ENSG00000060339

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265872 ENSG00000060339 HEK293_OSMI2_2hA HEK293_TMG_2hB CCAR1 protein_coding protein_coding 86.03207 46.90382 125.6355 4.696366 4.965055 1.421274 12.577488 8.697331 16.828078 0.7217668 1.2947265 0.9514250 0.15377083 0.18800000 0.13433333 -0.053666667 2.156331e-01 9.518039e-32 FALSE TRUE
ENST00000480627 ENSG00000060339 HEK293_OSMI2_2hA HEK293_TMG_2hB CCAR1 protein_coding retained_intron 86.03207 46.90382 125.6355 4.696366 4.965055 1.421274 25.698110 18.981494 32.335443 2.4142673 0.3716226 0.7682090 0.31981250 0.40270000 0.25836667 -0.144333333 1.161685e-06 9.518039e-32 FALSE FALSE
ENST00000538031 ENSG00000060339 HEK293_OSMI2_2hA HEK293_TMG_2hB CCAR1 protein_coding protein_coding 86.03207 46.90382 125.6355 4.696366 4.965055 1.421274 3.286272 0.000000 6.519838 0.0000000 0.5914856 9.3509035 0.02655000 0.00000000 0.05176667 0.051766667 9.518039e-32 9.518039e-32 FALSE FALSE
ENST00000539539 ENSG00000060339 HEK293_OSMI2_2hA HEK293_TMG_2hB CCAR1 protein_coding protein_coding 86.03207 46.90382 125.6355 4.696366 4.965055 1.421274 18.864806 2.207823 35.895139 1.1059680 1.7404970 4.0169740 0.18151250 0.04413333 0.28556667 0.241433333 2.132230e-01 9.518039e-32 FALSE TRUE
ENST00000543706 ENSG00000060339 HEK293_OSMI2_2hA HEK293_TMG_2hB CCAR1 protein_coding protein_coding 86.03207 46.90382 125.6355 4.696366 4.965055 1.421274 6.135619 8.004417 4.783856 0.9606697 0.5726553 -0.7414109 0.09473333 0.17793333 0.03783333 -0.140100000 9.662287e-06 9.518039e-32 FALSE TRUE
MSTRG.4089.22 ENSG00000060339 HEK293_OSMI2_2hA HEK293_TMG_2hB CCAR1 protein_coding   86.03207 46.90382 125.6355 4.696366 4.965055 1.421274 4.281371 3.670441 8.299621 1.1037842 1.3644536 1.1749040 0.05285000 0.07543333 0.06570000 -0.009733333 8.678855e-01 9.518039e-32 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000060339 E001 1.0404339 0.0117268467 4.832706e-01 6.213044e-01 10 68721012 68721136 125 + 0.329 0.194 -1.010
ENSG00000060339 E002 1.4101723 0.0098613094 5.945355e-01 7.167501e-01 10 68721137 68721143 7 + 0.329 0.429 0.575
ENSG00000060339 E003 1.5574213 0.0085159833 7.397548e-01 8.293815e-01 10 68721144 68721156 13 + 0.365 0.429 0.353
ENSG00000060339 E004 0.0000000       10 68721157 68721158 2 +      
ENSG00000060339 E005 1.1696869 0.1690199292 1.019334e-01 1.934463e-01 10 68721159 68721172 14 + 0.398 0.001 -9.585
ENSG00000060339 E006 6.4413912 0.0032485221 3.902047e-01 5.342000e-01 10 68721173 68721215 43 + 0.858 0.740 -0.467
ENSG00000060339 E007 10.8743392 0.0015204595 6.904981e-01 7.921854e-01 10 68721216 68721225 10 + 1.041 1.000 -0.151
ENSG00000060339 E008 12.8005564 0.0013093941 5.257652e-01 6.590964e-01 10 68721226 68721226 1 + 1.110 1.046 -0.231
ENSG00000060339 E009 21.5823064 0.0008389551 7.572771e-02 1.526666e-01 10 68721227 68721238 12 + 1.345 1.194 -0.530
ENSG00000060339 E010 30.1638148 0.0085513752 2.909607e-02 7.018825e-02 10 68721239 68721241 3 + 1.491 1.306 -0.641
ENSG00000060339 E011 64.1868596 0.0005181285 1.799500e-10 3.039226e-09 10 68721242 68721251 10 + 1.845 1.481 -1.238
ENSG00000060339 E012 73.3060732 0.0005039475 4.647993e-13 1.203593e-11 10 68721252 68721254 3 + 1.906 1.512 -1.337
ENSG00000060339 E013 145.3771333 0.0209203052 1.353697e-03 5.155368e-03 10 68721255 68721282 28 + 2.175 1.945 -0.770
ENSG00000060339 E014 30.3355156 0.0041540426 2.464693e-02 6.115475e-02 10 68721283 68721288 6 + 1.494 1.316 -0.613
ENSG00000060339 E015 21.7868419 0.0008792780 3.444814e-02 8.061986e-02 10 68721289 68721406 118 + 1.359 1.178 -0.638
ENSG00000060339 E016 5.6038840 0.0031249433 2.904399e-02 7.009206e-02 10 68721407 68721663 257 + 0.858 0.512 -1.468
ENSG00000060339 E017 234.3954500 0.0127926306 3.437521e-05 2.014246e-04 10 68722455 68722577 123 + 2.383 2.146 -0.792
ENSG00000060339 E018 261.4892355 0.0134835654 1.724778e-04 8.458773e-04 10 68736876 68737048 173 + 2.425 2.214 -0.706
