ENSG00000060749

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000399302 ENSG00000060749 HEK293_OSMI2_2hA HEK293_TMG_2hB QSER1 protein_coding protein_coding 11.6137 4.027283 17.24608 0.4553361 0.892102 2.095648 8.726520 1.54455529 14.2286502 0.37512409 0.3449593 3.195239 0.64830833 0.37663333 0.827700000 0.45106667 1.007133e-06 1.007133e-06 FALSE TRUE
ENST00000524678 ENSG00000060749 HEK293_OSMI2_2hA HEK293_TMG_2hB QSER1 protein_coding protein_coding 11.6137 4.027283 17.24608 0.4553361 0.892102 2.095648 1.025002 0.07612701 1.6584832 0.02680506 0.6133359 4.275928 0.07102917 0.01773333 0.093066667 0.07533333 8.662626e-02 1.007133e-06 FALSE TRUE
MSTRG.5334.3 ENSG00000060749 HEK293_OSMI2_2hA HEK293_TMG_2hB QSER1 protein_coding   11.6137 4.027283 17.24608 0.4553361 0.892102 2.095648 1.075378 2.40660084 0.1438834 0.29471500 0.1438834 -3.973069 0.22757083 0.60563333 0.007666667 -0.59796667 4.581917e-05 1.007133e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000060749 E001 0.2987644 0.0274038156 1.000000e+00   11 32891953 32892038 86 + 0.113 0.000 -9.262
ENSG00000060749 E002 1.7630631 0.0102961690 4.012673e-02 9.126904e-02 11 32892811 32893197 387 + 0.444 0.000 -11.839
ENSG00000060749 E003 1.8530783 0.0132953087 7.611489e-01 8.450623e-01 11 32893198 32893227 30 + 0.395 0.386 -0.051
ENSG00000060749 E004 3.2192314 0.0846857728 5.308763e-01 6.634011e-01 11 32893228 32893245 18 + 0.565 0.498 -0.312
ENSG00000060749 E005 5.0817478 0.1560236228 4.076780e-01 5.512614e-01 11 32893246 32893259 14 + 0.725 0.591 -0.572
ENSG00000060749 E006 12.3696661 0.0175866595 1.063723e-02 3.030045e-02 11 32893260 32893334 75 + 1.078 0.780 -1.126
ENSG00000060749 E007 0.2903454 0.3295993626 1.000000e+00   11 32925972 32926149 178 + 0.112 0.000 -9.249
ENSG00000060749 E008 0.3030308 0.3590776602 1.000000e+00   11 32926709 32927156 448 + 0.113 0.000 -9.261
ENSG00000060749 E009 26.6492685 0.0007360541 7.178137e-07 6.151061e-06 11 32927157 32927269 113 + 1.406 0.981 -1.510
ENSG00000060749 E010 47.0516079 0.0004574141 3.603936e-11 6.844375e-10 11 32927962 32928123 162 + 1.645 1.205 -1.521
ENSG00000060749 E011 123.2831054 0.0023007327 1.058160e-22 9.107917e-21 11 32931743 32932234 492 + 2.059 1.598 -1.554
ENSG00000060749 E012 62.4638859 0.0004074209 9.067919e-13 2.242676e-11 11 32932235 32932374 140 + 1.763 1.365 -1.360
ENSG00000060749 E013 102.3713857 0.0003147107 7.618604e-20 4.744647e-18 11 32932375 32932722 348 + 1.973 1.574 -1.351
ENSG00000060749 E014 114.8552212 0.0143667481 3.453640e-09 4.633395e-08 11 32932723 32933091 369 + 2.021 1.652 -1.243
ENSG00000060749 E015 349.2708176 0.0079395070 3.319869e-12 7.482027e-11 11 32933092 32934583 1492 + 2.486 2.243 -0.813
ENSG00000060749 E016 244.3958775 0.0003084162 1.665018e-12 3.932095e-11 11 32934584 32935435 852 + 2.315 2.188 -0.425
ENSG00000060749 E017 68.3654888 0.0011652912 2.106615e-05 1.299646e-04 11 32953857 32953972 116 + 1.774 1.606 -0.569
ENSG00000060749 E018 95.8108627 0.0003201801 1.945951e-04 9.408532e-04 11 32953973 32954179 207 + 1.905 1.815 -0.303
ENSG00000060749 E019 71.2727710 0.0046912606 2.471440e-01 3.825694e-01 11 32955296 32955412 117 + 1.759 1.772 0.043
ENSG00000060749 E020 80.3290744 0.0003215253 9.200915e-01 9.535219e-01 11 32955988 32956121 134 + 1.794 1.873 0.268
ENSG00000060749 E021 0.1515154 0.0428002616 1.000000e+00   11 32957806 32957868 63 + 0.060 0.000 -8.255
ENSG00000060749 E022 129.2062462 0.0003916408 4.526515e-01 5.934907e-01 11 32957869 32958086 218 + 1.991 2.103 0.378
ENSG00000060749 E023 110.0288083 0.0002995964 9.829562e-01 9.934123e-01 11 32966300 32966437 138 + 1.929 2.014 0.286
ENSG00000060749 E024 83.6665955 0.0004577945 4.069153e-01 5.505524e-01 11 32969046 32969143 98 + 1.820 1.865 0.152
ENSG00000060749 E025 103.9996153 0.0002790729 5.855660e-01 7.092450e-01 11 32973397 32973549 153 + 1.898 2.005 0.359
ENSG00000060749 E026 86.9582237 0.0003457478 6.436586e-01 7.561558e-01 11 32975248 32975343 96 + 1.823 1.928 0.354
ENSG00000060749 E027 3.0588564 0.2049090565 4.693505e-01 6.085957e-01 11 32975344 32975630 287 + 0.490 0.666 0.799
ENSG00000060749 E028 96.7632861 0.0002675249 3.351382e-01 4.789021e-01 11 32976334 32976453 120 + 1.864 1.989 0.420
ENSG00000060749 E029 195.4427763 0.0002370654 4.674639e-07 4.159291e-06 11 32976454 32977335 882 + 2.136 2.366 0.767
ENSG00000060749 E030 179.7067183 0.0002312751 3.593155e-02 8.345338e-02 11 32977336 32977861 526 + 2.122 2.272 0.500
ENSG00000060749 E031 693.4108826 0.0112283250 6.529696e-19 3.673987e-17 11 32977862 32980270 2409 + 2.610 3.060 1.496
ENSG00000060749 E032 0.0000000       11 32984159 32984225 67 +      
ENSG00000060749 E033 0.0000000       11 32993158 32993316 159 +