ENSG00000061273

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354334 ENSG00000061273 HEK293_OSMI2_2hA HEK293_TMG_2hB HDAC7 protein_coding protein_coding 7.987752 12.27779 6.097476 0.8070577 0.1830743 -1.008577 1.5694427 2.2310392 0.9053148 0.18363014 0.48320458 -1.2918279 0.20527917 0.18296667 0.15343333 -0.02953333 0.826407789 0.000137384 FALSE TRUE
ENST00000459625 ENSG00000061273 HEK293_OSMI2_2hA HEK293_TMG_2hB HDAC7 protein_coding retained_intron 7.987752 12.27779 6.097476 0.8070577 0.1830743 -1.008577 0.4347158 0.2012675 0.4545107 0.03297993 0.07628329 1.1366406 0.06685833 0.01623333 0.07403333 0.05780000 0.000137384 0.000137384 TRUE TRUE
ENST00000548938 ENSG00000061273 HEK293_OSMI2_2hA HEK293_TMG_2hB HDAC7 protein_coding nonsense_mediated_decay 7.987752 12.27779 6.097476 0.8070577 0.1830743 -1.008577 2.0020285 4.5227090 0.5271163 0.49352644 0.28222351 -3.0770671 0.21601250 0.37466667 0.08513333 -0.28953333 0.188200345 0.000137384 FALSE TRUE
MSTRG.7181.3 ENSG00000061273 HEK293_OSMI2_2hA HEK293_TMG_2hB HDAC7 protein_coding   7.987752 12.27779 6.097476 0.8070577 0.1830743 -1.008577 2.8965650 4.3075412 3.2537040 1.17734886 0.64339816 -0.4036997 0.36231250 0.34436667 0.52903333 0.18466667 0.442974656 0.000137384 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000061273 E001 0.2965864 0.2981781941 5.429237e-01   12 47782722 47782725 4 - 0.000 0.162 8.852
ENSG00000061273 E002 239.6791734 0.0036728017 4.488213e-05 2.557761e-04 12 47782726 47783386 661 - 2.227 2.384 0.524
ENSG00000061273 E003 105.7790145 0.0002910219 7.975819e-03 2.371713e-02 12 47783387 47783515 129 - 1.911 2.014 0.346
ENSG00000061273 E004 98.6435239 0.0003506242 1.568119e-02 4.202450e-02 12 47783516 47783637 122 - 1.886 1.983 0.327
ENSG00000061273 E005 47.1952997 0.0007987381 1.601068e-03 5.964595e-03 12 47783638 47783650 13 - 1.504 1.691 0.637
ENSG00000061273 E006 52.3692021 0.0004885382 5.949243e-03 1.847445e-02 12 47783651 47783673 23 - 1.572 1.724 0.517
ENSG00000061273 E007 65.6934798 0.0004057261 2.319956e-01 3.648224e-01 12 47783674 47783720 47 - 1.741 1.800 0.199
ENSG00000061273 E008 85.3414945 0.0012681183 1.729643e-01 2.920486e-01 12 47783721 47783799 79 - 1.845 1.909 0.216
ENSG00000061273 E009 69.0779797 0.0005245019 7.738706e-02 1.552815e-01 12 47783800 47783840 41 - 1.741 1.826 0.288
ENSG00000061273 E010 60.6293527 0.0052340103 4.304175e-01 5.730562e-01 12 47783841 47783886 46 - 1.715 1.766 0.173
ENSG00000061273 E011 85.6786060 0.0010203771 3.859768e-01 5.301852e-01 12 47784079 47784217 139 - 1.865 1.905 0.137
ENSG00000061273 E012 10.6003337 0.0042180907 3.779477e-04 1.689302e-03 12 47784218 47784694 477 - 1.251 0.890 -1.315
ENSG00000061273 E013 4.8057025 0.0034462274 2.246473e-01 3.560121e-01 12 47784695 47784801 107 - 0.839 0.675 -0.663
ENSG00000061273 E014 8.9191378 0.0047477323 2.181727e-06 1.682532e-05 12 47784802 47785232 431 - 1.251 0.735 -1.924
ENSG00000061273 E015 6.4988119 0.0033471353 4.635800e-07 4.128224e-06 12 47785233 47785386 154 - 1.165 0.552 -2.409
ENSG00000061273 E016 67.0444547 0.0006916431 8.228318e-01 8.882932e-01 12 47785387 47785450 64 - 1.775 1.789 0.046
ENSG00000061273 E017 49.5768310 0.0006662603 2.470245e-01 3.824339e-01 12 47785451 47785471 21 - 1.608 1.674 0.226
ENSG00000061273 E018 1.2920535 0.1063406029 6.512977e-01 7.621920e-01 12 47785472 47785710 239 - 0.374 0.291 -0.517
