ENSG00000060642

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000686422 ENSG00000060642 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGV protein_coding retained_intron 3.075706 3.112192 2.055981 0.100996 0.1360815 -0.5957327 1.1920547 0.7768076 1.09385480 0.01501770 0.141933104 0.4884676 0.39481250 0.25033333 0.52776667 0.2774333 0.0001687254 0.0001687254 FALSE TRUE
ENST00000688522 ENSG00000060642 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGV protein_coding protein_coding 3.075706 3.112192 2.055981 0.100996 0.1360815 -0.5957327 0.9690409 1.3225676 0.53621189 0.09544527 0.095802043 -1.2866761 0.31032500 0.42503333 0.26326667 -0.1617667 0.1537911171 0.0001687254 FALSE TRUE
ENST00000691135 ENSG00000060642 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGV protein_coding protein_coding 3.075706 3.112192 2.055981 0.100996 0.1360815 -0.5957327 0.1756672 0.1377258 0.07974728 0.02202665 0.003268295 -0.7189815 0.05434583 0.04463333 0.03893333 -0.0057000 0.9346121136 0.0001687254 FALSE TRUE
ENST00000691454 ENSG00000060642 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGV protein_coding protein_coding 3.075706 3.112192 2.055981 0.100996 0.1360815 -0.5957327 0.4639226 0.6338910 0.19351785 0.03919039 0.099764451 -1.6616612 0.14691250 0.20326667 0.09976667 -0.1035000 0.4959036449 0.0001687254 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000060642 E001 0.5149111 0.0202508334 1.000000e+00 1.000000e+00 1 26787054 26787218 165 + 0.165 0.164 -0.008
ENSG00000060642 E002 0.3289534 0.0293872768 6.148630e-01   1 26787645 26787674 30 + 0.165 0.090 -1.008
ENSG00000060642 E003 1.1018439 0.0378518717 4.936512e-02 1.080290e-01 1 26787675 26787806 132 + 0.520 0.164 -2.329
ENSG00000060642 E004 0.1472490 0.0425603548 2.482534e-01   1 26787944 26787947 4 + 0.165 0.000 -12.161
ENSG00000060642 E005 0.1472490 0.0425603548 2.482534e-01   1 26787948 26787949 2 + 0.165 0.000 -12.161
ENSG00000060642 E006 0.1472490 0.0425603548 2.482534e-01   1 26787950 26787951 2 + 0.165 0.000 -12.161
ENSG00000060642 E007 0.2987644 0.0274424043 7.178511e-02   1 26787952 26787957 6 + 0.284 0.000 -13.187
ENSG00000060642 E008 0.8157519 0.0150568068 2.280050e-01 3.600501e-01 1 26787958 26787961 4 + 0.377 0.164 -1.594
ENSG00000060642 E009 0.9974562 0.0131325227 4.059999e-01 5.496533e-01 1 26787962 26787963 2 + 0.377 0.227 -1.008
ENSG00000060642 E010 1.6219518 0.0334434459 3.086221e-01 4.508983e-01 1 26787964 26787966 3 + 0.520 0.332 -1.010
ENSG00000060642 E011 4.4650203 0.0062315113 4.308699e-01 5.734812e-01 1 26787967 26787977 11 + 0.784 0.669 -0.469
ENSG00000060642 E012 7.3081628 0.0121310975 4.431416e-01 5.847084e-01 1 26787978 26787989 12 + 0.947 0.844 -0.393
ENSG00000060642 E013 8.4882291 0.0022092142 2.431069e-01 3.778385e-01 1 26787990 26788093 104 + 1.029 0.897 -0.494
ENSG00000060642 E014 6.6039453 0.0026066542 5.752182e-01 7.008880e-01 1 26788094 26788120 27 + 0.899 0.828 -0.273
ENSG00000060642 E015 7.6787328 0.0023104188 4.691871e-01 6.084775e-01 1 26788121 26788176 56 + 0.969 0.884 -0.322
ENSG00000060642 E016 6.1966562 0.0027445466 4.248378e-01 5.677741e-01 1 26788177 26788194 18 + 0.899 0.797 -0.393
ENSG00000060642 E017 12.8127204 0.0046136688 3.854855e-01 5.296798e-01 1 26788195 26788268 74 + 1.172 1.087 -0.305
ENSG00000060642 E018 6.6890439 0.0046125105 6.113929e-03 1.890754e-02 1 26788269 26788394 126 + 1.048 0.711 -1.296
ENSG00000060642 E019 9.9769709 0.0017367153 7.235541e-05 3.915538e-04 1 26788395 26788819 425 + 1.246 0.843 -1.479
ENSG00000060642 E020 0.3666179 0.0295969853 6.143538e-01 7.328494e-01 1 26788820 26788927 108 + 0.165 0.090 -1.006
ENSG00000060642 E021 0.2955422 0.0287145586 6.112679e-01   1 26788928 26789030 103 + 0.165 0.090 -1.011
ENSG00000060642 E022 2.0574674 0.0073179434 9.981632e-01 1.000000e+00 1 26789031 26789308 278 + 0.454 0.453 -0.008
ENSG00000060642 E023 2.0961891 0.0072628447 5.361814e-01 6.679333e-01 1 26789309 26789556 248 + 0.377 0.487 0.577
ENSG00000060642 E024 5.6568522 0.0030267199 8.031387e-01 8.746893e-01 1 26789557 26790758 1202 + 0.816 0.781 -0.135
ENSG00000060642 E025 23.9016307 0.0013083375 6.219129e-01 7.388056e-01 1 26790759 26790893 135 + 1.390 1.353 -0.128
ENSG00000060642 E026 27.6002423 0.0007907580 1.650860e-01 2.818105e-01 1 26794113 26794206 94 + 1.485 1.391 -0.323
ENSG00000060642 E027 36.0729195 0.0021554952 9.350225e-01 9.630895e-01 1 26794207 26794388 182 + 1.529 1.532 0.011
ENSG00000060642 E028 69.1450401 0.0004431952 1.323133e-01 2.373259e-01 1 26794389 26794802 414 + 1.849 1.784 -0.219
ENSG00000060642 E029 28.8687624 0.0013776565 1.513529e-01 2.635079e-01 1 26794803 26794833 31 + 1.498 1.400 -0.338
ENSG00000060642 E030 70.6925396 0.0005156451 6.920320e-01 7.933495e-01 1 26794834 26795214 381 + 1.808 1.823 0.052
ENSG00000060642 E031 16.0597463 0.0013917737 1.743285e-02 4.589623e-02 1 26795215 26795234 20 + 1.029 1.254 0.807
ENSG00000060642 E032 4.2748954 0.0815247785 8.903785e-01 9.339651e-01 1 26795235 26795699 465 + 0.713 0.672 -0.169
ENSG00000060642 E033 9.1419015 0.0020072509 4.548647e-02 1.010883e-01 1 26797440 26797562 123 + 0.784 1.027 0.924
ENSG00000060642 E034 19.2763303 0.0118540706 1.817254e-01 3.033996e-01 1 26797563 26797573 11 + 1.172 1.305 0.469
ENSG00000060642 E035 22.6612791 0.0013682584 2.813989e-01 4.213010e-01 1 26797574 26797614 41 + 1.279 1.362 0.289
ENSG00000060642 E036 110.3034625 0.0004003740 7.788947e-07 6.623245e-06 1 26797615 26800659 3045 + 1.880 2.050 0.573