ENSG00000061936

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261674 ENSG00000061936 HEK293_OSMI2_2hA HEK293_TMG_2hB SFSWAP protein_coding protein_coding 33.93877 39.48823 31.79378 1.050712 0.6527668 -0.3125898 25.302528 31.2765759 23.075371 0.6391028 0.4355382 -0.4385648 0.74015000 0.792333333 0.72690000 -0.06543333 2.733448e-01 1.871824e-34 FALSE  
ENST00000537164 ENSG00000061936 HEK293_OSMI2_2hA HEK293_TMG_2hB SFSWAP protein_coding protein_coding 33.93877 39.48823 31.79378 1.050712 0.6527668 -0.3125898 1.637440 3.6222927 0.000000 0.2614162 0.0000000 -8.5047367 0.04796250 0.091733333 0.00000000 -0.09173333 1.871824e-34 1.871824e-34 FALSE  
ENST00000538548 ENSG00000061936 HEK293_OSMI2_2hA HEK293_TMG_2hB SFSWAP protein_coding nonsense_mediated_decay 33.93877 39.48823 31.79378 1.050712 0.6527668 -0.3125898 0.923948 0.0509232 1.814194 0.0509232 0.4982318 4.9041238 0.02974583 0.001333333 0.05653333 0.05520000 1.152261e-04 1.871824e-34 FALSE  
MSTRG.8322.7 ENSG00000061936 HEK293_OSMI2_2hA HEK293_TMG_2hB SFSWAP protein_coding   33.93877 39.48823 31.79378 1.050712 0.6527668 -0.3125898 1.245269 1.0182821 2.753196 0.5575036 0.1385638 1.4261018 0.03669583 0.025166667 0.08656667 0.06140000 3.989353e-01 1.871824e-34 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000061936 E001 0.4804688 0.0222146324 3.859029e-01 5.301073e-01 12 131710926 131711080 155 + 0.250 0.105 -1.515
ENSG00000061936 E002 1.1113958 0.0117603184 1.656207e-02 4.397773e-02 12 131711081 131711089 9 + 0.523 0.105 -3.099
ENSG00000061936 E003 8.3500588 0.0542247509 7.650791e-02 1.539108e-01 12 131711090 131711094 5 + 1.115 0.828 -1.071
ENSG00000061936 E004 11.5407075 0.0689735146 5.316394e-02 1.147817e-01 12 131711095 131711099 5 + 1.257 0.938 -1.156
ENSG00000061936 E005 12.7177667 0.0810480226 6.199852e-02 1.299834e-01 12 131711100 131711100 1 + 1.301 0.967 -1.201
ENSG00000061936 E006 30.0897613 0.0266683035 6.574081e-07 5.679161e-06 12 131711101 131711108 8 + 1.728 1.208 -1.792
ENSG00000061936 E007 84.4301265 0.0266006978 4.316043e-03 1.402964e-02 12 131711109 131711136 28 + 2.054 1.807 -0.830
ENSG00000061936 E008 313.5901322 0.0067475934 8.869497e-04 3.568500e-03 12 131711137 131711447 311 + 2.568 2.421 -0.492
ENSG00000061936 E009 94.6545783 0.0052254169 5.942518e-43 2.452706e-40 12 131711448 131714070 2623 + 2.279 1.548 -2.462
ENSG00000061936 E010 256.8776253 0.0013499768 1.670895e-05 1.054872e-04 12 131714071 131714193 123 + 2.470 2.346 -0.414
ENSG00000061936 E011 195.7207698 0.0003240012 5.602034e-03 1.755879e-02 12 131714194 131714240 47 + 2.324 2.246 -0.259
ENSG00000061936 E012 17.2943148 0.0010469812 7.837324e-05 4.203016e-04 12 131714241 131714821 581 + 1.426 1.104 -1.133