ENSG00000060339 E019 109.3323632 0.0004280291 1.642856e-07 1.600834e-06 10 68737845 68737889 45 + 2.048 1.832 -0.725
ENSG00000060339 E020 115.9206307 0.0030709333 3.400234e-06 2.514793e-05 10 68740629 68740661 33 + 2.074 1.855 -0.736
ENSG00000060339 E021 142.4344925 0.0072181779 1.979971e-07 1.898373e-06 10 68742376 68742427 52 + 2.176 1.892 -0.951
ENSG00000060339 E022 226.2328352 0.0004334525 1.803236e-17 8.548991e-16 10 68742428 68742569 142 + 2.371 2.115 -0.856
ENSG00000060339 E023 217.9050036 0.0006581739 5.825437e-11 1.069391e-09 10 68747161 68747275 115 + 2.344 2.143 -0.671
ENSG00000060339 E024 338.8838934 0.0022680580 1.864057e-08 2.186219e-07 10 68747374 68747566 193 + 2.530 2.354 -0.585
ENSG00000060339 E025 296.8618530 0.0044526992 3.532863e-06 2.603736e-05 10 68749136 68749265 130 + 2.474 2.294 -0.599
ENSG00000060339 E026 362.3948385 0.0066196066 1.183404e-04 6.062532e-04 10 68749524 68749685 162 + 2.556 2.397 -0.529
ENSG00000060339 E027 389.6028356 0.0047205220 2.085173e-03 7.487866e-03 10 68753852 68754077 226 + 2.575 2.468 -0.355
ENSG00000060339 E028 273.3293558 0.0018652016 1.077420e-03 4.226051e-03 10 68754714 68754827 114 + 2.419 2.320 -0.329
ENSG00000060339 E029 0.6192988 0.0207007776 1.000000e+00 1.000000e+00 10 68755172 68755181 10 + 0.195 0.194 -0.008
ENSG00000060339 E030 7.6961538 0.0268023621 8.010865e-02 1.597224e-01 10 68755182 68755285 104 + 0.798 1.051 0.955
ENSG00000060339 E031 295.1241715 0.0065740412 5.351394e-02 1.154014e-01 10 68755370 68755475 106 + 2.446 2.373 -0.246
ENSG00000060339 E032 294.0767892 0.0035976240 3.430892e-03 1.152608e-02 10 68755476 68755536 61 + 2.451 2.351 -0.333
ENSG00000060339 E033 489.2950001 0.0012162337 1.978202e-09 2.772747e-08 10 68756273 68756483 211 + 2.682 2.539 -0.477
ENSG00000060339 E034 8.3404408 0.0019892556 1.320847e-01 2.370079e-01 10 68756526 68756632 107 + 0.977 0.782 -0.746
ENSG00000060339 E035 267.4032908 0.0003111932 9.614807e-07 8.005522e-06 10 68757294 68757349 56 + 2.416 2.290 -0.418
ENSG00000060339 E036 214.7192345 0.0001939853 1.550839e-03 5.800513e-03 10 68757350 68757377 28 + 2.311 2.225 -0.286
ENSG00000060339 E037 9.0850163 0.0086916984 2.503990e-01 3.864108e-01 10 68760810 68761006 197 + 1.002 0.856 -0.549
ENSG00000060339 E038 488.9586967 0.0001408600 2.435935e-01 3.783961e-01 10 68761007 68761192 186 + 2.649 2.632 -0.058
ENSG00000060339 E039 505.7743561 0.0027456699 5.205993e-02 1.128211e-01 10 68765888 68766079 192 + 2.640 2.707 0.223
ENSG00000060339 E040 396.2668001 0.0153128199 9.752445e-01 9.885723e-01 10 68771206 68771445 240 + 2.555 2.558 0.010
ENSG00000060339 E041 118.7903453 0.0310890153 6.194633e-01 7.368637e-01 10 68772988 68772991 4 + 2.052 1.994 -0.193
ENSG00000060339 E042 259.1165192 0.0125645030 5.416331e-01 6.725929e-01 10 68772992 68773058 67 + 2.362 2.398 0.120
ENSG00000060339 E043 274.9267097 0.0088302446 2.056692e-01 3.332656e-01 10 68773059 68773099 41 + 2.378 2.444 0.223
ENSG00000060339 E044 6.1506296 0.0090377861 7.064825e-09 8.958567e-08 10 68774952 68775019 68 + 0.431 1.194 3.110
ENSG00000060339 E045 349.3582237 0.0059679765 1.009642e-02 2.899843e-02 10 68786136 68786218 83 + 2.466 2.579 0.379
ENSG00000060339 E046 452.0641146 0.0001530500 5.023406e-25 5.507345e-23 10 68786546 68786692 147 + 2.546 2.738 0.637
ENSG00000060339 E047 4.7014112 0.0035751656 4.392247e-01 5.809888e-01 10 68786693 68786986 294 + 0.757 0.640 -0.484
ENSG00000060339 E048 2.1788095 0.0143538174 7.862659e-01 8.631011e-01 10 68787836 68787926 91 + 0.460 0.511 0.253
ENSG00000060339 E049 499.4908272 0.0001801473 2.211682e-30 3.826453e-28 10 68787927 68788047 121 + 2.585 2.788 0.678
ENSG00000060339 E050 614.6290914 0.0009373533 7.208422e-28 1.010069e-25 10 68788143 68788328 186 + 2.663 2.893 0.764
ENSG00000060339 E051 550.2707595 0.0012220367 2.136446e-33 4.646880e-31 10 68789710 68789915 206 + 2.597 2.873 0.918
ENSG00000060339 E052 475.6779902 0.0092084708 1.047317e-12 2.561797e-11 10 68791207 68792377 1171 + 2.500 2.855 1.180