ENSG00000060237

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000315939 ENSG00000060237 HEK293_OSMI2_2hA HEK293_TMG_2hB WNK1 protein_coding protein_coding 38.46055 40.57942 35.65371 3.158179 0.7366182 -0.1866466 3.186541 1.9671380 3.79006490 0.6241805 0.25411801 0.9426105 0.08370417 0.046700000 0.10620000 0.05950000 6.359072e-02 5.105298e-23 FALSE TRUE
ENST00000535572 ENSG00000060237 HEK293_OSMI2_2hA HEK293_TMG_2hB WNK1 protein_coding protein_coding 38.46055 40.57942 35.65371 3.158179 0.7366182 -0.1866466 2.621803 1.2841293 4.26783519 0.6930351 0.20862670 1.7248991 0.07130417 0.030800000 0.11960000 0.08880000 1.879083e-02 5.105298e-23 FALSE TRUE
ENST00000540885 ENSG00000060237 HEK293_OSMI2_2hA HEK293_TMG_2hB WNK1 protein_coding retained_intron 38.46055 40.57942 35.65371 3.158179 0.7366182 -0.1866466 5.240005 15.0632035 0.01533553 1.5975070 0.01533553 -9.2166082 0.12739583 0.380700000 0.00040000 -0.38030000 5.105298e-23 5.105298e-23 FALSE FALSE
ENST00000545285 ENSG00000060237 HEK293_OSMI2_2hA HEK293_TMG_2hB WNK1 protein_coding protein_coding 38.46055 40.57942 35.65371 3.158179 0.7366182 -0.1866466 3.893081 1.7615945 4.64938290 0.9034758 0.14515595 1.3950905 0.10262083 0.040233333 0.13036667 0.09013333 4.545258e-01 5.105298e-23 FALSE FALSE
ENST00000676347 ENSG00000060237 HEK293_OSMI2_2hA HEK293_TMG_2hB WNK1 protein_coding protein_coding 38.46055 40.57942 35.65371 3.158179 0.7366182 -0.1866466 12.091326 13.9168380 7.70132429 1.6444994 0.71063604 -0.8528172 0.30690000 0.341500000 0.21610000 -0.12540000 9.752859e-03 5.105298e-23 FALSE TRUE
MSTRG.6611.10 ENSG00000060237 HEK293_OSMI2_2hA HEK293_TMG_2hB WNK1 protein_coding   38.46055 40.57942 35.65371 3.158179 0.7366182 -0.1866466 5.708154 3.5542726 7.74912985 1.2650973 0.56285871 1.1222872 0.15211250 0.084766667 0.21756667 0.13280000 1.562544e-02 5.105298e-23 FALSE TRUE
MSTRG.6611.16 ENSG00000060237 HEK293_OSMI2_2hA HEK293_TMG_2hB WNK1 protein_coding   38.46055 40.57942 35.65371 3.158179 0.7366182 -0.1866466 1.188076 0.2456852 2.87244029 0.1693473 0.75798225 3.4948499 0.03297500 0.005933333 0.08063333 0.07470000 1.049519e-02 5.105298e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000060237 E001 2.7551176 0.0160087980 5.615984e-01 6.893613e-01 12 752579 752592 14 + 0.591 0.552 -0.177
ENSG00000060237 E002 53.8803625 0.0160044336 1.624243e-06 1.288531e-05 12 752593 752922 330 + 1.856 1.560 -1.003
ENSG00000060237 E003 12.1802266 0.0016543234 7.329724e-07 6.268765e-06 12 752923 753055 133 + 1.271 0.836 -1.594
ENSG00000060237 E004 19.4482504 0.0009484520 6.774384e-15 2.292171e-13 12 753056 753154 99 + 1.505 0.900 -2.157
ENSG00000060237 E005 18.9775674 0.0159865471 8.012123e-09 1.005480e-07 12 753155 753213 59 + 1.481 0.941 -1.919
ENSG00000060237 E006 38.2009010 0.0107700894 1.968534e-17 9.263110e-16 12 753214 753351 138 + 1.793 1.165 -2.165
ENSG00000060237 E007 107.3407305 0.0172790989 1.345891e-11 2.744914e-10 12 753352 753693 342 + 2.188 1.774 -1.393
ENSG00000060237 E008 62.3386921 0.0010049680 3.792659e-18 1.942963e-16 12 753694 753782 89 + 1.934 1.588 -1.171
ENSG00000060237 E009 89.0864146 0.0056442042 2.763339e-09 3.778696e-08 12 753783 753958 176 + 2.050 1.816 -0.786
