ENSG00000064042

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000381753 ENSG00000064042 HEK293_OSMI2_2hA HEK293_TMG_2hB LIMCH1 protein_coding protein_coding 1.205567 0.6301009 1.919217 0.04717685 0.0938871 1.591644 0.13331351 0.11005297 0.0000000 0.11005297 0.0000000 -3.585599 0.18635833 0.1621333 0.0000000 -0.16213333 0.548520466 0.009505838 FALSE TRUE
ENST00000396595 ENSG00000064042 HEK293_OSMI2_2hA HEK293_TMG_2hB LIMCH1 protein_coding protein_coding 1.205567 0.6301009 1.919217 0.04717685 0.0938871 1.591644 0.11142995 0.00000000 0.0000000 0.00000000 0.0000000 0.000000 0.12076250 0.0000000 0.0000000 0.00000000   0.009505838 FALSE TRUE
ENST00000505705 ENSG00000064042 HEK293_OSMI2_2hA HEK293_TMG_2hB LIMCH1 protein_coding processed_transcript 1.205567 0.6301009 1.919217 0.04717685 0.0938871 1.591644 0.02645114 0.09599496 0.0000000 0.09599496 0.0000000 -3.405924 0.04152917 0.1420333 0.0000000 -0.14203333 0.586360104 0.009505838   FALSE
ENST00000508501 ENSG00000064042 HEK293_OSMI2_2hA HEK293_TMG_2hB LIMCH1 protein_coding protein_coding 1.205567 0.6301009 1.919217 0.04717685 0.0938871 1.591644 0.53849712 0.40946418 1.4326604 0.06754296 0.1119803 1.782112 0.39562500 0.6743333 0.7553667 0.08103333 0.926703340 0.009505838 FALSE TRUE
MSTRG.24791.13 ENSG00000064042 HEK293_OSMI2_2hA HEK293_TMG_2hB LIMCH1 protein_coding   1.205567 0.6301009 1.919217 0.04717685 0.0938871 1.591644 0.11861458 0.00000000 0.0000000 0.00000000 0.0000000 0.000000 0.06895000 0.0000000 0.0000000 0.00000000   0.009505838 FALSE TRUE
MSTRG.24791.3 ENSG00000064042 HEK293_OSMI2_2hA HEK293_TMG_2hB LIMCH1 protein_coding   1.205567 0.6301009 1.919217 0.04717685 0.0938871 1.591644 0.16625535 0.00000000 0.4081267 0.00000000 0.1353158 5.385868 0.08808333 0.0000000 0.2065667 0.20656667 0.009505838 0.009505838 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000064042 E001 0.0000000       4 41359607 41359803 197 +      
ENSG00000064042 E002 0.0000000       4 41360631 41360782 152 +      
ENSG00000064042 E003 0.1515154 0.045871457 1.00000000   4 41360783 41360784 2 + 0.075 0.000 -9.253
ENSG00000064042 E004 0.1515154 0.045871457 1.00000000   4 41360785 41360786 2 + 0.075 0.000 -11.169
ENSG00000064042 E005 1.0436561 0.042495739 0.09577664 0.18405776 4 41360787 41360806 20 + 0.366 0.000 -13.640
ENSG00000064042 E006 1.0436561 0.042495739 0.09577664 0.18405776 4 41360807 41360808 2 + 0.366 0.000 -13.640
ENSG00000064042 E007 1.1888288 0.022649369 0.06500298 0.13504513 4 41360809 41360814 6 + 0.400 0.000 -13.795
ENSG00000064042 E008 4.7965617 0.087266829 0.34354042 0.48757662 4 41360815 41360936 122 + 0.771 0.584 -0.792
ENSG00000064042 E009 0.0000000       4 41385803 41385893 91 +      
ENSG00000064042 E010 0.0000000       4 41385894 41385894 1 +      
ENSG00000064042 E011 0.0000000       4 41385979 41386006 28 +      
ENSG00000064042 E012 0.0000000       4 41418739 41418794 56 +      
ENSG00000064042 E013 0.0000000       4 41453565 41453686 122 +      
ENSG00000064042 E014 5.7396040 0.095921810 0.36857739 0.51298805 4 41494536 41494606 71 + 0.835 0.646 -0.771
ENSG00000064042 E015 4.0581029 0.049522999 0.03379808 0.07935338 4 41524409 41524478 70 + 0.757 0.327 -2.069
ENSG00000064042 E016 0.0000000       4 41538157 41538173 17 +      
ENSG00000064042 E017 0.0000000       4 41538174 41538350 177 +      
ENSG00000064042 E018 0.0000000       4 41551125 41551191 67 +      
ENSG00000064042 E019 0.0000000       4 41551321 41551395 75 +      
ENSG00000064042 E020 4.4632401 0.004529373 0.56453926 0.69182111 4 41598920 41599026 107 + 0.728 0.640 -0.366
ENSG00000064042 E021 0.0000000       4 41599027 41599121 95 +      
ENSG00000064042 E022 3.0550425 0.005285042 0.97598592 0.98901351 4 41603875 41603905 31 + 0.583 0.580 -0.013
ENSG00000064042 E023 4.6822943 0.003613779 0.95162923 0.97370433 4 41605894 41606004 111 + 0.728 0.739 0.048
