ENSG00000064419

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265388 ENSG00000064419 HEK293_OSMI2_2hA HEK293_TMG_2hB TNPO3 protein_coding protein_coding 34.74473 30.2413 37.36608 3.008977 0.8829358 0.3051184 32.98145 29.67053 34.22006 2.809565 1.683699 0.2057467 0.951625 0.9822 0.9146667 -0.06753333 0.01379178 0.0003887727 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000064419 E001 1.399461 0.0818614256 7.432255e-01 8.319311e-01 7 128954180 128954184 5 - 0.349 0.430 0.457
ENSG00000064419 E002 738.329722 0.0054242951 5.577164e-12 1.209313e-10 7 128954185 128954750 566 - 2.712 2.977 0.881
ENSG00000064419 E003 687.482357 0.0033945162 1.799763e-14 5.711219e-13 7 128954751 128955087 337 - 2.695 2.940 0.816
ENSG00000064419 E004 369.169158 0.0002108195 2.122493e-14 6.656181e-13 7 128955088 128955385 298 - 2.478 2.644 0.553
ENSG00000064419 E005 2.750853 0.1567054769 3.813554e-01 5.256528e-01 7 128957223 128957223 1 - 0.671 0.480 -0.869
ENSG00000064419 E006 240.046286 0.0002144649 9.131956e-05 4.811704e-04 7 128957224 128957315 92 - 2.327 2.438 0.370
ENSG00000064419 E007 241.115650 0.0009047362 7.171701e-04 2.960489e-03 7 128967280 128967392 113 - 2.329 2.439 0.366
ENSG00000064419 E008 360.365647 0.0001670790 2.114394e-02 5.390177e-02 7 128970148 128970315 168 - 2.528 2.591 0.210
ENSG00000064419 E009 364.384973 0.0006347722 9.459104e-01 9.700368e-01 7 128972426 128972582 157 - 2.556 2.572 0.053
ENSG00000064419 E010 275.172044 0.0002087502 7.512210e-01 8.377097e-01 7 128974868 128974962 95 - 2.438 2.451 0.041
ENSG00000064419 E011 256.978672 0.0001767323 1.224690e-01 2.234698e-01 7 128975819 128975935 117 - 2.386 2.440 0.179
ENSG00000064419 E012 324.390991 0.0001443436 4.867369e-01 6.244555e-01 7 128978983 128979123 141 - 2.500 2.533 0.111
ENSG00000064419 E013 274.822318 0.0001747508 2.304485e-01 3.629920e-01 7 128979971 128980031 61 - 2.449 2.443 -0.021
ENSG00000064419 E014 279.778122 0.0001610962 4.914712e-01 6.287398e-01 7 128982248 128982324 77 - 2.449 2.454 0.015
ENSG00000064419 E015 277.241256 0.0001627484 9.244667e-01 9.564133e-01 7 128984168 128984259 92 - 2.439 2.456 0.057
ENSG00000064419 E016 359.465588 0.0001831287 2.841943e-01 4.244163e-01 7 128986729 128986920 192 - 2.562 2.561 -0.003
ENSG00000064419 E017 290.681094 0.0001815508 8.059982e-05 4.307669e-04 7 128989961 128990100 140 - 2.501 2.437 -0.213
ENSG00000064419 E018 2.868958 0.0848677205 4.648877e-02 1.029174e-01 7 128990101 128990202 102 - 0.750 0.373 -1.764
ENSG00000064419 E019 223.075368 0.0009459259 9.211138e-03 2.681267e-02 7 128991999 128992090 92 - 2.379 2.324 -0.183
ENSG00000064419 E020 254.715168 0.0056012217 2.478041e-03 8.698328e-03 7 128993807 128993914 108 - 2.464 2.349 -0.386
ENSG00000064419 E021 282.296849 0.0064291845 3.837134e-03 1.268357e-02 7 128997389 128997535 147 - 2.509 2.393 -0.389
ENSG00000064419 E022 230.776200 0.0052157531 7.182516e-03 2.169770e-02 7 129000429 129000567 139 - 2.415 2.314 -0.336
ENSG00000064419 E023 250.962137 0.0002410200 9.228857e-16 3.500259e-14 7 129001059 129001234 176 - 2.482 2.315 -0.556
ENSG00000064419 E024 222.778287 0.0001874437 6.623547e-16 2.563455e-14 7 129005016 129005159 144 - 2.435 2.259 -0.586
ENSG00000064419 E025 220.664980 0.0028825137 1.054645e-09 1.557135e-08 7 129014979 129015135 157 - 2.439 2.241 -0.661
ENSG00000064419 E026 169.618744 0.0006908960 1.208326e-15 4.515955e-14 7 129016983 129017056 74 - 2.336 2.117 -0.732
ENSG00000064419 E027 265.428984 0.0046920743 1.551232e-08 1.845377e-07 7 129017957 129018157 201 - 2.522 2.313 -0.699
ENSG00000064419 E028 4.902731 0.0036770526 4.689126e-01 6.082536e-01 7 129019871 129019995 125 - 0.817 0.737 -0.319
ENSG00000064419 E029 8.213890 0.0330700276 1.648514e-02 4.380967e-02 7 129041557 129041717 161 - 1.105 0.786 -1.200
ENSG00000064419 E030 289.636802 0.0053769906 6.938782e-07 5.962946e-06 7 129054651 129055173 523 - 2.552 2.364 -0.625