ENSG00000062650

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000298767 ENSG00000062650 HEK293_OSMI2_2hA HEK293_TMG_2hB WAPL protein_coding protein_coding 21.46918 11.00351 34.64949 0.2618835 1.294635 1.653976 11.030784 4.2662483 19.678804 0.70439093 0.8793622 2.202958 0.4872958 0.39070000 0.5676667 0.1769667 1.555143e-01 1.720854e-22 FALSE TRUE
ENST00000372075 ENSG00000062650 HEK293_OSMI2_2hA HEK293_TMG_2hB WAPL protein_coding protein_coding 21.46918 11.00351 34.64949 0.2618835 1.294635 1.653976 2.391716 5.1505760 0.363296 0.17245908 0.1820254 -3.789140 0.2069167 0.46793333 0.0106000 -0.4573333 4.766695e-05 1.720854e-22 FALSE TRUE
MSTRG.4295.4 ENSG00000062650 HEK293_OSMI2_2hA HEK293_TMG_2hB WAPL protein_coding   21.46918 11.00351 34.64949 0.2618835 1.294635 1.653976 6.634846 0.2631559 12.486429 0.09827653 1.1090491 5.515648 0.2354333 0.02386667 0.3589333 0.3350667 1.720854e-22 1.720854e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000062650 E001 469.5725382 0.0098003391 1.712977e-06 1.352329e-05 10 86435256 86437009 1754 - 2.528 2.783 0.847
ENSG00000062650 E002 202.8674782 0.0078698702 1.035398e-16 4.443884e-15 10 86437010 86437271 262 - 2.094 2.527 1.446
ENSG00000062650 E003 342.4833290 0.0010477131 1.815893e-30 3.167731e-28 10 86437272 86437608 337 - 2.373 2.678 1.018
ENSG00000062650 E004 152.3582997 0.0003445494 7.858236e-11 1.411108e-09 10 86437920 86438015 96 - 2.047 2.280 0.777
ENSG00000062650 E005 154.7630111 0.0002200678 6.317142e-05 3.469886e-04 10 86443275 86443363 89 - 2.080 2.234 0.512
ENSG00000062650 E006 4.3519461 0.0403786542 3.965806e-01 5.403359e-01 10 86443364 86444032 669 - 0.697 0.553 -0.632
ENSG00000062650 E007 261.1108155 0.0006243207 7.246676e-03 2.186607e-02 10 86446242 86446449 208 - 2.323 2.421 0.327
ENSG00000062650 E008 215.4721377 0.0016051400 5.453988e-01 6.757453e-01 10 86451967 86452131 165 - 2.253 2.299 0.154
ENSG00000062650 E009 148.2372450 0.0002802106 4.068033e-02 9.228776e-02 10 86453220 86453335 116 - 2.079 2.173 0.315
ENSG00000062650 E010 168.3264121 0.0002074462 8.606338e-01 9.141205e-01 10 86453656 86453831 176 - 2.152 2.184 0.105
ENSG00000062650 E011 133.0561154 0.0012053323 5.850576e-01 7.088467e-01 10 86458989 86459065 77 - 2.046 2.093 0.156
ENSG00000062650 E012 150.9110432 0.0007649615 7.206954e-01 8.152718e-01 10 86460399 86460496 98 - 2.109 2.121 0.042
ENSG00000062650 E013 168.5502626 0.0064940642 9.311376e-01 9.606393e-01 10 86461176 86461287 112 - 2.153 2.175 0.073
ENSG00000062650 E014 0.2934659 0.0292661261 3.464108e-01   10 86467053 86467278 226 - 0.067 0.215 1.948
ENSG00000062650 E015 229.4320477 0.0001842137 4.764793e-05 2.698582e-04 10 86467279 86467506 228 - 2.312 2.220 -0.306
ENSG00000062650 E016 149.8285844 0.0021391629 9.357753e-04 3.739449e-03 10 86470992 86471103 112 - 2.133 2.020 -0.378
ENSG00000062650 E017 153.9067196 0.0002598221 1.691748e-04 8.316379e-04 10 86472208 86472344 137 - 2.144 2.035 -0.362
ENSG00000062650 E018 156.2382564 0.0003218773 3.797787e-06 2.777904e-05 10 86472612 86472764 153 - 2.156 2.015 -0.473
ENSG00000062650 E019 122.1324887 0.0014076241 3.104077e-08 3.481281e-07 10 86473878 86473973 96 - 2.064 1.838 -0.760
ENSG00000062650 E020 124.3834283 0.0002755053 3.190929e-11 6.117923e-10 10 86497201 86497301 101 - 2.077 1.821 -0.858
ENSG00000062650 E021 56.7954152 0.0004715948 7.349045e-05 3.969364e-04 10 86497302 86497319 18 - 1.735 1.518 -0.736
ENSG00000062650 E022 1.0351233 0.0120558199 1.337324e-01 2.393364e-01 10 86497320 86497337 18 - 0.334 0.000 -11.657
ENSG00000062650 E023 584.5743805 0.0001928699 6.330418e-52 4.267896e-49 10 86499718 86500743 1026 - 2.749 2.478 -0.904
ENSG00000062650 E024 284.8154553 0.0138966912 3.525468e-11 6.707736e-10 10 86517571 86518091 521 - 2.453 2.051 -1.344
ENSG00000062650 E025 0.7448917 0.0484454794 2.674196e-01 4.057297e-01 10 86518583 86518637 55 - 0.262 0.000 -10.457
ENSG00000062650 E026 103.9680207 0.0537785241 4.253756e-04 1.871658e-03 10 86521365 86521792 428 - 2.017 1.621 -1.336