ENSG00000064042 E024 0.0000000       4 41612339 41612603 265 +      
ENSG00000064042 E025 0.1482932 0.040811243 0.15574948   4 41612709 41612901 193 + 0.000 0.193 12.923
ENSG00000064042 E026 0.0000000       4 41612902 41613098 197 +      
ENSG00000064042 E027 0.0000000       4 41613099 41613104 6 +      
ENSG00000064042 E028 1.6564984 0.008455206 0.17625769 0.29636803 4 41613466 41613475 10 + 0.460 0.193 -1.749
ENSG00000064042 E029 8.3635595 0.002986996 0.54310515 0.67375396 4 41613476 41613661 186 + 0.960 0.888 -0.270
ENSG00000064042 E030 10.8804679 0.001583850 0.84876844 0.90612776 4 41619188 41619440 253 + 1.041 1.023 -0.068
ENSG00000064042 E031 0.4438354 0.048564731 0.14338109 0.25261437 4 41619441 41620294 854 + 0.075 0.326 2.565
ENSG00000064042 E032 0.0000000       4 41620424 41620690 267 +      
ENSG00000064042 E033 0.0000000       4 41626708 41627010 303 +      
ENSG00000064042 E034 0.0000000       4 41629492 41629734 243 +      
ENSG00000064042 E035 0.0000000       4 41631148 41631477 330 +      
ENSG00000064042 E036 0.0000000       4 41632749 41632867 119 +      
ENSG00000064042 E037 0.0000000       4 41632977 41633085 109 +      
ENSG00000064042 E038 0.0000000       4 41633548 41633808 261 +      
ENSG00000064042 E039 2.0639144 0.007113615 0.85813658 0.91247152 4 41638932 41638967 36 + 0.460 0.429 -0.163
ENSG00000064042 E040 5.3612165 0.073516376 0.69242159 0.79367685 4 41644500 41644626 127 + 0.784 0.699 -0.347
ENSG00000064042 E041 7.5868165 0.034193571 0.19241098 0.31679912 4 41646123 41646280 158 + 0.950 0.739 -0.821
ENSG00000064042 E042 19.9150470 0.000973162 0.42004227 0.56326844 4 41646485 41646893 409 + 1.302 1.237 -0.228
ENSG00000064042 E043 13.8752712 0.003928825 0.85346885 0.90931497 4 41650393 41650608 216 + 1.141 1.125 -0.056
ENSG00000064042 E044 6.9655540 0.002647009 0.35987931 0.50419352 4 41661420 41661510 91 + 0.902 0.782 -0.467
ENSG00000064042 E045 10.4010469 0.001708728 0.13150421 0.23623758 4 41662821 41662984 164 + 1.063 0.888 -0.650
ENSG00000064042 E046 9.4947256 0.001807889 0.08146959 0.16185993 4 41666561 41666666 106 + 1.034 0.820 -0.806
ENSG00000064042 E047 0.0000000       4 41670718 41670792 75 +      
ENSG00000064042 E048 7.3576697 0.002410563 0.46782436 0.60729809 4 41671554 41671594 41 + 0.912 0.820 -0.354
ENSG00000064042 E049 0.1472490 0.043636927 1.00000000   4 41676379 41676381 3 + 0.075 0.000 -11.169
ENSG00000064042 E050 7.7888316 0.004412090 0.73809820 0.82807552 4 41676382 41676462 81 + 0.902 0.947 0.168
ENSG00000064042 E051 8.9134394 0.003087764 0.84312786 0.90228226 4 41680006 41680098 93 + 0.969 0.947 -0.080
ENSG00000064042 E052 10.1259095 0.001925596 0.31774827 0.46063312 4 41680955 41681059 105 + 0.977 1.087 0.402
ENSG00000064042 E053 13.8297598 0.001735334 0.25001520 0.38592545 4 41682333 41682460 128 + 1.097 1.208 0.397
ENSG00000064042 E054 10.6649700 0.002032377 0.03690164 0.08527430 4 41684397 41684518 122 + 0.960 1.177 0.789
ENSG00000064042 E055 10.5300066 0.002758461 0.67540671 0.78070578 4 41685710 41685830 121 + 1.018 1.066 0.175
ENSG00000064042 E056 0.0000000       4 41687840 41687917 78 +      
ENSG00000064042 E057 8.4693155 0.014766394 0.72757489 0.82024279 4 41689527 41689635 109 + 0.959 0.917 -0.159
ENSG00000064042 E058 9.3227570 0.001948299 0.64897317 0.76035758 4 41692282 41692384 103 + 0.969 1.023 0.200
ENSG00000064042 E059 0.0000000       4 41692955 41693195 241 +      
ENSG00000064042 E060 0.0000000       4 41693196 41693347 152 +      
ENSG00000064042 E061 11.4659350 0.004889705 0.09561711 0.18381644 4 41697160 41697314 155 + 1.002 1.177 0.630
ENSG00000064042 E062 35.3771526 0.002144819 0.36105860 0.50543194 4 41697315 41698349 1035 + 1.507 1.567 0.204
ENSG00000064042 E063 50.3052704 0.034356255 0.17172966 0.29046881 4 41698350 41700044 1695 + 1.631 1.746 0.391