ENSG00000063587

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370249 ENSG00000063587 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF275 protein_coding protein_coding 22.49466 36.24017 15.23669 3.673742 0.02506814 -1.249492 2.164268 5.395719 0.000000 2.172853 0.0000000 -9.0783426 0.07354167 0.1551 0.0000000 -0.1551000 5.154515e-06 2.520081e-12 FALSE TRUE
ENST00000650114 ENSG00000063587 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF275 protein_coding protein_coding 22.49466 36.24017 15.23669 3.673742 0.02506814 -1.249492 9.049751 7.056785 11.838279 4.138138 0.3564193 0.7455516 0.51344167 0.1907 0.7769000 0.5862000 1.840261e-01 2.520081e-12 FALSE TRUE
MSTRG.35056.5 ENSG00000063587 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF275 protein_coding   22.49466 36.24017 15.23669 3.673742 0.02506814 -1.249492 9.693367 22.116369 2.324942 3.858999 0.1227332 -3.2443083 0.34417500 0.6036 0.1526333 -0.4509667 2.520081e-12 2.520081e-12   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000063587 E001 0.3666179 0.037215976 7.614884e-01 8.453455e-01 X 153334140 153334146 7 + 0.147 0.102 -0.603
ENSG00000063587 E002 0.5181333 0.021192193 3.516159e-01 4.958538e-01 X 153334147 153334152 6 + 0.256 0.102 -1.604
ENSG00000063587 E003 0.7395785 0.231805492 7.276123e-01 8.202654e-01 X 153334153 153334154 2 + 0.256 0.189 -0.563
ENSG00000063587 E004 0.7395785 0.231805492 7.276123e-01 8.202654e-01 X 153334155 153334159 5 + 0.256 0.189 -0.563
ENSG00000063587 E005 1.7985481 0.021187587 3.275579e-02 7.731633e-02 X 153334160 153334164 5 + 0.624 0.254 -2.016
ENSG00000063587 E006 25.6078707 0.088180905 1.369206e-05 8.811466e-05 X 153334165 153334285 121 + 1.718 1.036 -2.377
ENSG00000063587 E007 37.6736119 0.031783784 4.630261e-08 5.028023e-07 X 153336634 153336710 77 + 1.845 1.287 -1.911
ENSG00000063587 E008 25.5168841 0.017173878 2.901783e-04 1.339966e-03 X 153344277 153345519 1243 + 1.589 1.254 -1.158
ENSG00000063587 E009 59.8832828 0.017889821 6.509124e-11 1.183884e-09 X 153345520 153345621 102 + 2.026 1.512 -1.736
ENSG00000063587 E010 260.2381516 0.012987702 4.124403e-10 6.561604e-09 X 153346819 153347655 837 + 2.591 2.240 -1.170
ENSG00000063587 E011 53.4487073 0.017185231 5.175387e-04 2.225439e-03 X 153347656 153347753 98 + 1.876 1.599 -0.937
ENSG00000063587 E012 449.4505273 0.010464708 1.138299e-07 1.144382e-06 X 153347754 153349265 1512 + 2.776 2.532 -0.816
ENSG00000063587 E013 1312.5013256 0.002089627 9.625266e-02 1.847514e-01 X 153349266 153351916 2651 + 3.083 3.107 0.080
ENSG00000063587 E014 224.9705639 0.003949383 3.048490e-07 2.816382e-06 X 153351917 153352028 112 + 2.198 2.398 0.670
ENSG00000063587 E015 209.2930947 0.004723989 2.840323e-09 3.872549e-08 X 153352029 153352141 113 + 2.127 2.381 0.848
ENSG00000063587 E016 682.1960811 0.009033709 1.587636e-14 5.086638e-13 X 153352142 153352926 785 + 2.582 2.904 1.073
ENSG00000063587 E017 4.8263542 0.003347407 6.668953e-01 7.742735e-01 X 153357191 153357256 66 + 0.794 0.739 -0.220
ENSG00000063587 E018 6.0004921 0.122259657 4.445579e-01 5.861103e-01 X 153359699 153360110 412 + 0.735 0.882 0.579