ENSG00000060971

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000333167 ENSG00000060971 HEK293_OSMI2_2hA HEK293_TMG_2hB ACAA1 protein_coding protein_coding 78.54596 126.5321 48.19554 2.92018 2.226762 -1.392347 38.344019 68.383457 26.099800 2.7057773 0.3409315 -1.3892669 0.46642917 0.54100000 0.54423333 0.003233333 1.000000e+00 9.814245e-46 FALSE  
ENST00000411549 ENSG00000060971 HEK293_OSMI2_2hA HEK293_TMG_2hB ACAA1 protein_coding nonsense_mediated_decay 78.54596 126.5321 48.19554 2.92018 2.226762 -1.392347 1.954148 0.000000 3.903964 0.0000000 0.4615042 8.6124865 0.03316250 0.00000000 0.08086667 0.080866667 9.814245e-46 9.814245e-46 FALSE  
ENST00000452171 ENSG00000060971 HEK293_OSMI2_2hA HEK293_TMG_2hB ACAA1 protein_coding protein_coding 78.54596 126.5321 48.19554 2.92018 2.226762 -1.392347 14.554162 30.524765 7.435471 2.8811543 0.7695668 -2.0360178 0.17217500 0.24113333 0.15376667 -0.087366667 2.243168e-02 9.814245e-46 FALSE  
ENST00000469600 ENSG00000060971 HEK293_OSMI2_2hA HEK293_TMG_2hB ACAA1 protein_coding retained_intron 78.54596 126.5321 48.19554 2.92018 2.226762 -1.392347 5.111575 4.514947 3.617271 0.6460377 0.7660202 -0.3190164 0.07327917 0.03546667 0.07390000 0.038433333 4.024488e-02 9.814245e-46 TRUE  
ENST00000480865 ENSG00000060971 HEK293_OSMI2_2hA HEK293_TMG_2hB ACAA1 protein_coding processed_transcript 78.54596 126.5321 48.19554 2.92018 2.226762 -1.392347 7.605173 10.082695 3.428637 0.5634757 0.7157134 -1.5534027 0.10662917 0.07963333 0.07060000 -0.009033333 7.949907e-01 9.814245e-46 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000060971 E001 0.6997360 0.0166146538 2.779114e-01 4.175481e-01 3 38103129 38103793 665 - 0.001 0.243 8.863
ENSG00000060971 E002 0.4470576 0.0213462547 1.319152e-01 2.367845e-01 3 38122264 38122303 40 - 0.329 0.074 -2.595
ENSG00000060971 E003 4.8482974 0.0723924835 3.574998e-01 5.018972e-01 3 38122304 38122375 72 - 0.822 0.646 -0.721
ENSG00000060971 E004 0.3686942 0.0297647290 4.256661e-01 5.685723e-01 3 38122710 38122710 1 - 0.195 0.075 -1.590
ENSG00000060971 E005 0.6652806 0.0182098556 1.000000e+00 1.000000e+00 3 38122711 38122714 4 - 0.195 0.194 -0.009
ENSG00000060971 E006 5.4538357 0.0035551474 7.130460e-03 2.156329e-02 3 38122715 38122715 1 - 0.328 0.808 2.264
ENSG00000060971 E007 5.4538357 0.0035551474 7.130460e-03 2.156329e-02 3 38122716 38122718 3 - 0.328 0.808 2.264
ENSG00000060971 E008 8.8399028 0.0018855303 3.657925e-01 5.100976e-01 3 38122719 38122722 4 - 0.823 0.939 0.443
ENSG00000060971 E009 44.9181020 0.0005177892 9.761320e-01 9.890803e-01 3 38122723 38122727 5 - 1.583 1.579 -0.016
ENSG00000060971 E010 308.3367353 0.0026596929 5.578744e-03 1.749708e-02 3 38122728 38122832 105 - 2.331 2.425 0.316
ENSG00000060971 E011 421.4149434 0.0015315713 2.093787e-03 7.514587e-03 3 38122833 38122896 64 - 2.475 2.559 0.281
ENSG00000060971 E012 328.6268710 0.0026079828 3.286301e-02 7.753464e-02 3 38122897 38122909 13 - 2.377 2.449 0.240
ENSG00000060971 E013 986.1704355 0.0014844968 2.081852e-03 7.478349e-03 3 38122910 38123122 213 - 2.857 2.923 0.219
ENSG00000060971 E014 32.2133171 0.0006845034 1.187916e-02 3.324181e-02 3 38123123 38125291 2169 - 1.564 1.391 -0.592