ENSG00000060237 E010 46.9969165 0.0015578923 2.141128e-08 2.482437e-07 12 753959 753990 32 + 1.777 1.545 -0.789
ENSG00000060237 E011 45.7649494 0.0114514213 1.923888e-05 1.198028e-04 12 753991 754018 28 + 1.766 1.533 -0.791
ENSG00000060237 E012 167.7447468 0.0052196864 1.051829e-12 2.571173e-11 12 754019 754324 306 + 2.325 2.087 -0.794
ENSG00000060237 E013 151.8020420 0.0086682934 2.305048e-08 2.656231e-07 12 813642 813814 173 + 2.274 2.059 -0.722
ENSG00000060237 E014 179.9571570 0.0172742603 6.433968e-06 4.468421e-05 12 827042 827262 221 + 2.351 2.130 -0.737
ENSG00000060237 E015 1.7348593 0.0080973735 4.231948e-01 5.663012e-01 12 827263 827501 239 + 0.481 0.391 -0.472
ENSG00000060237 E016 0.9588482 0.0136968632 4.584842e-01 5.988008e-01 12 829925 830002 78 + 0.334 0.238 -0.664
ENSG00000060237 E017 156.9693364 0.0086981271 5.076480e-14 1.505988e-12 12 830003 830160 158 + 2.326 2.000 -1.092
ENSG00000060237 E018 0.0000000       12 851424 851782 359 +      
ENSG00000060237 E019 116.8250145 0.0124427629 1.392048e-07 1.376063e-06 12 857161 857249 89 + 2.174 1.924 -0.838
ENSG00000060237 E020 176.5803924 0.0314721987 4.672707e-05 2.651740e-04 12 859245 859464 220 + 2.358 2.095 -0.878
ENSG00000060237 E021 117.6678886 0.0157980175 1.717383e-06 1.355130e-05 12 861013 861123 111 + 2.177 1.930 -0.827
ENSG00000060237 E022 175.6472270 0.0074287905 8.704033e-07 7.322496e-06 12 861124 861343 220 + 2.316 2.157 -0.530
ENSG00000060237 E023 140.6176566 0.0036041103 8.751951e-11 1.560646e-09 12 862083 862173 91 + 2.231 2.039 -0.642
ENSG00000060237 E024 126.9280885 0.0045275688 1.722966e-09 2.443743e-08 12 862174 862234 61 + 2.189 1.994 -0.654
ENSG00000060237 E025 96.8301558 0.0060432060 3.687243e-09 4.918583e-08 12 862235 862270 36 + 2.088 1.851 -0.797
ENSG00000060237 E026 0.0000000       12 865110 865364 255 +      
ENSG00000060237 E027 3.4269669 0.0045920791 5.684840e-01 6.951686e-01 12 867866 868525 660 + 0.557 0.701 0.627
ENSG00000060237 E028 1.1352526 0.0329185331 8.604026e-02 1.690528e-01 12 868526 868567 42 + 0.110 0.453 2.666
ENSG00000060237 E029 1.8360352 0.0077921806 3.217322e-01 4.649781e-01 12 868568 869104 537 + 0.334 0.551 1.143
ENSG00000060237 E030 0.2998086 0.0308045010 9.653052e-01   12 869105 871264 2160 + 0.111 0.135 0.333
ENSG00000060237 E031 84.1395974 0.0054744679 9.223897e-08 9.424944e-07 12 871265 871348 84 + 2.018 1.810 -0.700
ENSG00000060237 E032 1.4705276 0.0818617985 1.630891e-03 6.060086e-03 12 877094 878014 921 + 0.590 0.000 -27.365
ENSG00000060237 E033 0.9158732 0.2419626152 2.036710e-01 3.307973e-01 12 878015 878211 197 + 0.388 0.136 -1.979
ENSG00000060237 E034 52.8041781 0.0004298981 1.385915e-08 1.663863e-07 12 878212 878214 3 + 1.817 1.611 -0.697
ENSG00000060237 E035 178.5845433 0.0004581749 8.879093e-23 7.694957e-21 12 878215 878361 147 + 2.341 2.137 -0.681
ENSG00000060237 E036 20.7201081 0.0032749198 3.826600e-01 5.268579e-01 12 879573 879660 88 + 1.328 1.333 0.017
ENSG00000060237 E037 43.7107487 0.0050369728 9.753133e-02 1.867214e-01 12 879661 880031 371 + 1.546 1.729 0.621
ENSG00000060237 E038 92.9231795 0.0032828382 1.528862e-05 9.738690e-05 12 880721 880999 279 + 2.022 1.902 -0.404
