ENSG00000064102

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261191 ENSG00000064102 HEK293_OSMI2_2hA HEK293_TMG_2hB INTS13 protein_coding protein_coding 26.22625 12.1913 33.11103 0.6501067 1.330309 1.440713 21.296761 7.241314 29.27010 0.3309621 1.1021676 2.013606 0.7776708 0.5985667 0.8842 0.2856333 1.496658e-08 1.496658e-08 FALSE TRUE
ENST00000538155 ENSG00000064102 HEK293_OSMI2_2hA HEK293_TMG_2hB INTS13 protein_coding protein_coding 26.22625 12.1913 33.11103 0.6501067 1.330309 1.440713 3.072297 4.224784 1.92349 1.2302120 0.2296794 -1.131081 0.1569375 0.3378333 0.0586 -0.2792333 1.402988e-04 1.496658e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000064102 E001 1.2094382 0.0308811002 3.486288e-01 4.928599e-01 12 26905181 26905184 4 - 0.249 0.424 1.098
ENSG00000064102 E002 9.1887558 0.0019867754 8.493891e-10 1.274972e-08 12 26905185 26905227 43 - 0.651 1.317 2.506
ENSG00000064102 E003 174.0137202 0.0038433061 2.044540e-13 5.562716e-12 12 26905228 26905536 309 - 2.095 2.391 0.989
ENSG00000064102 E004 190.2822747 0.0002752949 6.455188e-08 6.803049e-07 12 26906302 26906437 136 - 2.194 2.344 0.501
ENSG00000064102 E005 0.1515154 0.0432965174 1.000000e+00   12 26906438 26906484 47 - 0.077 0.000 -9.051
ENSG00000064102 E006 210.4931779 0.0001806969 2.783636e-10 4.554379e-09 12 26911178 26911317 140 - 2.230 2.394 0.546
ENSG00000064102 E007 310.5858396 0.0003609216 3.625427e-03 1.208287e-02 12 26913457 26913687 231 - 2.434 2.502 0.227
ENSG00000064102 E008 149.8966085 0.0002608839 7.279374e-02 1.479943e-01 12 26913974 26914019 46 - 2.122 2.181 0.197
ENSG00000064102 E009 113.8222875 0.0002754744 8.564930e-02 1.684320e-01 12 26914020 26914045 26 - 2.003 2.067 0.215
ENSG00000064102 E010 160.4856424 0.0002553386 1.367380e-02 3.748098e-02 12 26914046 26914128 83 - 2.146 2.223 0.257
ENSG00000064102 E011 172.3849465 0.0002384254 7.913474e-03 2.356133e-02 12 26914408 26914532 125 - 2.175 2.255 0.265
ENSG00000064102 E012 114.4441298 0.0002587126 6.236454e-01 7.401767e-01 12 26914533 26914578 46 - 2.019 2.040 0.068
ENSG00000064102 E013 200.5186914 0.0002330032 5.580566e-01 6.863560e-01 12 26916002 26916180 179 - 2.272 2.258 -0.045
ENSG00000064102 E014 134.7655976 0.0002708756 3.227082e-01 4.660466e-01 12 26917352 26917441 90 - 2.104 2.073 -0.104
ENSG00000064102 E015 132.0385247 0.0050722515 4.295695e-02 9.646601e-02 12 26917644 26917733 90 - 2.112 2.012 -0.336
ENSG00000064102 E016 0.8984834 0.0843557115 1.338629e-01 2.395226e-01 12 26917734 26917734 1 - 0.335 0.000 -11.638
ENSG00000064102 E017 1.0319011 0.0119569487 4.527097e-01 5.935485e-01 12 26919041 26919069 29 - 0.334 0.190 -1.081
ENSG00000064102 E018 66.5909391 0.0021421362 2.160430e-03 7.721668e-03 12 26922616 26922618 3 - 1.835 1.668 -0.565
ENSG00000064102 E019 111.0013139 0.0022444757 4.114673e-05 2.365241e-04 12 26922619 26922700 82 - 2.058 1.873 -0.623
ENSG00000064102 E020 140.1299116 0.0002785776 6.629062e-07 5.722743e-06 12 26924355 26924483 129 - 2.155 1.982 -0.579
ENSG00000064102 E021 99.5632487 0.0003282100 2.522290e-03 8.828785e-03 12 26925761 26925851 91 - 1.996 1.875 -0.406
ENSG00000064102 E022 81.4226274 0.0003716834 1.017970e-02 2.920664e-02 12 26928205 26928253 49 - 1.908 1.795 -0.381
ENSG00000064102 E023 70.1179860 0.0006477780 4.640388e-02 1.027643e-01 12 26928254 26928285 32 - 1.838 1.743 -0.320
ENSG00000064102 E024 61.0735524 0.0004420527 8.760468e-02 1.715054e-01 12 26928703 26928715 13 - 1.778 1.692 -0.288
ENSG00000064102 E025 142.6156719 0.0003495645 8.998619e-05 4.749411e-04 12 26928716 26928905 190 - 2.153 2.020 -0.446
ENSG00000064102 E026 0.1451727 0.0426588722 1.000000e+00   12 26928906 26929056 151 - 0.077 0.000 -9.050
ENSG00000064102 E027 87.2301647 0.0003198815 2.492817e-05 1.512092e-04 12 26934556 26934630 75 - 1.954 1.768 -0.626
ENSG00000064102 E028 136.2387221 0.0003159349 5.345146e-09 6.937192e-08 12 26936579 26936814 236 - 2.150 1.940 -0.703
ENSG00000064102 E029 1.6972965 0.0136919330 5.399860e-01 6.711864e-01 12 26937658 26937795 138 - 0.438 0.322 -0.664
ENSG00000064102 E030 55.2379273 0.0052751782 3.808065e-04 1.700515e-03 12 26937796 26937809 14 - 1.768 1.532 -0.801
ENSG00000064102 E031 92.7707982 0.0077882579 3.098921e-04 1.419785e-03 12 26937810 26938043 234 - 1.987 1.766 -0.744
ENSG00000064102 E032 1.6316200 0.0084633206 1.567020e-01 2.707060e-01 12 26938268 26938326 59 - 0.467 0.190 -1.818