ENSG00000063601

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
MSTRG.35036.9 ENSG00000063601 HEK293_OSMI2_2hA HEK293_TMG_2hB MTMR1 protein_coding   22.67976 23.92708 25.80127 2.579921 0.6762681 0.1087538 19.62724 21.84732 21.30783 2.457539 0.7897047 -0.03605583 0.8648083 0.9122333 0.8258 -0.08643333 0.002911268 0.002911268 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000063601 E001 0.0000000       X 150692907 150692970 64 +      
ENSG00000063601 E002 0.0000000       X 150692971 150692977 7 +      
ENSG00000063601 E003 0.0000000       X 150692978 150692982 5 +      
ENSG00000063601 E004 0.5900522 0.1849064697 4.643974e-01 6.041165e-01 X 150692983 150693008 26 + 0.118 0.298 1.661
ENSG00000063601 E005 1.4778128 0.2032614901 2.574251e-01 3.945410e-01 X 150693009 150693069 61 + 0.503 0.298 -1.150
ENSG00000063601 E006 0.3299976 0.0274424043 2.202182e-01   X 150693366 150693373 8 + 0.000 0.224 10.940
ENSG00000063601 E007 0.8481309 0.0145744508 7.164091e-01 8.120718e-01 X 150693374 150693378 5 + 0.211 0.305 0.700
ENSG00000063601 E008 0.8481309 0.0145744508 7.164091e-01 8.120718e-01 X 150693379 150693379 1 + 0.211 0.305 0.700
ENSG00000063601 E009 9.4756298 0.0036716818 9.840391e-04 3.904969e-03 X 150693380 150693395 16 + 1.150 0.851 -1.107
ENSG00000063601 E010 11.6502590 0.0040432877 8.837056e-04 3.557185e-03 X 150693396 150693407 12 + 1.221 0.944 -1.004
ENSG00000063601 E011 60.6678483 0.0140601699 1.626304e-06 1.289816e-05 X 150693408 150693676 269 + 1.923 1.623 -1.016
ENSG00000063601 E012 33.8597072 0.0152467670 1.821046e-05 1.140318e-04 X 150699195 150699202 8 + 1.682 1.376 -1.050
ENSG00000063601 E013 35.7970852 0.0182753953 3.533200e-05 2.063615e-04 X 150699203 150699207 5 + 1.707 1.394 -1.069
ENSG00000063601 E014 97.7200166 0.0114413751 1.546578e-04 7.677047e-04 X 150699208 150699300 93 + 2.083 1.897 -0.626
ENSG00000063601 E015 0.9201396 0.0158217116 7.825295e-02 1.566622e-01 X 150712342 150712365 24 + 0.409 0.127 -2.207
ENSG00000063601 E016 0.0000000       X 150712730 150712753 24 +      
ENSG00000063601 E017 0.1515154 0.0436198757 4.664552e-01   X 150712944 150712970 27 + 0.118 0.000 -9.988
ENSG00000063601 E018 0.0000000       X 150714479 150714529 51 +      
ENSG00000063601 E019 0.0000000       X 150714530 150714532 3 +      
ENSG00000063601 E020 108.0772379 0.0124639310 5.019296e-03 1.598404e-02 X 150718625 150718676 52 + 2.099 1.975 -0.416
ENSG00000063601 E021 87.5729334 0.0087089856 2.955649e-03 1.013171e-02 X 150718677 150718700 24 + 2.006 1.888 -0.395
ENSG00000063601 E022 2.6248073 0.0059736290 5.225170e-01 6.563199e-01 X 150727113 150727214 102 + 0.581 0.528 -0.248
ENSG00000063601 E023 167.6140019 0.0064889060 2.483837e-03 8.716089e-03 X 150727215 150727309 95 + 2.271 2.186 -0.283
ENSG00000063601 E024 195.5066297 0.0056150216 1.337058e-03 5.099998e-03 X 150727684 150727791 108 + 2.336 2.252 -0.281
ENSG00000063601 E025 164.0873630 0.0041144719 2.088157e-03 7.496732e-03 X 150730109 150730210 102 + 2.253 2.186 -0.225
ENSG00000063601 E026 140.7362073 0.0056902582 6.048047e-03 1.873727e-02 X 150730525 150730608 84 + 2.188 2.119 -0.232
ENSG00000063601 E027 209.6832783 0.0002414525 1.737081e-06 1.369569e-05 X 150731470 150731619 150 + 2.354 2.303 -0.172
ENSG00000063601 E028 278.8412455 0.0001638395 2.011102e-08 2.344165e-07 X 150732542 150732730 189 + 2.478 2.426 -0.173
ENSG00000063601 E029 1.4874915 0.0110109913 4.010861e-02 9.123219e-02 X 150735399 150735463 65 + 0.544 0.224 -1.888
ENSG00000063601 E030 37.1365653 0.0007387194 3.078072e-01 4.500443e-01 X 150735464 150736594 1131 + 1.586 1.594 0.026
ENSG00000063601 E031 286.1161847 0.0001612644 5.063617e-05 2.849847e-04 X 150736595 150736780 186 + 2.473 2.455 -0.059
ENSG00000063601 E032 268.4748740 0.0002331941 6.759717e-05 3.685309e-04 X 150737242 150737448 207 + 2.446 2.425 -0.069
ENSG00000063601 E033 194.0011659 0.0002454771 4.390103e-03 1.423764e-02 X 150744361 150744453 93 + 2.296 2.289 -0.023
ENSG00000063601 E034 209.8555595 0.0030961795 7.407343e-02 1.500437e-01 X 150750730 150750843 114 + 2.327 2.324 -0.012
ENSG00000063601 E035 12.9594736 0.0422714918 1.387487e-02 3.794373e-02 X 150751030 150751240 211 + 0.897 1.282 1.396
ENSG00000063601 E036 8.3091248 0.0021641398 7.261802e-05 3.927393e-04 X 150751241 150751376 136 + 0.616 1.152 2.077
ENSG00000063601 E037 199.2003651 0.0020829105 5.790483e-01 7.040288e-01 X 150755689 150755865 177 + 2.280 2.321 0.138
ENSG00000063601 E038 187.5720879 0.0006471438 3.579676e-01 5.023622e-01 X 150762565 150762737 173 + 2.258 2.298 0.133
ENSG00000063601 E039 1219.6967249 0.0034094619 5.051151e-06 3.590984e-05 X 150762738 150764328 1591 + 2.988 3.160 0.572
ENSG00000063601 E040 320.7053326 0.0086869335 1.395378e-09 2.014556e-08 X 150764329 150764511 183 + 2.281 2.644 1.208
ENSG00000063601 E041 411.7804241 0.0136304522 4.457195e-08 4.855677e-07 X 150764512 150765161 650 + 2.369 2.759 1.298