ENSG00000060237 E039 0.4427912 0.2306968841 6.643416e-01 7.721700e-01 12 881471 881691 221 + 0.198 0.134 -0.682
ENSG00000060237 E040 118.0156533 0.0018339073 5.535501e-09 7.168529e-08 12 881692 881763 72 + 2.137 1.989 -0.495
ENSG00000060237 E041 96.5771142 0.0013711197 4.035257e-09 5.347795e-08 12 881764 881789 26 + 2.055 1.894 -0.538
ENSG00000060237 E042 191.2902893 0.0074855940 1.379060e-05 8.868859e-05 12 881911 882073 163 + 2.338 2.212 -0.422
ENSG00000060237 E043 168.2983288 0.0032439516 1.416371e-09 2.041750e-08 12 882943 883059 117 + 2.294 2.139 -0.517
ENSG00000060237 E044 219.9756117 0.0031593205 3.010617e-08 3.387695e-07 12 883395 883568 174 + 2.396 2.277 -0.397
ENSG00000060237 E045 132.3297778 0.0013528002 1.943543e-03 7.051446e-03 12 883774 883831 58 + 2.136 2.104 -0.107
ENSG00000060237 E046 186.8812348 0.0002363666 3.984622e-07 3.593444e-06 12 884121 884243 123 + 2.298 2.239 -0.197
ENSG00000060237 E047 742.4848237 0.0019038041 3.244129e-04 1.478483e-03 12 884649 885704 1056 + 2.870 2.868 -0.004
ENSG00000060237 E048 428.8554332 0.0001589459 8.858730e-01 9.310270e-01 12 885705 886084 380 + 2.587 2.665 0.261
ENSG00000060237 E049 193.6552188 0.0001920783 6.800855e-01 7.840617e-01 12 887221 887304 84 + 2.239 2.325 0.288
ENSG00000060237 E050 194.6080714 0.0010782197 6.410506e-01 7.541516e-01 12 889140 889223 84 + 2.238 2.330 0.307
ENSG00000060237 E051 167.0227754 0.0012551929 3.655271e-01 5.098433e-01 12 890453 890510 58 + 2.167 2.274 0.357
ENSG00000060237 E052 97.8490329 0.0018359082 3.280481e-01 4.715020e-01 12 890511 890513 3 + 1.934 2.050 0.390
ENSG00000060237 E053 198.2655675 0.0032368205 2.594470e-01 3.968340e-01 12 894562 894635 74 + 2.234 2.354 0.401
ENSG00000060237 E054 583.7581482 0.0007662228 9.609575e-02 1.845153e-01 12 896071 896622 552 + 2.705 2.815 0.365
ENSG00000060237 E055 220.0723139 0.0008442013 2.932283e-04 1.352138e-03 12 896623 896732 110 + 2.242 2.419 0.591
ENSG00000060237 E056 325.4660807 0.0008208464 8.633360e-09 1.076879e-07 12 897479 897681 203 + 2.389 2.604 0.717
ENSG00000060237 E057 0.7739347 0.0148493930 7.043762e-01 8.029337e-01 12 900473 900475 3 + 0.272 0.238 -0.250
ENSG00000060237 E058 259.1070639 0.0018704695 2.683303e-08 3.050184e-07 12 900476 900596 121 + 2.274 2.520 0.820
ENSG00000060237 E059 249.9806542 0.0022073413 5.634314e-06 3.963918e-05 12 900597 900670 74 + 2.272 2.495 0.744
ENSG00000060237 E060 4.3448215 0.0039826338 7.041770e-06 4.847185e-05 12 900671 901074 404 + 0.198 0.957 3.796
ENSG00000060237 E061 3.6889075 0.0069154647 2.430185e-02 6.043782e-02 12 901561 901632 72 + 0.437 0.835 1.749
ENSG00000060237 E062 0.9233592 0.0161800219 6.108402e-01 7.301079e-01 12 904453 904494 42 + 0.198 0.322 0.924
ENSG00000060237 E063 1.0059890 0.1274104379 9.079699e-01 9.455783e-01 12 907720 907846 127 + 0.272 0.322 0.336
ENSG00000060237 E064 352.9269223 0.0024556608 1.188323e-08 1.444864e-07 12 907847 908034 188 + 2.405 2.656 0.837
ENSG00000060237 E065 20.6224238 0.0020794470 1.818343e-01 3.035293e-01 12 908035 908201 167 + 1.243 1.419 0.611
ENSG00000060237 E066 2545.7341127 0.0103165403 8.371825e-19 4.671627e-17 12 908475 911452 2978 + 3.143 3.574 1.432