ENSG00000061273 E019 0.8814403 0.0141698996 8.500078e-02 1.674080e-01 12 47785711 47785751 41 - 0.000 0.336 13.664
ENSG00000061273 E020 83.3890890 0.0003441922 7.786192e-01 8.575628e-01 12 47785752 47785885 134 - 1.870 1.884 0.048
ENSG00000061273 E021 67.6607054 0.0045093657 8.015091e-01 8.735264e-01 12 47786585 47786703 119 - 1.807 1.796 -0.037
ENSG00000061273 E022 58.1220483 0.0111888736 5.092804e-01 6.445990e-01 12 47787712 47787809 98 - 1.700 1.748 0.164
ENSG00000061273 E023 0.5244761 0.3029400331 3.322852e-01 4.759238e-01 12 47787810 47788044 235 - 0.282 0.093 -1.939
ENSG00000061273 E024 49.2686948 0.0042538427 1.844669e-01 3.068118e-01 12 47788045 47788095 51 - 1.598 1.683 0.291
ENSG00000061273 E025 63.2761745 0.0006814018 1.106240e-01 2.064513e-01 12 47788096 47788164 69 - 1.707 1.788 0.274
ENSG00000061273 E026 0.4815130 0.0220560374 1.000000e+00 1.000000e+00 12 47788165 47788169 5 - 0.163 0.166 0.036
ENSG00000061273 E027 0.0000000       12 47788835 47788951 117 -      
ENSG00000061273 E028 71.6077672 0.0003481279 2.890322e-01 4.297037e-01 12 47789261 47789348 88 - 1.782 1.832 0.170
ENSG00000061273 E029 59.7412083 0.0003968426 5.988465e-01 7.203697e-01 12 47789523 47789578 56 - 1.755 1.732 -0.077
ENSG00000061273 E030 60.1735117 0.0004109355 8.839559e-01 9.297962e-01 12 47789813 47789920 108 - 1.734 1.743 0.033
ENSG00000061273 E031 2.5109720 0.0060864431 9.080550e-04 3.641890e-03 12 47789921 47790376 456 - 0.810 0.286 -2.547
ENSG00000061273 E032 1.4016249 0.5034456684 7.236420e-01 8.174150e-01 12 47790377 47790463 87 - 0.449 0.297 -0.887
ENSG00000061273 E033 4.9036061 0.0703441989 3.843195e-01 5.284867e-01 12 47790464 47791258 795 - 0.839 0.678 -0.647
ENSG00000061273 E034 45.6413547 0.0005282372 7.414808e-01 8.306358e-01 12 47791259 47791308 50 - 1.608 1.629 0.072
ENSG00000061273 E035 58.7412922 0.0015766538 9.124979e-01 9.485504e-01 12 47791586 47791706 121 - 1.723 1.731 0.030
ENSG00000061273 E036 57.5821660 0.0142130345 6.528728e-01 7.634958e-01 12 47791871 47792004 134 - 1.737 1.716 -0.071
ENSG00000061273 E037 4.6438410 0.2761689410 1.573160e-01 2.715309e-01 12 47792005 47792537 533 - 0.866 0.612 -1.036
ENSG00000061273 E038 3.5751253 0.0079153930 1.351342e-04 6.818325e-04 12 47792538 47792669 132 - 0.941 0.380 -2.465
ENSG00000061273 E039 3.9534982 0.0040156161 2.128970e-05 1.311633e-04 12 47792670 47793368 699 - 0.984 0.380 -2.625
ENSG00000061273 E040 76.7699845 0.0043293126 3.301253e-01 4.737185e-01 12 47793369 47793588 220 - 1.804 1.861 0.194
ENSG00000061273 E041 34.5946231 0.0083670341 3.096896e-01 4.520334e-01 12 47794760 47794806 47 - 1.444 1.529 0.291
ENSG00000061273 E042 30.1156596 0.0070438749 1.762632e-01 2.963746e-01 12 47794807 47794835 29 - 1.358 1.474 0.400
ENSG00000061273 E043 33.0912774 0.0120198631 4.520023e-01 5.928980e-01 12 47794836 47794868 33 - 1.430 1.504 0.256
ENSG00000061273 E044 35.1085252 0.0145421205 4.539283e-01 5.946339e-01 12 47794869 47794933 65 - 1.451 1.531 0.274
ENSG00000061273 E045 57.5273182 0.0144606659 9.664277e-01 9.829268e-01 12 47795184 47795376 193 - 1.711 1.728 0.056
ENSG00000061273 E046 22.7883187 0.0065251712 3.938639e-01 5.377599e-01 12 47795377 47795380 4 - 1.383 1.314 -0.239
ENSG00000061273 E047 1.1437748 0.0108647759 4.483329e-02 9.989571e-02 12 47795381 47795586 206 - 0.515 0.166 -2.283
