ENSG00000064115

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343028 ENSG00000064115 HEK293_OSMI2_2hA HEK293_TMG_2hB TM7SF3 protein_coding protein_coding 43.75439 31.76503 47.7588 5.511643 0.4952695 0.5881749 11.389953 9.710836 13.514509 2.1245484 0.4237575 0.476424027 0.26827500 0.30840000 0.2828667 -0.025533333 0.86433337 0.01748237 FALSE  
ENST00000543088 ENSG00000064115 HEK293_OSMI2_2hA HEK293_TMG_2hB TM7SF3 protein_coding protein_coding 43.75439 31.76503 47.7588 5.511643 0.4952695 0.5881749 4.030801 1.355027 5.114737 1.1285819 0.2342222 1.908548832 0.08032917 0.04076667 0.1070333 0.066266667 0.44109770 0.01748237 FALSE  
ENST00000545344 ENSG00000064115 HEK293_OSMI2_2hA HEK293_TMG_2hB TM7SF3 protein_coding protein_coding 43.75439 31.76503 47.7588 5.511643 0.4952695 0.5881749 7.348717 6.460278 6.479867 0.7931990 0.5578035 0.004361031 0.17292083 0.20813333 0.1354667 -0.072666667 0.01748237 0.01748237 FALSE  
MSTRG.6992.2 ENSG00000064115 HEK293_OSMI2_2hA HEK293_TMG_2hB TM7SF3 protein_coding   43.75439 31.76503 47.7588 5.511643 0.4952695 0.5881749 3.829935 2.463033 3.945010 0.2945345 0.2338049 0.677400249 0.08700000 0.08000000 0.0827000 0.002700000 0.92909524 0.01748237 FALSE  
MSTRG.6992.5 ENSG00000064115 HEK293_OSMI2_2hA HEK293_TMG_2hB TM7SF3 protein_coding   43.75439 31.76503 47.7588 5.511643 0.4952695 0.5881749 10.389385 7.256130 11.133160 1.1627262 0.8253378 0.616899310 0.24160833 0.23090000 0.2328333 0.001933333 0.99949015 0.01748237 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000064115 E001 95.6616522 0.0154301666 2.024463e-01 3.292768e-01 12 26971579 26972020 442 - 2.030 1.948 -0.275
ENSG00000064115 E002 811.4122856 0.0024555852 8.566829e-01 9.114015e-01 12 26972021 26974095 2075 - 2.918 2.908 -0.034
ENSG00000064115 E003 269.6382543 0.0014883563 1.370001e-04 6.902729e-04 12 26974096 26974153 58 - 2.382 2.488 0.353
ENSG00000064115 E004 306.2630300 0.0003877062 3.713184e-04 1.663478e-03 12 26974154 26974227 74 - 2.455 2.532 0.258
ENSG00000064115 E005 295.8730218 0.0001660026 1.121010e-03 4.373931e-03 12 26975496 26975555 60 - 2.444 2.512 0.227
ENSG00000064115 E006 214.9109881 0.0001837629 1.038809e-02 2.971497e-02 12 26975556 26975576 21 - 2.309 2.372 0.211
ENSG00000064115 E007 299.7745532 0.0001845383 1.453145e-02 3.943605e-02 12 26975577 26975658 82 - 2.460 2.511 0.172
ENSG00000064115 E008 2.2163737 0.0812076128 3.010998e-01 4.428693e-01 12 26975659 26975775 117 - 0.607 0.431 -0.842
ENSG00000064115 E009 140.9186889 0.0003404100 4.069895e-02 9.232448e-02 12 26976260 26976261 2 - 2.125 2.187 0.209
ENSG00000064115 E010 247.5943290 0.0002430383 5.679152e-03 1.776465e-02 12 26976262 26976329 68 - 2.369 2.432 0.213
ENSG00000064115 E011 175.1738723 0.0007922627 6.519018e-02 1.353508e-01 12 26976330 26976357 28 - 2.225 2.278 0.176
ENSG00000064115 E012 2.1443541 0.0078519585 5.212250e-02 1.129416e-01 12 26977952 26978094 143 - 0.639 0.310 -1.688