ENSG00000061936 E013 306.8828352 0.0007970742 1.035536e-03 4.081128e-03 12 131714822 131714953 132 + 2.523 2.440 -0.276
ENSG00000061936 E014 239.3242860 0.0002281841 3.839202e-03 1.268974e-02 12 131719454 131719539 86 + 2.409 2.336 -0.242
ENSG00000061936 E015 0.1482932 0.0415081347 6.614561e-01   12 131723258 131723309 52 + 0.001 0.104 7.639
ENSG00000061936 E016 380.9667061 0.0007366171 2.457464e-03 8.636164e-03 12 131725405 131725630 226 + 2.610 2.540 -0.232
ENSG00000061936 E017 173.1920995 0.0005504745 8.170559e-02 1.622279e-01 12 131726940 131726988 49 + 2.260 2.205 -0.182
ENSG00000061936 E018 178.0855929 0.0004957506 2.848763e-01 4.251600e-01 12 131726989 131727052 64 + 2.259 2.224 -0.116
ENSG00000061936 E019 253.8844967 0.0002385731 3.271581e-02 7.723106e-02 12 131728293 131728428 136 + 2.422 2.368 -0.179
ENSG00000061936 E020 254.5321903 0.0001624638 4.896090e-01 6.270107e-01 12 131753123 131753363 241 + 2.404 2.384 -0.067
ENSG00000061936 E021 4.9324559 0.1165572908 2.548454e-01 3.916316e-01 12 131753364 131753489 126 + 0.904 0.653 -1.006
ENSG00000061936 E022 183.7881405 0.0002002506 1.590276e-03 5.927832e-03 12 131754368 131754499 132 + 2.198 2.280 0.273
ENSG00000061936 E023 204.6498440 0.0001770792 3.380757e-02 7.937370e-02 12 131755386 131755479 94 + 2.264 2.314 0.167
ENSG00000061936 E024 320.1984258 0.0004012733 2.731714e-01 4.121720e-01 12 131756473 131756644 172 + 2.478 2.498 0.065
ENSG00000061936 E025 340.0394487 0.0003677296 1.412500e-01 2.497517e-01 12 131764456 131764686 231 + 2.499 2.525 0.089
ENSG00000061936 E026 401.9410795 0.0001294032 6.127822e-07 5.328885e-06 12 131766118 131766308 191 + 2.531 2.619 0.292
ENSG00000061936 E027 533.7649132 0.0005912143 7.923986e-07 6.726601e-06 12 131778065 131778330 266 + 2.654 2.743 0.296
ENSG00000061936 E028 9.7953973 0.0024790965 7.912815e-05 4.237864e-04 12 131783468 131785072 1605 + 1.239 0.827 -1.516
ENSG00000061936 E029 6.1342866 0.0066727504 5.300364e-01 6.627293e-01 12 131785073 131785228 156 + 0.782 0.861 0.309
ENSG00000061936 E030 6.5757361 0.0737081178 2.780406e-01 4.176714e-01 12 131785229 131785919 691 + 0.980 0.800 -0.688
ENSG00000061936 E031 320.7642594 0.0025173399 8.141781e-10 1.226980e-08 12 131786463 131786588 126 + 2.360 2.552 0.638
ENSG00000061936 E032 0.0000000       12 131786589 131786597 9 +      
ENSG00000061936 E033 8.1276228 0.0078929212 2.413079e-02 6.008183e-02 12 131796118 131797177 1060 + 0.753 1.033 1.069
ENSG00000061936 E034 345.9919449 0.0033338550 5.999795e-06 4.197043e-05 12 131797178 131797360 183 + 2.423 2.574 0.501
ENSG00000061936 E035 219.9509149 0.0025842315 7.881505e-05 4.223601e-04 12 131799037 131799109 73 + 2.239 2.373 0.448
ENSG00000061936 E036 252.9276609 0.0014091841 4.854794e-16 1.910524e-14 12 131799423 131799738 316 + 2.224 2.463 0.796