ENSG00000061273 E048 29.7218668 0.0433401379 9.427230e-01 9.680346e-01 12 47795587 47795610 24 - 1.464 1.442 -0.076
ENSG00000061273 E049 38.9070246 0.0105326044 6.316307e-01 7.466045e-01 12 47795611 47795666 56 - 1.582 1.548 -0.117
ENSG00000061273 E050 48.8955804 0.0061000854 3.245097e-01 4.678715e-01 12 47795667 47795767 101 - 1.699 1.637 -0.210
ENSG00000061273 E051 0.0000000       12 47795768 47795850 83 -      
ENSG00000061273 E052 2.2153401 0.0077533055 2.191095e-01 3.493048e-01 12 47795906 47796016 111 - 0.621 0.420 -0.964
ENSG00000061273 E053 22.2451986 0.0011917235 7.583182e-02 1.528320e-01 12 47796207 47796214 8 - 1.415 1.283 -0.458
ENSG00000061273 E054 38.4873772 0.0007267141 2.821861e-02 6.844808e-02 12 47796215 47796298 84 - 1.640 1.515 -0.429
ENSG00000061273 E055 32.0410996 0.0054575051 1.301084e-01 2.343138e-01 12 47797017 47797106 90 - 1.550 1.445 -0.361
ENSG00000061273 E056 23.9613449 0.0010345751 1.110289e-01 2.070530e-01 12 47797107 47797117 11 - 1.437 1.323 -0.394
ENSG00000061273 E057 27.2181484 0.0008368487 4.403049e-02 9.844387e-02 12 47797118 47797142 25 - 1.504 1.369 -0.465
ENSG00000061273 E058 36.6014598 0.0007756455 1.504519e-02 4.058994e-02 12 47797384 47797427 44 - 1.631 1.489 -0.486
ENSG00000061273 E059 20.0808442 0.0010525757 4.363056e-04 1.913927e-03 12 47797428 47797429 2 - 1.451 1.183 -0.938
ENSG00000061273 E060 34.3845171 0.0005946199 1.576755e-04 7.813130e-04 12 47797430 47797499 70 - 1.654 1.429 -0.768
ENSG00000061273 E061 23.2265173 0.0117865228 2.148496e-02 5.461384e-02 12 47798108 47798113 6 - 1.478 1.282 -0.682
ENSG00000061273 E062 22.2678700 0.0111338350 3.170799e-02 7.528056e-02 12 47798114 47798117 4 - 1.451 1.267 -0.642
ENSG00000061273 E063 36.9146667 0.0036508532 5.502441e-04 2.347636e-03 12 47798118 47798187 70 - 1.679 1.462 -0.741
ENSG00000061273 E064 23.4975303 0.0008314953 2.877712e-03 9.903969e-03 12 47798188 47798219 32 - 1.485 1.272 -0.736
ENSG00000061273 E065 0.4031496 0.0243448996 4.505542e-01 5.916499e-01 12 47798560 47798561 2 - 0.000 0.166 12.348
ENSG00000061273 E066 31.9831132 0.0083383026 1.398535e-04 7.029572e-04 12 47798562 47798639 78 - 1.654 1.374 -0.959
ENSG00000061273 E067 20.0958833 0.0106596622 1.362341e-02 3.736340e-02 12 47798640 47798652 13 - 1.422 1.204 -0.762
ENSG00000061273 E068 33.9334350 0.0009476810 1.725409e-01 2.915052e-01 12 47798785 47798972 188 - 1.556 1.473 -0.285
ENSG00000061273 E069 0.0000000       12 47798973 47799140 168 -      
ENSG00000061273 E070 4.6500450 0.0088963668 6.572240e-01 7.666262e-01 12 47802224 47802274 51 - 0.666 0.735 0.286
ENSG00000061273 E071 0.1482932 0.0421166067 1.000000e+00   12 47802436 47802512 77 - 0.000 0.091 11.270
ENSG00000061273 E072 0.3634088 0.4180741343 5.712187e-01   12 47812930 47813051 122 - 0.000 0.167 11.266
ENSG00000061273 E073 0.0000000       12 47813373 47813484 112 -      
ENSG00000061273 E074 0.0000000       12 47819120 47819142 23 -      
ENSG00000061273 E075 0.0000000       12 47819143 47819262 120 -      
ENSG00000061273 E076 7.4301507 0.0027996668 4.733475e-01 6.122949e-01 12 47819767 47819980 214 - 0.810 0.903 0.362
ENSG00000061273 E077 0.2214452 0.0372876895 1.000000e+00   12 47820483 47820553 71 - 0.000 0.091 11.301
ENSG00000061273 E078 0.0000000       12 47820554 47820612 59 -      
ENSG00000061273 E079 0.0000000       12 47833046 47833132 87 -