 45891385 6 + 0.466 0.220 -1.547
ENSG00000064601 E022 3.8823444 0.0308782729 3.094927e-02 7.381558e-02 20 45891386 45891397 12 + 0.861 0.534 -1.376
ENSG00000064601 E023 5.0551623 0.0217021678 2.661240e-02 6.518547e-02 20 45891398 45891420 23 + 0.940 0.633 -1.226
ENSG00000064601 E024 5.2766075 0.0126190760 3.056676e-02 7.308178e-02 20 45891421 45891425 5 + 0.940 0.655 -1.131
ENSG00000064601 E025 3.0560826 0.0053329938 2.213090e-01 3.520010e-01 20 45891426 45891449 24 + 0.686 0.505 -0.809
ENSG00000064601 E026 4.4837569 0.0299931754 2.555264e-01 3.924246e-01 20 45891450 45891547 98 + 0.799 0.636 -0.671
ENSG00000064601 E027 4.5233960 0.0051205723 6.617443e-01 7.701623e-01 20 45891548 45891568 21 + 0.727 0.676 -0.213
ENSG00000064601 E028 182.3316338 0.0089038481 7.633524e-01 8.466736e-01 20 45891569 45891620 52 + 2.207 2.214 0.024
ENSG00000064601 E029 317.9037571 0.0105212659 2.855234e-01 4.258593e-01 20 45891621 45891762 142 + 2.477 2.444 -0.111
ENSG00000064601 E030 8.8663418 0.0033366033 7.185918e-05 3.892688e-04 20 45891763 45891822 60 + 1.202 0.783 -1.561
ENSG00000064601 E031 5.2286500 0.0031749627 3.039152e-03 1.038001e-02 20 45891823 45891845 23 + 0.986 0.611 -1.494
ENSG00000064601 E032 7.7729210 0.0021481349 8.250123e-07 6.976259e-06 20 45891846 45891915 70 + 1.215 0.675 -2.045
ENSG00000064601 E033 330.0279169 0.0032260664 6.194551e-01 7.368607e-01 20 45891916 45892027 112 + 2.466 2.469 0.010
ENSG00000064601 E034 5.1258592 0.0976304201 1.007697e-01 1.916352e-01 20 45892028 45892272 245 + 0.939 0.638 -1.200
ENSG00000064601 E035 248.8414708 0.0016581718 4.360921e-01 5.782259e-01 20 45892273 45892305 33 + 2.348 2.342 -0.020
ENSG00000064601 E036 220.8479117 0.0061961505 2.653793e-01 4.034321e-01 20 45892306 45892323 18 + 2.317 2.285 -0.105
ENSG00000064601 E037 11.1859442 0.0017475482 5.892632e-07 5.142605e-06 20 45892324 45892397 74 + 1.327 0.855 -1.717
ENSG00000064601 E038 414.3641952 0.0034914725 3.981701e-01 5.419170e-01 20 45892398 45892484 87 + 2.572 2.564 -0.027
ENSG00000064601 E039 2.6561803 0.2146300040 4.664203e-01 6.059449e-01 20 45892485 45892724 240 + 0.642 0.475 -0.772
ENSG00000064601 E040 577.4873519 0.0008376886 4.061184e-01 5.497684e-01 20 45892725 45892880 156 + 2.708 2.710 0.005
ENSG00000064601 E041 7.2879902 0.0023370858 1.503758e-01 2.621880e-01 20 45892881 45892887 7 + 0.986 0.827 -0.602
ENSG00000064601 E042 5.3873278 0.0227901419 3.884164e-04 1.729971e-03 20 45892888 45892978 91 + 1.064 0.584 -1.902
ENSG00000064601 E043 5.5045001 0.0028974450 1.041599e-04 5.412023e-04 20 45892979 45893039 61 + 1.064 0.586 -1.892
ENSG00000064601 E044 7.0995830 0.0045290892 2.837231e-04 1.313711e-03 20 45893040 45893145 106 + 1.116 0.696 -1.605
ENSG00000064601 E045 9.0644082 0.0302841636 1.366816e-04 6.888148e-04 20 45893146 45893219 74 + 1.241 0.753 -1.813
ENSG00000064601 E046 439.2463546 0.0001613156 1.880857e-01 3.113185e-01 20 45893220 45893311 92 + 2.597 2.589 -0.026
ENSG00000064601 E047 3.8008580 0.0057123255 3.122425e-01 4.547744e-01 20 45893312 45893987 676 + 0.727 0.587 -0.600
ENSG00000064601 E048 456.0944471 0.0002269240 9.217072e-01 9.545958e-01 20 45893988 45894072 85 + 2.595 2.614 0.063
ENSG00000064601 E049 2.6622959 0.0406537100 3.736127e-01 5.180287e-01 20 45894073 45894649 577 + 0.641 0.502 -0.634
ENSG00000064601 E050 453.1950719 0.0003389377 1.849304e-02 4.821572e-02 20 45894650 45894741 92 + 2.558 2.623 0.216
ENSG00000064601 E051 216.1634895 0.0002059849 7.544847e-01 8.401163e-01 20 45894823 45894832 10 + 2.266 2.291 0.084
ENSG00000064601 E052 367.8829127 0.0018499493 9.928758e-01 9.996457e-01 20 45894833 45894901 69 + 2.502 2.522 0.064
ENSG00000064601 E053 525.5863728 0.0025785602 4.222825e-01 5.654361e-01 20 45894994 45895133 140 + 2.639 2.683 0.145
ENSG00000064601 E054 13.5190404 0.0013244633 1.788513e-10 3.021208e-09 20 45895134 45895138 5 + 1.439 0.880 -2.007
ENSG00000064601 E055 91.3315850 0.0030875225 3.756522e-28 5.387295e-26 20 45895139 45896455 1317 + 2.203 1.722 -1.615
ENSG00000064601 E056 51.0961987 0.0006121936 1.720171e-16 7.190670e-15 20 45896456 45896964 509 + 1.914 1.520 -1.335
ENSG00000064601 E057 422.1378380 0.0011356945 6.105047e-02 1.284022e-01 20 45896965 45897040 76 + 2.528 2.593 0.216
ENSG00000064601 E058 73.9504128 0.0005544288 1.374552e-18 7.440135e-17 20 45897041 45897625 585 + 2.048 1.694 -1.196
ENSG00000064601 E059 21.1175464 0.0019504004 1.040643e-07 1.053415e-06 20 45897626 45897716 91 + 1.541 1.152 -1.355
ENSG00000064601 E060 248.7376323 0.0003130976 6.622552e-02 1.370954e-01 20 45897717 45897725 9 + 2.297 2.362 0.217
ENSG00000064601 E061 415.5171598 0.0021893180 4.019154e-05 2.315590e-04 20 45897726 45897806 81 + 2.462 2.603 0.472
ENSG00000064601 E062 29.1837217 0.0288464589 8.889801e-02 1.734374e-01 20 45897807 45897907 101 + 1.535 1.381 -0.532
ENSG00000064601 E063 26.9497168 0.0187344624 3.140502e-01 4.567154e-01 20 45897908 45898004 97 + 1.447 1.370 -0.267
ENSG00000064601 E064 523.0047514 0.0032890414 2.313138e-06 1.774877e-05 20 45898005 45898109 105 + 2.537 2.710 0.575
ENSG00000064601 E065 9.4033834 0.0018896933 8.151265e-02 1.619185e-01 20 45898110 45898366 257 + 1.082 0.905 -0.655
ENSG00000064601 E066 902.1742331 0.0034438477 1.639508e-08 1.942342e-07 20 45898367 45898949 583 + 2.761 2.950 0.628