ENSG00000064115 E013 282.2937744 0.0001784505 1.323449e-02 3.645985e-02 12 26979784 26979901 118 - 2.432 2.485 0.178
ENSG00000064115 E014 159.4533377 0.0002183316 9.699836e-02 1.858908e-01 12 26979902 26979936 35 - 2.188 2.236 0.160
ENSG00000064115 E015 5.7043684 0.0028785809 1.088787e-04 5.629108e-04 12 26979937 26980271 335 - 1.019 0.489 -2.182
ENSG00000064115 E016 254.0414869 0.0010086379 3.722232e-01 5.166806e-01 12 26980566 26980646 81 - 2.426 2.403 -0.075
ENSG00000064115 E017 236.9357587 0.0001896428 5.873552e-01 7.106534e-01 12 26982773 26982859 87 - 2.391 2.381 -0.036
ENSG00000064115 E018 2.4086726 0.0061879322 9.875575e-01 9.962926e-01 12 26983493 26983596 104 - 0.537 0.535 -0.006
ENSG00000064115 E019 349.6725583 0.0001418099 8.408344e-02 1.659425e-01 12 26990450 26990627 178 - 2.569 2.538 -0.104
ENSG00000064115 E020 0.1451727 0.0437152671 5.744659e-01   12 26995235 26995236 2 - 0.116 0.000 -8.201
ENSG00000064115 E021 143.6617111 0.0016821796 3.684606e-01 5.128745e-01 12 26995237 26995239 3 - 2.184 2.151 -0.109
ENSG00000064115 E022 191.8808768 0.0002443190 1.148958e-01 2.126876e-01 12 26995240 26995300 61 - 2.313 2.274 -0.131
ENSG00000064115 E023 167.2658004 0.0002202280 2.189482e-01 3.491358e-01 12 26995301 26995360 60 - 2.249 2.217 -0.109
ENSG00000064115 E024 172.4559795 0.0033842868 8.002039e-01 8.726280e-01 12 26995361 26995408 48 - 2.253 2.235 -0.060
ENSG00000064115 E025 157.9529225 0.0024765711 4.297094e-01 5.723991e-01 12 26996742 26996782 41 - 2.224 2.190 -0.114
ENSG00000064115 E026 184.1833916 0.0003505328 1.271320e-01 2.301439e-01 12 26996783 26996850 68 - 2.295 2.254 -0.135
ENSG00000064115 E027 125.2542425 0.0002694981 9.536308e-01 9.749625e-01 12 26996851 26996862 12 - 2.110 2.109 -0.002
ENSG00000064115 E028 182.4581457 0.0002288925 1.792850e-01 3.002245e-01 12 26999526 26999588 63 - 2.288 2.254 -0.115
ENSG00000064115 E029 175.7302957 0.0003082484 7.043031e-03 2.133507e-02 12 26999589 26999648 60 - 2.291 2.218 -0.242
ENSG00000064115 E030 143.1946703 0.0002414869 5.305500e-05 2.970537e-04 12 26999649 26999676 28 - 2.224 2.106 -0.395
ENSG00000064115 E031 5.0228959 0.0032782219 6.015957e-01 7.227228e-01 12 26999677 26999703 27 - 0.746 0.817 0.280
ENSG00000064115 E032 4.8294510 0.0036013386 8.773125e-01 9.251815e-01 12 26999704 26999766 63 - 0.769 0.792 0.092
ENSG00000064115 E033 0.0000000       12 26999767 26999794 28 -      
ENSG00000064115 E034 186.0585217 0.0002284674 2.543598e-05 1.539542e-04 12 27003236 27003390 155 - 2.332 2.223 -0.364
ENSG00000064115 E035 0.0000000       12 27003391 27003405 15 -      
ENSG00000064115 E036 1.2511813 0.0100689884 8.632638e-01 9.158214e-01 12 27012710 27013014 305 - 0.346 0.378 0.186
ENSG00000064115 E037 102.2296896 0.0017850858 4.129837e-08 4.531364e-07 12 27014078 27014308 231 - 2.120 1.897 -0.749
ENSG00000064115 E038 28.3822502 0.0007293924 1.331779e-12 3.200180e-11 12 27014309 27014434 126 - 1.655 1.163 -1.707