ENSG00000060971 E015 6.0356641 0.0092964953 3.848032e-02 8.824789e-02 3 38125292 38125563 272 - 0.977 0.694 -1.106
ENSG00000060971 E016 4.9953560 0.0033121598 9.130689e-01 9.489123e-01 3 38125564 38125564 1 - 0.695 0.710 0.059
ENSG00000060971 E017 858.1647023 0.0008065921 8.242270e-05 4.394679e-04 3 38125565 38125710 146 - 2.790 2.864 0.245
ENSG00000060971 E018 645.0273437 0.0001550330 7.896359e-02 1.578597e-01 3 38125826 38125881 56 - 2.703 2.731 0.091
ENSG00000060971 E019 54.0153313 0.0162333414 2.918350e-04 1.346532e-03 3 38125882 38126060 179 - 1.866 1.574 -0.990
ENSG00000060971 E020 30.7411461 0.0010934547 3.714461e-03 1.233857e-02 3 38126061 38126161 101 - 1.564 1.361 -0.699
ENSG00000060971 E021 789.6754031 0.0004496278 3.245870e-01 4.679652e-01 3 38126162 38126341 180 - 2.799 2.814 0.049
ENSG00000060971 E022 98.3574359 0.0003560798 1.495869e-14 4.808073e-13 3 38126342 38126492 151 - 2.125 1.828 -0.996
ENSG00000060971 E023 47.3611605 0.0007098450 2.065217e-06 1.601642e-05 3 38126493 38126509 17 - 1.789 1.524 -0.899
ENSG00000060971 E024 959.4973412 0.0001076905 1.568489e-02 4.203084e-02 3 38126510 38126700 191 - 2.872 2.902 0.101
ENSG00000060971 E025 8.3724182 0.0022170398 8.143573e-04 3.310535e-03 3 38127631 38127785 155 - 1.163 0.782 -1.423
ENSG00000060971 E026 608.1962853 0.0001471349 5.729175e-01 6.989523e-01 3 38127786 38127866 81 - 2.708 2.695 -0.041
ENSG00000060971 E027 448.5054751 0.0001640099 3.230634e-01 4.664004e-01 3 38129290 38129328 39 - 2.585 2.563 -0.073
ENSG00000060971 E028 486.2953128 0.0001165127 3.566472e-01 5.010288e-01 3 38129329 38129388 60 - 2.618 2.598 -0.066
ENSG00000060971 E029 414.0303431 0.0001417160 9.309553e-01 9.605507e-01 3 38131596 38131638 43 - 2.535 2.531 -0.015
ENSG00000060971 E030 478.5610751 0.0004217068 3.894399e-02 8.908369e-02 3 38131926 38132005 80 - 2.629 2.583 -0.151
ENSG00000060971 E031 6.5410458 0.0029310585 8.487506e-01 9.061226e-01 3 38132006 38132552 547 - 0.784 0.809 0.095
ENSG00000060971 E032 1.8068905 0.0076255678 4.089905e-01 5.525944e-01 3 38133491 38133582 92 - 0.513 0.364 -0.787
ENSG00000060971 E033 2.1787052 0.0066273255 6.429609e-01 7.556078e-01 3 38133780 38133872 93 - 0.513 0.429 -0.424
ENSG00000060971 E034 1.5070818 0.0088154752 5.811557e-01 7.057441e-01 3 38133873 38133951 79 - 0.431 0.327 -0.593
ENSG00000060971 E035 347.5463428 0.0022836486 1.962159e-01 3.214947e-01 3 38133952 38134009 58 - 2.489 2.445 -0.146
ENSG00000060971 E036 13.2906686 0.0143346441 3.549835e-02 8.261140e-02 3 38134010 38134395 386 - 1.240 1.003 -0.853
ENSG00000060971 E037 6.3702427 0.0164858121 5.883449e-02 1.246340e-01 3 38134396 38134508 113 - 0.977 0.712 -1.032
ENSG00000060971 E038 6.9645389 0.0024845023 1.909353e-04 9.251657e-04 3 38134509 38134552 44 - 1.128 0.677 -1.730
ENSG00000060971 E039 5.4133919 0.3699857293 4.944067e-01 6.313496e-01 3 38135184 38135294 111 - 0.856 0.686 -0.683
ENSG00000060971 E040 353.4494519 0.0059425935 6.664277e-04 2.775650e-03 3 38136592 38136685 94 - 2.573 2.428 -0.483
ENSG00000060971 E041 316.2201502 0.0146492820 2.691875e-03 9.349510e-03 3 38136865 38137242 378 - 2.554 2.368 -0.617