ENSG00000063046

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262056 ENSG00000063046 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF4B protein_coding protein_coding 178.8493 120.5886 215.0686 18.57421 2.96191 0.8346501 102.67210 96.9666698 100.49223 13.709421576 3.520172 0.0515179 0.61042083 0.80770000 0.46726667 -0.34043333 2.157992e-23 1.696041e-61 FALSE TRUE
ENST00000420463 ENSG00000063046 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF4B protein_coding protein_coding 178.8493 120.5886 215.0686 18.57421 2.96191 0.8346501 14.71073 12.0965215 17.50322 3.228832272 1.329522 0.5326600 0.08360833 0.09676667 0.08126667 -0.01550000 6.453085e-01 1.696041e-61 FALSE TRUE
ENST00000549481 ENSG00000063046 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF4B protein_coding protein_coding 178.8493 120.5886 215.0686 18.57421 2.96191 0.8346501 13.14273 1.5400888 16.70172 0.630067997 1.175103 3.4304373 0.06582500 0.01450000 0.07780000 0.06330000 3.786887e-02 1.696041e-61 FALSE TRUE
ENST00000550704 ENSG00000063046 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF4B protein_coding nonsense_mediated_decay 178.8493 120.5886 215.0686 18.57421 2.96191 0.8346501 21.16630 0.3628366 40.97376 0.009758528 2.829096 6.7803651 0.09711667 0.00320000 0.19080000 0.18760000 1.696041e-61 1.696041e-61 FALSE FALSE
ENST00000552490 ENSG00000063046 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF4B protein_coding protein_coding 178.8493 120.5886 215.0686 18.57421 2.96191 0.8346501 12.81392 2.9292466 18.66540 0.900804088 1.366073 2.6676209 0.06449583 0.02350000 0.08663333 0.06313333 2.006552e-04 1.696041e-61 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000063046 E001 0.8877725 1.351423e-02 5.201118e-01 6.541304e-01 12 53006282 53006296 15 + 0.334 0.238 -0.660
ENSG00000063046 E002 1.3963540 9.152671e-03 9.119665e-01 9.481619e-01 12 53006297 53006297 1 + 0.388 0.392 0.019
ENSG00000063046 E003 16.6269594 2.405755e-03 5.859887e-02 1.242265e-01 12 53006298 53006430 133 + 1.309 1.184 -0.440
ENSG00000063046 E004 24.7827132 7.708171e-04 1.999826e-03 7.225347e-03 12 53006431 53006447 17 + 1.496 1.317 -0.618
ENSG00000063046 E005 30.1072461 1.872453e-03 1.680223e-03 6.219607e-03 12 53006448 53006455 8 + 1.576 1.406 -0.584
ENSG00000063046 E006 28.9560949 1.814209e-03 7.164999e-03 2.165169e-02 12 53006456 53006456 1 + 1.549 1.406 -0.490
ENSG00000063046 E007 31.7335661 8.666553e-04 7.519307e-04 3.086228e-03 12 53006457 53006458 2 + 1.599 1.425 -0.596
ENSG00000063046 E008 35.5805367 1.980615e-03 2.174801e-03 7.764534e-03 12 53006459 53006467 9 + 1.638 1.486 -0.521
ENSG00000063046 E009 42.2680993 6.866044e-03 5.449848e-03 1.715435e-02 12 53006468 53006468 1 + 1.710 1.556 -0.525
ENSG00000063046 E010 170.8955457 6.555464e-03 1.211126e-08 1.471078e-07 12 53006469 53006483 15 + 2.343 2.091 -0.843
ENSG00000063046 E011 286.0668799 2.171472e-03 2.646558e-09 3.629525e-08 12 53006484 53006496 13 + 2.531 2.374 -0.522
ENSG00000063046 E012 4.3438632 4.239551e-03 2.299836e-02 5.774493e-02 12 53008486 53008596 111 + 0.849 0.552 -1.243
