ENSG00000062725

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000083182 ENSG00000062725 HEK293_OSMI2_2hA HEK293_TMG_2hB APPBP2 protein_coding protein_coding 13.10106 3.218131 21.33016 0.1820357 0.7264754 2.7248 6.470348 2.8915467 10.78639 0.2638638 0.4958149 1.895655 0.6142625 0.89923333 0.5053333 -0.3939000 0.02276484 0.02276484 FALSE TRUE
MSTRG.14824.2 ENSG00000062725 HEK293_OSMI2_2hA HEK293_TMG_2hB APPBP2 protein_coding   13.10106 3.218131 21.33016 0.1820357 0.7264754 2.7248 6.109383 0.2476654 10.20686 0.2476654 0.3724505 5.309309 0.3453833 0.07363333 0.4784667 0.4048333 0.04745344 0.02276484 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000062725 E001 766.2595857 0.0013363077 2.174495e-18 1.148457e-16 17 60443158 60447745 4588 - 2.755 2.928 0.576
ENSG00000062725 E002 95.7152854 0.0011122545 8.549528e-01 9.102897e-01 17 60447746 60447834 89 - 1.889 1.930 0.139
ENSG00000062725 E003 111.3747120 0.0061189825 3.731968e-01 5.176452e-01 17 60451880 60452045 166 - 1.944 2.018 0.249
ENSG00000062725 E004 127.7015674 0.0032064281 6.155524e-01 7.338080e-01 17 60454302 60454492 191 - 2.018 2.024 0.020
ENSG00000062725 E005 86.5804089 0.0002989648 4.608403e-03 1.484296e-02 17 60456296 60456381 86 - 1.874 1.769 -0.354
ENSG00000062725 E006 3.1399390 0.0049094106 5.495427e-02 1.179147e-01 17 60459507 60460662 1156 - 0.607 0.229 -2.129
ENSG00000062725 E007 108.9528118 0.0002608568 4.906474e-03 1.566980e-02 17 60460663 60460787 125 - 1.970 1.882 -0.296
ENSG00000062725 E008 2.3712011 0.0061490933 1.821097e-02 4.759165e-02 17 60460788 60461809 1022 - 0.536 0.000 -12.723
ENSG00000062725 E009 80.1825109 0.0003695133 6.361054e-02 1.327096e-01 17 60461810 60461915 106 - 1.833 1.774 -0.200
ENSG00000062725 E010 1.7810591 0.0078031672 3.016642e-01 4.434722e-01 17 60461916 60461993 78 - 0.427 0.229 -1.268
ENSG00000062725 E011 71.7423048 0.0003777805 1.699131e-01 2.881011e-01 17 60461994 60462061 68 - 1.785 1.748 -0.126
ENSG00000062725 E012 2.8140043 0.0053482797 7.038427e-01 8.024650e-01 17 60462062 60462690 629 - 0.536 0.489 -0.224
ENSG00000062725 E013 86.1691138 0.0004924080 1.621457e-05 1.026843e-04 17 60464021 60464110 90 - 1.889 1.702 -0.630
ENSG00000062725 E014 0.1451727 0.0431644613 1.000000e+00   17 60464788 60465161 374 - 0.062 0.000 -8.717
ENSG00000062725 E015 68.3925878 0.0020836076 2.540001e-05 1.537710e-04 17 60466291 60466350 60 - 1.795 1.569 -0.765
ENSG00000062725 E016 84.6973247 0.0007355241 8.751580e-05 4.633634e-04 17 60466351 60466459 109 - 1.878 1.708 -0.572
ENSG00000062725 E017 0.6319842 0.0268985570 7.644089e-01 8.474858e-01 17 60468439 60468510 72 - 0.163 0.229 0.608
ENSG00000062725 E018 0.2924217 0.0274336965 1.000000e+00   17 60477469 60477506 38 - 0.115 0.000 -9.756
ENSG00000062725 E019 43.6448557 0.0005176954 2.292754e-01 3.615771e-01 17 60479148 60479161 14 - 1.574 1.528 -0.160
ENSG00000062725 E020 66.8421558 0.0003662919 2.383381e-01 3.722193e-01 17 60479162 60479271 110 - 1.750 1.720 -0.102
ENSG00000062725 E021 37.1626143 0.0005848980 5.258141e-01 6.591360e-01 17 60494466 60494473 8 - 1.478 1.554 0.259
ENSG00000062725 E022 66.0009589 0.0021798087 8.021914e-01 8.739943e-01 17 60494474 60494617 144 - 1.728 1.774 0.155
ENSG00000062725 E023 0.2987644 0.0276347207 1.000000e+00   17 60496413 60496441 29 - 0.115 0.000 -9.756
ENSG00000062725 E024 76.0979784 0.0007524528 4.177190e-03 1.364196e-02 17 60500399 60500487 89 - 1.822 1.702 -0.406
ENSG00000062725 E025 75.2162125 0.0003661133 1.225628e-04 6.256003e-04 17 60525794 60525961 168 - 1.826 1.652 -0.592
ENSG00000062725 E026 31.7718412 0.0006350141 3.761821e-01 5.205401e-01 17 60525962 60526077 116 - 1.439 1.404 -0.121
ENSG00000062725 E027 38.2572567 0.0007625263 1.347362e-01 2.407282e-01 17 60526078 60526242 165 - 1.524 1.449 -0.257