ENSG00000063046 E013 9.5267993 1.739296e-03 2.724958e-03 9.447417e-03 12 53008597 53008643 47 + 1.146 0.859 -1.063
ENSG00000063046 E014 631.8138270 1.296078e-03 4.471710e-11 8.366934e-10 12 53016473 53016610 138 + 2.858 2.740 -0.393
ENSG00000063046 E015 675.8549076 1.069466e-03 5.450962e-11 1.005519e-09 12 53018798 53018859 62 + 2.883 2.777 -0.352
ENSG00000063046 E016 669.6442125 3.120384e-04 1.035741e-12 2.536427e-11 12 53018860 53019006 147 + 2.868 2.789 -0.264
ENSG00000063046 E017 890.8970389 2.739145e-04 4.165415e-18 2.127022e-16 12 53019910 53020026 117 + 2.996 2.907 -0.295
ENSG00000063046 E018 13.7510235 1.185181e-02 3.521343e-02 8.205104e-02 12 53021716 53021805 90 + 1.257 1.076 -0.645
ENSG00000063046 E019 901.0525752 2.030861e-03 4.824233e-07 4.279330e-06 12 53021806 53021860 55 + 3.003 2.904 -0.330
ENSG00000063046 E020 0.9202533 4.708398e-02 1.482783e-01 2.593300e-01 12 53021861 53021916 56 + 0.388 0.136 -1.979
ENSG00000063046 E021 3.3309125 6.032386e-02 4.340300e-01 5.764155e-01 12 53022254 53022366 113 + 0.557 0.727 0.735
ENSG00000063046 E022 1338.4434932 2.114719e-03 2.889005e-07 2.683434e-06 12 53022493 53022627 135 + 3.174 3.075 -0.331
ENSG00000063046 E023 6.8909054 2.536930e-03 7.697231e-05 4.137316e-04 12 53025227 53025345 119 + 1.068 0.594 -1.868
ENSG00000063046 E024 1295.3059640 2.051600e-03 2.564680e-06 1.949566e-05 12 53027782 53027919 138 + 3.155 3.066 -0.295
ENSG00000063046 E025 1641.9117429 8.174211e-04 6.958704e-09 8.832869e-08 12 53028015 53028188 174 + 3.249 3.184 -0.216
ENSG00000063046 E026 1886.3284461 3.946579e-04 5.896093e-06 4.130295e-05 12 53033806 53034034 229 + 3.291 3.267 -0.082
ENSG00000063046 E027 875.0615987 1.792745e-04 2.752546e-02 6.706212e-02 12 53034612 53034645 34 + 2.945 2.952 0.021
ENSG00000063046 E028 1174.4106456 3.195678e-04 7.109654e-02 1.451576e-01 12 53034646 53034709 64 + 3.070 3.080 0.032
ENSG00000063046 E029 94.8676972 5.786253e-03 8.695158e-01 9.201281e-01 12 53034710 53034724 15 + 1.964 2.015 0.172
ENSG00000063046 E030 1576.0580175 7.764642e-05 1.421618e-05 9.114395e-05 12 53037409 53037622 214 + 3.165 3.242 0.257
ENSG00000063046 E031 9.5274954 7.171799e-03 1.026800e-04 5.344367e-04 12 53037623 53037724 102 + 1.181 0.760 -1.575
ENSG00000063046 E032 25.9680032 7.920522e-04 3.604147e-11 6.844375e-10 12 53037726 53038355 630 + 1.596 1.152 -1.544
ENSG00000063046 E033 972.1738478 1.124532e-04 3.957957e-07 3.571096e-06 12 53038356 53038411 56 + 2.944 3.042 0.324
ENSG00000063046 E034 24.6929476 1.550773e-02 4.087164e-06 2.965080e-05 12 53038412 53039234 823 + 1.566 1.151 -1.447
ENSG00000063046 E035 19.8021028 9.228914e-04 1.671332e-01 2.844722e-01 12 53039235 53039237 3 + 1.356 1.286 -0.244
ENSG00000063046 E036 1340.4875530 8.113787e-05 3.869738e-08 4.266734e-07 12 53039238 53039343 106 + 3.087 3.180 0.308
ENSG00000063046 E037 961.8162975 9.052699e-05 2.981559e-08 3.357790e-07 12 53039630 53039702 73 + 2.938 3.041 0.343
ENSG00000063046 E038 6194.7362343 3.425035e-03 4.556621e-13 1.182032e-11 12 53040143 53042830 2688 + 3.689 3.880 0.635